This strain contains 23 protein-level mutations:
We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.
Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:
Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.
For each allele we calculated the number of peptides with increased and decreased affinitiy (two or more times). The absolute number of such peptides is showed on the left side of the figure (blue bars — weaker binding, orange bars — stronger).
While absolute numbers are of interest, they do not reflect the initial number of tighly binding peptides for the specific allele. Roughly speaking, if an allele had high number of tight binders, then vanished affinity of several peptides will not affect much the integral ability of peptide presentation. To the contrary, low number of vanished peptides could be important if the particular allele initially had narrow epitope repertoire. To account for this effect, we normalized the absolute numbers of new/vanished tight binders (IC50 affinity ≤ 50 nM) by the total number of tight binders for each allele. To avoid possible divisions by zero, we used + 1 regularization term in all denominators. For example, if some allele had no tight binders in the reference genome, and three new tight binders appeared as a result of the mutation, the relative increase will be 300%. The results are showed in the right part of the figure. Protein-specific plots are listed below.
Reference VSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
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Mutated VSGTNGTKRFDNPVLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIV
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*57:01 | STEKSNIIRGW | SIEKSNIIRGW | 135 | 2014 |
HLA-B*58:01 | STEKSNIIRGW | SIEKSNIIRGW | 183 | 2582 |
HLA-B*42:01 | LPFNDGVYFAST | LPFNDGVYFASI | 4329 | 325 |
HLA-B*53:01 | LPFNDGVYFAST | LPFNDGVYFASI | 6125 | 497 |
HLA-C*12:03 | ASTEKSNII | ASIEKSNII | 2443 | 439 |
HLA-A*31:01 | ASTEKSNIIR | ASIEKSNIIR | 1324 | 354 |
HLA-C*03:03 | FASTEKSNII | FASIEKSNII | 1633 | 453 |
HLA-C*03:04 | FASTEKSNII | FASIEKSNII | 1633 | 453 |
HLA-A*68:01 | ASTEKSNIIR | ASIEKSNIIR | 1387 | 410 |
HLA-C*12:03 | FASTEKSNII | FASIEKSNII | 902 | 268 |
HLA-A*11:01 | ASTEKSNIIR | ASIEKSNIIR | 1555 | 495 |
HLA-C*15:02 | ASTEKSNII | ASIEKSNII | 729 | 264 |
HLA-B*44:02 | TEKSNIIRGW | IEKSNIIRGW | 20 | 55 |
HLA-B*44:03 | TEKSNIIRGW | IEKSNIIRGW | 33 | 84 |
HLA-C*16:01 | ASTEKSNII | ASIEKSNII | 603 | 239 |
HLA-A*68:01 | STEKSNIIR | SIEKSNIIR | 186 | 458 |
HLA-A*33:03 | YFASTEKSNIIR | YFASIEKSNIIR | 337 | 148 |
HLA-A*11:01 | GVYFASTEKS | GVYFASIEKS | 648 | 298 |
HLA-A*11:01 | DGVYFASTEK | DGVYFASIEK | 205 | 96 |
HLA-B*58:01 | ASTEKSNIIRGW | ASIEKSNIIRGW | 245 | 122 |
Reference LLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCT
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Mutated LLIVNNATNVVIKVCEFQFCNDPFLDVYYHKNNKSWMKSEFRVYSSANNCT
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*68:01 | GVYYHKNNKSWME | DVYYHKNNKSWMK | 31773 | 121 |
HLA-A*03:01 | GVYYHKNNK | DVYYHKNNK | 27 | 2841 |
HLA-A*30:01 | GVYYHKNNK | DVYYHKNNK | 51 | 3035 |
HLA-A*11:01 | GVYYHKNNK | DVYYHKNNK | 51 | 1768 |
HLA-A*03:02 | GVYYHKNNK | DVYYHKNNK | 119 | 3887 |
HLA-A*31:01 | GVYYHKNNK | DVYYHKNNK | 375 | 5203 |
HLA-A*68:01 | GVYYHKNNK | DVYYHKNNK | 363 | 28 |
HLA-A*68:02 | FCNDPFLGV | FCNDPFLDV | 281 | 3555 |
HLA-A*33:03 | GVYYHKNNK | DVYYHKNNK | 3253 | 287 |
HLA-A*02:06 | FCNDPFLGV | FCNDPFLDV | 116 | 1132 |
HLA-A*02:11 | FCNDPFLGV | FCNDPFLDV | 87 | 751 |
HLA-A*02:06 | EFQFCNDPFLGV | EFQFCNDPFLDV | 87 | 554 |
HLA-A*30:02 | CNDPFLGVY | CNDPFLDVY | 310 | 1959 |
HLA-A*02:02 | FCNDPFLGV | FCNDPFLDV | 365 | 2187 |
HLA-A*02:06 | FQFCNDPFLGVY | FQFCNDPFLDVY | 135 | 784 |
HLA-A*30:02 | FCNDPFLGVY | FCNDPFLDVY | 408 | 1738 |
HLA-A*02:11 | EFQFCNDPFLGV | EFQFCNDPFLDV | 334 | 1214 |
HLA-A*02:02 | EFQFCNDPFLGV | EFQFCNDPFLDV | 477 | 1725 |
HLA-A*02:11 | FQFCNDPFLGVY | FQFCNDPFLDVY | 488 | 1737 |
HLA-A*02:06 | FQFCNDPFLGV | FQFCNDPFLDV | 7 | 21 |
HLA-A*02:11 | FQFCNDPFLGV | FQFCNDPFLDV | 17 | 49 |
HLA-A*02:01 | FQFCNDPFLGV | FQFCNDPFLDV | 39 | 111 |
HLA-A*30:02 | FQFCNDPFLGVY | FQFCNDPFLDVY | 336 | 923 |
HLA-A*02:02 | FQFCNDPFLGV | FQFCNDPFLDV | 45 | 122 |
HLA-B*15:01 | FQFCNDPFLGVY | FQFCNDPFLDVY | 28 | 56 |
Reference KVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDL
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Mutated KVCEFQFCNDPFLDVYYHKNNKSWMKSEFRVYSSANNCTFEYVSQPFLMDL
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*18:01 | MESEFRVY | MKSEFRVY | 11 | 4761 |
HLA-B*45:01 | MESEFRVYS | MKSEFRVYS | 54 | 16950 |
HLA-A*68:01 | GVYYHKNNKSWME | DVYYHKNNKSWMK | 31773 | 121 |
HLA-B*45:01 | MESEFRVYSS | MKSEFRVYSS | 143 | 21248 |
HLA-A*30:01 | ESEFRVYSSA | KSEFRVYSSA | 6456 | 81 |
HLA-B*40:06 | MESEFRVYS | MKSEFRVYS | 299 | 20127 |
HLA-B*50:01 | MESEFRVYS | MKSEFRVYS | 146 | 9501 |
HLA-B*44:03 | MESEFRVY | MKSEFRVY | 439 | 27546 |
HLA-B*18:01 | MESEFRVYS | MKSEFRVYS | 338 | 17124 |
HLA-B*40:02 | MESEFRVYS | MKSEFRVYS | 383 | 19249 |
HLA-A*31:01 | VYYHKNNKSWME | VYYHKNNKSWMK | 12963 | 261 |
HLA-A*68:02 | ESEFRVYSSA | KSEFRVYSSA | 187 | 8505 |
HLA-B*15:01 | WMESEFRVYS | WMKSEFRVYS | 2689 | 185 |
HLA-B*15:01 | SWMESEFRVY | SWMKSEFRVY | 308 | 31 |
HLA-A*31:01 | KSWMESEFRV | KSWMKSEFRV | 1326 | 140 |
HLA-A*31:01 | NKSWMESEFR | NKSWMKSEFR | 402 | 44 |
HLA-B*15:01 | WMESEFRVY | WMKSEFRVY | 67 | 8 |
HLA-A*02:11 | WMESEFRV | WMKSEFRV | 156 | 1027 |
HLA-B*45:01 | MESEFRVYSSA | MKSEFRVYSSA | 73 | 468 |
HLA-A*31:01 | HKNNKSWMESEFR | HKNNKSWMKSEFR | 806 | 137 |
HLA-A*31:01 | YHKNNKSWMESEFR | YHKNNKSWMKSEFR | 2775 | 483 |
HLA-A*02:11 | SWMESEFRV | SWMKSEFRV | 262 | 1409 |
HLA-A*33:03 | NKSWMESEFR | NKSWMKSEFR | 293 | 55 |
HLA-B*15:01 | KSWMESEFRVY | KSWMKSEFRVY | 888 | 168 |
HLA-A*02:02 | WMESEFRV | WMKSEFRV | 320 | 1577 |
HLA-A*30:01 | KSWMESEFR | KSWMKSEFR | 1652 | 343 |
HLA-B*40:02 | ESEFRVYSSA | KSEFRVYSSA | 1143 | 252 |
HLA-B*15:03 | MESEFRVY | MKSEFRVY | 180 | 40 |
HLA-A*30:01 | KSWMESEFRV | KSWMKSEFRV | 1735 | 390 |
HLA-A*33:03 | HKNNKSWMESEFR | HKNNKSWMKSEFR | 1069 | 243 |
HLA-A*31:01 | NNKSWMESEFR | NNKSWMKSEFR | 1040 | 240 |
HLA-A*31:01 | SWMESEFR | SWMKSEFR | 1908 | 442 |
HLA-A*33:03 | YHKNNKSWMESEFR | YHKNNKSWMKSEFR | 2028 | 496 |
HLA-C*12:03 | WMESEFRVY | WMKSEFRVY | 1352 | 336 |
HLA-A*74:01 | KSWMESEFR | KSWMKSEFR | 546 | 136 |
HLA-A*33:03 | KSWMESEFR | KSWMKSEFR | 541 | 135 |
HLA-C*12:02 | WMESEFRVY | WMKSEFRVY | 830 | 236 |
HLA-A*31:01 | KSWMESEFR | KSWMKSEFR | 17 | 5 |
HLA-B*40:06 | ESEFRVYSSA | KSEFRVYSSA | 581 | 171 |
HLA-A*31:01 | KNNKSWMESEFR | KNNKSWMKSEFR | 126 | 40 |
HLA-B*15:03 | WMESEFRVYS | WMKSEFRVYS | 1419 | 453 |
HLA-A*02:06 | KSWMESEFRV | KSWMKSEFRV | 255 | 723 |
HLA-B*15:03 | SWMESEFRVY | SWMKSEFRVY | 196 | 72 |
HLA-A*02:11 | KSWMESEFRV | KSWMKSEFRV | 212 | 532 |
HLA-B*50:01 | ESEFRVYSSA | KSEFRVYSSA | 314 | 132 |
HLA-A*33:03 | NNKSWMESEFR | NNKSWMKSEFR | 340 | 150 |
HLA-B*35:01 | WMESEFRVY | WMKSEFRVY | 336 | 731 |
HLA-B*58:01 | KSWMESEF | KSWMKSEF | 465 | 1002 |
HLA-A*03:02 | KSWMESEFR | KSWMKSEFR | 465 | 224 |
HLA-B*15:03 | WMESEFRVY | WMKSEFRVY | 10 | 5 |
Reference DDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGS
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Mutated DDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGS
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*31:01 | KVGGNYNYL | KVGGNYNYR | 5813 | 13 |
HLA-A*02:11 | YLYRLFRKSNL | YRYRLFRKSNL | 82 | 22451 |
HLA-A*68:01 | SKVGGNYNYL | SKVGGNYNYR | 24692 | 119 |
HLA-B*27:05 | YLYRLFRK | YRYRLFRK | 9806 | 50 |
HLA-A*02:11 | YLYRLFRKS | YRYRLFRKS | 179 | 28031 |
HLA-A*02:02 | YLYRLFRKSNL | YRYRLFRKSNL | 188 | 23354 |
HLA-A*02:11 | KVGGNYNYL | KVGGNYNYR | 111 | 13729 |
HLA-B*27:05 | YLYRLFRKS | YRYRLFRKS | 13862 | 117 |
HLA-A*33:03 | DSKVGGNYNYL | DSKVGGNYNYR | 30679 | 292 |
HLA-B*27:05 | YLYRLFRKSNLK | YRYRLFRKSNLK | 2218 | 22 |
HLA-A*31:01 | SKVGGNYNYL | SKVGGNYNYR | 21677 | 233 |
HLA-A*03:01 | YLYRLFRK | YRYRLFRK | 204 | 18425 |
HLA-A*68:01 | KVGGNYNYL | KVGGNYNYR | 25432 | 286 |
HLA-A*33:03 | KVGGNYNYL | KVGGNYNYR | 22954 | 269 |
HLA-A*11:01 | KVGGNYNYL | KVGGNYNYR | 16150 | 194 |
HLA-A*02:02 | KVGGNYNYL | KVGGNYNYR | 279 | 23086 |
HLA-A*68:01 | DSKVGGNYNYL | DSKVGGNYNYR | 28915 | 378 |
HLA-A*03:02 | YLYRLFRK | YRYRLFRK | 327 | 22983 |
HLA-A*02:01 | YLYRLFRKSNL | YRYRLFRKSNL | 471 | 28211 |
HLA-A*33:03 | SKVGGNYNYL | SKVGGNYNYR | 27973 | 469 |
HLA-A*03:02 | KVGGNYNYL | KVGGNYNYR | 12848 | 234 |
HLA-A*02:06 | KVGGNYNYL | KVGGNYNYR | 452 | 18600 |
HLA-B*27:05 | YLYRLFRKSNLKP | YRYRLFRKSNLKP | 13004 | 347 |
HLA-B*27:05 | YLYRLFRKSNLKPF | YRYRLFRKSNLKPF | 7101 | 214 |
HLA-B*27:05 | YLYRLFRKSNL | YRYRLFRKSNL | 1360 | 48 |
HLA-B*15:01 | YLYRLFRKSNLKPF | YRYRLFRKSNLKPF | 476 | 9205 |
HLA-B*08:01 | YLYRLFRKSNL | YRYRLFRKSNL | 160 | 1946 |
HLA-A*30:01 | LYRLFRKSN | RYRLFRKSN | 1444 | 120 |
HLA-A*30:01 | LYRLFRKSNL | RYRLFRKSNL | 1104 | 93 |
HLA-A*02:11 | KVGGNYNYLYRL | KVGGNYNYRYRL | 274 | 3087 |
HLA-A*30:01 | LYRLFRKSNLKP | RYRLFRKSNLKP | 3059 | 277 |
HLA-A*30:01 | LYRLFRKSNLK | RYRLFRKSNLK | 192 | 21 |
HLA-A*03:01 | LYRLFRKSNLKP | RYRLFRKSNLKP | 3564 | 430 |
HLA-A*30:01 | NYLYRLFRK | NYRYRLFRK | 512 | 64 |
HLA-B*27:05 | LYRLFRKSNL | RYRLFRKSNL | 932 | 123 |
HLA-A*23:01 | GNYNYLYRLF | GNYNYRYRLF | 181 | 1119 |
HLA-A*23:01 | NYNYLYRLF | NYNYRYRLF | 20 | 119 |
HLA-A*23:01 | KVGGNYNYLYRLF | KVGGNYNYRYRLF | 410 | 2404 |
HLA-A*23:01 | VGGNYNYLYRLF | VGGNYNYRYRLF | 222 | 1236 |
HLA-A*29:02 | VGGNYNYLY | VGGNYNYRY | 94 | 518 |
HLA-A*31:01 | LYRLFRKSNLK | RYRLFRKSNLK | 356 | 67 |
HLA-A*30:01 | YLYRLFRKSNLK | YRYRLFRKSNLK | 1354 | 258 |
HLA-A*24:02 | NYNYLYRLF | NYNYRYRLF | 21 | 108 |
HLA-A*29:02 | KVGGNYNYLY | KVGGNYNYRY | 100 | 505 |
HLA-A*24:02 | GNYNYLYRLF | GNYNYRYRLF | 325 | 1597 |
HLA-A*01:01 | NLDSKVGGNYNYLY | NLDSKVGGNYNYRY | 193 | 909 |
HLA-A*24:02 | VGGNYNYLYRLF | VGGNYNYRYRLF | 391 | 1596 |
HLA-A*03:01 | LYRLFRKSNLK | RYRLFRKSNLK | 65 | 18 |
HLA-A*03:02 | LYRLFRKSNLK | RYRLFRKSNLK | 242 | 72 |
HLA-A*30:01 | YNYLYRLFRK | YNYRYRLFRK | 379 | 125 |
HLA-A*11:01 | LYRLFRKSNLK | RYRLFRKSNLK | 952 | 401 |
HLA-B*15:03 | SKVGGNYNYLY | SKVGGNYNYRY | 313 | 720 |
HLA-A*30:02 | VGGNYNYLY | VGGNYNYRY | 45 | 93 |
Reference SNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYR
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Mutated SNLKPFERDISTEIYQAGSTPCNGVQGFNCYFPLQSYGFQPTNGVGYQPYR
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*15:01 | VEGFNCYFPLQSY | VQGFNCYFPLQSY | 6354 | 97 |
HLA-B*40:01 | VEGFNCYFPL | VQGFNCYFPL | 76 | 3485 |
HLA-B*40:02 | VEGFNCYFPL | VQGFNCYFPL | 31 | 1281 |
HLA-B*15:03 | VEGFNCYF | VQGFNCYF | 4146 | 152 |
HLA-A*02:06 | VEGFNCYFPL | VQGFNCYFPL | 1553 | 59 |
HLA-A*02:11 | VEGFNCYFPL | VQGFNCYFPL | 3440 | 135 |
HLA-B*15:03 | VEGFNCYFPLQSY | VQGFNCYFPLQSY | 1081 | 47 |
HLA-A*02:01 | VEGFNCYFPL | VQGFNCYFPL | 4675 | 254 |
HLA-A*02:02 | VEGFNCYFPL | VQGFNCYFPL | 2837 | 168 |
HLA-B*15:03 | VEGFNCYFPL | VQGFNCYFPL | 943 | 64 |
HLA-A*30:02 | VEGFNCYFPLQSY | VQGFNCYFPLQSY | 3237 | 368 |
HLA-A*68:02 | EGFNCYFPL | QGFNCYFPL | 117 | 844 |
HLA-B*15:01 | GVEGFNCYF | GVQGFNCYF | 3125 | 455 |
HLA-B*15:03 | EGFNCYFPL | QGFNCYFPL | 2980 | 473 |
HLA-B*15:03 | GVEGFNCYF | GVQGFNCYF | 1657 | 293 |
HLA-A*30:02 | EGFNCYFPLQSY | QGFNCYFPLQSY | 1806 | 340 |
HLA-A*02:06 | EGFNCYFPL | QGFNCYFPL | 1266 | 295 |
HLA-A*29:02 | EGFNCYFPLQSY | QGFNCYFPLQSY | 1164 | 466 |
HLA-B*35:01 | NGVEGFNCY | NGVQGFNCY | 346 | 838 |
Reference PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
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Mutated PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-C*05:01 | YQDVNCTEV | YQGVNCTEV | 82 | 8597 |
HLA-C*08:02 | YQDVNCTEV | YQGVNCTEV | 89 | 8066 |
HLA-A*02:11 | DVNCTEVPV | GVNCTEVPV | 2140 | 72 |
HLA-A*02:02 | DVNCTEVPV | GVNCTEVPV | 4099 | 213 |
HLA-A*68:02 | DVNCTEVPV | GVNCTEVPV | 36 | 659 |
HLA-A*02:06 | DVNCTEVPV | GVNCTEVPV | 3807 | 208 |
HLA-A*68:02 | QVAVLYQDV | QVAVLYQGV | 183 | 13 |
HLA-A*68:02 | NQVAVLYQDV | NQVAVLYQGV | 650 | 52 |
HLA-A*02:06 | QVAVLYQDV | QVAVLYQGV | 1312 | 148 |
HLA-A*02:11 | QVAVLYQDV | QVAVLYQGV | 2169 | 268 |
HLA-A*68:02 | NTSNQVAVLYQDV | NTSNQVAVLYQGV | 1858 | 231 |
HLA-A*68:02 | TSNQVAVLYQDV | TSNQVAVLYQGV | 3281 | 457 |
HLA-A*02:02 | QVAVLYQDV | QVAVLYQGV | 1107 | 188 |
HLA-A*02:01 | YQDVNCTEV | YQGVNCTEV | 75 | 315 |
HLA-A*02:06 | YQDVNCTEV | YQGVNCTEV | 17 | 57 |
HLA-A*02:11 | VLYQDVNCT | VLYQGVNCT | 224 | 74 |
HLA-A*02:11 | YQDVNCTEV | YQGVNCTEV | 31 | 93 |
HLA-A*02:11 | VLYQDVNCTEVP | VLYQGVNCTEVP | 1000 | 402 |
HLA-A*02:02 | NQVAVLYQDV | NQVAVLYQGV | 269 | 116 |
HLA-A*02:11 | AVLYQDVNCTEV | AVLYQGVNCTEV | 500 | 238 |
HLA-A*02:01 | NQVAVLYQDV | NQVAVLYQGV | 558 | 267 |
HLA-A*02:06 | NQVAVLYQDV | NQVAVLYQGV | 36 | 18 |
Reference VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVA
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Mutated VNNSYECDIPIGAGICASYQTQTNSRRRARSVASQSIIAYTMSLGAENSVA
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*07:02 | SPRRARSVA | SRRRARSVA | 4 | 4441 |
HLA-B*42:01 | SPRRARSVA | SRRRARSVA | 8 | 6100 |
HLA-B*07:02 | SPRRARSVASQSI | SRRRARSVASQSI | 17 | 12179 |
HLA-B*07:02 | SPRRARSV | SRRRARSV | 24 | 14015 |
HLA-B*07:02 | SPRRARSVAS | SRRRARSVAS | 37 | 16690 |
HLA-A*31:01 | ASYQTQTNSP | ASYQTQTNSR | 32767 | 83 |
HLA-B*07:02 | SPRRARSVASQSII | SRRRARSVASQSII | 55 | 18257 |
HLA-A*31:01 | SYQTQTNSP | SYQTQTNSR | 28695 | 96 |
HLA-B*42:01 | SPRRARSV | SRRRARSV | 38 | 11288 |
HLA-B*42:01 | SPRRARSVASQSI | SRRRARSVASQSI | 48 | 14255 |
HLA-A*33:03 | SYQTQTNSP | SYQTQTNSR | 32767 | 122 |
HLA-A*11:01 | ASYQTQTNSP | ASYQTQTNSR | 28751 | 146 |
HLA-B*07:02 | TNSPRRARSVA | TNSRRRARSVA | 125 | 19949 |
HLA-A*68:01 | ASYQTQTNSP | ASYQTQTNSR | 32767 | 212 |
HLA-B*42:01 | SPRRARSVAS | SRRRARSVAS | 158 | 19305 |
HLA-B*07:02 | NSPRRARSVA | NSRRRARSVA | 69 | 6677 |
HLA-B*07:02 | TQTNSPRRARSVA | TQTNSRRRARSVA | 270 | 18446 |
HLA-B*42:01 | SPRRARSVASQSII | SRRRARSVASQSII | 321 | 21055 |
HLA-B*07:02 | QTNSPRRARSVA | QTNSRRRARSVA | 249 | 14015 |
HLA-B*42:01 | TNSPRRARSVA | TNSRRRARSVA | 437 | 20986 |
HLA-B*42:01 | NSPRRARSVA | NSRRRARSVA | 217 | 7845 |
HLA-A*30:01 | NSPRRARSV | NSRRRARSV | 7195 | 290 |
HLA-B*08:01 | NSPRRARSV | NSRRRARSV | 881 | 45 |
HLA-A*68:01 | TQTNSPRRAR | TQTNSRRRAR | 254 | 2467 |
HLA-A*68:01 | QTNSPRRAR | QTNSRRRAR | 95 | 788 |
HLA-B*27:05 | PRRARSVASQSI | RRRARSVASQSI | 3476 | 498 |
HLA-B*08:01 | SPRRARSVA | SRRRARSVA | 372 | 1939 |
HLA-A*68:01 | CASYQTQTNSPR | CASYQTQTNSRR | 142 | 592 |
HLA-A*31:01 | YQTQTNSPR | YQTQTNSRR | 441 | 1618 |
HLA-B*08:01 | SPRRARSV | SRRRARSV | 428 | 1510 |
HLA-A*11:01 | ASYQTQTNSPR | ASYQTQTNSRR | 346 | 1046 |
HLA-A*31:01 | ASYQTQTNSPR | ASYQTQTNSRR | 139 | 389 |
HLA-A*68:01 | QTQTNSPRR | QTQTNSRRR | 119 | 315 |
HLA-A*68:01 | YQTQTNSPRR | YQTQTNSRRR | 206 | 538 |
HLA-A*31:01 | SYQTQTNSPR | SYQTQTNSRR | 62 | 153 |
HLA-A*33:03 | YQTQTNSPRRAR | YQTQTNSRRRAR | 306 | 723 |
HLA-A*33:03 | TQTNSPRRAR | TQTNSRRRAR | 195 | 455 |
HLA-A*33:03 | SYQTQTNSPR | SYQTQTNSRR | 130 | 287 |
HLA-A*31:01 | QTQTNSPRRAR | QTQTNSRRRAR | 394 | 846 |
HLA-A*31:01 | SYQTQTNSPRRAR | SYQTQTNSRRRAR | 193 | 408 |
HLA-A*31:01 | TQTNSPRRAR | TQTNSRRRAR | 144 | 295 |
Reference GYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFV
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated GYHLMSFPQSAPHGVVFLHVTYVPAHEKNFTTAPAICHDGKAHFPREGVFV
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*15:03 | LHVTYVPAQ | LHVTYVPAH | 4284 | 296 |
HLA-A*31:01 | VTYVPAQEK | VTYVPAHEK | 1216 | 347 |
HLA-A*68:01 | FLHVTYVPAQEK | FLHVTYVPAHEK | 235 | 78 |
HLA-A*68:01 | VTYVPAQEK | VTYVPAHEK | 126 | 42 |
HLA-A*11:01 | VTYVPAQEKN | VTYVPAHEKN | 747 | 269 |
HLA-B*45:01 | QEKNFTTAPA | HEKNFTTAPA | 24 | 61 |
HLA-A*11:01 | FLHVTYVPAQEK | FLHVTYVPAHEK | 419 | 182 |
HLA-C*14:02 | TYVPAQEKNF | TYVPAHEKNF | 481 | 209 |
HLA-A*24:02 | TYVPAQEKNF | TYVPAHEKNF | 100 | 46 |
HLA-B*45:01 | QEKNFTTAP | HEKNFTTAP | 91 | 194 |
HLA-A*03:02 | VTYVPAQEK | VTYVPAHEK | 65 | 31 |
HLA-A*11:01 | VFLHVTYVPAQEK | VFLHVTYVPAHEK | 398 | 190 |
HLA-A*23:01 | TYVPAQEKNF | TYVPAHEKNF | 83 | 40 |
HLA-A*03:02 | FLHVTYVPAQEK | FLHVTYVPAHEK | 819 | 401 |
Reference GGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLN
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated GGSQASSRSSSRSRNSSRNSTPGSSMGTSPARMAGNGGDAALALLLLDRLN
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*15:03 | RNSTPGSSR | RNSTPGSSM | 16125 | 70 |
HLA-A*31:01 | SSRNSTPGSSR | SSRNSTPGSSM | 127 | 22198 |
HLA-A*31:01 | RNSTPGSSR | RNSTPGSSM | 123 | 18362 |
HLA-A*68:01 | NSSRNSTPGSSR | NSSRNSTPGSSM | 270 | 29029 |
HLA-B*15:03 | SRNSTPGSSR | SRNSTPGSSM | 25421 | 299 |
HLA-C*16:01 | NSTPGSSR | NSTPGSSM | 29183 | 443 |
HLA-A*11:01 | SSRGTSPAR | SSMGTSPAR | 1462 | 49 |
HLA-A*68:01 | TPGSSRGTSPAR | TPGSSMGTSPAR | 2549 | 139 |
HLA-C*03:03 | SSRGTSPARM | SSMGTSPARM | 3138 | 197 |
HLA-C*03:04 | SSRGTSPARM | SSMGTSPARM | 3138 | 197 |
HLA-A*30:01 | SSRGTSPARM | SSMGTSPARM | 186 | 2270 |
HLA-A*68:01 | STPGSSRGTSPAR | STPGSSMGTSPAR | 860 | 74 |
HLA-A*30:01 | SSRGTSPARMA | SSMGTSPARMA | 147 | 1705 |
HLA-B*15:03 | SRGTSPARM | SMGTSPARM | 2669 | 248 |
HLA-A*68:01 | SSRGTSPAR | SSMGTSPAR | 186 | 19 |
HLA-A*30:01 | SSRGTSPAR | SSMGTSPAR | 36 | 350 |
HLA-A*30:01 | SSRGTSPA | SSMGTSPA | 297 | 2503 |
HLA-A*03:02 | SSRGTSPAR | SSMGTSPAR | 2510 | 340 |
HLA-C*03:02 | SSRGTSPARM | SSMGTSPARM | 1244 | 176 |
HLA-B*15:03 | SSRGTSPARM | SSMGTSPARM | 1402 | 217 |
HLA-C*16:01 | SSRGTSPARM | SSMGTSPARM | 843 | 153 |
HLA-A*30:01 | RGTSPARMAG | MGTSPARMAG | 226 | 1123 |
HLA-A*30:01 | SSRGTSPARMAG | SSMGTSPARMAG | 449 | 2001 |
HLA-A*68:01 | NSTPGSSRGTSPAR | NSTPGSSMGTSPAR | 1348 | 416 |
HLA-A*68:01 | GSSRGTSPAR | GSSMGTSPAR | 615 | 219 |
HLA-A*33:03 | STPGSSRGTSPAR | STPGSSMGTSPAR | 968 | 432 |
HLA-A*11:01 | GSSRGTSPAR | GSSMGTSPAR | 505 | 251 |
Reference LLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDD
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated LLNKHIDAYKTFPPTEPKKDKKKKAYETQALPQRQKKQQTVTLLPAADLDD
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-C*08:02 | KADETQAL | KAYETQAL | 84 | 11531 |
HLA-C*05:01 | KADETQAL | KAYETQAL | 164 | 15121 |
HLA-A*31:01 | ADETQALPQR | AYETQALPQR | 17747 | 476 |
HLA-C*16:01 | KADETQAL | KAYETQAL | 1681 | 76 |
HLA-C*03:03 | KADETQAL | KAYETQAL | 2621 | 200 |
HLA-C*03:04 | KADETQAL | KAYETQAL | 2621 | 200 |
HLA-A*31:01 | KADETQALPQR | KAYETQALPQR | 1771 | 140 |
HLA-C*03:02 | KADETQAL | KAYETQAL | 4694 | 456 |
HLA-A*03:01 | KADETQALPQRQK | KAYETQALPQRQK | 3113 | 316 |
HLA-B*15:03 | KKADETQAL | KKAYETQAL | 48 | 18 |
HLA-B*15:03 | KKKADETQAL | KKKAYETQAL | 560 | 253 |
Reference LWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTR
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated LWPVTLACFVLAAVYRINWITGGIASAMACLVGLMWLSYFIASFRLFARTR
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-C*14:02 | NWITGGIAI | NWITGGIAS | 109 | 6985 |
HLA-A*02:11 | AIAMACLVGL | ASAMACLVGL | 53 | 735 |
HLA-B*27:05 | YRINWITGGIAI | YRINWITGGIAS | 85 | 867 |
HLA-A*02:01 | AIAMACLVGL | ASAMACLVGL | 97 | 843 |
HLA-A*02:02 | AIAMACLVGL | ASAMACLVGL | 41 | 335 |
HLA-A*68:02 | IAMACLVGL | SAMACLVGL | 424 | 68 |
HLA-A*02:11 | GIAIAMACL | GIASAMACL | 350 | 71 |
HLA-A*02:11 | WITGGIAIA | WITGGIASA | 788 | 179 |
HLA-A*02:02 | GIAIAMACL | GIASAMACL | 110 | 28 |
HLA-A*02:02 | GGIAIAMACL | GGIASAMACL | 596 | 163 |
HLA-A*02:06 | WITGGIAIA | WITGGIASA | 477 | 139 |
HLA-B*57:01 | AIAMACLVGLMW | ASAMACLVGLMW | 538 | 157 |
HLA-A*02:06 | GIAIAMACL | GIASAMACL | 662 | 200 |
HLA-A*02:01 | GIAIAMACL | GIASAMACL | 1243 | 376 |
HLA-A*02:02 | GIAIAMACLV | GIASAMACLV | 84 | 26 |
HLA-B*58:01 | IAIAMACLVGLMW | IASAMACLVGLMW | 54 | 17 |
HLA-B*58:01 | AIAMACLVGLMW | ASAMACLVGLMW | 235 | 74 |
HLA-A*02:02 | WITGGIAIA | WITGGIASA | 333 | 106 |
HLA-B*42:01 | IAMACLVGL | SAMACLVGL | 840 | 327 |
HLA-A*02:06 | GIAIAMACLV | GIASAMACLV | 279 | 109 |
HLA-A*02:02 | GIAIAMACLVGL | GIASAMACLVGL | 476 | 187 |
HLA-A*02:11 | GIAIAMACLV | GIASAMACLV | 124 | 49 |
HLA-A*68:02 | GIAIAMACLV | GIASAMACLV | 909 | 367 |
HLA-B*57:01 | IAIAMACLVGLMW | IASAMACLVGLMW | 173 | 70 |
HLA-A*02:02 | IAIAMACLV | IASAMACLV | 462 | 189 |
HLA-C*16:01 | IAIAMACLV | IASAMACLV | 148 | 62 |
HLA-A*02:06 | IAIAMACLV | IASAMACLV | 90 | 207 |
HLA-A*02:01 | GIAIAMACLV | GIASAMACLV | 396 | 176 |
HLA-A*02:06 | IAMACLVGLMWL | SAMACLVGLMWL | 874 | 392 |
HLA-C*15:02 | IAIAMACLV | IASAMACLV | 274 | 125 |
HLA-A*68:02 | WITGGIAIA | WITGGIASA | 918 | 428 |
HLA-A*02:06 | IAMACLVGLM | SAMACLVGLM | 390 | 188 |
Reference MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVA
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated MDLFMRIFTIGTVTLKQGEIKDATPLDFVRATATIPIQASLPFGWLIVGVA
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*40:01 | GEIKDATPS | GEIKDATPL | 3209 | 6 |
HLA-B*40:01 | QGEIKDATPS | QGEIKDATPL | 19790 | 91 |
HLA-B*40:01 | KQGEIKDATPS | KQGEIKDATPL | 24194 | 242 |
HLA-B*40:02 | GEIKDATPS | GEIKDATPL | 890 | 18 |
HLA-B*40:02 | QGEIKDATPS | QGEIKDATPL | 9115 | 250 |
HLA-B*15:03 | KQGEIKDATPS | KQGEIKDATPL | 9550 | 310 |
HLA-B*40:02 | KQGEIKDATPS | KQGEIKDATPL | 9835 | 345 |
HLA-B*15:03 | GEIKDATPS | GEIKDATPL | 11520 | 472 |
HLA-A*31:01 | KDATPSDFVR | KDATPLDFVR | 1003 | 448 |
Reference TCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAI
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated TCFSTQFAFACPDGVKHVYQLRARSASPKLFIRQEEVQELYSPIFLIVAAI
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*03:02 | SVSPKLFIR | SASPKLFIR | 308 | 1994 |
HLA-C*14:02 | VYQLRARSV | VYQLRARSA | 26 | 165 |
HLA-A*68:02 | HVYQLRARSV | HVYQLRARSA | 354 | 2232 |
HLA-A*11:01 | SVSPKLFIR | SASPKLFIR | 75 | 415 |
HLA-A*74:01 | SVSPKLFIR | SASPKLFIR | 316 | 1586 |
HLA-A*02:11 | SVSPKLFIRQEEV | SASPKLFIRQEEV | 228 | 464 |
HLA-B*27:05 | LRARSVSPKL | LRARSASPKL | 201 | 407 |
HLA-A*31:01 | SVSPKLFIR | SASPKLFIR | 17 | 34 |
Reference AAVKPLLVPHHVVATVQEIQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
||||||||||||||||||||||||| |||||||||||||||||||||||
Mutated AAVKPLLVPHHVVATVQEIQLQAAVWELLLLEWLAMAVMLLLLYCCLTD
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*44:02 | QEIQLQAAVG | QEIQLQAAVW | 1217 | 7 |
HLA-B*44:03 | QEIQLQAAVG | QEIQLQAAVW | 1214 | 9 |
HLA-B*57:01 | ATVQEIQLQAAVG | ATVQEIQLQAAVW | 26533 | 223 |
HLA-B*58:01 | ATVQEIQLQAAVG | ATVQEIQLQAAVW | 20797 | 177 |
HLA-A*02:01 | QLQAAVGEL | QLQAAVWEL | 1290 | 14 |
HLA-A*02:06 | QLQAAVGEL | QLQAAVWEL | 2794 | 38 |
HLA-B*44:02 | VQEIQLQAAVG | VQEIQLQAAVW | 21030 | 295 |
HLA-B*44:03 | VQEIQLQAAVG | VQEIQLQAAVW | 20104 | 294 |
HLA-B*58:01 | TVQEIQLQAAVG | TVQEIQLQAAVW | 25991 | 417 |
HLA-A*02:11 | LQAAVGEL | LQAAVWEL | 10677 | 233 |
HLA-A*02:11 | IQLQAAVGEL | IQLQAAVWEL | 338 | 8 |
HLA-A*02:11 | QLQAAVGEL | QLQAAVWEL | 120 | 3 |
HLA-A*02:11 | QEIQLQAAVGEL | QEIQLQAAVWEL | 6768 | 188 |
HLA-A*02:01 | IQLQAAVGEL | IQLQAAVWEL | 1138 | 33 |
HLA-A*02:11 | VQEIQLQAAVGEL | VQEIQLQAAVWEL | 4401 | 128 |
HLA-B*44:03 | QEIQLQAAVGE | QEIQLQAAVWE | 13040 | 406 |
HLA-B*44:02 | QEIQLQAAVGE | QEIQLQAAVWE | 13676 | 445 |
HLA-A*02:11 | TVQEIQLQAAVGEL | TVQEIQLQAAVWEL | 10392 | 366 |
HLA-A*23:01 | VGELLLLEW | VWELLLLEW | 12678 | 450 |
HLA-A*02:11 | EIQLQAAVGEL | EIQLQAAVWEL | 8016 | 329 |
HLA-A*32:01 | QLQAAVGEL | QLQAAVWEL | 9675 | 426 |
HLA-A*02:06 | LQAAVGEL | LQAAVWEL | 4676 | 218 |
HLA-B*58:01 | VGELLLLEW | VWELLLLEW | 330 | 6053 |
HLA-A*02:11 | AVGELLLLEWL | AVWELLLLEWL | 3883 | 254 |
HLA-A*02:11 | QLQAAVGELL | QLQAAVWELL | 303 | 23 |
HLA-A*02:02 | QLQAAVGEL | QLQAAVWEL | 92 | 8 |
HLA-A*02:06 | IQLQAAVGEL | IQLQAAVWEL | 280 | 28 |
HLA-A*02:02 | LQAAVGEL | LQAAVWEL | 3894 | 402 |
HLA-A*02:11 | IQLQAAVGELL | IQLQAAVWELL | 3459 | 401 |
HLA-A*02:01 | QLQAAVGELL | QLQAAVWELL | 961 | 127 |
HLA-A*02:06 | AVGELLLLEWL | AVWELLLLEWL | 3303 | 475 |
HLA-A*02:02 | IQLQAAVGEL | IQLQAAVWEL | 170 | 25 |
HLA-A*02:11 | QLQAAVGELLL | QLQAAVWELLL | 733 | 108 |
HLA-A*02:11 | LQAAVGELL | LQAAVWELL | 386 | 69 |
HLA-B*58:01 | QAAVGELLL | QAAVWELLL | 1295 | 280 |
HLA-A*02:01 | LQAAVGELL | LQAAVWELL | 938 | 204 |
HLA-A*02:11 | AVGELLLLEWLA | AVWELLLLEWLA | 837 | 192 |
HLA-A*02:02 | VQEIQLQAAVGEL | VQEIQLQAAVWEL | 1944 | 456 |
HLA-C*12:03 | QAAVGELLL | QAAVWELLL | 1550 | 382 |
HLA-A*02:06 | LQAAVGELL | LQAAVWELL | 65 | 17 |
HLA-B*58:01 | AAVGELLLLEW | AAVWELLLLEW | 36 | 135 |
HLA-A*02:11 | QLQAAVGELLLL | QLQAAVWELLLL | 563 | 151 |
HLA-A*02:11 | LQAAVGELLL | LQAAVWELLL | 1331 | 368 |
HLA-C*15:02 | QAAVGELLL | QAAVWELLL | 1474 | 409 |
HLA-A*02:06 | AVGELLLLEWLA | AVWELLLLEWLA | 1441 | 409 |
HLA-A*02:06 | QLQAAVGELL | QLQAAVWELL | 850 | 246 |
HLA-B*44:03 | QEIQLQAAVGEL | QEIQLQAAVWEL | 1386 | 402 |
HLA-A*02:01 | QLQAAVGELLL | QLQAAVWELLL | 1401 | 435 |
HLA-B*57:01 | AAVGELLLLEW | AAVWELLLLEW | 138 | 418 |
HLA-B*40:02 | QEIQLQAAVGEL | QEIQLQAAVWEL | 334 | 111 |
HLA-B*15:01 | LQAAVGELLL | LQAAVWELLL | 109 | 275 |
HLA-A*02:06 | LQAAVGELLL | LQAAVWELLL | 162 | 73 |
HLA-A*02:02 | LQAAVGELL | LQAAVWELL | 44 | 20 |
HLA-A*02:01 | LQAAVGELLL | LQAAVWELLL | 917 | 423 |
HLA-B*44:02 | GELLLLEWL | WELLLLEWL | 497 | 1059 |
HLA-B*44:03 | GELLLLEWL | WELLLLEWL | 430 | 910 |
HLA-A*02:02 | QLQAAVGELLL | QLQAAVWELLL | 530 | 253 |
HLA-C*16:01 | QAAVGELLL | QAAVWELLL | 263 | 127 |
HLA-C*03:02 | QAAVGELLL | QAAVWELLL | 898 | 443 |
Reference IQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
||||||||||||||||||||||||| |||||
Mutated IQLQAAVWELLLLEWLAMAVMLLLLYCCLTD
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*29:02 | MAVMLLLLC | MAVMLLLLY | 24878 | 11 |
HLA-B*35:01 | MAVMLLLLC | MAVMLLLLY | 11298 | 13 |
HLA-A*29:02 | AMAVMLLLLC | AMAVMLLLLY | 23598 | 32 |
HLA-B*15:03 | MAVMLLLLC | MAVMLLLLY | 10508 | 38 |
HLA-C*03:02 | MAVMLLLLC | MAVMLLLLY | 4825 | 23 |
HLA-A*29:02 | LAMAVMLLLLC | LAMAVMLLLLY | 32767 | 215 |
HLA-A*29:02 | AVMLLLLC | AVMLLLLY | 32767 | 296 |
HLA-A*30:02 | AMAVMLLLLC | AMAVMLLLLY | 21990 | 202 |
HLA-B*15:01 | MAVMLLLLC | MAVMLLLLY | 23361 | 251 |
HLA-A*03:01 | AMAVMLLLLC | AMAVMLLLLY | 19426 | 230 |
HLA-A*30:02 | MAVMLLLLC | MAVMLLLLY | 25456 | 329 |
HLA-B*15:01 | AMAVMLLLLC | AMAVMLLLLY | 14761 | 201 |
HLA-A*68:01 | MAVMLLLLC | MAVMLLLLY | 22307 | 304 |
HLA-C*16:01 | MAVMLLLLC | MAVMLLLLY | 5909 | 86 |
HLA-C*12:03 | MAVMLLLLC | MAVMLLLLY | 7575 | 121 |
HLA-C*12:02 | MAVMLLLLC | MAVMLLLLY | 9238 | 164 |
HLA-B*53:01 | MAVMLLLLC | MAVMLLLLY | 12960 | 238 |
HLA-B*15:03 | AMAVMLLLLC | AMAVMLLLLY | 18967 | 406 |
HLA-B*58:01 | MAVMLLLLC | MAVMLLLLY | 3134 | 94 |
HLA-C*02:02 | MAVMLLLLC | MAVMLLLLY | 13680 | 434 |
HLA-C*02:10 | MAVMLLLLC | MAVMLLLLY | 13680 | 434 |
HLA-A*02:11 | LLLLCCCLT | LLLLYCCLT | 1022 | 310 |
HLA-A*02:11 | VMLLLLCCCL | VMLLLLYCCL | 787 | 336 |
HLA-A*02:11 | MLLLLCCCL | MLLLLYCCL | 91 | 44 |
Reference TTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQ
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated TTFHLDGEVITFDNLKTLLSLREVRIIKVFTTVDNINLHTQVVDMSMTYGQ
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*58:01 | RTIKVFTTV | RIIKVFTTV | 127 | 3637 |
HLA-B*57:01 | RTIKVFTTV | RIIKVFTTV | 216 | 6126 |
HLA-A*02:11 | TLLSLREVRT | TLLSLREVRI | 3465 | 135 |
HLA-A*02:02 | LLSLREVRT | LLSLREVRI | 2163 | 169 |
HLA-A*02:11 | LLSLREVRT | LLSLREVRI | 3193 | 266 |
HLA-A*02:01 | TLLSLREVRT | TLLSLREVRI | 5083 | 428 |
HLA-A*02:02 | TLLSLREVRT | TLLSLREVRI | 4591 | 401 |
HLA-C*15:02 | RTIKVFTTV | RIIKVFTTV | 19 | 204 |
HLA-A*68:02 | SLREVRTIKVFTTV | SLREVRIIKVFTTV | 443 | 4613 |
HLA-A*68:02 | VRTIKVFTTV | VRIIKVFTTV | 123 | 1180 |
HLA-C*16:01 | RTIKVFTTV | RIIKVFTTV | 146 | 1383 |
HLA-A*68:02 | RTIKVFTTV | RIIKVFTTV | 41 | 301 |
HLA-C*12:03 | RTIKVFTTV | RIIKVFTTV | 90 | 616 |
HLA-A*02:11 | VRTIKVFTTV | VRIIKVFTTV | 617 | 116 |
HLA-A*02:01 | RTIKVFTTV | RIIKVFTTV | 147 | 32 |
HLA-A*30:01 | RTIKVFTTV | RIIKVFTTV | 35 | 149 |
HLA-A*02:11 | REVRTIKVFTTV | REVRIIKVFTTV | 1436 | 341 |
HLA-A*02:02 | RTIKVFTTV | RIIKVFTTV | 141 | 37 |
HLA-A*68:02 | REVRTIKVFTTV | REVRIIKVFTTV | 345 | 1306 |
HLA-A*68:02 | EVRTIKVFTTV | EVRIIKVFTTV | 43 | 153 |
HLA-C*17:01 | RTIKVFTTV | RIIKVFTTV | 341 | 1121 |
HLA-A*02:11 | RTIKVFTTV | RIIKVFTTV | 16 | 5 |
HLA-C*03:02 | RTIKVFTTV | RIIKVFTTV | 494 | 1577 |
HLA-A*02:02 | VRTIKVFTTV | VRIIKVFTTV | 1273 | 409 |
HLA-B*58:01 | LSLREVRTI | LSLREVRII | 140 | 322 |
HLA-A*11:01 | SLREVRTIK | SLREVRIIK | 905 | 408 |
HLA-B*40:02 | REVRTIKV | REVRIIKV | 234 | 108 |
HLA-B*57:01 | LSLREVRTI | LSLREVRII | 160 | 342 |
HLA-B*15:01 | SLREVRTIKVF | SLREVRIIKVF | 321 | 648 |
Reference MSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVD
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated MSAFAMMFVKHKHAFLCLFLLPSLAAVAYFNMVYMPASWVMRIMTWLDMVD
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*68:02 | TVAYFNMVYMPA | AVAYFNMVYMPA | 106 | 1416 |
HLA-A*01:01 | ATVAYFNMVY | AAVAYFNMVY | 189 | 1727 |
HLA-A*68:02 | TVAYFNMV | AVAYFNMV | 417 | 3615 |
HLA-A*68:02 | TVAYFNMVYM | AVAYFNMVYM | 25 | 212 |
HLA-A*68:01 | TVAYFNMVY | AVAYFNMVY | 46 | 380 |
HLA-C*12:03 | ATVAYFNMV | AAVAYFNMV | 632 | 78 |
HLA-A*26:01 | TVAYFNMVY | AVAYFNMVY | 76 | 590 |
HLA-C*03:02 | ATVAYFNMVY | AAVAYFNMVY | 432 | 59 |
HLA-A*68:02 | ATVAYFNMV | AAVAYFNMV | 14 | 102 |
HLA-C*16:01 | ATVAYFNMV | AAVAYFNMV | 1321 | 188 |
HLA-B*35:01 | ATVAYFNMVY | AAVAYFNMVY | 2554 | 365 |
HLA-A*02:01 | FLLPSLAT | FLLPSLAA | 1095 | 159 |
HLA-A*02:02 | FLLPSLAT | FLLPSLAA | 1973 | 304 |
HLA-A*68:01 | TVAYFNMVYM | AVAYFNMVYM | 280 | 1812 |
HLA-B*35:01 | TVAYFNMVY | AVAYFNMVY | 21 | 135 |
HLA-A*02:11 | FLLPSLAT | FLLPSLAA | 408 | 64 |
HLA-C*16:01 | ATVAYFNMVY | AAVAYFNMVY | 799 | 130 |
HLA-A*02:06 | FLLPSLAT | FLLPSLAA | 992 | 173 |
HLA-C*12:03 | ATVAYFNMVY | AAVAYFNMVY | 1554 | 332 |
HLA-C*12:02 | ATVAYFNMVY | AAVAYFNMVY | 1194 | 269 |
HLA-A*68:02 | SLATVAYFNMV | SLAAVAYFNMV | 185 | 693 |
HLA-A*02:11 | ATVAYFNMV | AAVAYFNMV | 27 | 100 |
HLA-A*02:02 | CLFLLPSLAT | CLFLLPSLAA | 655 | 178 |
HLA-A*02:11 | CLFLLPSLAT | CLFLLPSLAA | 501 | 138 |
HLA-B*15:03 | ATVAYFNMVY | AAVAYFNMVY | 103 | 31 |
HLA-A*02:01 | CLFLLPSLAT | CLFLLPSLAA | 1040 | 325 |
HLA-A*02:01 | ATVAYFNMV | AAVAYFNMV | 179 | 552 |
HLA-A*03:01 | TVAYFNMVY | AVAYFNMVY | 563 | 187 |
HLA-A*02:02 | ATVAYFNMV | AAVAYFNMV | 80 | 232 |
HLA-A*68:01 | ATVAYFNMVY | AAVAYFNMVY | 471 | 1322 |
HLA-B*07:02 | LPSLATVAYFNM | LPSLAAVAYFNM | 324 | 871 |
HLA-A*11:01 | ATVAYFNMVY | AAVAYFNMVY | 68 | 173 |
HLA-A*02:11 | LLPSLATVA | LLPSLAAVA | 231 | 92 |
HLA-B*42:01 | LPSLATVAYFNM | LPSLAAVAYFNM | 141 | 345 |
HLA-A*02:02 | LLPSLATVA | LLPSLAAVA | 197 | 83 |
HLA-A*02:11 | FLCLFLLPSLAT | FLCLFLLPSLAA | 406 | 173 |
HLA-A*03:02 | TVAYFNMVY | AVAYFNMVY | 578 | 252 |
HLA-A*02:01 | FLCLFLLPSLAT | FLCLFLLPSLAA | 696 | 309 |
HLA-B*15:03 | LATVAYFNM | LAAVAYFNM | 596 | 266 |
HLA-C*03:03 | LATVAYFNM | LAAVAYFNM | 195 | 88 |
HLA-C*03:04 | LATVAYFNM | LAAVAYFNM | 195 | 88 |
HLA-A*11:01 | TVAYFNMVY | AVAYFNMVY | 85 | 39 |
HLA-B*07:02 | LPSLATVAYF | LPSLAAVAYF | 145 | 314 |
HLA-C*12:03 | TVAYFNMVY | AVAYFNMVY | 136 | 292 |
HLA-C*16:01 | TVAYFNMVY | AVAYFNMVY | 100 | 213 |
HLA-B*35:01 | LATVAYFNM | LAAVAYFNM | 468 | 221 |
HLA-A*32:01 | TVAYFNMVY | AVAYFNMVY | 838 | 398 |
HLA-B*42:01 | LPSLATVAY | LPSLAAVAY | 424 | 880 |
HLA-B*35:01 | LPSLATVAYFNM | LPSLAAVAYFNM | 89 | 180 |
HLA-B*35:01 | FLLPSLATVAYF | FLLPSLAAVAYF | 210 | 422 |
HLA-A*02:06 | ATVAYFNMV | AAVAYFNMV | 8 | 16 |
HLA-C*12:03 | LATVAYFNM | LAAVAYFNM | 466 | 233 |
Reference CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*02:01 | FPPTSFGPLV | FPLTSFGPLV | 8999 | 21 |
HLA-A*02:02 | FPPTSFGPLV | FPLTSFGPLV | 7237 | 18 |
HLA-A*02:11 | FPPTSFGPLV | FPLTSFGPLV | 3405 | 9 |
HLA-A*32:01 | VLFSTVFPP | VLFSTVFPL | 5415 | 27 |
HLA-A*02:11 | LFSTVFPP | LFSTVFPL | 6706 | 35 |
HLA-A*02:11 | ANFNVLFSTVFPP | ANFNVLFSTVFPL | 1827 | 12 |
HLA-A*02:11 | NFNVLFSTVFPP | NFNVLFSTVFPL | 1779 | 13 |
HLA-A*02:11 | NVLFSTVFPP | NVLFSTVFPL | 739 | 6 |
HLA-C*03:03 | VLFSTVFPP | VLFSTVFPL | 28468 | 265 |
HLA-C*03:04 | VLFSTVFPP | VLFSTVFPL | 28468 | 265 |
HLA-A*02:11 | FNVLFSTVFPP | FNVLFSTVFPL | 413 | 4 |
HLA-C*14:02 | VLFSTVFPP | VLFSTVFPL | 21407 | 220 |
HLA-A*02:11 | FNVLFSTVFPPT | FNVLFSTVFPLT | 2618 | 27 |
HLA-A*02:01 | LFSTVFPP | LFSTVFPL | 7475 | 81 |
HLA-C*14:02 | LFSTVFPP | LFSTVFPL | 11979 | 138 |
HLA-B*15:03 | VLFSTVFPP | VLFSTVFPL | 3115 | 36 |
HLA-A*02:11 | VLFSTVFPP | VLFSTVFPL | 78 | 1 |
HLA-C*03:02 | VLFSTVFPP | VLFSTVFPL | 20533 | 273 |
HLA-A*02:01 | FNVLFSTVFPP | FNVLFSTVFPL | 656 | 9 |
HLA-A*02:01 | ANFNVLFSTVFPP | ANFNVLFSTVFPL | 2569 | 37 |
HLA-A*02:11 | FNVLFSTVFPPTS | FNVLFSTVFPLTS | 9448 | 142 |
HLA-A*02:02 | NVLFSTVFPP | NVLFSTVFPL | 1088 | 17 |
HLA-A*02:11 | CANFNVLFSTVFPP | CANFNVLFSTVFPL | 6143 | 96 |
HLA-A*02:02 | FNVLFSTVFPP | FNVLFSTVFPL | 1014 | 16 |
HLA-A*68:02 | NVLFSTVFPP | NVLFSTVFPL | 2213 | 37 |
HLA-A*02:02 | ANFNVLFSTVFPP | ANFNVLFSTVFPL | 3126 | 53 |
HLA-A*02:11 | PPTSFGPLV | PLTSFGPLV | 28329 | 483 |
HLA-C*16:01 | VLFSTVFPP | VLFSTVFPL | 24733 | 432 |
HLA-C*17:01 | VLFSTVFPP | VLFSTVFPL | 25087 | 439 |
HLA-A*02:01 | FNVLFSTVFPPT | FNVLFSTVFPLT | 3765 | 66 |
HLA-A*02:02 | LFSTVFPP | LFSTVFPL | 9311 | 167 |
HLA-A*02:01 | NVLFSTVFPP | NVLFSTVFPL | 928 | 17 |
HLA-A*02:02 | NFNVLFSTVFPP | NFNVLFSTVFPL | 2542 | 47 |
HLA-A*02:02 | VLFSTVFPP | VLFSTVFPL | 269 | 5 |
HLA-A*02:01 | NFNVLFSTVFPP | NFNVLFSTVFPL | 2286 | 44 |
HLA-A*02:06 | FPPTSFGPLV | FPLTSFGPLV | 3379 | 73 |
HLA-A*02:01 | VLFSTVFPP | VLFSTVFPL | 179 | 4 |
HLA-A*02:06 | FNVLFSTVFPP | FNVLFSTVFPL | 1609 | 37 |
HLA-A*02:02 | FNVLFSTVFPPT | FNVLFSTVFPLT | 4116 | 110 |
HLA-A*02:11 | FSTVFPPTSFGPLV | FSTVFPLTSFGPLV | 6695 | 180 |
HLA-A*02:01 | FNVLFSTVFPPTS | FNVLFSTVFPLTS | 11451 | 311 |
HLA-A*02:06 | VLFSTVFPP | VLFSTVFPL | 368 | 10 |
HLA-A*02:11 | ANFNVLFSTVFPPT | ANFNVLFSTVFPLT | 14639 | 409 |
HLA-A*02:01 | FSTVFPPTSFGPLV | FSTVFPLTSFGPLV | 12596 | 425 |
HLA-A*68:01 | PTSFGPLVR | LTSFGPLVR | 908 | 36 |
HLA-A*02:06 | NVLFSTVFPP | NVLFSTVFPL | 1611 | 66 |
HLA-B*15:01 | VLFSTVFPP | VLFSTVFPL | 5731 | 243 |
HLA-B*35:01 | FPPTSFGPL | FPLTSFGPL | 304 | 13 |
HLA-B*53:01 | FPPTSFGPL | FPLTSFGPL | 3581 | 154 |
HLA-C*01:02 | FPPTSFGPL | FPLTSFGPL | 217 | 4855 |
HLA-A*02:01 | CANFNVLFSTVFPP | CANFNVLFSTVFPL | 8519 | 384 |
HLA-A*02:02 | FNVLFSTVFPPTS | FNVLFSTVFPLTS | 10920 | 497 |
HLA-A*02:02 | FSTVFPPTSFGPLV | FSTVFPLTSFGPLV | 6958 | 322 |
HLA-A*02:11 | VFPPTSFGPLV | VFPLTSFGPLV | 4242 | 199 |
HLA-A*02:02 | CANFNVLFSTVFPP | CANFNVLFSTVFPL | 8183 | 391 |
HLA-A*02:11 | NFNVLFSTVFPPT | NFNVLFSTVFPLT | 9111 | 472 |
HLA-A*02:06 | ANFNVLFSTVFPP | ANFNVLFSTVFPL | 5191 | 304 |
HLA-A*02:06 | NFNVLFSTVFPP | NFNVLFSTVFPL | 4220 | 274 |
HLA-A*02:06 | FNVLFSTVFPPT | FNVLFSTVFPLT | 4868 | 388 |
HLA-B*35:03 | FPPTSFGPL | FPLTSFGPL | 286 | 24 |
HLA-A*03:01 | PTSFGPLVRK | LTSFGPLVRK | 554 | 47 |
HLA-A*31:01 | PTSFGPLVR | LTSFGPLVR | 4402 | 390 |
HLA-A*11:01 | PTSFGPLVR | LTSFGPLVR | 4068 | 379 |
HLA-A*03:02 | PTSFGPLVRK | LTSFGPLVRK | 868 | 88 |
HLA-B*07:02 | STVFPPTSFGPL | STVFPLTSFGPL | 777 | 79 |
HLA-A*68:01 | PTSFGPLVRK | LTSFGPLVRK | 308 | 34 |
HLA-B*07:02 | TVFPPTSFGPL | TVFPLTSFGPL | 1498 | 171 |
HLA-A*02:11 | STVFPPTSFGPLV | STVFPLTSFGPLV | 2427 | 285 |
HLA-A*02:11 | NVLFSTVFPPT | NVLFSTVFPLT | 1183 | 139 |
HLA-A*33:03 | PTSFGPLVR | LTSFGPLVR | 3228 | 381 |
HLA-A*26:01 | STVFPPTSF | STVFPLTSF | 786 | 95 |
HLA-B*07:02 | VFPPTSFGPL | VFPLTSFGPL | 339 | 43 |
HLA-A*02:01 | NVLFSTVFPPT | NVLFSTVFPLT | 2111 | 290 |
HLA-B*42:01 | FSTVFPPTSFGPL | FSTVFPLTSFGPL | 1320 | 185 |
HLA-B*42:01 | STVFPPTSFGPL | STVFPLTSFGPL | 738 | 111 |
HLA-A*02:01 | VLFSTVFPPTSF | VLFSTVFPLTSF | 2225 | 342 |
HLA-B*08:01 | FPPTSFGPL | FPLTSFGPL | 973 | 153 |
HLA-B*42:01 | TVFPPTSFGPL | TVFPLTSFGPL | 843 | 142 |
HLA-A*11:01 | PTSFGPLVRK | LTSFGPLVRK | 123 | 21 |
HLA-B*42:01 | VFPPTSFGPL | VFPLTSFGPL | 274 | 47 |
HLA-A*02:01 | VLFSTVFPPTS | VLFSTVFPLTS | 708 | 124 |
HLA-B*07:02 | FSTVFPPTSFGPL | FSTVFPLTSFGPL | 2537 | 466 |
HLA-B*07:02 | FPPTSFGPL | FPLTSFGPL | 42 | 8 |
HLA-A*02:11 | VLFSTVFPPTSF | VLFSTVFPLTSF | 1019 | 195 |
HLA-A*25:01 | STVFPPTSF | STVFPLTSF | 1533 | 296 |
HLA-B*07:02 | FPPTSFGPLV | FPLTSFGPLV | 1131 | 236 |
HLA-B*42:01 | FPPTSFGPL | FPLTSFGPL | 21 | 5 |
HLA-A*26:01 | FSTVFPPTSF | FSTVFPLTSF | 1667 | 398 |
HLA-B*51:01 | FPPTSFGPL | FPLTSFGPL | 1809 | 433 |
HLA-A*02:11 | VLFSTVFPPTS | VLFSTVFPLTS | 309 | 74 |
HLA-B*42:01 | FPPTSFGPLV | FPLTSFGPLV | 368 | 89 |
HLA-A*02:02 | VLFSTVFPPTS | VLFSTVFPLTS | 1210 | 377 |
HLA-C*03:02 | FPPTSFGPL | FPLTSFGPL | 960 | 313 |
HLA-A*32:01 | STVFPPTSF | STVFPLTSF | 230 | 86 |
HLA-B*58:01 | FSTVFPPTSF | FSTVFPLTSF | 88 | 33 |
HLA-B*15:01 | STVFPPTSF | STVFPLTSF | 130 | 49 |
HLA-A*02:01 | VLFSTVFPPT | VLFSTVFPLT | 61 | 23 |
HLA-C*03:03 | FPPTSFGPL | FPLTSFGPL | 375 | 145 |
HLA-C*03:04 | FPPTSFGPL | FPLTSFGPL | 375 | 145 |
HLA-A*02:02 | VLFSTVFPPT | VLFSTVFPLT | 113 | 44 |
HLA-C*16:01 | FSTVFPPTS | FSTVFPLTS | 1127 | 460 |
HLA-C*14:02 | LFSTVFPPTSF | LFSTVFPLTSF | 396 | 950 |
HLA-C*01:02 | VFPPTSFGPL | VFPLTSFGPL | 429 | 997 |
HLA-A*02:02 | TVFPPTSFGPLV | TVFPLTSFGPLV | 789 | 343 |
HLA-A*68:02 | STVFPPTSFGPLV | STVFPLTSFGPLV | 169 | 74 |
HLA-A*02:11 | VLFSTVFPPT | VLFSTVFPLT | 25 | 11 |
HLA-A*03:01 | TVFPPTSFGPLVRK | TVFPLTSFGPLVRK | 92 | 198 |
HLA-C*14:02 | VFPPTSFGPL | VFPLTSFGPL | 47 | 99 |
HLA-A*23:01 | LFSTVFPPTSF | LFSTVFPLTSF | 370 | 179 |
Reference VFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHT
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated VFTGYRVTKNSKVQIGEYTFEKGDYCDAVVYRGTTTYKLNVGDYFVLTSHT
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*02:11 | YTFEKGDYG | YTFEKGDYC | 4841 | 126 |
HLA-A*02:06 | YTFEKGDYG | YTFEKGDYC | 2831 | 128 |
HLA-A*02:02 | YTFEKGDYG | YTFEKGDYC | 2588 | 422 |
HLA-A*68:02 | YTFEKGDYG | YTFEKGDYC | 868 | 204 |
HLA-A*31:01 | GDYGDAVVYR | GDYCDAVVYR | 265 | 85 |
HLA-A*31:01 | EKGDYGDAVVYR | EKGDYCDAVVYR | 921 | 314 |
HLA-A*33:03 | TFEKGDYGDAVVYR | TFEKGDYCDAVVYR | 525 | 203 |
HLA-A*33:03 | FEKGDYGDAVVYR | FEKGDYCDAVVYR | 472 | 185 |
HLA-A*31:01 | KGDYGDAVVYR | KGDYCDAVVYR | 111 | 45 |
HLA-A*33:03 | EKGDYGDAVVYR | EKGDYCDAVVYR | 276 | 113 |
HLA-A*33:03 | GDYGDAVVYR | GDYCDAVVYR | 558 | 250 |
HLA-A*31:01 | DYGDAVVYR | DYCDAVVYR | 978 | 462 |
Reference QLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSA
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated QLPAPRTLLTKGTLEPEYFNSVCRLIKTIGPDMFLGTCRRCPAEIVDTVSA
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*68:02 | MKTIGPDMFL | IKTIGPDMFL | 18 | 701 |
HLA-B*15:03 | LMKTIGPDM | LIKTIGPDM | 63 | 2177 |
HLA-A*02:11 | LMKTIGPDMFL | LIKTIGPDMFL | 87 | 1755 |
HLA-A*02:02 | LMKTIGPDMFL | LIKTIGPDMFL | 82 | 1556 |
HLA-A*02:01 | LMKTIGPDMFL | LIKTIGPDMFL | 145 | 2274 |
HLA-B*15:01 | LMKTIGPDMF | LIKTIGPDMF | 39 | 520 |
HLA-B*15:01 | LMKTIGPDM | LIKTIGPDM | 144 | 1891 |
HLA-B*15:03 | LMKTIGPDMF | LIKTIGPDMF | 115 | 1497 |
HLA-B*15:03 | YFNSVCRLM | YFNSVCRLI | 496 | 5388 |
HLA-A*29:02 | YFNSVCRLM | YFNSVCRLI | 119 | 1216 |
HLA-C*03:02 | YFNSVCRLM | YFNSVCRLI | 333 | 3299 |
HLA-C*14:02 | EYFNSVCRLM | EYFNSVCRLI | 229 | 1920 |
HLA-C*14:02 | YFNSVCRLM | YFNSVCRLI | 6 | 50 |
HLA-C*07:02 | YFNSVCRLM | YFNSVCRLI | 145 | 1148 |
HLA-A*02:11 | CRLMKTIGPDMFL | CRLIKTIGPDMFL | 174 | 816 |
HLA-A*02:02 | MKTIGPDMFL | IKTIGPDMFL | 360 | 1649 |
HLA-A*02:11 | RLMKTIGPDMFLG | RLIKTIGPDMFLG | 209 | 923 |
HLA-A*02:06 | MKTIGPDMFL | IKTIGPDMFL | 180 | 788 |
HLA-B*15:03 | MKTIGPDMFL | IKTIGPDMFL | 308 | 1305 |
HLA-A*02:11 | RLMKTIGPDM | RLIKTIGPDM | 70 | 280 |
HLA-A*02:01 | RLMKTIGPDMFL | RLIKTIGPDMFL | 25 | 98 |
HLA-A*23:01 | EYFNSVCRLM | EYFNSVCRLI | 983 | 275 |
HLA-A*02:11 | RLMKTIGPDMFL | RLIKTIGPDMFL | 9 | 32 |
HLA-A*32:01 | RLMKTIGPDMF | RLIKTIGPDMF | 305 | 1065 |
HLA-A*02:11 | RLMKTIGPDMFLGT | RLIKTIGPDMFLGT | 495 | 1694 |
HLA-C*07:01 | YFNSVCRLM | YFNSVCRLI | 355 | 1200 |
HLA-A*24:02 | YFNSVCRLM | YFNSVCRLI | 1005 | 299 |
HLA-B*15:03 | MKTIGPDMF | IKTIGPDMF | 46 | 149 |
HLA-A*02:06 | LMKTIGPDMFL | LIKTIGPDMFL | 328 | 1031 |
HLA-A*02:01 | RLMKTIGPDMFLG | RLIKTIGPDMFLG | 432 | 1329 |
HLA-A*02:01 | CRLMKTIGPDMFL | CRLIKTIGPDMFL | 482 | 1458 |
HLA-A*02:01 | RLMKTIGPDM | RLIKTIGPDM | 250 | 745 |
HLA-A*23:01 | YFNSVCRLM | YFNSVCRLI | 617 | 215 |
HLA-A*02:02 | RLMKTIGPDMFL | RLIKTIGPDMFL | 30 | 76 |
HLA-A*02:06 | RLMKTIGPDMFL | RLIKTIGPDMFL | 119 | 291 |
HLA-A*02:02 | CRLMKTIGPDMFL | CRLIKTIGPDMFL | 432 | 972 |
HLA-A*02:02 | RLMKTIGPDM | RLIKTIGPDM | 254 | 525 |
Reference VELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKR
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated VELFENKTTLPVNVAFELWAKRNIKSVPEVKILNNLGVDIAANTVIWDYKR
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-B*42:01 | KPVPEVKIL | KSVPEVKIL | 126 | 16481 |
HLA-B*07:02 | KPVPEVKIL | KSVPEVKIL | 262 | 21946 |
HLA-B*58:01 | KPVPEVKIL | KSVPEVKIL | 22550 | 321 |
HLA-C*15:02 | KPVPEVKIL | KSVPEVKIL | 19259 | 358 |
HLA-C*16:01 | KPVPEVKIL | KSVPEVKIL | 5935 | 316 |
Reference HIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQ
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated HIVYGDFSHSQLGGLHLLIGLAKRFREAPFELEDFIPMDSTVKNYFITDAQ
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*02:11 | GLAKRFKES | GLAKRFREA | 4370 | 112 |
HLA-A*03:01 | LLIGLAKRFK | LLIGLAKRFR | 73 | 2474 |
HLA-A*33:03 | LIGLAKRFK | LIGLAKRFR | 3361 | 130 |
HLA-A*33:03 | LLIGLAKRFK | LLIGLAKRFR | 3111 | 126 |
HLA-A*03:01 | HLLIGLAKRFK | HLLIGLAKRFR | 269 | 6612 |
HLA-A*02:02 | GLAKRFKES | GLAKRFREA | 4677 | 200 |
HLA-A*03:01 | LIGLAKRFK | LIGLAKRFR | 359 | 7802 |
HLA-A*33:03 | HLLIGLAKRFK | HLLIGLAKRFR | 6373 | 309 |
HLA-A*30:01 | LIGLAKRFK | LIGLAKRFR | 441 | 8269 |
HLA-A*31:01 | LIGLAKRFK | LIGLAKRFR | 841 | 56 |
HLA-A*11:01 | LIGLAKRFK | LIGLAKRFR | 479 | 7085 |
HLA-A*03:02 | LLIGLAKRFK | LLIGLAKRFR | 130 | 1918 |
HLA-A*11:01 | LLIGLAKRFK | LLIGLAKRFR | 458 | 6344 |
HLA-A*31:01 | LLIGLAKRFK | LLIGLAKRFR | 1047 | 83 |
HLA-A*31:01 | HLLIGLAKRFK | HLLIGLAKRFR | 1705 | 149 |
HLA-A*03:02 | HLLIGLAKRFK | HLLIGLAKRFR | 409 | 4359 |
HLA-A*03:02 | LIGLAKRFK | LIGLAKRFR | 399 | 3992 |
HLA-A*30:01 | KRFKESPFEL | KRFREAPFEL | 1394 | 403 |
HLA-B*40:02 | KESPFELEDF | REAPFELEDF | 543 | 164 |
HLA-A*30:01 | RFKESPFELE | RFREAPFELE | 1025 | 313 |
HLA-B*40:01 | KESPFELEDFIPM | REAPFELEDFIPM | 636 | 200 |
HLA-A*30:01 | RFKESPFEL | RFREAPFEL | 160 | 51 |
HLA-B*40:01 | KESPFELEDF | REAPFELEDF | 1039 | 345 |
HLA-B*40:02 | KESPFELEDFI | REAPFELEDFI | 802 | 274 |
HLA-B*40:01 | KESPFELEDFI | REAPFELEDFI | 1238 | 424 |
HLA-B*40:02 | KESPFELEDFIPM | REAPFELEDFIPM | 269 | 93 |
HLA-B*15:03 | KESPFELEDFIPM | REAPFELEDFIPM | 1164 | 432 |
HLA-A*68:01 | LLIGLAKRFK | LLIGLAKRFR | 988 | 377 |
HLA-B*15:03 | KESPFELEDF | REAPFELEDF | 462 | 178 |
HLA-B*27:05 | KRFKESPFEL | KRFREAPFEL | 75 | 36 |
Reference VYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTG
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated VYGDFSHSQLGGLHLLIGLAKRFREAPFELEDFIPMDSTVKNYFITDAQTG
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-A*02:11 | GLAKRFKES | GLAKRFREA | 4370 | 112 |
HLA-A*02:02 | GLAKRFKES | GLAKRFREA | 4677 | 200 |
HLA-B*35:01 | SPFELEDFIPM | APFELEDFIPM | 87 | 315 |
HLA-A*30:01 | KRFKESPFEL | KRFREAPFEL | 1394 | 403 |
HLA-B*40:02 | KESPFELEDF | REAPFELEDF | 543 | 164 |
HLA-A*30:01 | RFKESPFELE | RFREAPFELE | 1025 | 313 |
HLA-B*40:01 | KESPFELEDFIPM | REAPFELEDFIPM | 636 | 200 |
HLA-A*30:01 | RFKESPFEL | RFREAPFEL | 160 | 51 |
HLA-B*40:01 | KESPFELEDF | REAPFELEDF | 1039 | 345 |
HLA-B*53:01 | SPFELEDFI | APFELEDFI | 137 | 403 |
HLA-B*40:02 | KESPFELEDFI | REAPFELEDFI | 802 | 274 |
HLA-B*40:01 | KESPFELEDFI | REAPFELEDFI | 1238 | 424 |
HLA-B*40:02 | KESPFELEDFIPM | REAPFELEDFIPM | 269 | 93 |
HLA-B*15:03 | KESPFELEDFIPM | REAPFELEDFIPM | 1164 | 432 |
HLA-B*15:03 | KESPFELEDF | REAPFELEDF | 462 | 178 |
HLA-B*27:05 | KRFKESPFEL | KRFREAPFEL | 75 | 36 |