Summary

This strain contains 48 protein-level mutations:

  • 29 mutations in Spike protein: A67V, HV 69-70 deletion, T95I, GVY 142-144 deletion, Y145D, N211 deletion, L212I, EPE 212-214 insertion, G339D, S371L, S373P, S375F, 477-478 ST->NK, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, D796Y, N856K, Q954H, N969K, L981F
  • 3 mutations in N protein: P13L, ERS 31-33 deletion, 203-204 RG->KR
  • 3 mutations in M protein: D3G, Q19E, A63T
  • 1 mutation in E protein: T9I
  • 2 mutations in NS9b protein: P10S, ENA 27-29 deletion
  • 1 mutation in NS9c protein: G50N
  • 4 mutations in NSP3 protein: K38R, S1265 deletion, L1266I, A1892T
  • 1 mutation in NSP4 protein: T492I
  • 1 mutation in NSP5 protein: P132H
  • 2 mutations in NSP6 protein: LSG 105-107 deletion, I189V
  • 1 mutation in NSP12 protein: P323L

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of HLA-peptide interactions affected by the mutations

For each allele we calculated the number of peptides with increased and decreased affinitiy (two or more times). The absolute number of such peptides is showed on the left side of the figure (blue bars — weaker binding, orange bars — stronger).

While absolute numbers are of interest, they do not reflect the initial number of tighly binding peptides for the specific allele. Roughly speaking, if an allele had high number of tight binders, then vanished affinity of several peptides will not affect much the integral ability of peptide presentation. To the contrary, low number of vanished peptides could be important if the particular allele initially had narrow epitope repertoire. To account for this effect, we normalized the absolute numbers of new/vanished tight binders (IC50 affinity ≤ 50 nM) by the total number of tight binders for each allele. To avoid possible divisions by zero, we used + 1 regularization term in all denominators. For example, if some allele had no tight binders in the reference genome, and three new tight binders appeared as a result of the mutation, the relative increase will be 300%. The results are showed in the right part of the figure. Protein-specific plots are listed below.

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Summary

Spike protein

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Spike

A67V

Reference  VFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF
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Mutated    VFRSSVLHSTQDLFLPFFSNVTWFHVI‑‑SGTNGTKRFDNPVLPFNDGVYF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 VTWFHAIHV VTWFHVI 18 -
HLA-A*02:06 VTWFHAIHV VTWFHVI 40 -
HLA-A*68:02 VTWFHAIHV VTWFHVI 45 -
HLA-C*15:02 VTWFHAIHV VTWFHVI 107 -
HLA-A*02:01 VTWFHAIHV VTWFHVI 134 -
HLA-C*12:03 VTWFHAIHV VTWFHVI 341 -
HLA-A*02:02 VTWFHAIHV VTWFHVI 369 -
HLA-C*16:01 VTWFHAIHV VTWFHVI 421 -
HLA-A*32:01 VTWFHAIHV VTWFHVI 442 -
HLA-A*68:02 NVTWFHAIHV NVTWFHVI 16 5547
HLA-A*02:11 NVTWFHAIHV NVTWFHVI 125 10192
HLA-A*02:06 NVTWFHAIHV NVTWFHVI 263 10869
HLA-C*15:02 FSNVTWFHAIH FSNVTWFHVI 15930 389
HLA-A*68:02 FSNVTWFHAIH FSNVTWFHVI 13953 418
HLA-A*02:02 NVTWFHAIHV NVTWFHVI 468 14619
HLA-B*58:01 FSNVTWFHAIH FSNVTWFHVI 7866 292
HLA-B*51:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 11466 430
HLA-B*58:01 FSNVTWFHAIHV FSNVTWFHVI 6877 292
HLA-A*11:01 HAIHVSGTNGTK HVISGTNGTK 2998 135
HLA-C*12:03 FSNVTWFHAIH FSNVTWFHVI 8069 365
HLA-A*02:06 FSNVTWFHAIH FSNVTWFHVI 7820 387
HLA-C*15:02 FSNVTWFHA FSNVTWFHV 1444 73
HLA-A*68:01 AIHVSGTNGTKR VISGTNGTKR 5916 313
HLA-A*68:02 HAIHVSGTNGT HVISGTNGT 7705 415
HLA-C*16:01 FSNVTWFHAIH FSNVTWFHVI 5156 295
HLA-B*42:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 7318 437
HLA-A*03:01 HAIHVSGTNGTK HVISGTNGTK 3368 205
HLA-A*02:11 FSNVTWFHA FSNVTWFHV 366 23
HLA-C*03:02 FSNVTWFHAIHV FSNVTWFHVI 7468 494
HLA-C*16:01 FSNVTWFHAIHV FSNVTWFHVI 4412 295
HLA-C*12:03 FSNVTWFHAIHV FSNVTWFHVI 4736 365
HLA-A*03:02 HAIHVSGTNGTK HVISGTNGTK 4597 368
HLA-C*03:02 FSNVTWFHAIH FSNVTWFHVI 4526 494
HLA-A*68:02 FSNVTWFHA FSNVTWFHV 189 22
HLA-A*02:01 FSNVTWFHA FSNVTWFHV 1863 240
HLA-A*68:02 FFSNVTWFHAIHV FFSNVTWFHVI 492 3778
HLA-A*02:06 FSNVTWFHA FSNVTWFHV 182 24
HLA-C*12:03 FSNVTWFHA FSNVTWFHV 1369 181
HLA-A*02:11 FFSNVTWFHA FFSNVTWFHV 362 50
HLA-C*15:02 FSNVTWFHAIHV FSNVTWFHVI 2711 389
HLA-A*02:02 FSNVTWFHA FSNVTWFHV 741 115
HLA-A*02:11 FLPFFSNVTWFHA FLPFFSNVTWFHV 93 15
HLA-C*16:01 FSNVTWFHA FSNVTWFHV 906 156
HLA-A*68:01 HAIHVSGTNGTK HVISGTNGTK 174 30
HLA-A*68:02 FFSNVTWFHA FFSNVTWFHV 639 128
HLA-A*02:11 FFSNVTWFHAIHV FFSNVTWFHVI 219 1076
HLA-A*02:01 FFSNVTWFHA FFSNVTWFHV 1440 306
HLA-A*02:01 FLPFFSNVTWFHA FLPFFSNVTWFHV 424 94
HLA-A*02:06 FFSNVTWFHA FFSNVTWFHV 972 227
HLA-A*02:02 FFSNVTWFHA FFSNVTWFHV 328 79
HLA-A*02:11 FSNVTWFHAIHV FSNVTWFHVI 250 973
HLA-A*68:02 SNVTWFHAI SNVTWFHVI 196 729
HLA-A*02:02 FLPFFSNVTWFHA FLPFFSNVTWFHV 117 32
HLA-A*03:02 AIHVSGTNGTK VISGTNGTK 1179 326
HLA-A*02:06 SNVTWFHAI SNVTWFHVI 317 1145
HLA-A*02:06 FLPFFSNVTWFHA FLPFFSNVTWFHV 608 172
HLA-C*03:02 FSNVTWFHA FSNVTWFHV 1383 404
HLA-A*68:02 FSNVTWFHAI FSNVTWFHVI 124 418
HLA-A*02:11 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 54 176
HLA-A*02:06 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 457 1475
HLA-A*02:06 FSNVTWFHAI FSNVTWFHVI 123 387
HLA-B*58:01 FSNVTWFHA FSNVTWFHV 1061 354
HLA-A*02:01 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 484 1319
HLA-A*02:02 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 151 392
HLA-A*02:11 FSNVTWFHAI FSNVTWFHVI 398 973
HLA-B*42:01 LPFFSNVTWFHAI LPFFSNVTWFHVI 199 437
HLA-A*11:01 AIHVSGTNGTK VISGTNGTK 742 341
HLA-A*03:01 AIHVSGTNGTK VISGTNGTK 534 251

HV 69-70 deletion

Reference  RSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST
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Mutated    RSSVLHSTQDLFLPFFSNVTWFHVI‑‑SGTNGTKRFDNPVLPFNDGVYFASI

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 VTWFHAIHV VTWFHVI 18 -
HLA-A*02:06 VTWFHAIHV VTWFHVI 40 -
HLA-A*68:01 HVSGTNGTKR - 42 -
HLA-A*68:02 VTWFHAIHV VTWFHVI 45 -
HLA-A*68:01 HVSGTNGTK SGTNGTK 54 -
HLA-C*15:02 VTWFHAIHV VTWFHVI 107 -
HLA-A*02:01 VTWFHAIHV VTWFHVI 134 -
HLA-C*12:03 VTWFHAIHV VTWFHVI 341 -
HLA-A*02:02 VTWFHAIHV VTWFHVI 369 -
HLA-C*16:01 VTWFHAIHV VTWFHVI 421 -
HLA-A*32:01 VTWFHAIHV VTWFHVI 442 -
HLA-A*68:02 NVTWFHAIHV NVTWFHVI 16 5547
HLA-A*02:11 NVTWFHAIHV NVTWFHVI 125 10192
HLA-A*02:06 NVTWFHAIHV NVTWFHVI 263 10869
HLA-C*15:02 FSNVTWFHAIH FSNVTWFHVI 15930 389
HLA-A*68:02 FSNVTWFHAIH FSNVTWFHVI 13953 418
HLA-A*02:02 NVTWFHAIHV NVTWFHVI 468 14619
HLA-B*58:01 FSNVTWFHAIH FSNVTWFHVI 7866 292
HLA-B*51:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 11466 430
HLA-B*58:01 FSNVTWFHAIHV FSNVTWFHVI 6877 292
HLA-A*11:01 HAIHVSGTNGTK HVISGTNGTK 2998 135
HLA-C*12:03 FSNVTWFHAIH FSNVTWFHVI 8069 365
HLA-A*02:06 FSNVTWFHAIH FSNVTWFHVI 7820 387
HLA-A*68:01 AIHVSGTNGTKR VISGTNGTKR 5916 313
HLA-A*68:02 HAIHVSGTNGT HVISGTNGT 7705 415
HLA-C*16:01 FSNVTWFHAIH FSNVTWFHVI 5156 295
HLA-B*42:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 7318 437
HLA-A*03:01 HAIHVSGTNGTK HVISGTNGTK 3368 205
HLA-C*03:02 FSNVTWFHAIHV FSNVTWFHVI 7468 494
HLA-C*16:01 FSNVTWFHAIHV FSNVTWFHVI 4412 295
HLA-C*12:03 FSNVTWFHAIHV FSNVTWFHVI 4736 365
HLA-A*03:02 HAIHVSGTNGTK HVISGTNGTK 4597 368
HLA-C*03:02 FSNVTWFHAIH FSNVTWFHVI 4526 494
HLA-A*68:02 FFSNVTWFHAIHV FFSNVTWFHVI 492 3778
HLA-C*15:02 FSNVTWFHAIHV FSNVTWFHVI 2711 389
HLA-A*68:01 HAIHVSGTNGTK HVISGTNGTK 174 30
HLA-A*02:11 FFSNVTWFHAIHV FFSNVTWFHVI 219 1076
HLA-A*02:11 FSNVTWFHAIHV FSNVTWFHVI 250 973
HLA-A*03:02 AIHVSGTNGTK VISGTNGTK 1179 326
HLA-A*11:01 AIHVSGTNGTK VISGTNGTK 742 341
HLA-A*03:01 AIHVSGTNGTK VISGTNGTK 534 251

T95I

Reference  VSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
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Mutated    ‑SGTNGTKRFDNPVLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*57:01 STEKSNIIRGW SIEKSNIIRGW 135 2014
HLA-B*58:01 STEKSNIIRGW SIEKSNIIRGW 183 2582
HLA-B*42:01 LPFNDGVYFAST LPFNDGVYFASI 4329 325
HLA-B*53:01 LPFNDGVYFAST LPFNDGVYFASI 6125 497
HLA-C*12:03 ASTEKSNII ASIEKSNII 2443 439
HLA-A*31:01 ASTEKSNIIR ASIEKSNIIR 1324 354
HLA-C*03:03 FASTEKSNII FASIEKSNII 1633 453
HLA-C*03:04 FASTEKSNII FASIEKSNII 1633 453
HLA-A*68:01 ASTEKSNIIR ASIEKSNIIR 1387 410
HLA-C*12:03 FASTEKSNII FASIEKSNII 902 268
HLA-A*11:01 ASTEKSNIIR ASIEKSNIIR 1555 495
HLA-C*15:02 ASTEKSNII ASIEKSNII 729 264
HLA-B*44:02 TEKSNIIRGW IEKSNIIRGW 20 55
HLA-B*44:03 TEKSNIIRGW IEKSNIIRGW 33 84
HLA-C*16:01 ASTEKSNII ASIEKSNII 603 239
HLA-A*68:01 STEKSNIIR SIEKSNIIR 186 458
HLA-A*33:03 YFASTEKSNIIR YFASIEKSNIIR 337 148
HLA-A*11:01 GVYFASTEKS GVYFASIEKS 648 298
HLA-A*11:01 DGVYFASTEK DGVYFASIEK 205 96
HLA-B*58:01 ASTEKSNIIRGW ASIEKSNIIRGW 245 122

GVY 142-144 deletion

Reference  LLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFE
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Mutated    LLIVNNATNVVIKVCEFQFCNDPFL‑‑‑DHKNNKSWMESEFRVYSSANNCTFE

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:06 FQFCNDPFLGV - 7 -
HLA-B*15:03 FQFCNDPFLGVY - 11 -
HLA-A*02:11 FQFCNDPFLGV - 17 -
HLA-A*03:01 GVYYHKNNK DHKNNK 27 -
HLA-B*15:01 FQFCNDPFLGVY - 28 -
HLA-A*02:01 FQFCNDPFLGV - 39 -
HLA-A*02:02 FQFCNDPFLGV - 45 -
HLA-A*11:01 GVYYHKNNK DHKNNK 51 -
HLA-A*30:01 GVYYHKNNK DHKNNK 51 -
HLA-A*02:06 EFQFCNDPFLGV - 87 -
HLA-A*02:11 FCNDPFLGV FCNDPFL 87 -
HLA-A*02:06 FCNDPFLGV FCNDPFL 116 -
HLA-A*03:02 GVYYHKNNK DHKNNK 119 -
HLA-A*03:01 LGVYYHKNNK LDHKNNK 131 -
HLA-A*02:06 FQFCNDPFLGVY - 135 -
HLA-C*03:02 FCNDPFLGVY FCNDPFL 164 -
HLA-A*29:02 QFCNDPFLGVY - 192 -
HLA-A*01:01 CNDPFLGVYY CNDPFLD 202 -
HLA-A*02:06 FQFCNDPFLG - 207 -
HLA-A*01:01 CNDPFLGVY CNDPFL 232 -
HLA-B*15:03 EFQFCNDPFLGVY - 253 -
HLA-A*33:03 DPFLGVYYHK DPFLDHK 280 -
HLA-A*68:02 FCNDPFLGV FCNDPFL 281 -
HLA-A*30:02 CNDPFLGVY CNDPFL 310 -
HLA-A*01:01 FCNDPFLGVY FCNDPFL 317 -
HLA-A*02:11 EFQFCNDPFLGV - 334 -
HLA-A*30:02 FQFCNDPFLGVY - 336 -
HLA-A*68:01 GVYYHKNNK DHKNNK 363 -
HLA-A*02:02 FCNDPFLGV FCNDPFL 365 -
HLA-A*31:01 GVYYHKNNK DHKNNK 375 -
HLA-A*29:02 FQFCNDPFLGVY - 388 -
HLA-A*02:02 FQFCNDPFLG - 392 -
HLA-A*68:01 DPFLGVYYHK DPFLDHK 398 -
HLA-A*30:02 FCNDPFLGVY FCNDPFL 408 -
HLA-A*29:02 CNDPFLGVYY CNDPFLD 439 -
HLA-A*02:02 EFQFCNDPFLGV - 477 -
HLA-A*02:11 FQFCNDPFLGVY - 488 -
HLA-A*68:01 LGVYYHKNNK LDHKNNK 494 -
HLA-C*14:02 YYHKNNKSWM DHKNNKSWM 19 12782
HLA-C*14:02 YYHKNNKSW DHKNNKSW 52 32767
HLA-A*24:02 YYHKNNKSW DHKNNKSW 116 32767
HLA-A*23:01 YYHKNNKSW DHKNNKSW 150 32767
HLA-A*29:02 QFCNDPFLGVYY QFCNDPFLD 113 23669
HLA-A*23:01 VYYHKNNKSW DHKNNKSW 230 32767
HLA-C*14:02 YYHKNNKSWMESEF DHKNNKSWMESEF 227 28734
HLA-A*24:02 VYYHKNNKSW DHKNNKSW 326 32767
HLA-A*29:02 FQFCNDPFLGVYY FQFCNDPFLD 184 14059
HLA-B*15:01 FQFCNDPFLGVYY FQFCNDPFLD 129 7936
HLA-B*15:03 FQFCNDPFLGVYY FQFCNDPFLD 47 2235
HLA-C*14:02 VYYHKNNKSWM DHKNNKSWM 327 12782
HLA-A*03:01 FLGVYYHKNNK FLDHKNNK 455 10120
HLA-A*02:11 FLGVYYHKNNKSWM FLDHKNNKSWM 5849 374
HLA-A*02:11 FLGVYYHKNNKS FLDHKNNKS 5702 488
HLA-A*02:06 FQFCNDPFLGVYY FQFCNDPFLD 1024 258

Y145D

Reference  VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY
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Mutated    VNNATNVVIKVCEFQFCNDPFL‑‑‑DHKNNKSWMESEFRVYSSANNCTFEY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 GVYYHKNNK DHKNNK 27 -
HLA-A*11:01 GVYYHKNNK DHKNNK 51 -
HLA-A*30:01 GVYYHKNNK DHKNNK 51 -
HLA-A*03:02 GVYYHKNNK DHKNNK 119 -
HLA-A*03:01 LGVYYHKNNK LDHKNNK 131 -
HLA-A*01:01 CNDPFLGVYY CNDPFLD 202 -
HLA-A*33:03 DPFLGVYYHK DPFLDHK 280 -
HLA-A*68:01 GVYYHKNNK DHKNNK 363 -
HLA-A*31:01 GVYYHKNNK DHKNNK 375 -
HLA-A*68:01 DPFLGVYYHK DPFLDHK 398 -
HLA-A*29:02 CNDPFLGVYY CNDPFLD 439 -
HLA-A*68:01 LGVYYHKNNK LDHKNNK 494 -
HLA-C*14:02 YYHKNNKSWM DHKNNKSWM 19 12782
HLA-C*14:02 YYHKNNKSW DHKNNKSW 52 32767
HLA-A*24:02 YYHKNNKSW DHKNNKSW 116 32767
HLA-A*23:01 YYHKNNKSW DHKNNKSW 150 32767
HLA-A*29:02 QFCNDPFLGVYY QFCNDPFLD 113 23669
HLA-A*23:01 VYYHKNNKSW DHKNNKSW 230 32767
HLA-C*14:02 YYHKNNKSWMESEF DHKNNKSWMESEF 227 28734
HLA-A*24:02 VYYHKNNKSW DHKNNKSW 326 32767
HLA-A*29:02 FQFCNDPFLGVYY FQFCNDPFLD 184 14059
HLA-B*15:01 FQFCNDPFLGVYY FQFCNDPFLD 129 7936
HLA-B*15:03 FQFCNDPFLGVYY FQFCNDPFLD 47 2235
HLA-C*14:02 VYYHKNNKSWM DHKNNKSWM 327 12782
HLA-C*14:02 YHKNNKSWM DHKNNKSWM 392 12782
HLA-A*03:01 FLGVYYHKNNK FLDHKNNK 455 10120
HLA-A*02:11 FLGVYYHKNNKSWM FLDHKNNKSWM 5849 374
HLA-A*02:11 FLGVYYHKNNKS FLDHKNNKS 5702 488
HLA-A*02:06 FQFCNDPFLGVYY FQFCNDPFLD 1024 258

N211 deletion

Reference  FKNLREFVFKNIDGYFKIYSKHTPINLVR‑‑‑DLPQGFSALEPLVDLPIGI
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Mutated    FKNLREFVFKNIDGYFKIYSKHTPI‑IVREPEDLPQGFSALEPLVDLPIGI

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 HTPINLVR HTPIIVR 480 -
HLA-C*03:03 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:04 YSKHTPINL YSKHTPII 83 6095
HLA-C*12:03 YSKHTPINLV YSKHTPIIV 1188 31
HLA-C*03:02 YSKHTPINL YSKHTPII 132 4883
HLA-C*16:01 YSKHTPINLV YSKHTPIIV 1785 56
HLA-C*12:03 YSKHTPINL YSKHTPII 47 1130
HLA-C*17:01 YSKHTPINL YSKHTPII 368 6895
HLA-C*16:01 YSKHTPINL YSKHTPII 31 571
HLA-C*12:02 YSKHTPINL YSKHTPII 388 4751
HLA-A*68:02 YSKHTPINLV YSKHTPIIV 199 2110
HLA-B*42:01 HTPINLVRDL HTPIIVREPEDL 250 2272
HLA-C*15:02 YSKHTPINL YSKHTPII 175 1560
HLA-C*12:02 YSKHTPINLV YSKHTPIIV 3439 393
HLA-A*24:02 IYSKHTPINL IYSKHTPII 278 34
HLA-A*30:01 KIYSKHTPINL KIYSKHTPII 645 85
HLA-C*15:02 YSKHTPINLV YSKHTPIIV 601 101
HLA-A*23:01 IYSKHTPINL IYSKHTPII 345 65
HLA-A*32:01 KIYSKHTPINL KIYSKHTPII 1321 333
HLA-A*68:01 YSKHTPINLVR YSKHTPIIVR 362 103
HLA-C*07:02 IYSKHTPINL IYSKHTPII 1553 464
HLA-A*33:03 YSKHTPINLVR YSKHTPIIVR 762 228
HLA-C*14:02 IYSKHTPINL IYSKHTPII 139 44
HLA-B*42:01 TPINLVRDL TPIIVREPEDL 43 133
HLA-A*31:01 FKIYSKHTPINLVR FKIYSKHTPIIVR 990 352
HLA-A*31:01 YSKHTPINLVR YSKHTPIIVR 337 122
HLA-B*07:02 TPINLVRDL TPIIVREPEDL 213 490
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPIIV 104 221

L212I

Reference  KNLREFVFKNIDGYFKIYSKHTPINLVR‑‑‑DLPQGFSALEPLVDLPIGIN
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KNLREFVFKNIDGYFKIYSKHTPI‑IVREPEDLPQGFSALEPLVDLPIGIN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 HTPINLVR HTPIIVR 480 -
HLA-C*03:03 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:04 YSKHTPINL YSKHTPII 83 6095
HLA-C*12:03 YSKHTPINLV YSKHTPIIV 1188 31
HLA-C*03:02 LVRDLPQGF IVREPEDLPQGF 259 9894
HLA-C*03:02 YSKHTPINL YSKHTPII 132 4883
HLA-C*16:01 YSKHTPINLV YSKHTPIIV 1785 56
HLA-B*15:03 LVRDLPQGF IVREPEDLPQGF 254 7524
HLA-B*15:01 LVRDLPQGF IVREPEDLPQGF 160 4573
HLA-C*12:03 YSKHTPINL YSKHTPII 47 1130
HLA-C*17:01 YSKHTPINL YSKHTPII 368 6895
HLA-C*16:01 YSKHTPINL YSKHTPII 31 571
HLA-C*12:02 YSKHTPINL YSKHTPII 388 4751
HLA-A*68:02 YSKHTPINLV YSKHTPIIV 199 2110
HLA-B*42:01 HTPINLVRDL HTPIIVREPEDL 250 2272
HLA-C*15:02 YSKHTPINL YSKHTPII 175 1560
HLA-C*12:02 YSKHTPINLV YSKHTPIIV 3439 393
HLA-A*24:02 IYSKHTPINL IYSKHTPII 278 34
HLA-A*30:01 KIYSKHTPINL KIYSKHTPII 645 85
HLA-C*15:02 YSKHTPINLV YSKHTPIIV 601 101
HLA-A*23:01 IYSKHTPINL IYSKHTPII 345 65
HLA-A*32:01 KIYSKHTPINL KIYSKHTPII 1321 333
HLA-A*68:01 YSKHTPINLVR YSKHTPIIVR 362 103
HLA-C*07:02 IYSKHTPINL IYSKHTPII 1553 464
HLA-A*33:03 YSKHTPINLVR YSKHTPIIVR 762 228
HLA-C*14:02 IYSKHTPINL IYSKHTPII 139 44
HLA-B*42:01 TPINLVRDL TPIIVREPEDL 43 133
HLA-A*31:01 FKIYSKHTPINLVR FKIYSKHTPIIVR 990 352
HLA-A*31:01 YSKHTPINLVR YSKHTPIIVR 337 122
HLA-B*07:02 TPINLVRDL TPIIVREPEDL 213 490
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPIIV 104 221

EPE 212-214 insertion

Reference  REFVFKNIDGYFKIYSKHTPINLVR‑‑‑DLPQGFSALEPLVDLPIGINITRFQ
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    REFVFKNIDGYFKIYSKHTPI‑IVREPEDLPQGFSALEPLVDLPIGINITRFQ

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:02 LVRDLPQGF IVREPEDLPQGF 259 9894
HLA-B*15:03 LVRDLPQGF IVREPEDLPQGF 254 7524
HLA-B*15:01 LVRDLPQGF IVREPEDLPQGF 160 4573
HLA-C*01:02 RDLPQGFSAL REPEDLPQGFSAL 148 1731
HLA-B*42:01 HTPINLVRDL HTPIIVREPEDL 250 2272
HLA-A*02:11 RDLPQGFSAL REPEDLPQGFSAL 295 2282
HLA-A*02:02 RDLPQGFSAL REPEDLPQGFSAL 252 1535
HLA-C*01:02 VRDLPQGFSAL VREPEDLPQGFSAL 431 2353
HLA-B*40:02 RDLPQGFSAL REPEDLPQGFSAL 386 1893
HLA-B*42:01 TPINLVRDL TPIIVREPEDL 43 133
HLA-B*40:06 RDLPQGFSA REPEDLPQGFSA 986 422
HLA-B*07:02 TPINLVRDL TPIIVREPEDL 213 490

G339D

Reference  QTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVAD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:01 GEVFNATRF DEVFNATRF 164 7112
HLA-B*18:01 GEVFNATRFASVY DEVFNATRFASVY 2165 64
HLA-B*18:01 GEVFNATRF DEVFNATRF 971 32
HLA-B*50:01 GEVFNATRFA DEVFNATRFA 147 4233
HLA-B*40:02 GEVFNATRF DEVFNATRF 283 7625
HLA-B*40:06 GEVFNATRFA DEVFNATRFA 201 5089
HLA-B*15:03 GEVFNATRF DEVFNATRF 359 4698
HLA-A*68:01 FGEVFNATR FDEVFNATR 338 2409
HLA-B*45:01 GEVFNATRFA DEVFNATRFA 116 688
HLA-B*44:02 GEVFNATRF DEVFNATRF 158 889
HLA-B*44:03 GEVFNATRF DEVFNATRF 136 673
HLA-B*15:01 TNLCPFGEVF TNLCPFDEVF 368 1059
HLA-B*15:03 TNLCPFGEVF TNLCPFDEVF 442 1176
HLA-B*15:03 NLCPFGEVF NLCPFDEVF 130 341
HLA-A*68:02 GEVFNATRFA DEVFNATRFA 879 342
HLA-B*15:01 NLCPFGEVF NLCPFDEVF 315 773

S371L

Reference  RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    RFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVY

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNLAPFF 22186 50
HLA-A*23:01 VLYNSASFS VLYNLAPFF 32767 117
HLA-B*15:03 VLYNSASFS VLYNLAPFF 3280 14
HLA-C*05:01 VADYSVLYNS VADYSVLYNL 11802 69
HLA-A*02:11 NSASFSTFKCYGV NLAPFFTFKCYGV 3754 28
HLA-C*08:02 VADYSVLYNS VADYSVLYNL 16435 160
HLA-A*29:02 VLYNSASFS VLYNLAPFF 10439 102
HLA-B*15:01 VLYNSASFS VLYNLAPFF 8189 100
HLA-A*23:01 LYNSASFS LYNLAPFF 22508 301
HLA-A*02:01 NSASFSTFKCYGV NLAPFFTFKCYGV 7542 105
HLA-C*17:01 VADYSVLYNS VADYSVLYNL 23423 345
HLA-A*02:02 NSASFSTFKCYGV NLAPFFTFKCYGV 1841 28
HLA-A*02:11 NSASFSTFKC NLAPFFTFKC 18569 286
HLA-B*40:02 ADYSVLYNS ADYSVLYNL 4645 81
HLA-A*24:02 LYNSASFS LYNLAPFF 25164 448
HLA-C*03:02 VLYNSASFS VLYNLAPFF 13004 300
HLA-A*32:01 SVLYNSASFS SVLYNLAPFF 14340 350
HLA-A*02:02 NSASFSTFKC NLAPFFTFKC 12584 399
HLA-C*14:02 LYNSASFS LYNLAPFF 5693 182
HLA-B*58:01 YSVLYNSASFS YSVLYNLAPFF 6920 250
HLA-C*16:01 NSASFSTF NLAPFFTF 243 6716
HLA-A*02:02 CVADYSVLYNS CVADYSVLYNL 10665 425
HLA-C*14:02 VLYNSASFS VLYNLAPFF 11085 485
HLA-B*15:03 SVLYNSASFS SVLYNLAPFF 2850 135
HLA-B*15:01 SVLYNSASFS SVLYNLAPFF 2838 153
HLA-A*23:01 YNSASFSTF YNLAPFFTF 352 23
HLA-A*02:06 NSASFSTFKCYGV NLAPFFTFKCYGV 2140 141
HLA-B*15:03 YSVLYNSASFS YSVLYNLAPFF 3170 219
HLA-A*01:01 NSASFSTFKCY NLAPFFTFKCY 328 4639
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2385 192
HLA-B*15:01 VLYNSASFSTF VLYNLAPFFTF 50 617
HLA-B*15:01 YNSASFSTF YNLAPFFTF 123 1270
HLA-A*02:06 SVLYNSASF SVLYNLAPF 2112 217
HLA-C*12:02 YNSASFSTF YNLAPFFTF 196 1777
HLA-C*03:02 YSVLYNSASFS YSVLYNLAPFF 2405 266
HLA-C*14:02 LYNSASFSTF LYNLAPFFTF 20 176
HLA-B*15:01 YSVLYNSASFSTF YSVLYNLAPFFTF 164 1378
HLA-B*15:01 LYNSASFSTF LYNLAPFFTF 468 3846
HLA-A*30:02 SASFSTFKCY LAPFFTFKCY 71 576
HLA-A*24:02 YNSASFSTF YNLAPFFTF 473 63
HLA-A*74:01 NSASFSTFK NLAPFFTFK 1882 259
HLA-A*68:02 NSASFSTFKCYGV NLAPFFTFKCYGV 48 332
HLA-A*29:02 YNSASFSTF YNLAPFFTF 1671 273
HLA-A*03:02 NSASFSTFKC NLAPFFTFKC 2724 452
HLA-A*23:01 YSVLYNSASFSTF YSVLYNLAPFFTF 1474 248
HLA-B*15:01 SVLYNSASFSTF SVLYNLAPFFTF 221 1313
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2634 467
HLA-A*29:02 NSASFSTFKCY NLAPFFTFKCY 662 122
HLA-C*16:01 YNSASFSTF YNLAPFFTF 100 542
HLA-A*02:06 YSVLYNSASF YSVLYNLAPF 2478 463
HLA-C*12:03 YNSASFSTF YNLAPFFTF 294 1568
HLA-A*03:01 LYNSASFSTFK LYNLAPFFTFK 295 60
HLA-A*03:01 NSASFSTFK NLAPFFTFK 113 23
HLA-B*15:03 VLYNSASFSTF VLYNLAPFFTF 38 186
HLA-C*03:02 YSVLYNSASFSTF YSVLYNLAPFFTF 113 552
HLA-A*01:01 SASFSTFKCY LAPFFTFKCY 461 2229
HLA-C*03:02 YNSASFSTF YNLAPFFTF 40 189
HLA-A*23:01 SVLYNSASFSTF SVLYNLAPFFTF 656 145
HLA-C*14:02 YNSASFSTF YNLAPFFTF 194 850
HLA-B*15:03 LYNSASFSTF LYNLAPFFTF 85 359
HLA-A*02:01 VLYNSASFST VLYNLAPFFT 243 58
HLA-A*03:01 YNSASFSTFK YNLAPFFTFK 80 21
HLA-C*03:03 YNSASFSTF YNLAPFFTF 251 949
HLA-C*03:04 YNSASFSTF YNLAPFFTF 251 949
HLA-A*31:01 NSASFSTFK NLAPFFTFK 293 83
HLA-A*23:01 LYNSASFSTFKC LYNLAPFFTFKC 1642 470
HLA-A*30:02 YNSASFSTFKCY YNLAPFFTFKCY 496 1717
HLA-A*30:02 VLYNSASFSTFKCY VLYNLAPFFTFKCY 272 939
HLA-A*26:01 SVLYNSASF SVLYNLAPF 1313 382
HLA-C*16:01 SASFSTFKCY LAPFFTFKCY 167 572
HLA-A*03:02 NSASFSTFK NLAPFFTFK 37 11
HLA-A*02:11 VLYNSASFST VLYNLAPFFT 77 23
HLA-A*31:01 SVLYNSASFSTFK SVLYNLAPFFTFK 857 259
HLA-A*33:03 NSASFSTFK NLAPFFTFK 181 55
HLA-A*23:01 VLYNSASFSTF VLYNLAPFFTF 133 41
HLA-B*15:03 YNSASFSTFKCY YNLAPFFTFKCY 385 1204
HLA-A*03:02 LYNSASFSTFK LYNLAPFFTFK 202 65
HLA-B*15:03 YNSASFSTF YNLAPFFTF 6 18
HLA-A*29:02 YNSASFSTFKCY YNLAPFFTFKCY 842 281
HLA-A*68:02 SASFSTFKCYGV LAPFFTFKCYGV 131 391
HLA-B*15:03 SVLYNSASFSTF SVLYNLAPFFTF 325 970
HLA-A*31:01 YNSASFSTFK YNLAPFFTFK 607 211
HLA-B*15:03 YSVLYNSASFSTF YSVLYNLAPFFTF 181 519
HLA-A*68:01 LYNSASFSTFK LYNLAPFFTFK 201 566
HLA-A*30:02 NSASFSTFKCY NLAPFFTFKCY 387 1088
HLA-A*32:01 VLYNSASFSTF VLYNLAPFFTF 699 254
HLA-A*23:01 LYNSASFSTFK LYNLAPFFTFK 265 97
HLA-A*02:02 VLYNSASFST VLYNLAPFFT 202 76
HLA-A*33:03 YNSASFSTFK YNLAPFFTFK 823 313
HLA-A*68:01 YNSASFSTFK YNLAPFFTFK 9 23
HLA-A*11:01 LYNSASFSTFK LYNLAPFFTFK 43 107
HLA-B*15:01 SASFSTFKCY LAPFFTFKCY 256 632
HLA-B*15:03 SASFSTFKCY LAPFFTFKCY 173 420
HLA-A*03:02 YSVLYNSASFSTFK YSVLYNLAPFFTFK 670 276
HLA-A*68:01 VLYNSASFSTFK VLYNLAPFFTFK 257 618
HLA-A*03:02 YNSASFSTFK YNLAPFFTFK 40 17
HLA-A*23:01 LYNSASFSTF LYNLAPFFTF 7 3
HLA-A*02:06 VLYNSASFST VLYNLAPFFT 710 312
HLA-A*68:01 NSASFSTFKC NLAPFFTFKC 281 626
HLA-A*03:01 VLYNSASFSTFKC VLYNLAPFFTFKC 312 688
HLA-C*03:03 YSVLYNSASF YSVLYNLAPF 74 161
HLA-C*03:04 YSVLYNSASF YSVLYNLAPF 74 161
HLA-C*03:02 SASFSTFKCY LAPFFTFKCY 212 459
HLA-C*03:03 SVLYNSASF SVLYNLAPF 114 239
HLA-C*03:04 SVLYNSASF SVLYNLAPF 114 239
HLA-A*31:01 VLYNSASFSTFK VLYNLAPFFTFK 565 276
HLA-A*68:01 NSASFSTFK NLAPFFTFK 4 8
HLA-A*03:01 VLYNSASFSTFK VLYNLAPFFTFK 7 14
HLA-A*02:11 VLYNSASFS VLYNLAPFF 258 129

S373P

Reference  ASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYAD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNLAPFF 22186 50
HLA-A*23:01 VLYNSASFS VLYNLAPFF 32767 117
HLA-B*15:03 VLYNSASFS VLYNLAPFF 3280 14
HLA-A*02:11 NSASFSTFKCYGV NLAPFFTFKCYGV 3754 28
HLA-A*29:02 VLYNSASFS VLYNLAPFF 10439 102
HLA-B*15:01 VLYNSASFS VLYNLAPFF 8189 100
HLA-A*23:01 LYNSASFS LYNLAPFF 22508 301
HLA-A*02:01 NSASFSTFKCYGV NLAPFFTFKCYGV 7542 105
HLA-A*02:02 NSASFSTFKCYGV NLAPFFTFKCYGV 1841 28
HLA-A*02:11 NSASFSTFKC NLAPFFTFKC 18569 286
HLA-A*30:02 ASFSTFKCY APFFTFKCY 43 2759
HLA-A*02:06 ASFSTFKCYGV APFFTFKCYGV 231 13051
HLA-B*15:01 ASFSTFKCY APFFTFKCY 107 6034
HLA-A*24:02 LYNSASFS LYNLAPFF 25164 448
HLA-C*03:02 VLYNSASFS VLYNLAPFF 13004 300
HLA-C*16:01 ASFSTFKCY APFFTFKCY 68 2875
HLA-C*12:03 ASFSTFKCY APFFTFKCY 115 4791
HLA-A*32:01 SVLYNSASFS SVLYNLAPFF 14340 350
HLA-C*03:02 ASFSTFKCY APFFTFKCY 64 2361
HLA-A*11:01 ASFSTFKCY APFFTFKCY 379 12650
HLA-A*02:02 NSASFSTFKC NLAPFFTFKC 12584 399
HLA-C*14:02 LYNSASFS LYNLAPFF 5693 182
HLA-B*58:01 YSVLYNSASFS YSVLYNLAPFF 6920 250
HLA-C*16:01 NSASFSTF NLAPFFTF 243 6716
HLA-B*35:01 ASFSTFKCY APFFTFKCY 2345 92
HLA-C*14:02 VLYNSASFS VLYNLAPFF 11085 485
HLA-C*12:02 ASFSTFKCY APFFTFKCY 338 7588
HLA-B*15:03 SVLYNSASFS SVLYNLAPFF 2850 135
HLA-B*15:03 ASFSTFKCY APFFTFKCY 25 495
HLA-B*15:01 SVLYNSASFS SVLYNLAPFF 2838 153
HLA-C*14:02 SFSTFKCY PFFTFKCY 386 6068
HLA-A*23:01 YNSASFSTF YNLAPFFTF 352 23
HLA-A*02:06 NSASFSTFKCYGV NLAPFFTFKCYGV 2140 141
HLA-B*15:03 YSVLYNSASFS YSVLYNLAPFF 3170 219
HLA-A*01:01 NSASFSTFKCY NLAPFFTFKCY 328 4639
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2385 192
HLA-B*15:01 VLYNSASFSTF VLYNLAPFFTF 50 617
HLA-B*15:01 YNSASFSTF YNLAPFFTF 123 1270
HLA-A*02:06 SVLYNSASF SVLYNLAPF 2112 217
HLA-C*12:02 YNSASFSTF YNLAPFFTF 196 1777
HLA-C*03:02 YSVLYNSASFS YSVLYNLAPFF 2405 266
HLA-C*14:02 LYNSASFSTF LYNLAPFFTF 20 176
HLA-B*15:01 YSVLYNSASFSTF YSVLYNLAPFFTF 164 1378
HLA-A*29:02 ASFSTFKCY APFFTFKCY 201 1653
HLA-B*15:01 LYNSASFSTF LYNLAPFFTF 468 3846
HLA-A*30:02 SASFSTFKCY LAPFFTFKCY 71 576
HLA-A*24:02 YNSASFSTF YNLAPFFTF 473 63
HLA-A*74:01 NSASFSTFK NLAPFFTFK 1882 259
HLA-A*68:02 NSASFSTFKCYGV NLAPFFTFKCYGV 48 332
HLA-A*29:02 YNSASFSTF YNLAPFFTF 1671 273
HLA-A*03:02 NSASFSTFKC NLAPFFTFKC 2724 452
HLA-A*23:01 YSVLYNSASFSTF YSVLYNLAPFFTF 1474 248
HLA-B*15:01 SVLYNSASFSTF SVLYNLAPFFTF 221 1313
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2634 467
HLA-A*29:02 NSASFSTFKCY NLAPFFTFKCY 662 122
HLA-C*16:01 YNSASFSTF YNLAPFFTF 100 542
HLA-A*02:06 YSVLYNSASF YSVLYNLAPF 2478 463
HLA-C*12:03 YNSASFSTF YNLAPFFTF 294 1568
HLA-A*03:01 LYNSASFSTFK LYNLAPFFTFK 295 60
HLA-A*03:01 NSASFSTFK NLAPFFTFK 113 23
HLA-B*15:03 VLYNSASFSTF VLYNLAPFFTF 38 186
HLA-C*03:02 YSVLYNSASFSTF YSVLYNLAPFFTF 113 552
HLA-A*01:01 SASFSTFKCY LAPFFTFKCY 461 2229
HLA-C*03:02 YNSASFSTF YNLAPFFTF 40 189
HLA-A*23:01 SVLYNSASFSTF SVLYNLAPFFTF 656 145
HLA-C*14:02 YNSASFSTF YNLAPFFTF 194 850
HLA-B*15:03 LYNSASFSTF LYNLAPFFTF 85 359
HLA-A*02:01 VLYNSASFST VLYNLAPFFT 243 58
HLA-A*03:01 YNSASFSTFK YNLAPFFTFK 80 21
HLA-C*03:03 YNSASFSTF YNLAPFFTF 251 949
HLA-C*03:04 YNSASFSTF YNLAPFFTF 251 949
HLA-A*31:01 NSASFSTFK NLAPFFTFK 293 83
HLA-A*23:01 LYNSASFSTFKC LYNLAPFFTFKC 1642 470
HLA-A*30:02 YNSASFSTFKCY YNLAPFFTFKCY 496 1717
HLA-A*30:02 VLYNSASFSTFKCY VLYNLAPFFTFKCY 272 939
HLA-A*26:01 SVLYNSASF SVLYNLAPF 1313 382
HLA-C*16:01 SASFSTFKCY LAPFFTFKCY 167 572
HLA-A*03:02 NSASFSTFK NLAPFFTFK 37 11
HLA-A*02:11 VLYNSASFST VLYNLAPFFT 77 23
HLA-A*31:01 SVLYNSASFSTFK SVLYNLAPFFTFK 857 259
HLA-A*33:03 NSASFSTFK NLAPFFTFK 181 55
HLA-A*23:01 VLYNSASFSTF VLYNLAPFFTF 133 41
HLA-B*15:03 YNSASFSTFKCY YNLAPFFTFKCY 385 1204
HLA-A*03:02 LYNSASFSTFK LYNLAPFFTFK 202 65
HLA-B*15:03 YNSASFSTF YNLAPFFTF 6 18
HLA-A*29:02 YNSASFSTFKCY YNLAPFFTFKCY 842 281
HLA-A*68:02 SASFSTFKCYGV LAPFFTFKCYGV 131 391
HLA-B*15:03 SVLYNSASFSTF SVLYNLAPFFTF 325 970
HLA-A*31:01 YNSASFSTFK YNLAPFFTFK 607 211
HLA-B*15:03 YSVLYNSASFSTF YSVLYNLAPFFTF 181 519
HLA-A*68:01 LYNSASFSTFK LYNLAPFFTFK 201 566
HLA-A*30:02 NSASFSTFKCY NLAPFFTFKCY 387 1088
HLA-A*32:01 VLYNSASFSTF VLYNLAPFFTF 699 254
HLA-A*23:01 LYNSASFSTFK LYNLAPFFTFK 265 97
HLA-A*02:02 VLYNSASFST VLYNLAPFFT 202 76
HLA-A*33:03 YNSASFSTFK YNLAPFFTFK 823 313
HLA-A*68:01 YNSASFSTFK YNLAPFFTFK 9 23
HLA-A*11:01 LYNSASFSTFK LYNLAPFFTFK 43 107
HLA-B*15:01 SASFSTFKCY LAPFFTFKCY 256 632
HLA-B*15:03 SASFSTFKCY LAPFFTFKCY 173 420
HLA-A*03:02 YSVLYNSASFSTFK YSVLYNLAPFFTFK 670 276
HLA-A*68:01 VLYNSASFSTFK VLYNLAPFFTFK 257 618
HLA-A*03:02 YNSASFSTFK YNLAPFFTFK 40 17
HLA-A*23:01 LYNSASFSTF LYNLAPFFTF 7 3
HLA-A*02:06 VLYNSASFST VLYNLAPFFT 710 312
HLA-A*68:01 NSASFSTFKC NLAPFFTFKC 281 626
HLA-A*03:01 VLYNSASFSTFKC VLYNLAPFFTFKC 312 688
HLA-C*03:03 YSVLYNSASF YSVLYNLAPF 74 161
HLA-C*03:04 YSVLYNSASF YSVLYNLAPF 74 161
HLA-C*03:02 SASFSTFKCY LAPFFTFKCY 212 459
HLA-C*03:03 SVLYNSASF SVLYNLAPF 114 239
HLA-C*03:04 SVLYNSASF SVLYNLAPF 114 239
HLA-A*31:01 VLYNSASFSTFK VLYNLAPFFTFK 565 276
HLA-A*68:01 NSASFSTFK NLAPFFTFK 4 8
HLA-A*03:01 VLYNSASFSTFK VLYNLAPFFTFK 7 14
HLA-A*02:11 VLYNSASFS VLYNLAPFF 258 129

S375F

Reference  VYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNLAPFF 22186 50
HLA-A*23:01 VLYNSASFS VLYNLAPFF 32767 117
HLA-B*15:03 VLYNSASFS VLYNLAPFF 3280 14
HLA-A*02:11 NSASFSTFKCYGV NLAPFFTFKCYGV 3754 28
HLA-A*29:02 VLYNSASFS VLYNLAPFF 10439 102
HLA-B*15:01 VLYNSASFS VLYNLAPFF 8189 100
HLA-A*23:01 LYNSASFS LYNLAPFF 22508 301
HLA-A*02:01 NSASFSTFKCYGV NLAPFFTFKCYGV 7542 105
HLA-A*02:02 NSASFSTFKCYGV NLAPFFTFKCYGV 1841 28
HLA-A*02:11 NSASFSTFKC NLAPFFTFKC 18569 286
HLA-A*30:02 ASFSTFKCY APFFTFKCY 43 2759
HLA-C*15:02 FSTFKCYGV FFTFKCYGV 431 24744
HLA-A*68:02 FSTFKCYGV FFTFKCYGV 17 973
HLA-A*02:06 ASFSTFKCYGV APFFTFKCYGV 231 13051
HLA-B*15:01 ASFSTFKCY APFFTFKCY 107 6034
HLA-A*24:02 LYNSASFS LYNLAPFF 25164 448
HLA-A*02:06 FSTFKCYGV FFTFKCYGV 61 2768
HLA-C*03:02 VLYNSASFS VLYNLAPFF 13004 300
HLA-C*16:01 ASFSTFKCY APFFTFKCY 68 2875
HLA-C*12:03 ASFSTFKCY APFFTFKCY 115 4791
HLA-A*32:01 SVLYNSASFS SVLYNLAPFF 14340 350
HLA-C*03:02 ASFSTFKCY APFFTFKCY 64 2361
HLA-C*16:01 FSTFKCYGV FFTFKCYGV 302 11120
HLA-A*11:01 ASFSTFKCY APFFTFKCY 379 12650
HLA-A*02:02 NSASFSTFKC NLAPFFTFKC 12584 399
HLA-C*14:02 LYNSASFS LYNLAPFF 5693 182
HLA-B*58:01 YSVLYNSASFS YSVLYNLAPFF 6920 250
HLA-C*16:01 NSASFSTF NLAPFFTF 243 6716
HLA-B*35:01 ASFSTFKCY APFFTFKCY 2345 92
HLA-C*14:02 VLYNSASFS VLYNLAPFF 11085 485
HLA-C*12:02 ASFSTFKCY APFFTFKCY 338 7588
HLA-B*15:03 SVLYNSASFS SVLYNLAPFF 2850 135
HLA-B*15:03 ASFSTFKCY APFFTFKCY 25 495
HLA-B*15:01 SVLYNSASFS SVLYNLAPFF 2838 153
HLA-C*14:02 SFSTFKCY PFFTFKCY 386 6068
HLA-A*23:01 YNSASFSTF YNLAPFFTF 352 23
HLA-A*02:06 NSASFSTFKCYGV NLAPFFTFKCYGV 2140 141
HLA-B*15:03 YSVLYNSASFS YSVLYNLAPFF 3170 219
HLA-A*01:01 NSASFSTFKCY NLAPFFTFKCY 328 4639
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2385 192
HLA-B*15:01 VLYNSASFSTF VLYNLAPFFTF 50 617
HLA-B*15:01 YNSASFSTF YNLAPFFTF 123 1270
HLA-C*12:02 YNSASFSTF YNLAPFFTF 196 1777
HLA-C*03:02 YSVLYNSASFS YSVLYNLAPFF 2405 266
HLA-C*14:02 LYNSASFSTF LYNLAPFFTF 20 176
HLA-A*11:01 FSTFKCYGVSPTK FFTFKCYGVSPTK 426 3618
HLA-B*15:01 YSVLYNSASFSTF YSVLYNLAPFFTF 164 1378
HLA-A*29:02 ASFSTFKCY APFFTFKCY 201 1653
HLA-B*15:01 LYNSASFSTF LYNLAPFFTF 468 3846
HLA-A*30:02 SASFSTFKCY LAPFFTFKCY 71 576
HLA-A*11:01 STFKCYGVSPTK FTFKCYGVSPTK 25 191
HLA-A*02:02 FSTFKCYGV FFTFKCYGV 89 676
HLA-A*30:01 STFKCYGVS FTFKCYGVS 438 3311
HLA-A*24:02 YNSASFSTF YNLAPFFTF 473 63
HLA-A*74:01 NSASFSTFK NLAPFFTFK 1882 259
HLA-A*30:01 STFKCYGVSPTK FTFKCYGVSPTK 194 1399
HLA-A*68:02 NSASFSTFKCYGV NLAPFFTFKCYGV 48 332
HLA-A*02:01 FSTFKCYGV FFTFKCYGV 457 3016
HLA-A*02:11 STFKCYGV FTFKCYGV 2124 327
HLA-A*02:11 FSTFKCYGV FFTFKCYGV 75 475
HLA-A*02:06 STFKCYGV FTFKCYGV 2045 328
HLA-A*29:02 YNSASFSTF YNLAPFFTF 1671 273
HLA-A*03:02 NSASFSTFKC NLAPFFTFKC 2724 452
HLA-A*23:01 YSVLYNSASFSTF YSVLYNLAPFFTF 1474 248
HLA-B*15:01 SVLYNSASFSTF SVLYNLAPFFTF 221 1313
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNLAPFFTF 2634 467
HLA-A*29:02 NSASFSTFKCY NLAPFFTFKCY 662 122
HLA-C*16:01 YNSASFSTF YNLAPFFTF 100 542
HLA-C*12:03 YNSASFSTF YNLAPFFTF 294 1568
HLA-A*03:01 STFKCYGVSPTK FTFKCYGVSPTK 83 419
HLA-A*03:01 LYNSASFSTFK LYNLAPFFTFK 295 60
HLA-A*03:01 NSASFSTFK NLAPFFTFK 113 23
HLA-B*15:03 VLYNSASFSTF VLYNLAPFFTF 38 186
HLA-C*03:02 YSVLYNSASFSTF YSVLYNLAPFFTF 113 552
HLA-A*01:01 SASFSTFKCY LAPFFTFKCY 461 2229
HLA-C*03:02 YNSASFSTF YNLAPFFTF 40 189
HLA-A*23:01 SVLYNSASFSTF SVLYNLAPFFTF 656 145
HLA-C*14:02 YNSASFSTF YNLAPFFTF 194 850
HLA-B*15:03 LYNSASFSTF LYNLAPFFTF 85 359
HLA-A*02:01 VLYNSASFST VLYNLAPFFT 243 58
HLA-A*68:02 STFKCYGVSPT FTFKCYGVSPT 1247 305
HLA-A*03:02 STFKCYGVSPTK FTFKCYGVSPTK 142 572
HLA-A*68:02 STFKCYGV FTFKCYGV 745 193
HLA-A*03:01 YNSASFSTFK YNLAPFFTFK 80 21
HLA-C*03:03 YNSASFSTF YNLAPFFTF 251 949
HLA-C*03:04 YNSASFSTF YNLAPFFTF 251 949
HLA-A*31:01 NSASFSTFK NLAPFFTFK 293 83
HLA-A*23:01 LYNSASFSTFKC LYNLAPFFTFKC 1642 470
HLA-A*30:02 YNSASFSTFKCY YNLAPFFTFKCY 496 1717
HLA-A*30:02 VLYNSASFSTFKCY VLYNLAPFFTFKCY 272 939
HLA-C*16:01 SASFSTFKCY LAPFFTFKCY 167 572
HLA-A*03:02 NSASFSTFK NLAPFFTFK 37 11
HLA-A*02:11 VLYNSASFST VLYNLAPFFT 77 23
HLA-A*31:01 SVLYNSASFSTFK SVLYNLAPFFTFK 857 259
HLA-A*33:03 NSASFSTFK NLAPFFTFK 181 55
HLA-A*23:01 VLYNSASFSTF VLYNLAPFFTF 133 41
HLA-B*15:03 YNSASFSTFKCY YNLAPFFTFKCY 385 1204
HLA-A*03:02 LYNSASFSTFK LYNLAPFFTFK 202 65
HLA-B*15:03 YNSASFSTF YNLAPFFTF 6 18
HLA-A*29:02 YNSASFSTFKCY YNLAPFFTFKCY 842 281
HLA-A*68:02 SASFSTFKCYGV LAPFFTFKCYGV 131 391
HLA-B*15:03 SVLYNSASFSTF SVLYNLAPFFTF 325 970
HLA-A*31:01 YNSASFSTFK YNLAPFFTFK 607 211
HLA-B*15:03 YSVLYNSASFSTF YSVLYNLAPFFTF 181 519
HLA-A*68:01 LYNSASFSTFK LYNLAPFFTFK 201 566
HLA-A*30:02 NSASFSTFKCY NLAPFFTFKCY 387 1088
HLA-A*32:01 VLYNSASFSTF VLYNLAPFFTF 699 254
HLA-A*23:01 LYNSASFSTFK LYNLAPFFTFK 265 97
HLA-A*02:02 VLYNSASFST VLYNLAPFFT 202 76
HLA-A*33:03 YNSASFSTFK YNLAPFFTFK 823 313
HLA-A*68:01 STFKCYGVSPTK FTFKCYGVSPTK 106 41
HLA-A*68:01 YNSASFSTFK YNLAPFFTFK 9 23
HLA-A*11:01 LYNSASFSTFK LYNLAPFFTFK 43 107
HLA-B*15:01 SASFSTFKCY LAPFFTFKCY 256 632
HLA-B*15:03 SASFSTFKCY LAPFFTFKCY 173 420
HLA-A*03:02 YSVLYNSASFSTFK YSVLYNLAPFFTFK 670 276
HLA-A*68:01 VLYNSASFSTFK VLYNLAPFFTFK 257 618
HLA-A*03:02 YNSASFSTFK YNLAPFFTFK 40 17
HLA-A*23:01 LYNSASFSTF LYNLAPFFTF 7 3
HLA-A*02:06 VLYNSASFST VLYNLAPFFT 710 312
HLA-A*68:01 NSASFSTFKC NLAPFFTFKC 281 626
HLA-A*03:01 VLYNSASFSTFKC VLYNLAPFFTFKC 312 688
HLA-C*03:02 SASFSTFKCY LAPFFTFKCY 212 459
HLA-A*68:01 FSTFKCYGVSPTK FFTFKCYGVSPTK 288 603
HLA-A*31:01 VLYNSASFSTFK VLYNLAPFFTFK 565 276
HLA-A*68:01 NSASFSTFK NLAPFFTFK 4 8
HLA-A*03:01 VLYNSASFSTFK VLYNLAPFFTFK 7 14
HLA-A*02:11 VLYNSASFS VLYNLAPFF 258 129

477-478 ST->NK

Reference  LYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    LYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 STEIYQAGST STEIYQAGNK 30358 67
HLA-A*68:01 STEIYQAGST STEIYQAGNK 22142 157
HLA-A*03:01 STEIYQAGST STEIYQAGNK 32241 308
HLA-B*35:01 TPCNGVEGF KPCNGVAGF 319 1522
HLA-B*42:01 TPCNGVEGF KPCNGVAGF 2031 454
HLA-A*02:11 YQAGSTPCNGV YQAGNKPCNGV 173 678
HLA-B*50:01 TEIYQAGSTP TEIYQAGNKP 464 1807
HLA-A*02:06 YQAGSTPCNGV YQAGNKPCNGV 39 146
HLA-A*02:01 YQAGSTPCNGV YQAGNKPCNGV 420 1490
HLA-C*14:02 IYQAGSTPC IYQAGNKPC 134 459
HLA-A*02:02 YQAGSTPCNGV YQAGNKPCNGV 107 233

E484A

Reference  SNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYR
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYR

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 EGFNCYFPLQ AGFNCYFPLR 13906 13
HLA-B*40:02 VEGFNCYFPL VAGFNCYFPL 31 10868
HLA-A*68:01 GVEGFNCYFPLQ GVAGFNCYFPLR 27995 107
HLA-B*40:01 VEGFNCYFPL VAGFNCYFPL 76 19416
HLA-A*31:01 GVEGFNCYFPLQ GVAGFNCYFPLR 15109 90
HLA-A*31:01 VEGFNCYFPLQ VAGFNCYFPLR 15897 151
HLA-A*11:01 EGFNCYFPLQ AGFNCYFPLR 25719 362
HLA-A*33:03 GVEGFNCYFPLQ GVAGFNCYFPLR 24534 414
HLA-A*33:03 NGVEGFNCYFPLQ NGVAGFNCYFPLR 23008 416
HLA-A*33:03 EGFNCYFPLQ AGFNCYFPLR 7445 148
HLA-B*15:01 GVEGFNCYF GVAGFNCYF 3125 128
HLA-A*68:02 EGFNCYFPL AGFNCYFPL 117 2032
HLA-A*68:01 EGFNCYFPLQ AGFNCYFPLR 5231 331
HLA-A*32:01 GVEGFNCYF GVAGFNCYF 5606 430
HLA-B*15:03 GVEGFNCYF GVAGFNCYF 1657 141
HLA-B*15:03 EGFNCYFPL AGFNCYFPL 2980 308
HLA-A*30:02 EGFNCYFPLQSY AGFNCYFPLRSY 1806 189
HLA-A*02:06 EGFNCYFPL AGFNCYFPL 1266 185
HLA-A*02:11 EGFNCYFPL AGFNCYFPL 2508 401
HLA-A*02:02 GVEGFNCYFPL GVAGFNCYFPL 666 124
HLA-A*02:06 VEGFNCYFPL VAGFNCYFPL 1553 310
HLA-B*35:01 TPCNGVEGF KPCNGVAGF 319 1522
HLA-B*42:01 TPCNGVEGF KPCNGVAGF 2031 454
HLA-A*02:11 GVEGFNCYFPL GVAGFNCYFPL 464 172
HLA-A*02:06 GVEGFNCYFPL GVAGFNCYFPL 400 174

Q493R

Reference  ISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELL

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYSFRPTY 6543 4
HLA-C*16:01 QSYGFQPTN RSYSFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYSFRPTY 12903 12
HLA-A*31:01 EGFNCYFPLQ AGFNCYFPLR 13906 13
HLA-A*32:01 QSYGFQPTN RSYSFRPTY 16619 18
HLA-A*33:03 YFPLQSYGFQ YFPLRSYSFR 11148 17
HLA-A*31:01 YFPLQSYGFQ YFPLRSYSFR 16290 26
HLA-A*31:01 CYFPLQSYGFQ CYFPLRSYSFR 8535 15
HLA-A*30:02 QSYGFQPTN RSYSFRPTY 5297 10
HLA-C*12:03 QSYGFQPTN RSYSFRPTY 12696 26
HLA-A*29:02 QSYGFQPTN RSYSFRPTY 26152 54
HLA-A*33:03 FPLQSYGFQ FPLRSYSFR 23527 50
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 19514 44
HLA-A*33:03 CYFPLQSYGFQ CYFPLRSYSFR 11311 30
HLA-B*15:01 QSYGFQPTN RSYSFRPTY 21529 63
HLA-A*31:01 GFNCYFPLQ GFNCYFPLR 8660 27
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18230 64
HLA-A*30:01 QSYGFQPTN RSYSFRPTY 3720 14
HLA-A*68:01 GVEGFNCYFPLQ GVAGFNCYFPLR 27995 107
HLA-C*14:02 QSYGFQPTN RSYSFRPTY 25941 102
HLA-A*03:01 QSYGFQPTN RSYSFRPTY 24499 97
HLA-A*11:01 QSYGFQPTN RSYSFRPTY 22068 90
HLA-B*35:01 FPLQSYGFQPTN FPLRSYSFRPTY 8715 38
HLA-B*27:05 LQSYGFQPTN LRSYSFRPTY 22303 102
HLA-A*30:01 QSYGFQPTNG RSYSFRPTYG 4998 24
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLRSYSFR 21321 109
HLA-C*03:02 FPLQSYGFQPTN FPLRSYSFRPTY 23840 122
HLA-A*68:01 FPLQSYGFQ FPLRSYSFR 17691 92
HLA-C*12:02 QSYGFQPTN RSYSFRPTY 21029 113
HLA-A*31:01 GVEGFNCYFPLQ GVAGFNCYFPLR 15109 90
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLRSYSFR 22134 133
HLA-C*03:02 LQSYGFQPTN LRSYSFRPTY 23421 153
HLA-C*16:01 LQSYGFQPTN LRSYSFRPTY 27149 179
HLA-A*30:02 LQSYGFQPTN LRSYSFRPTY 7508 51
HLA-B*15:03 FPLQSYGFQPTN FPLRSYSFRPTY 20159 140
HLA-B*15:01 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 180 25255
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 27639 197
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYSFRPTY 22168 161
HLA-A*33:03 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23280 170
HLA-A*33:03 GFNCYFPLQ GFNCYFPLR 15908 119
HLA-C*16:01 FPLQSYGFQPTN FPLRSYSFRPTY 27733 222
HLA-C*02:02 QSYGFQPTN RSYSFRPTY 26598 213
HLA-C*02:10 QSYGFQPTN RSYSFRPTY 26598 213
HLA-A*31:01 QSYGFQPTN RSYSFRPTY 23046 191
HLA-B*57:01 QSYGFQPTN RSYSFRPTY 4070 37
HLA-B*15:03 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 113 12262
HLA-A*31:01 VEGFNCYFPLQ VAGFNCYFPLR 15897 151
HLA-B*15:03 QSYGFQPTNG RSYSFRPTYG 16794 170
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYSFRPTY 29358 298
HLA-A*31:01 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23471 255
HLA-A*29:02 LQSYGFQPTN LRSYSFRPTY 28458 328
HLA-A*68:01 YFPLQSYGFQ YFPLRSYSFR 14480 173
HLA-B*15:03 LQSYGFQPTN LRSYSFRPTY 2045 25
HLA-A*02:06 LQSYGFQPT LRSYSFRPT 339 27414
HLA-A*30:02 QSYGFQPTNG RSYSFRPTYG 9959 133
HLA-A*31:01 GFNCYFPLQSYGFQ GFNCYFPLRSYSFR 25301 339
HLA-C*07:01 QSYGFQPTN RSYSFRPTY 29907 402
HLA-C*12:03 FPLQSYGFQPTN FPLRSYSFRPTY 27893 375
HLA-A*30:02 PLQSYGFQPTN PLRSYSFRPTY 26291 368
HLA-A*11:01 EGFNCYFPLQ AGFNCYFPLR 25719 362
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 27182 410
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18743 295
HLA-A*30:01 QSYGFQPTNGV RSYSFRPTYGV 5404 89
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 24158 399
HLA-A*30:02 FPLQSYGFQPTN FPLRSYSFRPTY 21475 358
HLA-C*12:03 LQSYGFQPTN LRSYSFRPTY 26641 445
HLA-A*33:03 GVEGFNCYFPLQ GVAGFNCYFPLR 24534 414
HLA-B*58:01 QSYGFQPTN RSYSFRPTY 1532 27
HLA-B*08:01 FPLQSYGF FPLRSYSF 3941 70
HLA-A*33:03 NGVEGFNCYFPLQ NGVAGFNCYFPLR 23008 416
HLA-A*31:01 CYFPLQSYGFQP CYFPLRSYSFRP 17123 334
HLA-A*33:03 EGFNCYFPLQ AGFNCYFPLR 7445 148
HLA-A*30:01 LQSYGFQPTN LRSYSFRPTY 9833 210
HLA-A*30:01 QSYGFQPTNGVG RSYSFRPTYGVG 11201 247
HLA-B*15:03 LQSYGFQPT LRSYSFRPT 138 5279
HLA-B*27:05 LQSYGFQPTNGV LRSYSFRPTYGV 17291 463
HLA-B*58:02 QSYGFQPTN RSYSFRPTY 16990 494
HLA-A*30:01 QSYGFQPT RSYSFRPT 11364 334
HLA-B*15:01 LQSYGFQPTN LRSYSFRPTY 6135 204
HLA-B*08:01 YFPLQSYGF YFPLRSYSF 9297 410
HLA-B*53:01 FPLQSYGFQPTN FPLRSYSFRPTY 8451 381
HLA-A*68:02 FPLQSYGFQPTNGV FPLRSYSFRPTYGV 2978 145
HLA-A*68:01 EGFNCYFPLQ AGFNCYFPLR 5231 331
HLA-B*57:01 LQSYGFQPTN LRSYSFRPTY 3839 290
HLA-B*42:01 FPLQSYGF FPLRSYSF 551 49
HLA-A*30:02 EGFNCYFPLQSY AGFNCYFPLRSY 1806 189
HLA-A*02:06 LQSYGFQPTNGV LRSYSFRPTYGV 249 2086
HLA-C*07:02 YFPLQSYGF YFPLRSYSF 447 54
HLA-C*14:02 YFPLQSYGFQ YFPLRSYSFR 2320 343
HLA-A*02:11 QSYGFQPTNGV RSYSFRPTYGV 2666 442
HLA-B*07:02 FPLQSYGF FPLRSYSF 2797 499
HLA-B*58:01 QSYGFQPTNG RSYSFRPTYG 2069 381
HLA-A*68:02 QSYGFQPTNGV RSYSFRPTYGV 122 650
HLA-C*15:02 QSYGFQPTNGV RSYSFRPTYGV 2452 486
HLA-A*30:02 QSYGFQPTNGVGY RSYSFRPTYGVGH 258 1298
HLA-C*14:02 CYFPLQSYGF CYFPLRSYSF 115 23
HLA-B*58:01 LQSYGFQPTN LRSYSFRPTY 1885 411
HLA-C*07:02 CYFPLQSYGF CYFPLRSYSF 1057 255
HLA-A*68:02 LQSYGFQPTNGV LRSYSFRPTYGV 1606 399
HLA-B*35:01 NCYFPLQSY NCYFPLRSY 330 1198
HLA-B*15:03 CYFPLQSYGF CYFPLRSYSF 1213 335
HLA-C*14:02 YFPLQSYGF YFPLRSYSF 18 5
HLA-A*02:06 QSYGFQPTNGV RSYSFRPTYGV 1121 320
HLA-A*24:02 CYFPLQSYGFQ CYFPLRSYSFR 1378 469
HLA-A*24:02 NCYFPLQSYGF NCYFPLRSYSF 725 252
HLA-A*23:01 CYFPLQSYGFQ CYFPLRSYSFR 498 191
HLA-A*24:02 YFPLQSYGF YFPLRSYSF 50 20
HLA-A*23:01 NCYFPLQSYGF NCYFPLRSYSF 271 112
HLA-A*23:01 FNCYFPLQSYGF FNCYFPLRSYSF 795 334
HLA-B*35:01 FPLQSYGF FPLRSYSF 197 94
HLA-A*23:01 YFPLQSYGF YFPLRSYSF 49 24

G496S

Reference  EIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAP
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAP

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYSFRPTY 6543 4
HLA-C*16:01 QSYGFQPTN RSYSFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYSFRPTY 12903 12
HLA-A*32:01 QSYGFQPTN RSYSFRPTY 16619 18
HLA-A*33:03 YFPLQSYGFQ YFPLRSYSFR 11148 17
HLA-A*31:01 YFPLQSYGFQ YFPLRSYSFR 16290 26
HLA-A*31:01 CYFPLQSYGFQ CYFPLRSYSFR 8535 15
HLA-A*30:02 QSYGFQPTN RSYSFRPTY 5297 10
HLA-C*12:03 QSYGFQPTN RSYSFRPTY 12696 26
HLA-A*29:02 QSYGFQPTN RSYSFRPTY 26152 54
HLA-A*33:03 FPLQSYGFQ FPLRSYSFR 23527 50
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 19514 44
HLA-C*14:02 SYGFQPTN SYSFRPTY 20230 46
HLA-A*33:03 CYFPLQSYGFQ CYFPLRSYSFR 11311 30
HLA-B*15:01 QSYGFQPTN RSYSFRPTY 21529 63
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18230 64
HLA-A*30:01 QSYGFQPTN RSYSFRPTY 3720 14
HLA-C*14:02 QSYGFQPTN RSYSFRPTY 25941 102
HLA-A*03:01 QSYGFQPTN RSYSFRPTY 24499 97
HLA-A*11:01 QSYGFQPTN RSYSFRPTY 22068 90
HLA-B*35:01 FPLQSYGFQPTN FPLRSYSFRPTY 8715 38
HLA-B*27:05 LQSYGFQPTN LRSYSFRPTY 22303 102
HLA-A*30:01 QSYGFQPTNG RSYSFRPTYG 4998 24
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLRSYSFR 21321 109
HLA-C*03:02 FPLQSYGFQPTN FPLRSYSFRPTY 23840 122
HLA-A*68:01 FPLQSYGFQ FPLRSYSFR 17691 92
HLA-C*12:02 QSYGFQPTN RSYSFRPTY 21029 113
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLRSYSFR 22134 133
HLA-C*03:02 LQSYGFQPTN LRSYSFRPTY 23421 153
HLA-C*16:01 LQSYGFQPTN LRSYSFRPTY 27149 179
HLA-A*30:02 LQSYGFQPTN LRSYSFRPTY 7508 51
HLA-B*15:03 FPLQSYGFQPTN FPLRSYSFRPTY 20159 140
HLA-B*15:01 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 180 25255
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 27639 197
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYSFRPTY 22168 161
HLA-A*33:03 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23280 170
HLA-C*16:01 FPLQSYGFQPTN FPLRSYSFRPTY 27733 222
HLA-C*02:02 QSYGFQPTN RSYSFRPTY 26598 213
HLA-C*02:10 QSYGFQPTN RSYSFRPTY 26598 213
HLA-A*31:01 QSYGFQPTN RSYSFRPTY 23046 191
HLA-B*57:01 QSYGFQPTN RSYSFRPTY 4070 37
HLA-B*15:03 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 113 12262
HLA-B*15:03 QSYGFQPTNG RSYSFRPTYG 16794 170
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYSFRPTY 29358 298
HLA-A*31:01 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23471 255
HLA-A*29:02 LQSYGFQPTN LRSYSFRPTY 28458 328
HLA-A*68:01 YFPLQSYGFQ YFPLRSYSFR 14480 173
HLA-B*15:03 LQSYGFQPTN LRSYSFRPTY 2045 25
HLA-A*02:06 LQSYGFQPT LRSYSFRPT 339 27414
HLA-A*30:02 QSYGFQPTNG RSYSFRPTYG 9959 133
HLA-A*31:01 GFNCYFPLQSYGFQ GFNCYFPLRSYSFR 25301 339
HLA-C*07:01 QSYGFQPTN RSYSFRPTY 29907 402
HLA-C*12:03 FPLQSYGFQPTN FPLRSYSFRPTY 27893 375
HLA-A*30:02 PLQSYGFQPTN PLRSYSFRPTY 26291 368
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 27182 410
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18743 295
HLA-A*30:01 QSYGFQPTNGV RSYSFRPTYGV 5404 89
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 24158 399
HLA-A*30:01 GFQPTNGVG SFRPTYGVG 11700 194
HLA-A*29:02 GFQPTNGVGY SFRPTYGVGH 188 11320
HLA-A*30:02 FPLQSYGFQPTN FPLRSYSFRPTY 21475 358
HLA-C*12:03 LQSYGFQPTN LRSYSFRPTY 26641 445
HLA-B*58:01 QSYGFQPTN RSYSFRPTY 1532 27
HLA-B*08:01 FPLQSYGF FPLRSYSF 3941 70
HLA-A*31:01 CYFPLQSYGFQP CYFPLRSYSFRP 17123 334
HLA-A*32:01 YGFQPTNGV YSFRPTYGV 13051 263
HLA-A*30:01 LQSYGFQPTN LRSYSFRPTY 9833 210
HLA-A*68:02 SYGFQPTNGV SYSFRPTYGV 1210 26
HLA-A*30:01 QSYGFQPTNGVG RSYSFRPTYGVG 11201 247
HLA-A*68:02 YGFQPTNGVG YSFRPTYGVG 7086 171
HLA-A*02:11 YGFQPTNGV YSFRPTYGV 307 8
HLA-B*15:03 LQSYGFQPT LRSYSFRPT 138 5279
HLA-B*27:05 LQSYGFQPTNGV LRSYSFRPTYGV 17291 463
HLA-B*58:02 QSYGFQPTN RSYSFRPTY 16990 494
HLA-A*30:01 QSYGFQPT RSYSFRPT 11364 334
HLA-B*58:01 YGFQPTNGV YSFRPTYGV 14381 443
HLA-C*15:02 YGFQPTNGV YSFRPTYGV 891 28
HLA-B*15:01 LQSYGFQPTN LRSYSFRPTY 6135 204
HLA-A*02:01 YGFQPTNGV YSFRPTYGV 2160 87
HLA-A*68:02 YGFQPTNGV YSFRPTYGV 73 3
HLA-B*08:01 YFPLQSYGF YFPLRSYSF 9297 410
HLA-B*53:01 FPLQSYGFQPTN FPLRSYSFRPTY 8451 381
HLA-A*68:02 FPLQSYGFQPTNGV FPLRSYSFRPTYGV 2978 145
HLA-A*02:06 YGFQPTNGV YSFRPTYGV 174 10
HLA-A*30:02 GFQPTNGVGY SFRPTYGVGH 169 2666
HLA-A*02:02 YGFQPTNGV YSFRPTYGV 868 59
HLA-B*57:01 LQSYGFQPTN LRSYSFRPTY 3839 290
HLA-A*33:03 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 2507 191
HLA-A*29:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1751 138
HLA-B*15:03 YGFQPTNGVGY YSFRPTYGVGH 368 4552
HLA-B*42:01 FPLQSYGF FPLRSYSF 551 49
HLA-C*16:01 YGFQPTNGV YSFRPTYGV 447 42
HLA-A*31:01 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 616 65
HLA-C*14:02 GFQPTNGVGYQPY SFRPTYGVGHQPY 3457 369
HLA-C*17:01 YGFQPTNGV YSFRPTYGV 1282 140
HLA-A*02:06 SYGFQPTNGV SYSFRPTYGV 3944 455
HLA-C*16:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 2950 348
HLA-A*02:06 LQSYGFQPTNGV LRSYSFRPTYGV 249 2086
HLA-C*07:02 YFPLQSYGF YFPLRSYSF 447 54
HLA-C*03:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 964 122
HLA-C*14:02 YFPLQSYGFQ YFPLRSYSFR 2320 343
HLA-A*30:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1643 263
HLA-C*02:02 YGFQPTNGV YSFRPTYGV 2190 356
HLA-C*02:10 YGFQPTNGV YSFRPTYGV 2190 356
HLA-A*02:11 QSYGFQPTNGV RSYSFRPTYGV 2666 442
HLA-C*03:02 YGFQPTNGV YSFRPTYGV 688 117
HLA-B*07:02 FPLQSYGF FPLRSYSF 2797 499
HLA-A*23:01 SYGFQPTNGV SYSFRPTYGV 2697 488
HLA-C*12:03 YGFQPTNGV YSFRPTYGV 127 23
HLA-B*58:01 QSYGFQPTNG RSYSFRPTYG 2069 381
HLA-A*68:02 QSYGFQPTNGV RSYSFRPTYGV 122 650
HLA-C*15:02 QSYGFQPTNGV RSYSFRPTYGV 2452 486
HLA-A*30:02 QSYGFQPTNGVGY RSYSFRPTYGVGH 258 1298
HLA-C*14:02 CYFPLQSYGF CYFPLRSYSF 115 23
HLA-B*15:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 939 204
HLA-B*58:01 LQSYGFQPTN LRSYSFRPTY 1885 411
HLA-C*07:02 CYFPLQSYGF CYFPLRSYSF 1057 255
HLA-C*03:03 YGFQPTNGV YSFRPTYGV 569 139
HLA-C*03:04 YGFQPTNGV YSFRPTYGV 569 139
HLA-A*68:02 LQSYGFQPTNGV LRSYSFRPTYGV 1606 399
HLA-B*15:03 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 519 136
HLA-C*12:02 YGFQPTNGV YSFRPTYGV 1034 273
HLA-B*15:03 CYFPLQSYGF CYFPLRSYSF 1213 335
HLA-C*14:02 YFPLQSYGF YFPLRSYSF 18 5
HLA-A*02:06 QSYGFQPTNGV RSYSFRPTYGV 1121 320
HLA-A*24:02 CYFPLQSYGFQ CYFPLRSYSFR 1378 469
HLA-A*24:02 NCYFPLQSYGF NCYFPLRSYSF 725 252
HLA-A*23:01 CYFPLQSYGFQ CYFPLRSYSFR 498 191
HLA-A*24:02 YFPLQSYGF YFPLRSYSF 50 20
HLA-A*23:01 NCYFPLQSYGF NCYFPLRSYSF 271 112
HLA-A*23:01 FNCYFPLQSYGF FNCYFPLRSYSF 795 334
HLA-B*35:01 FPLQSYGF FPLRSYSF 197 94
HLA-A*23:01 YFPLQSYGF YFPLRSYSF 49 24

Q498R

Reference  YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPAT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPAT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYSFRPTY 6543 4
HLA-C*16:01 QSYGFQPTN RSYSFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYSFRPTY 12903 12
HLA-A*32:01 QSYGFQPTN RSYSFRPTY 16619 18
HLA-A*33:03 YFPLQSYGFQ YFPLRSYSFR 11148 17
HLA-A*31:01 YFPLQSYGFQ YFPLRSYSFR 16290 26
HLA-A*31:01 CYFPLQSYGFQ CYFPLRSYSFR 8535 15
HLA-A*30:02 QSYGFQPTN RSYSFRPTY 5297 10
HLA-C*12:03 QSYGFQPTN RSYSFRPTY 12696 26
HLA-A*29:02 QSYGFQPTN RSYSFRPTY 26152 54
HLA-A*33:03 FPLQSYGFQ FPLRSYSFR 23527 50
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 19514 44
HLA-C*14:02 SYGFQPTN SYSFRPTY 20230 46
HLA-A*33:03 CYFPLQSYGFQ CYFPLRSYSFR 11311 30
HLA-B*15:01 QSYGFQPTN RSYSFRPTY 21529 63
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18230 64
HLA-A*30:01 QSYGFQPTN RSYSFRPTY 3720 14
HLA-C*14:02 QSYGFQPTN RSYSFRPTY 25941 102
HLA-A*03:01 QSYGFQPTN RSYSFRPTY 24499 97
HLA-A*11:01 QSYGFQPTN RSYSFRPTY 22068 90
HLA-B*35:01 FPLQSYGFQPTN FPLRSYSFRPTY 8715 38
HLA-B*27:05 LQSYGFQPTN LRSYSFRPTY 22303 102
HLA-A*30:01 QSYGFQPTNG RSYSFRPTYG 4998 24
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLRSYSFR 21321 109
HLA-C*03:02 FPLQSYGFQPTN FPLRSYSFRPTY 23840 122
HLA-A*68:01 FPLQSYGFQ FPLRSYSFR 17691 92
HLA-C*12:02 QSYGFQPTN RSYSFRPTY 21029 113
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLRSYSFR 22134 133
HLA-C*03:02 LQSYGFQPTN LRSYSFRPTY 23421 153
HLA-C*16:01 LQSYGFQPTN LRSYSFRPTY 27149 179
HLA-A*30:02 LQSYGFQPTN LRSYSFRPTY 7508 51
HLA-B*15:03 FPLQSYGFQPTN FPLRSYSFRPTY 20159 140
HLA-B*15:01 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 180 25255
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 27639 197
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYSFRPTY 22168 161
HLA-A*33:03 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23280 170
HLA-C*16:01 FPLQSYGFQPTN FPLRSYSFRPTY 27733 222
HLA-C*02:02 QSYGFQPTN RSYSFRPTY 26598 213
HLA-C*02:10 QSYGFQPTN RSYSFRPTY 26598 213
HLA-A*31:01 QSYGFQPTN RSYSFRPTY 23046 191
HLA-B*57:01 QSYGFQPTN RSYSFRPTY 4070 37
HLA-B*15:03 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 113 12262
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-B*15:03 QSYGFQPTNG RSYSFRPTYG 16794 170
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYSFRPTY 29358 298
HLA-A*31:01 FNCYFPLQSYGFQ FNCYFPLRSYSFR 23471 255
HLA-A*29:02 LQSYGFQPTN LRSYSFRPTY 28458 328
HLA-A*68:01 YFPLQSYGFQ YFPLRSYSFR 14480 173
HLA-B*15:03 LQSYGFQPTN LRSYSFRPTY 2045 25
HLA-A*02:06 LQSYGFQPT LRSYSFRPT 339 27414
HLA-A*30:02 QSYGFQPTNG RSYSFRPTYG 9959 133
HLA-A*31:01 GFNCYFPLQSYGFQ GFNCYFPLRSYSFR 25301 339
HLA-C*07:01 QSYGFQPTN RSYSFRPTY 29907 402
HLA-C*12:03 FPLQSYGFQPTN FPLRSYSFRPTY 27893 375
HLA-A*30:02 PLQSYGFQPTN PLRSYSFRPTY 26291 368
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 27182 410
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18743 295
HLA-A*30:01 QSYGFQPTNGV RSYSFRPTYGV 5404 89
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 24158 399
HLA-A*30:01 GFQPTNGVG SFRPTYGVG 11700 194
HLA-A*29:02 GFQPTNGVGY SFRPTYGVGH 188 11320
HLA-A*30:02 FPLQSYGFQPTN FPLRSYSFRPTY 21475 358
HLA-C*12:03 LQSYGFQPTN LRSYSFRPTY 26641 445
HLA-B*58:01 QSYGFQPTN RSYSFRPTY 1532 27
HLA-A*31:01 CYFPLQSYGFQP CYFPLRSYSFRP 17123 334
HLA-A*32:01 YGFQPTNGV YSFRPTYGV 13051 263
HLA-A*30:01 LQSYGFQPTN LRSYSFRPTY 9833 210
HLA-A*68:02 SYGFQPTNGV SYSFRPTYGV 1210 26
HLA-A*30:01 QSYGFQPTNGVG RSYSFRPTYGVG 11201 247
HLA-A*68:02 YGFQPTNGVG YSFRPTYGVG 7086 171
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-A*02:11 YGFQPTNGV YSFRPTYGV 307 8
HLA-B*15:03 LQSYGFQPT LRSYSFRPT 138 5279
HLA-B*27:05 LQSYGFQPTNGV LRSYSFRPTYGV 17291 463
HLA-B*58:02 QSYGFQPTN RSYSFRPTY 16990 494
HLA-A*30:01 QSYGFQPT RSYSFRPT 11364 334
HLA-B*58:01 YGFQPTNGV YSFRPTYGV 14381 443
HLA-C*15:02 YGFQPTNGV YSFRPTYGV 891 28
HLA-B*15:01 LQSYGFQPTN LRSYSFRPTY 6135 204
HLA-A*02:01 YGFQPTNGV YSFRPTYGV 2160 87
HLA-A*68:02 YGFQPTNGV YSFRPTYGV 73 3
HLA-B*53:01 FPLQSYGFQPTN FPLRSYSFRPTY 8451 381
HLA-A*68:02 FPLQSYGFQPTNGV FPLRSYSFRPTYGV 2978 145
HLA-A*02:06 YGFQPTNGV YSFRPTYGV 174 10
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*30:02 GFQPTNGVGY SFRPTYGVGH 169 2666
HLA-A*02:02 YGFQPTNGV YSFRPTYGV 868 59
HLA-B*57:01 LQSYGFQPTN LRSYSFRPTY 3839 290
HLA-A*33:03 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 2507 191
HLA-A*29:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1751 138
HLA-B*15:03 YGFQPTNGVGY YSFRPTYGVGH 368 4552
HLA-C*16:01 YGFQPTNGV YSFRPTYGV 447 42
HLA-A*31:01 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 616 65
HLA-C*14:02 GFQPTNGVGYQPY SFRPTYGVGHQPY 3457 369
HLA-C*17:01 YGFQPTNGV YSFRPTYGV 1282 140
HLA-A*02:06 SYGFQPTNGV SYSFRPTYGV 3944 455
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-C*16:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 2950 348
HLA-A*02:06 LQSYGFQPTNGV LRSYSFRPTYGV 249 2086
HLA-C*03:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 964 122
HLA-C*14:02 YFPLQSYGFQ YFPLRSYSFR 2320 343
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-A*30:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1643 263
HLA-C*02:02 YGFQPTNGV YSFRPTYGV 2190 356
HLA-C*02:10 YGFQPTNGV YSFRPTYGV 2190 356
HLA-A*02:11 QSYGFQPTNGV RSYSFRPTYGV 2666 442
HLA-C*03:02 YGFQPTNGV YSFRPTYGV 688 117
HLA-A*23:01 SYGFQPTNGV SYSFRPTYGV 2697 488
HLA-C*12:03 YGFQPTNGV YSFRPTYGV 127 23
HLA-B*58:01 QSYGFQPTNG RSYSFRPTYG 2069 381
HLA-A*68:02 QSYGFQPTNGV RSYSFRPTYGV 122 650
HLA-C*15:02 QSYGFQPTNGV RSYSFRPTYGV 2452 486
HLA-A*30:02 QSYGFQPTNGVGY RSYSFRPTYGVGH 258 1298
HLA-B*15:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 939 204
HLA-B*58:01 LQSYGFQPTN LRSYSFRPTY 1885 411
HLA-C*03:03 YGFQPTNGV YSFRPTYGV 569 139
HLA-C*03:04 YGFQPTNGV YSFRPTYGV 569 139
HLA-A*68:02 LQSYGFQPTNGV LRSYSFRPTYGV 1606 399
HLA-B*15:03 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 519 136
HLA-C*12:02 YGFQPTNGV YSFRPTYGV 1034 273
HLA-A*02:06 QSYGFQPTNGV RSYSFRPTYGV 1121 320
HLA-A*24:02 CYFPLQSYGFQ CYFPLRSYSFR 1378 469
HLA-A*23:01 CYFPLQSYGFQ CYFPLRSYSFR 498 191

N501Y

Reference  GSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYSFRPTY 6543 4
HLA-C*16:01 QSYGFQPTN RSYSFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYSFRPTY 12903 12
HLA-A*32:01 QSYGFQPTN RSYSFRPTY 16619 18
HLA-A*30:02 QSYGFQPTN RSYSFRPTY 5297 10
HLA-C*12:03 QSYGFQPTN RSYSFRPTY 12696 26
HLA-A*29:02 QSYGFQPTN RSYSFRPTY 26152 54
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 19514 44
HLA-C*14:02 SYGFQPTN SYSFRPTY 20230 46
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*15:01 QSYGFQPTN RSYSFRPTY 21529 63
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18230 64
HLA-A*30:01 QSYGFQPTN RSYSFRPTY 3720 14
HLA-C*14:02 QSYGFQPTN RSYSFRPTY 25941 102
HLA-A*03:01 QSYGFQPTN RSYSFRPTY 24499 97
HLA-A*11:01 QSYGFQPTN RSYSFRPTY 22068 90
HLA-B*35:01 FPLQSYGFQPTN FPLRSYSFRPTY 8715 38
HLA-B*27:05 LQSYGFQPTN LRSYSFRPTY 22303 102
HLA-A*30:01 QSYGFQPTNG RSYSFRPTYG 4998 24
HLA-C*03:02 FPLQSYGFQPTN FPLRSYSFRPTY 23840 122
HLA-C*12:02 QSYGFQPTN RSYSFRPTY 21029 113
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-C*03:02 LQSYGFQPTN LRSYSFRPTY 23421 153
HLA-C*16:01 LQSYGFQPTN LRSYSFRPTY 27149 179
HLA-A*30:02 LQSYGFQPTN LRSYSFRPTY 7508 51
HLA-B*15:03 FPLQSYGFQPTN FPLRSYSFRPTY 20159 140
HLA-B*15:01 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 180 25255
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 27639 197
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYSFRPTY 22168 161
HLA-C*16:01 FPLQSYGFQPTN FPLRSYSFRPTY 27733 222
HLA-C*02:02 QSYGFQPTN RSYSFRPTY 26598 213
HLA-C*02:10 QSYGFQPTN RSYSFRPTY 26598 213
HLA-A*31:01 QSYGFQPTN RSYSFRPTY 23046 191
HLA-B*57:01 QSYGFQPTN RSYSFRPTY 4070 37
HLA-B*15:03 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 113 12262
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-B*15:03 QSYGFQPTNG RSYSFRPTYG 16794 170
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYSFRPTY 29358 298
HLA-A*29:02 LQSYGFQPTN LRSYSFRPTY 28458 328
HLA-B*15:03 LQSYGFQPTN LRSYSFRPTY 2045 25
HLA-A*30:02 QSYGFQPTNG RSYSFRPTYG 9959 133
HLA-C*07:01 QSYGFQPTN RSYSFRPTY 29907 402
HLA-C*12:03 FPLQSYGFQPTN FPLRSYSFRPTY 27893 375
HLA-A*30:02 PLQSYGFQPTN PLRSYSFRPTY 26291 368
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 27182 410
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYSFRPTY 18743 295
HLA-A*30:01 QSYGFQPTNGV RSYSFRPTYGV 5404 89
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYSFRPTY 24158 399
HLA-A*30:01 GFQPTNGVG SFRPTYGVG 11700 194
HLA-A*29:02 GFQPTNGVGY SFRPTYGVGH 188 11320
HLA-A*30:02 FPLQSYGFQPTN FPLRSYSFRPTY 21475 358
HLA-C*12:03 LQSYGFQPTN LRSYSFRPTY 26641 445
HLA-B*58:01 QSYGFQPTN RSYSFRPTY 1532 27
HLA-A*32:01 YGFQPTNGV YSFRPTYGV 13051 263
HLA-A*30:01 LQSYGFQPTN LRSYSFRPTY 9833 210
HLA-A*68:02 SYGFQPTNGV SYSFRPTYGV 1210 26
HLA-A*30:01 QSYGFQPTNGVG RSYSFRPTYGVG 11201 247
HLA-A*68:02 YGFQPTNGVG YSFRPTYGVG 7086 171
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-A*02:11 YGFQPTNGV YSFRPTYGV 307 8
HLA-B*27:05 LQSYGFQPTNGV LRSYSFRPTYGV 17291 463
HLA-B*58:02 QSYGFQPTN RSYSFRPTY 16990 494
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-B*58:01 YGFQPTNGV YSFRPTYGV 14381 443
HLA-C*15:02 YGFQPTNGV YSFRPTYGV 891 28
HLA-B*15:01 LQSYGFQPTN LRSYSFRPTY 6135 204
HLA-A*02:01 YGFQPTNGV YSFRPTYGV 2160 87
HLA-A*68:02 YGFQPTNGV YSFRPTYGV 73 3
HLA-B*53:01 FPLQSYGFQPTN FPLRSYSFRPTY 8451 381
HLA-A*68:02 FPLQSYGFQPTNGV FPLRSYSFRPTYGV 2978 145
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-A*02:06 YGFQPTNGV YSFRPTYGV 174 10
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*30:02 GFQPTNGVGY SFRPTYGVGH 169 2666
HLA-A*02:02 YGFQPTNGV YSFRPTYGV 868 59
HLA-B*57:01 LQSYGFQPTN LRSYSFRPTY 3839 290
HLA-A*33:03 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 2507 191
HLA-A*29:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1751 138
HLA-B*15:03 YGFQPTNGVGY YSFRPTYGVGH 368 4552
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-C*16:01 YGFQPTNGV YSFRPTYGV 447 42
HLA-A*31:01 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 616 65
HLA-C*14:02 GFQPTNGVGYQPY SFRPTYGVGHQPY 3457 369
HLA-C*17:01 YGFQPTNGV YSFRPTYGV 1282 140
HLA-A*02:06 SYGFQPTNGV SYSFRPTYGV 3944 455
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-C*16:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 2950 348
HLA-A*02:06 LQSYGFQPTNGV LRSYSFRPTYGV 249 2086
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-C*03:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 964 122
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-A*30:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1643 263
HLA-C*02:02 YGFQPTNGV YSFRPTYGV 2190 356
HLA-C*02:10 YGFQPTNGV YSFRPTYGV 2190 356
HLA-A*02:11 QSYGFQPTNGV RSYSFRPTYGV 2666 442
HLA-C*03:02 YGFQPTNGV YSFRPTYGV 688 117
HLA-A*23:01 SYGFQPTNGV SYSFRPTYGV 2697 488
HLA-C*12:03 YGFQPTNGV YSFRPTYGV 127 23
HLA-B*58:01 QSYGFQPTNG RSYSFRPTYG 2069 381
HLA-A*68:02 QSYGFQPTNGV RSYSFRPTYGV 122 650
HLA-C*15:02 QSYGFQPTNGV RSYSFRPTYGV 2452 486
HLA-A*30:02 QSYGFQPTNGVGY RSYSFRPTYGVGH 258 1298
HLA-B*15:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 939 204
HLA-B*58:01 LQSYGFQPTN LRSYSFRPTY 1885 411
HLA-C*03:03 YGFQPTNGV YSFRPTYGV 569 139
HLA-C*03:04 YGFQPTNGV YSFRPTYGV 569 139
HLA-A*68:02 LQSYGFQPTNGV LRSYSFRPTYGV 1606 399
HLA-B*15:03 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 519 136
HLA-C*12:02 YGFQPTNGV YSFRPTYGV 1034 273
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-A*02:06 QSYGFQPTNGV RSYSFRPTYGV 1121 320
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

Y505H

Reference  CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-B*15:01 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 180 25255
HLA-B*15:03 LQSYGFQPTNGVGY LRSYSFRPTYGVGH 113 12262
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY SFRPTYGVGH 188 11320
HLA-C*14:02 GYQPYRVVV GHQPYRVVV 78 3539
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-A*24:02 GYQPYRVVVLSF GHQPYRVVVLSF 220 6955
HLA-A*23:01 GYQPYRVVVLSF GHQPYRVVVLSF 107 3241
HLA-C*14:02 GYQPYRVVVL GHQPYRVVVL 213 4430
HLA-C*14:02 VGYQPYRVVV VGHQPYRVVV 413 7561
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*30:02 GFQPTNGVGY SFRPTYGVGH 169 2666
HLA-A*33:03 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 2507 191
HLA-A*29:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1751 138
HLA-B*15:03 YGFQPTNGVGY YSFRPTYGVGH 368 4552
HLA-A*02:11 YQPYRVVVL HQPYRVVVL 332 4009
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-A*02:06 YQPYRVVVL HQPYRVVVL 223 2206
HLA-A*31:01 GFQPTNGVGYQPYR SFRPTYGVGHQPYR 616 65
HLA-C*14:02 GFQPTNGVGYQPY SFRPTYGVGHQPY 3457 369
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-C*16:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 2950 348
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-C*03:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 964 122
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*02:02 YQPYRVVVL HQPYRVVVL 360 2683
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-A*30:02 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 1643 263
HLA-C*01:02 YQPYRVVVL HQPYRVVVL 41 241
HLA-A*02:06 YQPYRVVVLSFEL HQPYRVVVLSFEL 430 2495
HLA-C*03:03 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*03:04 YQPYRVVVL HQPYRVVVL 410 2128
HLA-A*30:02 QSYGFQPTNGVGY RSYSFRPTYGVGH 258 1298
HLA-B*15:01 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 939 204
HLA-C*07:02 YQPYRVVVL HQPYRVVVL 135 590
HLA-C*12:03 YQPYRVVVL HQPYRVVVL 132 555
HLA-B*15:03 YGFQPTNGVGYQPY YSFRPTYGVGHQPY 519 136
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-C*14:02 YQPYRVVVL HQPYRVVVL 102 347
HLA-C*16:01 YQPYRVVVL HQPYRVVVL 214 726
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-C*12:03 VGYQPYRVV VGHQPYRVV 398 1196
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*23:01 YQPYRVVVLSF HQPYRVVVLSF 465 1280
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

T547K

Reference  ATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ATVCGPKKSTNLVKNKCVNFNFNGLKGTGVLTESNKKFLPFQQFGRDIADT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 CVNFNFNGLT CVNFNFNGLK 24617 47
HLA-A*68:01 CVNFNFNGLT CVNFNFNGLK 11776 29
HLA-A*03:01 CVNFNFNGLT CVNFNFNGLK 20560 54
HLA-A*03:02 CVNFNFNGLT CVNFNFNGLK 20328 65
HLA-A*68:01 VNFNFNGLT VNFNFNGLK 21996 226
HLA-A*11:01 VNFNFNGLT VNFNFNGLK 30452 398

D614G

Reference  PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*05:01 YQDVNCTEV YQGVNCTEV 82 8597
HLA-C*08:02 YQDVNCTEV YQGVNCTEV 89 8066
HLA-A*02:11 DVNCTEVPV GVNCTEVPV 2140 72
HLA-A*02:02 DVNCTEVPV GVNCTEVPV 4099 213
HLA-A*68:02 DVNCTEVPV GVNCTEVPV 36 659
HLA-A*02:06 DVNCTEVPV GVNCTEVPV 3807 208
HLA-A*68:02 QVAVLYQDV QVAVLYQGV 183 13
HLA-A*68:02 NQVAVLYQDV NQVAVLYQGV 650 52
HLA-A*02:06 QVAVLYQDV QVAVLYQGV 1312 148
HLA-A*02:11 QVAVLYQDV QVAVLYQGV 2169 268
HLA-A*68:02 NTSNQVAVLYQDV NTSNQVAVLYQGV 1858 231
HLA-A*68:02 TSNQVAVLYQDV TSNQVAVLYQGV 3281 457
HLA-A*02:02 QVAVLYQDV QVAVLYQGV 1107 188
HLA-A*02:01 YQDVNCTEV YQGVNCTEV 75 315
HLA-A*02:06 YQDVNCTEV YQGVNCTEV 17 57
HLA-A*02:11 VLYQDVNCT VLYQGVNCT 224 74
HLA-A*02:11 YQDVNCTEV YQGVNCTEV 31 93
HLA-A*02:11 VLYQDVNCTEVP VLYQGVNCTEVP 1000 402
HLA-A*02:02 NQVAVLYQDV NQVAVLYQGV 269 116
HLA-A*02:11 AVLYQDVNCTEV AVLYQGVNCTEV 500 238
HLA-A*02:01 NQVAVLYQDV NQVAVLYQGV 558 267
HLA-A*02:06 NQVAVLYQDV NQVAVLYQGV 36 18

H655Y

Reference  TPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:01 RAGCLIGAEH RAGCLIGAEY 7377 156
HLA-A*30:02 RAGCLIGAEH RAGCLIGAEY 1881 43
HLA-B*15:01 FQTRAGCLIGAEH FQTRAGCLIGAEY 7512 178
HLA-B*15:03 FQTRAGCLIGAEH FQTRAGCLIGAEY 5076 125
HLA-A*30:02 AGCLIGAEH AGCLIGAEY 5331 179
HLA-B*15:03 RAGCLIGAEH RAGCLIGAEY 5254 179
HLA-A*30:02 QTRAGCLIGAEH QTRAGCLIGAEY 8425 342
HLA-B*15:03 AGCLIGAEH AGCLIGAEY 9025 461
HLA-A*02:11 HVNNSYECDIPI YVNNSYECDIPI 1593 109
HLA-A*02:01 HVNNSYECDIPI YVNNSYECDIPI 2384 226
HLA-A*02:06 HVNNSYECDIPI YVNNSYECDIPI 837 92
HLA-A*02:02 HVNNSYECDIPI YVNNSYECDIPI 1466 187
HLA-A*02:11 CLIGAEHV CLIGAEYV 983 221
HLA-B*15:03 AEHVNNSY AEYVNNSY 986 267
HLA-B*18:01 AEHVNNSY AEYVNNSY 902 286

N679K

Reference  EHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-A*68:01 CASYQTQTN CASYQTQTK 28102 123
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-A*11:01 CASYQTQTN CASYQTQTK 32767 431
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

P681H

Reference  VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVA
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVA

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 SPRRARSVA SHRRARSVA 4 4721
HLA-B*42:01 SPRRARSVA SHRRARSVA 8 6169
HLA-B*07:02 SPRRARSVASQSI SHRRARSVASQSI 17 11433
HLA-B*07:02 SPRRARSV SHRRARSV 24 12728
HLA-B*07:02 SPRRARSVAS SHRRARSVAS 37 14758
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-B*07:02 SPRRARSVASQSII SHRRARSVASQSII 55 17736
HLA-B*42:01 SPRRARSV SHRRARSV 38 11622
HLA-B*42:01 SPRRARSVASQSI SHRRARSVASQSI 48 14418
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*42:01 SPRRARSVAS SHRRARSVAS 158 17461
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-B*42:01 SPRRARSVASQSII SHRRARSVASQSII 321 21521
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-B*08:01 SPRRARSVA SHRRARSVA 372 3831
HLA-B*08:01 SPRRARSV SHRRARSV 428 2448
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

D796Y

Reference  AVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDL

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*23:01 KDFGGFNF KYFGGFNF 15419 23
HLA-A*23:01 KDFGGFNFSQI KYFGGFNFSQI 15932 37
HLA-A*24:02 KDFGGFNF KYFGGFNF 21008 55
HLA-C*14:02 IYKTPPIKD IYKTPPIKY 16538 55
HLA-A*24:02 KDFGGFNFSQI KYFGGFNFSQI 20251 68
HLA-B*15:03 KQIYKTPPIKD KQIYKTPPIKY 7773 29
HLA-A*23:01 KDFGGFNFSQIL KYFGGFNFSQIL 15831 63
HLA-C*14:02 KDFGGFNF KYFGGFNF 22081 90
HLA-A*24:02 KDFGGFNFSQIL KYFGGFNFSQIL 21565 126
HLA-B*15:01 KQIYKTPPIKD KQIYKTPPIKY 22193 141
HLA-C*14:02 KDFGGFNFSQIL KYFGGFNFSQIL 14873 165
HLA-A*30:01 KDFGGFNFS KYFGGFNFS 9496 156
HLA-C*14:02 DFGGFNFSQIL YFGGFNFSQIL 6960 139
HLA-A*30:02 KQIYKTPPIKD KQIYKTPPIKY 15917 386
HLA-B*15:03 VKQIYKTPPIKD VKQIYKTPPIKY 16977 446
HLA-B*15:03 IKDFGGFNF IKYFGGFNF 97 4
HLA-B*15:03 PIKDFGGFNF PIKYFGGFNF 7546 321
HLA-B*15:03 TPPIKDFGGFNF TPPIKYFGGFNF 10071 484
HLA-B*15:03 KTPPIKDFGGFNF KTPPIKYFGGFNF 6427 331
HLA-A*32:01 KTPPIKDFGGFNF KTPPIKYFGGFNF 6031 381
HLA-A*23:01 DFGGFNFSQI YFGGFNFSQI 5424 461
HLA-B*15:03 YKTPPIKDFGGFNF YKTPPIKYFGGFNF 2588 394
HLA-C*06:02 YKTPPIKDF YKTPPIKYF 2488 460
HLA-C*07:02 YKTPPIKDF YKTPPIKYF 1804 378
HLA-A*23:01 IYKTPPIKDF IYKTPPIKYF 273 98
HLA-A*24:02 IYKTPPIKDF IYKTPPIKYF 375 147
HLA-C*14:02 IYKTPPIKDF IYKTPPIKYF 341 158
HLA-B*15:03 YKTPPIKDF YKTPPIKYF 92 43

N856K

Reference  AGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AGFIKQYGDCLGDIAARDLICAQKFKGLTVLPPLLTDEMIAQYTSALLAGT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 RDLICAQKFN RDLICAQKFK 22000 33
HLA-A*03:02 RDLICAQKFN RDLICAQKFK 21844 52
HLA-A*68:01 DLICAQKFN DLICAQKFK 26980 78
HLA-A*11:01 RDLICAQKFN RDLICAQKFK 32492 164
HLA-A*03:01 ARDLICAQKFN ARDLICAQKFK 32767 411
HLA-A*03:02 ARDLICAQKFN ARDLICAQKFK 32767 454
HLA-A*03:02 AARDLICAQKFN AARDLICAQKFK 29448 479
HLA-A*30:01 AARDLICAQKFN AARDLICAQKFK 8580 165
HLA-A*30:01 RDLICAQKFN RDLICAQKFK 10169 297
HLA-B*15:03 FNGLTVLPPL FKGLTVLPPL 5291 406
HLA-A*30:01 KFNGLTVLP KFKGLTVLP 2539 318
HLA-A*02:11 NGLTVLPPLL KGLTVLPPLL 1288 244
HLA-A*30:01 KFNGLTVLPPL KFKGLTVLPPL 2305 466
HLA-B*15:03 AQKFNGLTV AQKFKGLTV 65 262
HLA-B*15:01 AQKFNGLTV AQKFKGLTV 210 516
HLA-A*02:06 AQKFNGLTVL AQKFKGLTVL 85 182
HLA-A*02:02 NGLTVLPPLL KGLTVLPPLL 449 219
HLA-B*15:03 ICAQKFNGLTVL ICAQKFKGLTVL 434 878

Q954H

Reference  SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLND

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*38:01 NQNAQALNTL NHNAQALNTL 2805 97
HLA-A*68:02 DVVNQNAQA DVVNHNAQA 703 344

N969K

Reference  ALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQID
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDIFSRLDKVEAEVQID

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 TLVKQLSSN TLVKQLSSK 29207 56
HLA-A*68:01 NTLVKQLSSN NTLVKQLSSK 28063 86
HLA-A*11:01 TLVKQLSSN TLVKQLSSK 32767 125
HLA-B*15:03 SNFGAISSVLNDIL SKFGAISSVLNDIF 14449 59
HLA-A*03:02 TLVKQLSSN TLVKQLSSK 31915 131
HLA-A*11:01 NTLVKQLSSN NTLVKQLSSK 32767 147
HLA-A*03:01 ALNTLVKQLSSN ALNTLVKQLSSK 32767 154
HLA-A*03:02 ALNTLVKQLSSN ALNTLVKQLSSK 32767 304
HLA-A*03:01 NTLVKQLSSN NTLVKQLSSK 32767 482
HLA-A*68:02 SNFGAISSV SKFGAISSV 117 5329
HLA-B*15:03 SNFGAISSVL SKFGAISSVL 688 25
HLA-B*08:01 QLSSNFGAI QLSSKFGAI 4755 265
HLA-C*15:02 SNFGAISSV SKFGAISSV 374 5700
HLA-A*30:01 SSNFGAISS SSKFGAISS 1320 88
HLA-B*15:03 SNFGAISSV SKFGAISSV 727 49
HLA-A*30:01 SSNFGAISSV SSKFGAISSV 587 71
HLA-A*02:06 KQLSSNFGA KQLSSKFGA 62 269
HLA-A*02:01 KQLSSNFGAI KQLSSKFGAI 407 1567
HLA-A*02:11 KQLSSNFGA KQLSSKFGA 228 807
HLA-A*02:06 SNFGAISSV SKFGAISSV 361 1100
HLA-C*06:02 SNFGAISSV SKFGAISSV 1423 485
HLA-A*02:11 KQLSSNFGAI KQLSSKFGAI 152 428
HLA-A*02:06 KQLSSNFGAI KQLSSKFGAI 58 159
HLA-A*02:02 KQLSSNFGAI KQLSSKFGAI 261 668
HLA-B*15:03 KQLSSNFGA KQLSSKFGA 497 1076

L981F

Reference  AQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AQALNTLVKQLSSKFGAISSVLNDIFSRLDKVEAEVQIDRLITGRLQSLQT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 SNFGAISSVLNDIL SKFGAISSVLNDIF 14449 59
HLA-A*02:02 ILSRLDKVEA IFSRLDKVEA 324 11654
HLA-A*02:02 AISSVLNDIL AISSVLNDIF 168 3555
HLA-B*15:01 AISSVLNDIL AISSVLNDIF 7070 350
HLA-A*68:02 DILSRLDKV DIFSRLDKV 1033 74
HLA-B*15:03 ISSVLNDIL ISSVLNDIF 2698 235
HLA-A*02:01 LSRLDKVEAEV FSRLDKVEAEV 1233 145
HLA-A*02:02 ILSRLDKVEAEV IFSRLDKVEAEV 102 836
HLA-A*02:02 LSRLDKVEAEV FSRLDKVEAEV 1120 140
HLA-B*58:01 ISSVLNDIL ISSVLNDIF 207 27
HLA-B*58:01 AISSVLNDIL AISSVLNDIF 2169 307
HLA-B*57:01 ISSVLNDIL ISSVLNDIF 2329 346
HLA-A*02:11 LSRLDKVEAEV FSRLDKVEAEV 231 36
HLA-A*31:01 SVLNDILSR SVLNDIFSR 164 29
HLA-A*33:03 SVLNDILSR SVLNDIFSR 305 55
HLA-A*02:11 SVLNDILSRLDKV SVLNDIFSRLDKV 238 47
HLA-A*31:01 SSVLNDILSR SSVLNDIFSR 601 125
HLA-A*33:03 SSVLNDILSR SSVLNDIFSR 1322 279
HLA-C*03:02 ISSVLNDIL ISSVLNDIF 1374 290
HLA-A*02:06 SVLNDILSRLDKV SVLNDIFSRLDKV 162 37
HLA-A*02:01 SVLNDILSRLDKV SVLNDIFSRLDKV 590 140
HLA-A*68:01 SVLNDILSR SVLNDIFSR 109 28
HLA-A*31:01 ISSVLNDILSR ISSVLNDIFSR 1117 324
HLA-A*02:06 SVLNDILSRL SVLNDIFSRL 206 66
HLA-A*30:01 LSRLDKVEA FSRLDKVEA 324 946
HLA-A*68:01 SSVLNDILSR SSVLNDIFSR 97 36
HLA-A*74:01 SVLNDILSR SVLNDIFSR 1208 457
HLA-A*31:01 AISSVLNDILSR AISSVLNDIFSR 464 176
HLA-A*68:01 AISSVLNDILSR AISSVLNDIFSR 871 393
HLA-A*68:02 SVLNDILSRL SVLNDIFSRL 702 332

N protein

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N

P13L

Reference  MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSK
           |||||||||||| |||||||||||||||||||||||||
Mutated    MSDNGPQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 MSDNGPQNQRNAP MSDNGPQNQRNAL 11146 27
HLA-B*07:02 GPQNQRNAP GPQNQRNAL 2464 6
HLA-B*42:01 GPQNQRNAP GPQNQRNAL 3035 8
HLA-B*07:02 SDNGPQNQRNAP SDNGPQNQRNAL 11353 32
HLA-B*42:01 SDNGPQNQRNAP SDNGPQNQRNAL 13042 39
HLA-B*42:01 NGPQNQRNAP NGPQNQRNAL 12875 41
HLA-B*07:02 MSDNGPQNQRNAP MSDNGPQNQRNAL 13138 58
HLA-B*07:02 NGPQNQRNAP NGPQNQRNAL 14898 72
HLA-B*07:02 APRITFGGPS ALRITFGGPS 191 17534
HLA-B*42:01 PQNQRNAP PQNQRNAL 30142 436
HLA-B*07:02 GPQNQRNAPR GPQNQRNALR 13964 345
HLA-B*27:05 QRNAPRITF QRNALRITF 509 83
HLA-B*27:05 NQRNAPRITF NQRNALRITF 1716 350
HLA-B*27:05 GPQNQRNAPRITF GPQNQRNALRITF 2076 442
HLA-B*15:01 NQRNAPRITF NQRNALRITF 96 40

ERS 31-33 deletion

Reference  PQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQ
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    PQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSKQRRPQGLPNNTASWFTALTQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 RSGARSKQR GARSKQR 77 -
HLA-A*68:01 STGSNQNGER - 137 -
HLA-A*31:01 RSGARSKQRR - 254 -

203-204 RG->KR

Reference  GGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQ
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    GGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 NSTPGSSRG NSTPGSSKR 32767 34
HLA-A*33:03 NSTPGSSRG NSTPGSSKR 32767 300
HLA-B*15:03 SRGTSPARM SKRTSPARM 2669 106
HLA-A*31:01 RNSTPGSSRG RNSTPGSSKR 7013 340
HLA-A*30:01 SSRNSTPGSSR SSRNSTPGSSK 356 20
HLA-A*30:01 GTSPARMAG RTSPARMAG 493 30
HLA-A*31:01 SSRNSTPGSSRG SSRNSTPGSSKR 3757 231
HLA-A*30:01 GTSPARMAGNGG RTSPARMAGNGG 6051 411
HLA-A*31:01 SSRNSTPGSSR SSRNSTPGSSK 127 1853
HLA-A*30:01 NSSRNSTPGSSR NSSRNSTPGSSK 4255 353
HLA-A*30:01 RNSTPGSSR RNSTPGSSK 2120 188
HLA-A*31:01 RNSTPGSSR RNSTPGSSK 123 1335
HLA-A*03:01 SSRNSTPGSSR SSRNSTPGSSK 4753 442
HLA-A*11:01 SSRNSTPGSSR SSRNSTPGSSK 2231 263
HLA-A*68:01 NSSRNSTPGSSR NSSRNSTPGSSK 270 1385
HLA-A*30:01 GSSRGTSPA GSSKRTSPA 555 145
HLA-A*30:01 SSRNSTPGSSRG SSRNSTPGSSKR 1625 469
HLA-A*30:01 SSRGTSPARMAG SSKRTSPARMAG 449 1031

M protein

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M

D3G

Reference  MADSNGTITVEELKKLLEQWNLVIGFLF
           || |||||||||||||||||||||||||
Mutated    MAGSNGTITVEELKKLLEEWNLVIGFLF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*08:02 MADSNGTI MAGSNGTI 136 17519
HLA-C*05:01 MADSNGTITV MAGSNGTITV 73 8987
HLA-C*08:02 MADSNGTITV MAGSNGTITV 94 10283
HLA-C*08:02 MADSNGTITVEEL MAGSNGTITVEEL 237 21647
HLA-C*05:01 MADSNGTI MAGSNGTI 235 19848
HLA-C*05:01 MADSNGTITVEEL MAGSNGTITVEEL 380 23399
HLA-A*11:01 DSNGTITVEELK GSNGTITVEELK 3204 174
HLA-A*68:01 DSNGTITVEELK GSNGTITVEELK 104 1189
HLA-A*02:11 MADSNGTITV MAGSNGTITV 455 1274
HLA-A*02:06 MADSNGTITV MAGSNGTITV 355 772

Q19E

Reference  MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MAGSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*44:03 EQWNLVIGF EEWNLVIGF 1268 15
HLA-B*44:02 EQWNLVIGF EEWNLVIGF 2396 34
HLA-B*44:03 EQWNLVIGFLF EEWNLVIGFLF 5200 85
HLA-B*44:03 EQWNLVIGFL EEWNLVIGFL 8038 135
HLA-B*44:03 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5966 126
HLA-B*44:02 EQWNLVIGFLF EEWNLVIGFLF 6607 162
HLA-B*44:02 EQWNLVIGFL EEWNLVIGFL 9054 237
HLA-B*44:02 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5922 170
HLA-B*15:01 LEQWNLVIGF LEEWNLVIGF 256 8100
HLA-B*18:01 EQWNLVIGF EEWNLVIGF 482 16
HLA-A*02:06 EQWNLVIGFL EEWNLVIGFL 418 10916
HLA-B*15:03 EQWNLVIGF EEWNLVIGF 101 2397
HLA-B*18:01 EQWNLVIGFLF EEWNLVIGFLF 3471 190
HLA-B*40:02 EQWNLVIGFL EEWNLVIGFL 3775 245
HLA-B*15:03 LEQWNLVIGF LEEWNLVIGF 88 1227
HLA-B*40:02 EQWNLVIGF EEWNLVIGF 1765 242
HLA-B*15:03 KLLEQWNLVIGF KLLEEWNLVIGF 365 2285
HLA-A*02:11 LLEQWNLVI LLEEWNLVI 142 24
HLA-A*02:11 LLEQWNLVIGFL LLEEWNLVIGFL 1120 210
HLA-A*02:01 LLEQWNLVI LLEEWNLVI 644 131
HLA-A*29:02 QWNLVIGFLF EWNLVIGFLF 159 780
HLA-A*24:02 QWNLVIGFLF EWNLVIGFLF 53 246
HLA-A*23:01 QWNLVIGFLF EWNLVIGFLF 18 79
HLA-A*02:02 LLEQWNLVI LLEEWNLVI 781 187
HLA-A*02:06 LLEQWNLVI LLEEWNLVI 1869 487
HLA-B*40:02 LEQWNLVI LEEWNLVI 367 1301
HLA-A*02:02 LLEQWNLVIGFL LLEEWNLVIGFL 1047 329

A63T

Reference  AYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*35:01 LACFVLAAVY LTCFVLAAVY 121 1943
HLA-A*68:01 ACFVLAAVYR TCFVLAAVYR 694 80
HLA-B*35:01 ACFVLAAVY TCFVLAAVY 2289 331
HLA-C*03:02 LACFVLAAVY LTCFVLAAVY 145 935
HLA-C*16:01 LACFVLAAV LTCFVLAAV 346 1994
HLA-A*02:01 WLLWPVTLA WLLWPVTLT 33 190
HLA-A*02:02 WLLWPVTLA WLLWPVTLT 32 180
HLA-A*02:11 LWLLWPVTLA LWLLWPVTLT 66 363
HLA-A*02:11 IFLWLLWPVTLA IFLWLLWPVTLT 190 1034
HLA-A*02:11 LLWPVTLA LLWPVTLT 242 1313
HLA-A*33:03 ACFVLAAVYR TCFVLAAVYR 252 47
HLA-A*02:02 LWLLWPVTLA LWLLWPVTLT 304 1623
HLA-C*12:03 LACFVLAAV LTCFVLAAV 214 1116
HLA-A*02:06 WLLWPVTLA WLLWPVTLT 60 302
HLA-A*02:01 LWLLWPVTLA LWLLWPVTLT 228 1142
HLA-A*02:02 TLACFVLAAVY TLTCFVLAAVY 337 1467
HLA-A*02:02 VTLACFVLAAV VTLTCFVLAAV 160 678
HLA-A*68:02 LACFVLAAV LTCFVLAAV 44 11
HLA-A*02:02 PVTLACFVLAAV PVTLTCFVLAAV 479 1907
HLA-A*02:11 LIFLWLLWPVTLA LIFLWLLWPVTLT 406 1602
HLA-A*02:02 TLACFVLAAVYRI TLTCFVLAAVYRI 293 1148
HLA-A*02:11 LACFVLAAV LTCFVLAAV 122 32
HLA-A*02:11 WLLWPVTLA WLLWPVTLT 6 22
HLA-B*15:03 LACFVLAAVY LTCFVLAAVY 81 284
HLA-A*68:02 TLACFVLAA TLTCFVLAA 395 1376
HLA-A*02:02 FLWLLWPVTLACFV FLWLLWPVTLTCFV 485 146
HLA-A*68:01 LACFVLAAVY LTCFVLAAVY 1184 359
HLA-A*02:02 TLACFVLAA TLTCFVLAA 13 41
HLA-A*02:11 TLACFVLAAVY TLTCFVLAAVY 310 929
HLA-A*02:02 FLWLLWPVTLA FLWLLWPVTLT 291 867
HLA-A*02:11 KLIFLWLLWPVTLA KLIFLWLLWPVTLT 290 859
HLA-A*29:02 LACFVLAAVY LTCFVLAAVY 232 81
HLA-A*02:02 VTLACFVLAA VTLTCFVLAA 100 285
HLA-A*02:06 TLACFVLAAV TLTCFVLAAV 16 45
HLA-A*68:02 VTLACFVLAA VTLTCFVLAA 481 1321
HLA-B*15:01 TLACFVLAAVY TLTCFVLAAVY 414 1136
HLA-A*23:01 LWPVTLACF LWPVTLTCF 57 155
HLA-A*24:02 LWPVTLACF LWPVTLTCF 49 133
HLA-A*02:11 FLWLLWPVTLA FLWLLWPVTLT 25 67
HLA-A*02:06 TLACFVLAA TLTCFVLAA 40 107
HLA-A*02:01 LACFVLAAV LTCFVLAAV 471 179
HLA-A*02:02 TLACFVLAAV TLTCFVLAAV 5 13
HLA-A*02:11 VTLACFVLAA VTLTCFVLAA 97 245
HLA-A*02:01 FLWLLWPVTLA FLWLLWPVTLT 107 269
HLA-A*02:06 FLWLLWPVTLA FLWLLWPVTLT 495 1240
HLA-A*02:11 TLACFVLAA TLTCFVLAA 8 20
HLA-A*02:11 VTLACFVLAAV VTLTCFVLAAV 128 318
HLA-A*02:01 TLACFVLAAV TLTCFVLAAV 11 27
HLA-A*02:02 LACFVLAAV LTCFVLAAV 198 81
HLA-A*02:01 TLACFVLAA TLTCFVLAA 25 61
HLA-A*02:01 VTLACFVLAAV VTLTCFVLAAV 436 1029
HLA-B*07:02 WPVTLACFVL WPVTLTCFVL 362 155
HLA-A*02:01 FLWLLWPVTLACFV FLWLLWPVTLTCFV 329 142
HLA-A*02:11 TLACFVLAAV TLTCFVLAAV 4 9
HLA-A*30:02 LACFVLAAVY LTCFVLAAVY 218 98
HLA-A*02:06 LACFVLAAV LTCFVLAAV 51 23
HLA-A*03:02 TLACFVLAAVYR TLTCFVLAAVYR 480 1047
HLA-A*68:02 TLACFVLAAV TLTCFVLAAV 26 12
HLA-B*42:01 WPVTLACFV WPVTLTCFV 209 102
HLA-A*32:01 LLWPVTLACF LLWPVTLTCF 427 212

E protein

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E

T9I

Reference  MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAIL
           |||||||| |||||||||||||||||||||||||
Mutated    MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAIL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*24:02 MYSFVSEET MYSFVSEEI 5532 18
HLA-A*23:01 MYSFVSEET MYSFVSEEI 5604 31
HLA-C*16:01 YSFVSEET YSFVSEEI 7157 226
HLA-C*14:02 MYSFVSEET MYSFVSEEI 901 30
HLA-C*12:03 YSFVSEET YSFVSEEI 10273 457
HLA-A*68:02 MYSFVSEET MYSFVSEEI 3879 472
HLA-A*68:02 ETGTLIVNSV EIGTLIVNSV 13 91
HLA-A*68:02 FVSEETGTLI FVSEEIGTLI 247 60
HLA-A*68:02 TGTLIVNSV IGTLIVNSV 491 1976
HLA-A*02:11 FVSEETGTLI FVSEEIGTLI 307 89
HLA-B*40:01 EETGTLIVNSVL EEIGTLIVNSVL 1578 499
HLA-A*02:01 FVSEETGTL FVSEEIGTL 575 186
HLA-A*02:11 FVSEETGTL FVSEEIGTL 97 32
HLA-A*02:06 FVSEETGTLI FVSEEIGTLI 423 144
HLA-A*02:06 FVSEETGTL FVSEEIGTL 120 41
HLA-A*02:01 FVSEETGTLI FVSEEIGTLI 1293 442
HLA-A*02:06 FVSEETGTLIV FVSEEIGTLIV 670 266
HLA-C*03:03 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-C*03:04 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-B*44:03 EETGTLIVNSVLLF EEIGTLIVNSVLLF 877 375
HLA-A*02:11 FVSEETGTLIV FVSEEIGTLIV 538 251
HLA-A*02:02 FVSEETGTLI FVSEEIGTLI 85 40
HLA-A*68:02 YSFVSEETGTLI YSFVSEEIGTLI 1008 485

NS9b protein

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NS9b

P10S

Reference  MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQN
           ||||||||| |||||||||||||||||||||||||
Mutated    MDPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 HPALRLVDPQIQL HSALRLVDPQIQL 148 15057
HLA-B*42:01 HPALRLVDPQI HSALRLVDPQI 297 15937
HLA-A*02:11 PALRLVDPQIQL SALRLVDPQIQL 3683 325
HLA-B*38:01 MHPALRLVDPQI MHSALRLVDPQI 3064 395
HLA-A*02:02 PALRLVDPQIQL SALRLVDPQIQL 2220 388
HLA-A*02:01 KISEMHPAL KISEMHSAL 139 774
HLA-A*02:06 KISEMHPAL KISEMHSAL 62 310
HLA-B*07:02 KISEMHPAL KISEMHSAL 436 134
HLA-A*02:11 KISEMHPAL KISEMHSAL 14 42
HLA-C*08:02 ISEMHPAL ISEMHSAL 896 414
HLA-B*15:03 SEMHPALRL SEMHSALRL 493 245

ENA 27-29 deletion

Reference  DPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSL
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    DPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQNNVGPKVYPIILRLGSPLSL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 VTRMENAVGR VTRMVGR 28 -
HLA-A*31:01 VTRMENAVGR VTRMVGR 113 -
HLA-A*03:01 RMENAVGRDQNNVGPK RMVGRDQNNVGPK - 168
HLA-A*33:03 VTRMENAVGR VTRMVGR 218 -
HLA-B*27:05 TRMENAVGR TRMVGR 260 -
HLA-A*11:01 VTRMENAVGR VTRMVGR 268 -
HLA-A*30:01 VTRMENAVG VTRMVG 395 -
HLA-A*68:02 MENAVGRDQNNV MVGRDQNNV 13036 480
HLA-A*33:03 LAVTRMENAVGR LAVTRMVGR 927 45
HLA-A*02:11 IQLAVTRMENAV IQLAVTRMV 1418 70
HLA-A*31:01 LAVTRMENAVGR LAVTRMVGR 1898 115
HLA-A*02:02 RMENAVGRDQNNV RMVGRDQNNV 3078 195
HLA-A*68:01 QLAVTRMENAVGR QLAVTRMVGR 1673 108
HLA-B*15:03 IQLAVTRMENAV IQLAVTRMV 2775 183
HLA-A*33:03 QLAVTRMENAVGR QLAVTRMVGR 1778 188
HLA-A*02:11 RMENAVGRDQNNV RMVGRDQNNV 1928 213
HLA-A*31:01 IQLAVTRMENAVGR IQLAVTRMVGR 1758 236
HLA-A*31:01 QLAVTRMENAVGR QLAVTRMVGR 2442 329
HLA-A*68:01 LAVTRMENAVGR LAVTRMVGR 207 32
HLA-A*02:06 IQLAVTRMENAV IQLAVTRMV 263 47
HLA-A*02:01 IQLAVTRMENAV IQLAVTRMV 2387 463

NS9c protein

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NS9c

G50N

Reference  AAVKPLLVPHHVVATVQEIQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
           ||||||||||||||||||||||||| |||||||||||||||||||||||
Mutated    AAVKPLLVPHHVVATVQEIQLQAAVNELLLLEWLAMAVMLLLLCCCLTD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*18:01 GELLLLEWLAM NELLLLEWLAM 4979 247
HLA-B*18:01 GELLLLEW NELLLLEW 3915 401
HLA-B*40:01 GELLLLEWL NELLLLEWL 28 140
HLA-A*02:11 QLQAAVGEL QLQAAVNEL 120 27
HLA-A*02:11 IQLQAAVGEL IQLQAAVNEL 338 81
HLA-B*40:02 GELLLLEWL NELLLLEWL 52 204
HLA-B*40:02 GELLLLEWLAM NELLLLEWLAM 201 772
HLA-A*02:01 QLQAAVGEL QLQAAVNEL 1290 358
HLA-A*02:02 QLQAAVGEL QLQAAVNEL 92 28
HLA-B*58:01 VGELLLLEW VNELLLLEW 330 1071
HLA-A*02:02 IQLQAAVGEL IQLQAAVNEL 170 58
HLA-A*02:01 LQAAVGELL LQAAVNELL 938 352
HLA-A*02:02 LQAAVGELL LQAAVNELL 44 17
HLA-B*40:06 GELLLLEWLA NELLLLEWLA 268 677
HLA-B*40:02 GELLLLEWLA NELLLLEWLA 475 1195
HLA-A*02:11 LQAAVGELL LQAAVNELL 386 154
HLA-A*02:01 IQLQAAVGEL IQLQAAVNEL 1138 475
HLA-A*02:01 QLQAAVGELL QLQAAVNELL 961 403
HLA-A*02:01 GELLLLEWLAMA NELLLLEWLAMA 109 258
HLA-A*02:02 QLQAAVGELL QLQAAVNELL 35 15
HLA-A*02:02 IQLQAAVGELL IQLQAAVNELL 724 313
HLA-A*02:11 QLQAAVGELL QLQAAVNELL 303 131
HLA-B*58:01 AVGELLLLEW AVNELLLLEW 196 87
HLA-A*02:11 GELLLLEWLAMA NELLLLEWLAMA 29 61
HLA-B*57:01 AVGELLLLEW AVNELLLLEW 432 206
HLA-A*68:02 EIQLQAAVGELL EIQLQAAVNELL 697 346

NSP3 protein

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NSP3

K38R

Reference  IEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    IEVQGYKSVNITFELDERIDKVLNERCSAYTVELGTEVNEFACVVADAVIK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 RIDKVLNEK RIDKVLNER 168 2173
HLA-A*31:01 RIDKVLNEK RIDKVLNER 1923 163
HLA-A*11:01 RIDKVLNEK RIDKVLNER 74 646
HLA-A*03:02 RIDKVLNEK RIDKVLNER 80 419
HLA-A*30:01 KVLNEKCSA KVLNERCSA 465 121
HLA-A*68:01 ERIDKVLNEK ERIDKVLNER 911 302
HLA-A*30:01 KVLNEKCSAYTV KVLNERCSAYTV 316 106
HLA-B*50:01 NEKCSAYTV NERCSAYTV 845 420

S1265 deletion

Reference  QKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QKDVLECNVKTTEVVGDIILKPANN‑IKITEEVGHTDLMAAYVDNSSLTIK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 ILKPANNSLKITEEV ILKPANNIKITEEV - 267
HLA-A*02:02 ILKPANNSLKITEEV ILKPANNIKITEEV - 287
HLA-A*02:11 SLKITEEV IKITEEV 356 -
HLA-A*02:02 SLKITEEV IKITEEV 489 -
HLA-A*02:02 ILKPANNSL ILKPANNI 39 7300
HLA-A*68:02 NSLKITEEV NIKITEEV 92 9308
HLA-A*02:11 ILKPANNSL ILKPANNI 83 7970
HLA-B*42:01 ILKPANNSL ILKPANNI 280 18842
HLA-B*15:03 ILKPANNSL ILKPANNI 343 17572
HLA-B*15:01 ILKPANNSL ILKPANNI 301 14996
HLA-C*14:02 ILKPANNSL ILKPANNI 416 18754
HLA-B*07:02 KPANNSLKI KPANNIKI 112 2435
HLA-B*42:01 KPANNSLKI KPANNIKI 134 2096
HLA-A*30:01 IILKPANNSLK IILKPANNIK 3370 265
HLA-A*02:02 IILKPANNSL IILKPANNI 325 3406
HLA-A*68:02 NNSLKITEEV NNIKITEEV 849 212
HLA-A*03:01 ILKPANNSLK ILKPANNIK 46 155
HLA-A*02:11 IILKPANNSL IILKPANNI 1193 369
HLA-A*30:01 ILKPANNSLK ILKPANNIK 131 42

L1266I

Reference  KDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KDVLECNVKTTEVVGDIILKPANN‑IKITEEVGHTDLMAAYVDNSSLTIKK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 ILKPANNSLKITEEV ILKPANNIKITEEV - 267
HLA-A*02:02 ILKPANNSLKITEEV ILKPANNIKITEEV - 287
HLA-A*02:11 SLKITEEV IKITEEV 356 -
HLA-A*02:02 SLKITEEV IKITEEV 489 -
HLA-A*02:02 ILKPANNSL ILKPANNI 39 7300
HLA-A*68:02 NSLKITEEV NIKITEEV 92 9308
HLA-A*02:11 ILKPANNSL ILKPANNI 83 7970
HLA-B*42:01 ILKPANNSL ILKPANNI 280 18842
HLA-B*15:03 ILKPANNSL ILKPANNI 343 17572
HLA-B*15:01 ILKPANNSL ILKPANNI 301 14996
HLA-C*14:02 ILKPANNSL ILKPANNI 416 18754
HLA-B*07:02 KPANNSLKI KPANNIKI 112 2435
HLA-B*42:01 KPANNSLKI KPANNIKI 134 2096
HLA-A*30:01 IILKPANNSLK IILKPANNIK 3370 265
HLA-A*02:02 IILKPANNSL IILKPANNI 325 3406
HLA-A*68:02 NNSLKITEEV NNIKITEEV 849 212
HLA-A*03:01 ILKPANNSLK ILKPANNIK 46 155
HLA-A*02:11 IILKPANNSL IILKPANNI 1193 369
HLA-A*30:01 ILKPANNSLK ILKPANNIK 131 42

A1892T

Reference  PRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    PRDLGACIDCSARHINAQVAKSHNITLIWNVKDFMSLSEQLRKQIRSAAKK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 VAKSHNIAL VAKSHNITL 199 724
HLA-B*57:01 IALIWNVKDF ITLIWNVKDF 1222 391
HLA-A*11:01 NIALIWNVK NITLIWNVK 202 543
HLA-B*42:01 VAKSHNIAL VAKSHNITL 53 136
HLA-A*03:02 NIALIWNVK NITLIWNVK 329 840
HLA-A*02:11 NIALIWNV NITLIWNV 191 456
HLA-A*68:01 NIALIWNVK NITLIWNVK 19 44
HLA-B*08:01 VAKSHNIAL VAKSHNITL 97 223
HLA-A*03:02 HNIALIWNVK HNITLIWNVK 419 894

NSP4 protein

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NSP4

T492I

Reference  ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ
           ||||||||||||||||||||||||| ||||||||
Mutated    ACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*16:01 QTSITSAVL QISITSAVL 201 1829
HLA-A*68:02 QTSITSAVL QISITSAVL 206 1702
HLA-A*02:06 QPPQTSITSAV QPPQISITSAV 3097 393
HLA-A*02:06 LYQPPQTSITSAV LYQPPQISITSAV 1485 214
HLA-A*02:06 YQPPQTSITSAV YQPPQISITSAV 156 26
HLA-A*02:01 YQPPQTSITSAV YQPPQISITSAV 1613 341
HLA-A*02:11 YQPPQTSITSAV YQPPQISITSAV 498 120
HLA-C*03:03 TSITSAVL ISITSAVL 532 198
HLA-C*03:04 TSITSAVL ISITSAVL 532 198
HLA-C*03:03 QTSITSAVL QISITSAVL 311 831
HLA-C*03:04 QTSITSAVL QISITSAVL 311 831
HLA-C*16:01 TSITSAVL ISITSAVL 381 156
HLA-A*02:01 VLYQPPQTSI VLYQPPQISI 1084 474
HLA-A*23:01 VLYQPPQTSI VLYQPPQISI 979 462
HLA-A*23:01 LYQPPQTSI LYQPPQISI 278 132

NSP5 protein

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NSP5

P132H

Reference  QPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 RPNFTIKGSF RHNFTIKGSF 14 15756
HLA-B*07:02 RPNFTIKGSFL RHNFTIKGSFL 24 18650
HLA-B*42:01 RPNFTIKGSF RHNFTIKGSF 31 15129
HLA-B*42:01 RPNFTIKGSFL RHNFTIKGSFL 39 17143
HLA-B*15:03 PNFTIKGSF HNFTIKGSF 7728 117
HLA-A*03:01 GVYQCAMRP GVYQCAMRH 20799 417
HLA-B*08:01 CAMRPNFTI CAMRHNFTI 3487 242
HLA-B*27:05 MRPNFTIKG MRHNFTIKG 4762 366
HLA-B*27:05 MRPNFTIKGSFL MRHNFTIKGSFL 827 86
HLA-B*15:03 RPNFTIKGSF RHNFTIKGSF 432 54
HLA-B*27:05 MRPNFTIK MRHNFTIK 2132 276
HLA-B*15:03 MRPNFTIKGSF MRHNFTIKGSF 397 96
HLA-C*07:02 MRPNFTIKGSF MRHNFTIKGSF 361 1054
HLA-B*27:05 MRPNFTIKGSF MRHNFTIKGSF 218 78
HLA-A*30:01 QCAMRPNFTIK QCAMRHNFTIK 199 513
HLA-A*68:02 CAMRPNFTI CAMRHNFTI 199 493
HLA-C*16:01 CAMRPNFTI CAMRHNFTI 125 52
HLA-A*30:01 AMRPNFTIKG AMRHNFTIKG 123 279
HLA-C*12:03 CAMRPNFTI CAMRHNFTI 317 143
HLA-A*30:01 VYQCAMRPNFTIK VYQCAMRHNFTIK 316 683
HLA-A*11:01 AMRPNFTIK AMRHNFTIK 175 376
HLA-A*11:01 CAMRPNFTIK CAMRHNFTIK 42 88
HLA-A*68:01 CAMRPNFTIK CAMRHNFTIK 127 254

NSP6 protein

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NSP6

LSG 105-107 deletion

Reference  YFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVY
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    YFNMVYMPASWVMRIMTWLDMVDTS‑‑‑FKLKDCVMYASAVVLLILMTARTVY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:02 WLDMVDTSL - 11 -
HLA-A*02:11 WLDMVDTSL - 12 -
HLA-A*68:01 MVDTSLSGFK MVDTSFK 13 -
HLA-A*03:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSFK - 20
HLA-A*11:01 MVDTSLSGFK MVDTSFK 21 -
HLA-A*68:01 MTWLDMVDTSLSGFK MTWLDMVDTSFK - 21
HLA-A*11:01 TSLSGFKLK TSFKLK 22 -
HLA-A*02:01 WLDMVDTSL - 23 -
HLA-A*68:01 DTSLSGFKLK DTSFKLK 33 -
HLA-C*08:02 WLDMVDTSL - 34 -
HLA-A*03:02 MVDTSLSGFK MVDTSFK 35 -
HLA-A*11:01 MTWLDMVDTSLSGFK MTWLDMVDTSFK - 35
HLA-C*05:01 WLDMVDTSL - 37 -
HLA-A*03:02 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSFK - 38
HLA-A*02:02 MTWLDMVDTSLSGFKL MTWLDMVDTSFKL - 45
HLA-A*02:11 MTWLDMVDTSLSGFKL MTWLDMVDTSFKL - 49
HLA-A*03:01 MVDTSLSGFK MVDTSFK 54 -
HLA-A*02:06 WLDMVDTSL - 63 -
HLA-C*05:01 MVDTSLSGF MVDTSF 64 -
HLA-A*11:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSFK - 71
HLA-A*03:02 MTWLDMVDTSLSGFK MTWLDMVDTSFK - 73
HLA-A*03:02 IMTWLDMVDTSLSGFK IMTWLDMVDTSFK - 88
HLA-A*02:02 IMTWLDMVDTSL - 98 -
HLA-A*30:01 TSLSGFKLK TSFKLK 107 -
HLA-A*02:11 RIMTWLDMVDTSL - 111 -
HLA-B*15:01 RIMTWLDMVDTSLSGF RIMTWLDMVDTSF - 112
HLA-A*02:02 SGFKLKDCVMYA - 126 -
HLA-A*02:01 MTWLDMVDTSLSGFKL MTWLDMVDTSFKL - 127
HLA-A*32:01 RIMTWLDMVDTSLSGF RIMTWLDMVDTSF - 138
HLA-A*02:02 TWLDMVDTSLSGFKL TWLDMVDTSFKL - 152
HLA-C*08:02 MVDTSLSGF MVDTSF 159 -
HLA-B*15:03 MRIMTWLDMVDTSLSGF MRIMTWLDMVDTSF - 176
HLA-A*68:02 MTWLDMVDTSLSGFKL MTWLDMVDTSFKL - 182
HLA-A*01:01 MVDTSLSGFKLKDCVMY MVDTSFKLKDCVMY - 186
HLA-A*03:01 IMTWLDMVDTSLSGFK IMTWLDMVDTSFK - 186
HLA-A*02:11 SGFKLKDCVMYA - 200 -
HLA-A*02:02 TWLDMVDTSL - 202 -
HLA-A*02:11 TWLDMVDTSLSGFKL TWLDMVDTSFKL - 210
HLA-C*03:02 MVDTSLSGF MVDTSF 211 -
HLA-A*02:02 TSLSGFKLKDCVMYA TSFKLKDCVMYA - 225
HLA-A*02:02 IMTWLDMVDTSLSGFKL IMTWLDMVDTSFKL - 236
HLA-A*02:02 GFKLKDCVMYA - 239 -
HLA-A*31:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSFK - 243
HLA-A*03:01 TSLSGFKLK TSFKLK 244 -
HLA-A*03:01 MTWLDMVDTSLSGFK MTWLDMVDTSFK - 260
HLA-B*27:05 MRIMTWLDMVDTSL - 261 -
HLA-A*02:06 MTWLDMVDTSLSGFKL MTWLDMVDTSFKL - 265
HLA-B*15:03 MVDTSLSGF MVDTSF 276 -
HLA-A*68:01 TSLSGFKLK TSFKLK 286 -
HLA-A*03:02 TSLSGFKLK TSFKLK 289 -
HLA-A*02:02 MTWLDMVDTSL - 291 -
HLA-A*02:11 IMTWLDMVDTSL - 293 -
HLA-A*02:11 MTWLDMVDTSL - 298 -
HLA-A*02:02 LSGFKLKDCVMYA - 305 -
HLA-A*68:02 DTSLSGFKL DTSFKL 313 -
HLA-A*02:11 IMTWLDMVDTSLSGFKL IMTWLDMVDTSFKL - 319
HLA-A*02:06 RIMTWLDMVDTSL - 342 -
HLA-C*17:01 WLDMVDTSL - 344 -
HLA-B*15:03 IMTWLDMVDTSLSGF IMTWLDMVDTSF - 348
HLA-B*15:01 IMTWLDMVDTSLSGF IMTWLDMVDTSF - 357
HLA-B*27:05 MRIMTWLDMVDTSLSGF MRIMTWLDMVDTSF - 360
HLA-B*15:01 DMVDTSLSGF DMVDTSF 362 -
HLA-A*02:02 RIMTWLDMVDTSL - 374 -
HLA-A*68:01 IMTWLDMVDTSLSGFK IMTWLDMVDTSFK - 386
HLA-A*11:01 IMTWLDMVDTSLSGFK IMTWLDMVDTSFK - 390
HLA-A*02:11 GFKLKDCVMYA - 394 -
HLA-A*26:01 DMVDTSLSGF DMVDTSF 417 -
HLA-B*15:03 RIMTWLDMVDTSLSGF RIMTWLDMVDTSF - 417
HLA-A*02:11 TWLDMVDTSL - 438 -
HLA-A*02:02 WLDMVDTSLS - 441 -
HLA-A*02:11 TSLSGFKLKDCVMYA TSFKLKDCVMYA - 457
HLA-C*08:01 WLDMVDTSL - 477 -
HLA-A*02:01 IMTWLDMVDTSL - 484 -
HLA-A*11:01 DTSLSGFKLK DTSFKLK 488 -
HLA-B*35:01 MVDTSLSGF MVDTSF 490 -
HLA-A*02:11 LDMVDTSLSGFKL LDMVDTSFKL 16396 25
HLA-A*02:02 LDMVDTSLSGFKL LDMVDTSFKL 9971 23
HLA-A*02:01 LDMVDTSLSGFKL LDMVDTSFKL 20579 58
HLA-A*02:11 SLSGFKLKDCV SFKLKDCV 122 32184
HLA-C*14:02 SLSGFKLKDCVM SFKLKDCVM 6779 38
HLA-A*02:02 SLSGFKLKDCV SFKLKDCV 408 30687
HLA-C*08:02 WLDMVDTSLSGF WLDMVDTSF 6548 91
HLA-A*02:06 LDMVDTSLSGFKL LDMVDTSFKL 12977 187
HLA-A*02:11 WLDMVDTSLSGFKL WLDMVDTSFKL 1342 20
HLA-C*05:01 WLDMVDTSLSGF WLDMVDTSF 3956 66
HLA-A*02:01 WLDMVDTSLSGFKL WLDMVDTSFKL 2214 39
HLA-B*15:03 WLDMVDTSLSGF WLDMVDTSF 5688 115
HLA-A*02:06 WLDMVDTSLSGFKL WLDMVDTSFKL 4589 98
HLA-B*35:01 WLDMVDTSLSGF WLDMVDTSF 12664 299
HLA-A*02:02 WLDMVDTSLSGFKL WLDMVDTSFKL 788 28
HLA-A*68:01 DMVDTSLSGFKLK DMVDTSFKLK 1679 62
HLA-A*03:02 WLDMVDTSLSGFK WLDMVDTSFK 1756 75
HLA-A*02:11 DMVDTSLSGFKL DMVDTSFKL 6564 285
HLA-B*58:01 MTWLDMVDTSLSGF MTWLDMVDTSF 3426 177
HLA-A*03:01 WLDMVDTSLSGFK WLDMVDTSFK 2900 155
HLA-A*11:01 WLDMVDTSLSGFK WLDMVDTSFK 4020 219
HLA-A*23:01 TWLDMVDTSLSGF TWLDMVDTSF 387 34
HLA-A*24:02 TWLDMVDTSLSGF TWLDMVDTSF 728 66
HLA-A*68:01 WLDMVDTSLSGFK WLDMVDTSFK 3175 305
HLA-A*02:02 DMVDTSLSGFKL DMVDTSFKL 4456 457
HLA-A*02:02 WLDMVDTSLSGF WLDMVDTSF 4418 457
HLA-B*57:01 MTWLDMVDTSLSGF MTWLDMVDTSF 2809 307
HLA-B*15:03 SLSGFKLKDCVMY SFKLKDCVMY 3626 434
HLA-A*11:01 DMVDTSLSGFKLK DMVDTSFKLK 3425 413
HLA-C*08:02 MVDTSLSGFKL MVDTSFKL 2134 274
HLA-A*68:01 DMVDTSLSGFK DMVDTSFK 366 2480
HLA-A*68:02 DTSLSGFKLKDCV DTSFKLKDCV 3009 475
HLA-C*05:01 MVDTSLSGFKL MVDTSFKL 1125 193
HLA-A*11:01 MVDTSLSGFKLK MVDTSFKLK 143 29
HLA-A*68:01 MVDTSLSGFKLK MVDTSFKLK 602 125
HLA-B*08:01 SLSGFKLKDCVM SFKLKDCVM 929 248
HLA-A*03:02 MVDTSLSGFKLK MVDTSFKLK 312 86
HLA-A*02:01 SLSGFKLKDCVMYA SFKLKDCVMYA 203 694
HLA-A*03:01 MVDTSLSGFKLK MVDTSFKLK 441 130
HLA-A*02:11 SLSGFKLKDCVMYA SFKLKDCVMYA 64 191
HLA-A*02:02 SLSGFKLKDCVMYA SFKLKDCVMYA 55 142

I189V

Reference  MWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    MWALIISVTSNYSGVVTTVMFLARGVVFMCVEYCPIFFITGNTLQCIMLVY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 TVMFLARGI TVMFLARGV 362 2130
HLA-A*02:11 TTVMFLARGI TTVMFLARGV 1051 184
HLA-A*02:11 TVMFLARGI TVMFLARGV 276 52
HLA-A*02:06 TTVMFLARGI TTVMFLARGV 259 49
HLA-A*02:06 TVMFLARGI TVMFLARGV 300 61
HLA-A*02:01 TVMFLARGI TVMFLARGV 1757 400
HLA-A*02:02 TTVMFLARGI TTVMFLARGV 774 225
HLA-A*02:02 TVMFLARGI TVMFLARGV 789 257
HLA-A*68:02 TVMFLARGI TVMFLARGV 21 8
HLA-A*68:02 TTVMFLARGI TTVMFLARGV 15 6
HLA-B*15:03 VMFLARGIV VMFLARGVV 221 92

NSP12 protein

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NSP12

P323L

Reference  CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:01 FPPTSFGPLV FPLTSFGPLV 8999 21
HLA-A*02:02 FPPTSFGPLV FPLTSFGPLV 7237 18
HLA-A*02:11 FPPTSFGPLV FPLTSFGPLV 3405 9
HLA-A*32:01 VLFSTVFPP VLFSTVFPL 5415 27
HLA-A*02:11 LFSTVFPP LFSTVFPL 6706 35
HLA-A*02:11 ANFNVLFSTVFPP ANFNVLFSTVFPL 1827 12
HLA-A*02:11 NFNVLFSTVFPP NFNVLFSTVFPL 1779 13
HLA-A*02:11 NVLFSTVFPP NVLFSTVFPL 739 6
HLA-C*03:03 VLFSTVFPP VLFSTVFPL 28468 265
HLA-C*03:04 VLFSTVFPP VLFSTVFPL 28468 265
HLA-A*02:11 FNVLFSTVFPP FNVLFSTVFPL 413 4
HLA-C*14:02 VLFSTVFPP VLFSTVFPL 21407 220
HLA-A*02:11 FNVLFSTVFPPT FNVLFSTVFPLT 2618 27
HLA-A*02:01 LFSTVFPP LFSTVFPL 7475 81
HLA-C*14:02 LFSTVFPP LFSTVFPL 11979 138
HLA-B*15:03 VLFSTVFPP VLFSTVFPL 3115 36
HLA-A*02:11 VLFSTVFPP VLFSTVFPL 78 1
HLA-C*03:02 VLFSTVFPP VLFSTVFPL 20533 273
HLA-A*02:01 FNVLFSTVFPP FNVLFSTVFPL 656 9
HLA-A*02:01 ANFNVLFSTVFPP ANFNVLFSTVFPL 2569 37
HLA-A*02:11 FNVLFSTVFPPTS FNVLFSTVFPLTS 9448 142
HLA-A*02:02 NVLFSTVFPP NVLFSTVFPL 1088 17
HLA-A*02:11 CANFNVLFSTVFPP CANFNVLFSTVFPL 6143 96
HLA-A*02:02 FNVLFSTVFPP FNVLFSTVFPL 1014 16
HLA-A*68:02 NVLFSTVFPP NVLFSTVFPL 2213 37
HLA-A*02:02 ANFNVLFSTVFPP ANFNVLFSTVFPL 3126 53
HLA-A*02:11 PPTSFGPLV PLTSFGPLV 28329 483
HLA-C*16:01 VLFSTVFPP VLFSTVFPL 24733 432
HLA-C*17:01 VLFSTVFPP VLFSTVFPL 25087 439
HLA-A*02:01 FNVLFSTVFPPT FNVLFSTVFPLT 3765 66
HLA-A*02:02 LFSTVFPP LFSTVFPL 9311 167
HLA-A*02:01 NVLFSTVFPP NVLFSTVFPL 928 17
HLA-A*02:02 NFNVLFSTVFPP NFNVLFSTVFPL 2542 47
HLA-A*02:02 VLFSTVFPP VLFSTVFPL 269 5
HLA-A*02:01 NFNVLFSTVFPP NFNVLFSTVFPL 2286 44
HLA-A*02:06 FPPTSFGPLV FPLTSFGPLV 3379 73
HLA-A*02:01 VLFSTVFPP VLFSTVFPL 179 4
HLA-A*02:06 FNVLFSTVFPP FNVLFSTVFPL 1609 37
HLA-A*02:02 FNVLFSTVFPPT FNVLFSTVFPLT 4116 110
HLA-A*02:11 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6695 180
HLA-A*02:01 FNVLFSTVFPPTS FNVLFSTVFPLTS 11451 311
HLA-A*02:06 VLFSTVFPP VLFSTVFPL 368 10
HLA-A*02:11 ANFNVLFSTVFPPT ANFNVLFSTVFPLT 14639 409
HLA-A*02:01 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 12596 425
HLA-A*68:01 PTSFGPLVR LTSFGPLVR 908 36
HLA-A*02:06 NVLFSTVFPP NVLFSTVFPL 1611 66
HLA-B*15:01 VLFSTVFPP VLFSTVFPL 5731 243
HLA-B*35:01 FPPTSFGPL FPLTSFGPL 304 13
HLA-B*53:01 FPPTSFGPL FPLTSFGPL 3581 154
HLA-C*01:02 FPPTSFGPL FPLTSFGPL 217 4855
HLA-A*02:01 CANFNVLFSTVFPP CANFNVLFSTVFPL 8519 384
HLA-A*02:02 FNVLFSTVFPPTS FNVLFSTVFPLTS 10920 497
HLA-A*02:02 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6958 322
HLA-A*02:11 VFPPTSFGPLV VFPLTSFGPLV 4242 199
HLA-A*02:02 CANFNVLFSTVFPP CANFNVLFSTVFPL 8183 391
HLA-A*02:11 NFNVLFSTVFPPT NFNVLFSTVFPLT 9111 472
HLA-A*02:06 ANFNVLFSTVFPP ANFNVLFSTVFPL 5191 304
HLA-A*02:06 NFNVLFSTVFPP NFNVLFSTVFPL 4220 274
HLA-A*02:06 FNVLFSTVFPPT FNVLFSTVFPLT 4868 388
HLA-B*35:03 FPPTSFGPL FPLTSFGPL 286 24
HLA-A*03:01 PTSFGPLVRK LTSFGPLVRK 554 47
HLA-A*31:01 PTSFGPLVR LTSFGPLVR 4402 390
HLA-A*11:01 PTSFGPLVR LTSFGPLVR 4068 379
HLA-A*03:02 PTSFGPLVRK LTSFGPLVRK 868 88
HLA-B*07:02 STVFPPTSFGPL STVFPLTSFGPL 777 79
HLA-A*68:01 PTSFGPLVRK LTSFGPLVRK 308 34
HLA-B*07:02 TVFPPTSFGPL TVFPLTSFGPL 1498 171
HLA-A*02:11 STVFPPTSFGPLV STVFPLTSFGPLV 2427 285
HLA-A*02:11 NVLFSTVFPPT NVLFSTVFPLT 1183 139
HLA-A*33:03 PTSFGPLVR LTSFGPLVR 3228 381
HLA-A*26:01 STVFPPTSF STVFPLTSF 786 95
HLA-B*07:02 VFPPTSFGPL VFPLTSFGPL 339 43
HLA-A*02:01 NVLFSTVFPPT NVLFSTVFPLT 2111 290
HLA-B*42:01 FSTVFPPTSFGPL FSTVFPLTSFGPL 1320 185
HLA-B*42:01 STVFPPTSFGPL STVFPLTSFGPL 738 111
HLA-A*02:01 VLFSTVFPPTSF VLFSTVFPLTSF 2225 342
HLA-B*08:01 FPPTSFGPL FPLTSFGPL 973 153
HLA-B*42:01 TVFPPTSFGPL TVFPLTSFGPL 843 142
HLA-A*11:01 PTSFGPLVRK LTSFGPLVRK 123 21
HLA-B*42:01 VFPPTSFGPL VFPLTSFGPL 274 47
HLA-A*02:01 VLFSTVFPPTS VLFSTVFPLTS 708 124
HLA-B*07:02 FSTVFPPTSFGPL FSTVFPLTSFGPL 2537 466
HLA-B*07:02 FPPTSFGPL FPLTSFGPL 42 8
HLA-A*02:11 VLFSTVFPPTSF VLFSTVFPLTSF 1019 195
HLA-A*25:01 STVFPPTSF STVFPLTSF 1533 296
HLA-B*07:02 FPPTSFGPLV FPLTSFGPLV 1131 236
HLA-B*42:01 FPPTSFGPL FPLTSFGPL 21 5
HLA-A*26:01 FSTVFPPTSF FSTVFPLTSF 1667 398
HLA-B*51:01 FPPTSFGPL FPLTSFGPL 1809 433
HLA-A*02:11 VLFSTVFPPTS VLFSTVFPLTS 309 74
HLA-B*42:01 FPPTSFGPLV FPLTSFGPLV 368 89
HLA-A*02:02 VLFSTVFPPTS VLFSTVFPLTS 1210 377
HLA-C*03:02 FPPTSFGPL FPLTSFGPL 960 313
HLA-A*32:01 STVFPPTSF STVFPLTSF 230 86
HLA-B*58:01 FSTVFPPTSF FSTVFPLTSF 88 33
HLA-B*15:01 STVFPPTSF STVFPLTSF 130 49
HLA-A*02:01 VLFSTVFPPT VLFSTVFPLT 61 23
HLA-C*03:03 FPPTSFGPL FPLTSFGPL 375 145
HLA-C*03:04 FPPTSFGPL FPLTSFGPL 375 145
HLA-A*02:02 VLFSTVFPPT VLFSTVFPLT 113 44
HLA-C*16:01 FSTVFPPTS FSTVFPLTS 1127 460
HLA-C*14:02 LFSTVFPPTSF LFSTVFPLTSF 396 950
HLA-C*01:02 VFPPTSFGPL VFPLTSFGPL 429 997
HLA-A*02:02 TVFPPTSFGPLV TVFPLTSFGPLV 789 343
HLA-A*68:02 STVFPPTSFGPLV STVFPLTSFGPLV 169 74
HLA-A*02:11 VLFSTVFPPT VLFSTVFPLT 25 11
HLA-A*03:01 TVFPPTSFGPLVRK TVFPLTSFGPLVRK 92 198
HLA-C*14:02 VFPPTSFGPL VFPLTSFGPL 47 99
HLA-A*23:01 LFSTVFPPTSF LFSTVFPLTSF 370 179