Summary

This strain contains 53 protein-level mutations:

  • 27 mutations in Spike protein: V3G, T19I, G142D, V213G, G339D, S371F, S373P, 375-376 ST->FA, D405N, R408S, K417N, N440K, L452R, 477-478 ST->NK, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
  • 5 mutations in N protein: P13L, ERS 31-33 deletion, P151S, 203-204 RG->KR, S413R
  • 2 mutations in M protein: Q19E, A63T
  • 1 mutation in E protein: T9I
  • 1 mutation in NS3 protein: T223I
  • 2 mutations in NS9b protein: P10S, ENA 27-29 deletion
  • 1 mutation in NS9c protein: G50N
  • 2 mutations in NSP1 protein: S135R, KSF 141-143 deletion
  • 2 mutations in NSP3 protein: T24I, G489S
  • 3 mutations in NSP4 protein: L264F, T327I, T492I
  • 1 mutation in NSP5 protein: P132H
  • 1 mutation in NSP6 protein: SGF 106-108 deletion
  • 1 mutation in NSP12 protein: P323L
  • 1 mutation in NSP13 protein: R392C
  • 2 mutations in NSP14 protein: I42V, D301G
  • 1 mutation in NSP15 protein: T112I

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of HLA-peptide interactions affected by the mutations

For each allele we calculated the number of peptides with increased and decreased affinitiy (two or more times). The absolute number of such peptides is showed on the left side of the figure (blue bars — weaker binding, orange bars — stronger).

While absolute numbers are of interest, they do not reflect the initial number of tighly binding peptides for the specific allele. Roughly speaking, if an allele had high number of tight binders, then vanished affinity of several peptides will not affect much the integral ability of peptide presentation. To the contrary, low number of vanished peptides could be important if the particular allele initially had narrow epitope repertoire. To account for this effect, we normalized the absolute numbers of new/vanished tight binders (IC50 affinity ≤ 50 nM) by the total number of tight binders for each allele. To avoid possible divisions by zero, we used + 1 regularization term in all denominators. For example, if some allele had no tight binders in the reference genome, and three new tight binders appeared as a result of the mutation, the relative increase will be 300%. The results are showed in the right part of the figure. Protein-specific plots are listed below.

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Summary

Spike protein

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Spike

V3G

Reference  MFVFLVLLPLVSSQCVNLTTRTQLPPAY
           || |||||||||||||||||||||||||
Mutated    MFGFLVLLPLVSSQCVNLITRTQLPPAY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 FVFLVLLPL FGFLVLLPL 17 584
HLA-A*02:11 FVFLVLLPLV FGFLVLLPLV 20 335
HLA-A*02:01 FVFLVLLPL FGFLVLLPL 125 1770
HLA-A*02:01 FVFLVLLPLV FGFLVLLPLV 62 835
HLA-A*68:02 FVFLVLLPL FGFLVLLPL 212 2359
HLA-A*68:02 FVFLVLLPLV FGFLVLLPLV 128 1166
HLA-A*02:02 FVFLVLLPL FGFLVLLPL 132 1193
HLA-A*02:11 MFVFLVLL MFGFLVLL 4346 496
HLA-A*68:02 MFVFLVLLPL MFGFLVLLPL 354 2873
HLA-A*02:02 FVFLVLLPLV FGFLVLLPLV 104 826
HLA-A*02:06 FVFLVLLPLV FGFLVLLPLV 26 203
HLA-A*02:11 MFVFLVLLPL MFGFLVLLPL 269 1834
HLA-A*02:06 FVFLVLLPL FGFLVLLPL 67 434
HLA-A*02:06 MFVFLVLLPL MFGFLVLLPL 336 1502
HLA-A*02:02 MFVFLVLLPL MFGFLVLLPL 395 1255
HLA-C*03:02 FVFLVLLPL FGFLVLLPL 79 214
HLA-C*03:03 FVFLVLLPL FGFLVLLPL 58 140
HLA-C*03:04 FVFLVLLPL FGFLVLLPL 58 140

T19I

Reference  MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MFGFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*58:01 VSSQCVNLT VSSQCVNLI 3986 159
HLA-C*15:02 VSSQCVNLT VSSQCVNLI 10208 479
HLA-A*02:02 LVSSQCVNLT LVSSQCVNLI 3376 271
HLA-A*02:11 VLLPLVSSQCVNLT VLLPLVSSQCVNLI 4460 394
HLA-A*02:11 NLTTRTQLPPA NLITRTQLPPA 4965 468
HLA-B*08:01 NLTTRTQL NLITRTQL 531 100
HLA-B*15:03 TTRTQLPPAY ITRTQLPPAY 888 426

G142D

Reference  LLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCT
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Mutated    LLIVNNATNVVIKVCEFQFCNDPFLDVYYHKNNKSWMESEFRVYSSANNCT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 GVYYHKNNK DVYYHKNNK 27 2841
HLA-A*30:01 GVYYHKNNK DVYYHKNNK 51 3035
HLA-A*11:01 GVYYHKNNK DVYYHKNNK 51 1768
HLA-A*03:02 GVYYHKNNK DVYYHKNNK 119 3887
HLA-A*31:01 GVYYHKNNK DVYYHKNNK 375 5203
HLA-A*68:01 GVYYHKNNK DVYYHKNNK 363 28
HLA-A*68:02 FCNDPFLGV FCNDPFLDV 281 3555
HLA-A*33:03 GVYYHKNNK DVYYHKNNK 3253 287
HLA-A*02:06 FCNDPFLGV FCNDPFLDV 116 1132
HLA-A*02:11 FCNDPFLGV FCNDPFLDV 87 751
HLA-A*02:06 EFQFCNDPFLGV EFQFCNDPFLDV 87 554
HLA-A*30:02 CNDPFLGVY CNDPFLDVY 310 1959
HLA-A*02:02 FCNDPFLGV FCNDPFLDV 365 2187
HLA-A*02:06 FQFCNDPFLGVY FQFCNDPFLDVY 135 784
HLA-A*30:02 FCNDPFLGVY FCNDPFLDVY 408 1738
HLA-A*02:11 EFQFCNDPFLGV EFQFCNDPFLDV 334 1214
HLA-A*02:02 EFQFCNDPFLGV EFQFCNDPFLDV 477 1725
HLA-A*02:11 FQFCNDPFLGVY FQFCNDPFLDVY 488 1737
HLA-A*02:06 FQFCNDPFLGV FQFCNDPFLDV 7 21
HLA-A*02:11 FQFCNDPFLGV FQFCNDPFLDV 17 49
HLA-A*02:01 FQFCNDPFLGV FQFCNDPFLDV 39 111
HLA-A*30:02 FQFCNDPFLGVY FQFCNDPFLDVY 336 923
HLA-A*02:02 FQFCNDPFLGV FQFCNDPFLDV 45 122
HLA-B*15:01 FQFCNDPFLGVY FQFCNDPFLDVY 28 56

V213G

Reference  NLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NLREFVFKNIDGYFKIYSKHTPINLGRDLPQGFSALEPLVDLPIGINITRF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:02 YSKHTPINLV YSKHTPINLG 199 16298
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPINLG 104 6984
HLA-B*15:01 LVRDLPQGF LGRDLPQGF 160 2486
HLA-C*01:02 VRDLPQGFSAL GRDLPQGFSAL 431 3580
HLA-C*03:02 LVRDLPQGF LGRDLPQGF 259 1765
HLA-B*15:03 LVRDLPQGF LGRDLPQGF 254 793
HLA-B*07:02 HTPINLVRDL HTPINLGRDL 892 311
HLA-B*27:05 VRDLPQGFSA GRDLPQGFSA 1057 375
HLA-A*68:01 YSKHTPINLVR YSKHTPINLGR 362 130
HLA-B*07:02 TPINLVRDL TPINLGRDL 213 81
HLA-A*68:01 HTPINLVR HTPINLGR 480 202
HLA-A*33:03 YSKHTPINLVR YSKHTPINLGR 762 337

G339D

Reference  QTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD
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Mutated    QTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVAD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:01 GEVFNATRF DEVFNATRF 164 7112
HLA-B*18:01 GEVFNATRFASVY DEVFNATRFASVY 2165 64
HLA-B*18:01 GEVFNATRF DEVFNATRF 971 32
HLA-B*50:01 GEVFNATRFA DEVFNATRFA 147 4233
HLA-B*40:02 GEVFNATRF DEVFNATRF 283 7625
HLA-B*40:06 GEVFNATRFA DEVFNATRFA 201 5089
HLA-B*15:03 GEVFNATRF DEVFNATRF 359 4698
HLA-A*68:01 FGEVFNATR FDEVFNATR 338 2409
HLA-B*45:01 GEVFNATRFA DEVFNATRFA 116 688
HLA-B*44:02 GEVFNATRF DEVFNATRF 158 889
HLA-B*44:03 GEVFNATRF DEVFNATRF 136 673
HLA-B*15:01 TNLCPFGEVF TNLCPFDEVF 368 1059
HLA-B*15:03 TNLCPFGEVF TNLCPFDEVF 442 1176
HLA-B*15:03 NLCPFGEVF NLCPFDEVF 130 341
HLA-A*68:02 GEVFNATRFA DEVFNATRFA 879 342
HLA-B*15:01 NLCPFGEVF NLCPFDEVF 315 773

S371F

Reference  RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVY
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Mutated    RFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-C*05:01 VADYSVLYNS VADYSVLYNF 11802 122
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-C*03:02 VADYSVLYNS VADYSVLYNF 20606 367
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-B*58:01 VADYSVLYNS VADYSVLYNF 6124 129
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-C*08:02 VADYSVLYNS VADYSVLYNF 16435 470
HLA-A*02:11 SVLYNSASFST SVLYNFAPFFA 3830 120
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-A*02:01 VLYNSASFST VLYNFAPFFA 243 8
HLA-B*57:01 VADYSVLYNS VADYSVLYNF 11273 384
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-A*02:02 VLYNSASFST VLYNFAPFFA 202 10
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-A*02:06 VLYNSASFST VLYNFAPFFA 710 36
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*02:11 VLYNSASFST VLYNFAPFFA 77 4
HLA-A*02:01 SVLYNSASFST SVLYNFAPFFA 5674 301
HLA-A*11:01 LYNSASFSTFK LYNFAPFFAFK 43 797
HLA-B*40:02 ADYSVLYNS ADYSVLYNF 4645 259
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-A*02:11 YSVLYNSASFST YSVLYNFAPFFA 7859 469
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*02:06 SVLYNSASFST SVLYNFAPFFA 4097 319
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-A*02:11 VLYNSASFSTF VLYNFAPFFAF 2537 236
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-A*02:01 VLYNSASFSTF VLYNFAPFFAF 4199 455
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-A*02:06 SVLYNSASF SVLYNFAPF 2112 234
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFAF 50 420
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-A*30:01 LYNSASFST LYNFAPFFA 3467 433
HLA-A*33:03 SVLYNSASFSTFK SVLYNFAPFFAFK 2778 357
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-A*29:02 LYNSASFSTF LYNFAPFFAF 387 63
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFAFK 857 148
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 LYNSASFSTFK LYNFAPFFAFK 295 1614
HLA-A*23:01 SVLYNSASF SVLYNFAPF 990 197
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*03:02 LYNSASFSTFK LYNFAPFFAFK 202 831
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFAF 164 629
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*29:02 SVLYNSASF SVLYNFAPF 1130 313
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-C*14:02 LYNSASFSTF LYNFAPFFAF 20 69
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFAFKCY 272 923
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFAF 1624 488
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFAFK 565 170
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-A*31:01 LYNSASFSTFK LYNFAPFFAFK 299 92
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*24:02 LYNSASFSTFK LYNFAPFFAFK 356 1101
HLA-A*26:01 SVLYNSASF SVLYNFAPF 1313 431
HLA-A*33:03 LYNSASFSTFK LYNFAPFFAFK 1158 383
HLA-A*24:02 VLYNSASFSTF VLYNFAPFFAF 186 551
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFAFKC 312 920
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFAF 113 329
HLA-A*23:01 YSVLYNSASF YSVLYNFAPF 1120 403
HLA-B*58:01 YSVLYNSASFSTF YSVLYNFAPFFAF 429 1160
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFAFKCY 297 115
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFAF 38 96
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*03:01 VLYNSASFSTFK VLYNFAPFFAFK 7 17
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-A*11:01 VLYNSASFSTFK VLYNFAPFFAFK 22 51
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFAF 221 509
HLA-B*15:01 LYNSASFSTF LYNFAPFFAF 468 1064
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-A*23:01 DYSVLYNSASF DYSVLYNFAPF 1039 482
HLA-A*68:01 YSVLYNSASFSTFK YSVLYNFAPFFAFK 144 67

S373P

Reference  ASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYAD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-A*30:02 ASFSTFKCY APFFAFKCY 43 2647
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-B*15:01 ASFSTFKCY APFFAFKCY 107 6085
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-A*02:06 ASFSTFKCYGV APFFAFKCYGV 231 11537
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-C*16:01 ASFSTFKCY APFFAFKCY 68 3117
HLA-C*12:03 ASFSTFKCY APFFAFKCY 115 5066
HLA-C*03:02 ASFSTFKCY APFFAFKCY 64 2656
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-A*11:01 ASFSTFKCY APFFAFKCY 379 12606
HLA-A*02:11 SVLYNSASFST SVLYNFAPFFA 3830 120
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-A*02:01 VLYNSASFST VLYNFAPFFA 243 8
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-B*35:01 ASFSTFKCY APFFAFKCY 2345 92
HLA-C*12:02 ASFSTFKCY APFFAFKCY 338 8222
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-B*15:03 ASFSTFKCY APFFAFKCY 25 529
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-A*02:02 VLYNSASFST VLYNFAPFFA 202 10
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-A*02:06 VLYNSASFST VLYNFAPFFA 710 36
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*02:11 VLYNSASFST VLYNFAPFFA 77 4
HLA-A*02:01 SVLYNSASFST SVLYNFAPFFA 5674 301
HLA-A*11:01 LYNSASFSTFK LYNFAPFFAFK 43 797
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-A*02:11 YSVLYNSASFST YSVLYNFAPFFA 7859 469
HLA-C*14:02 SFSTFKCY PFFAFKCY 386 6449
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*02:06 SVLYNSASFST SVLYNFAPFFA 4097 319
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-A*02:11 VLYNSASFSTF VLYNFAPFFAF 2537 236
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-A*02:01 VLYNSASFSTF VLYNFAPFFAF 4199 455
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-A*29:02 ASFSTFKCY APFFAFKCY 201 1830
HLA-A*02:06 SVLYNSASF SVLYNFAPF 2112 234
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFAF 50 420
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-A*30:01 LYNSASFST LYNFAPFFA 3467 433
HLA-A*33:03 SVLYNSASFSTFK SVLYNFAPFFAFK 2778 357
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-A*29:02 LYNSASFSTF LYNFAPFFAF 387 63
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFAFK 857 148
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 LYNSASFSTFK LYNFAPFFAFK 295 1614
HLA-A*23:01 SVLYNSASF SVLYNFAPF 990 197
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*03:02 LYNSASFSTFK LYNFAPFFAFK 202 831
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFAF 164 629
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*29:02 SVLYNSASF SVLYNFAPF 1130 313
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-C*14:02 LYNSASFSTF LYNFAPFFAF 20 69
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFAFKCY 272 923
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFAF 1624 488
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFAFK 565 170
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-A*31:01 LYNSASFSTFK LYNFAPFFAFK 299 92
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*24:02 LYNSASFSTFK LYNFAPFFAFK 356 1101
HLA-A*26:01 SVLYNSASF SVLYNFAPF 1313 431
HLA-A*33:03 LYNSASFSTFK LYNFAPFFAFK 1158 383
HLA-A*24:02 VLYNSASFSTF VLYNFAPFFAF 186 551
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFAFKC 312 920
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFAF 113 329
HLA-A*23:01 YSVLYNSASF YSVLYNFAPF 1120 403
HLA-B*58:01 YSVLYNSASFSTF YSVLYNFAPFFAF 429 1160
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFAFKCY 297 115
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFAF 38 96
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*03:01 VLYNSASFSTFK VLYNFAPFFAFK 7 17
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-A*11:01 VLYNSASFSTFK VLYNFAPFFAFK 22 51
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFAF 221 509
HLA-B*15:01 LYNSASFSTF LYNFAPFFAF 468 1064
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-A*23:01 DYSVLYNSASF DYSVLYNFAPF 1039 482
HLA-A*68:01 YSVLYNSASFSTFK YSVLYNFAPFFAFK 144 67

375-376 ST->FA

Reference  VYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    VYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-A*30:02 ASFSTFKCY APFFAFKCY 43 2647
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-B*15:01 ASFSTFKCY APFFAFKCY 107 6085
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-A*02:06 ASFSTFKCYGV APFFAFKCYGV 231 11537
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-C*15:02 FSTFKCYGV FFAFKCYGV 431 20837
HLA-C*16:01 ASFSTFKCY APFFAFKCY 68 3117
HLA-C*12:03 ASFSTFKCY APFFAFKCY 115 5066
HLA-C*03:02 ASFSTFKCY APFFAFKCY 64 2656
HLA-A*11:01 STFKCYGVSPTK FAFKCYGVSPTK 25 1030
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-A*11:01 ASFSTFKCY APFFAFKCY 379 12606
HLA-A*02:11 SVLYNSASFST SVLYNFAPFFA 3830 120
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-A*02:01 VLYNSASFST VLYNFAPFFA 243 8
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-C*16:01 FSTFKCYGV FFAFKCYGV 302 8277
HLA-B*35:01 ASFSTFKCY APFFAFKCY 2345 92
HLA-C*12:02 ASFSTFKCY APFFAFKCY 338 8222
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-A*03:01 STFKCYGVSPTK FAFKCYGVSPTK 83 1880
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-B*15:03 ASFSTFKCY APFFAFKCY 25 529
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-A*02:02 VLYNSASFST VLYNFAPFFA 202 10
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-C*03:02 STFKCYGVS FAFKCYGVS 8370 424
HLA-A*02:06 VLYNSASFST VLYNFAPFFA 710 36
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*02:11 VLYNSASFST VLYNFAPFFA 77 4
HLA-A*02:01 SVLYNSASFST SVLYNFAPFFA 5674 301
HLA-A*11:01 LYNSASFSTFK LYNFAPFFAFK 43 797
HLA-A*03:02 STFKCYGVSPTK FAFKCYGVSPTK 142 2541
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-A*02:11 YSVLYNSASFST YSVLYNFAPFFA 7859 469
HLA-C*14:02 SFSTFKCY PFFAFKCY 386 6449
HLA-A*30:01 STFKCYGVS FAFKCYGVS 438 6895
HLA-A*68:02 FSTFKCYGV FFAFKCYGV 17 261
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*02:06 FSTFKCYGV FFAFKCYGV 61 882
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*11:01 FSTFKCYGVSPTK FFAFKCYGVSPTK 426 5482
HLA-A*02:06 SVLYNSASFST SVLYNFAPFFA 4097 319
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-C*14:02 FSTFKCYGV FFAFKCYGV 4043 371
HLA-A*02:11 VLYNSASFSTF VLYNFAPFFAF 2537 236
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-A*02:01 VLYNSASFSTF VLYNFAPFFAF 4199 455
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-A*29:02 ASFSTFKCY APFFAFKCY 201 1830
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFAF 50 420
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-A*30:01 LYNSASFST LYNFAPFFA 3467 433
HLA-A*33:03 SVLYNSASFSTFK SVLYNFAPFFAFK 2778 357
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*30:01 STFKCYGVSPTK FAFKCYGVSPTK 194 1428
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-A*29:02 LYNSASFSTF LYNFAPFFAF 387 63
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFAFK 857 148
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 LYNSASFSTFK LYNFAPFFAFK 295 1614
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*03:02 LYNSASFSTFK LYNFAPFFAFK 202 831
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFAF 164 629
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-C*14:02 LYNSASFSTF LYNFAPFFAF 20 69
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFAFKCY 272 923
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFAF 1624 488
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFAFK 565 170
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-A*31:01 LYNSASFSTFK LYNFAPFFAFK 299 92
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*24:02 LYNSASFSTFK LYNFAPFFAFK 356 1101
HLA-A*33:03 LYNSASFSTFK LYNFAPFFAFK 1158 383
HLA-A*24:02 VLYNSASFSTF VLYNFAPFFAF 186 551
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFAFKC 312 920
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFAF 113 329
HLA-A*68:01 FSTFKCYGVSPTK FFAFKCYGVSPTK 288 832
HLA-B*58:01 YSVLYNSASFSTF YSVLYNFAPFFAF 429 1160
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFAFKCY 297 115
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFAF 38 96
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*03:01 VLYNSASFSTFK VLYNFAPFFAFK 7 17
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-A*11:01 VLYNSASFSTFK VLYNFAPFFAFK 22 51
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFAF 221 509
HLA-B*15:01 LYNSASFSTF LYNFAPFFAF 468 1064
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-A*68:01 YSVLYNSASFSTFK YSVLYNFAPFFAFK 144 67
HLA-A*30:01 TFKCYGVSPTK AFKCYGVSPTK 319 155
HLA-A*02:01 FSTFKCYGV FFAFKCYGV 457 926

D405N

Reference  YGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 FVIRGDEVR FVIRGNEVS 23 15265
HLA-A*68:01 SFVIRGDEVR SFVIRGNEVS 186 29639
HLA-A*68:01 DSFVIRGDEVR DSFVIRGNEVS 220 29286
HLA-A*33:03 FVIRGDEVR FVIRGNEVS 320 29448
HLA-A*33:03 SFVIRGDEVR SFVIRGNEVS 459 31986
HLA-C*14:02 SFVIRGDEV SFVIRGNEV 216 46
HLA-C*06:02 IRGDEVRQI IRGNEVSQI 147 642

R408S

Reference  SPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 FVIRGDEVR FVIRGNEVS 23 15265
HLA-A*03:01 RQIAPGQTGK SQIAPGQTGN 49 32429
HLA-A*11:01 RQIAPGQTGK SQIAPGQTGN 103 32387
HLA-A*03:02 RQIAPGQTGK SQIAPGQTGN 123 32767
HLA-A*68:01 EVRQIAPGQTGK EVSQIAPGQTGN 144 32361
HLA-A*68:01 SFVIRGDEVR SFVIRGNEVS 186 29639
HLA-A*68:01 DSFVIRGDEVR DSFVIRGNEVS 220 29286
HLA-A*33:03 FVIRGDEVR FVIRGNEVS 320 29448
HLA-A*33:03 SFVIRGDEVR SFVIRGNEVS 459 31986
HLA-A*30:01 RQIAPGQTGK SQIAPGQTGN 275 18394
HLA-C*06:02 IRGDEVRQI IRGNEVSQI 147 642
HLA-B*15:03 RQIAPGQT SQIAPGQT 478 1764
HLA-B*15:03 RQIAPGQTGKIADY SQIAPGQTGNIADY 17 55
HLA-A*30:02 RQIAPGQTGKIADY SQIAPGQTGNIADY 324 951
HLA-B*15:03 RQIAPGQTGKI SQIAPGQTGNI 236 691
HLA-B*15:03 RQIAPGQTG SQIAPGQTG 39 107

K417N

Reference  FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 RQIAPGQTGK SQIAPGQTGN 49 32429
HLA-A*11:01 RQIAPGQTGK SQIAPGQTGN 103 32387
HLA-A*03:02 RQIAPGQTGK SQIAPGQTGN 123 32767
HLA-A*68:01 EVRQIAPGQTGK EVSQIAPGQTGN 144 32361
HLA-A*68:01 QIAPGQTGK QIAPGQTGN 136 27997
HLA-A*11:01 QIAPGQTGK QIAPGQTGN 165 32767
HLA-A*03:02 QIAPGQTGK QIAPGQTGN 278 32767
HLA-A*03:01 QIAPGQTGK QIAPGQTGN 296 32767
HLA-A*32:01 KIADYNYKL NIADYNYKL 58 4480
HLA-A*30:01 RQIAPGQTGK SQIAPGQTGN 275 18394
HLA-A*68:02 KIADYNYKL NIADYNYKL 1274 39
HLA-A*03:02 KIADYNYK NIADYNYK 476 6850
HLA-A*02:06 KIADYNYKL NIADYNYKL 20 101
HLA-A*02:01 KIADYNYKL NIADYNYKL 23 110
HLA-C*17:01 KIADYNYKL NIADYNYKL 155 669
HLA-A*30:01 TGKIADYNYK TGNIADYNYK 292 1164
HLA-A*02:11 KIADYNYKL NIADYNYKL 5 19
HLA-B*15:03 RQIAPGQTGKIADY SQIAPGQTGNIADY 17 55
HLA-A*30:02 RQIAPGQTGKIADY SQIAPGQTGNIADY 324 951
HLA-B*15:03 RQIAPGQTGKI SQIAPGQTGNI 236 691
HLA-A*68:01 TGKIADYNYK TGNIADYNYK 957 343
HLA-A*01:01 QTGKIADYNY QTGNIADYNY 580 270

N440K

Reference  TGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFE
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFE

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 CVIAWNSNN CVIAWNSNK 24486 26
HLA-A*68:01 CVIAWNSNN CVIAWNSNK 11802 16
HLA-A*68:01 FTGCVIAWNSNN FTGCVIAWNSNK 25655 59
HLA-A*03:01 CVIAWNSNN CVIAWNSNK 24643 61
HLA-A*03:02 CVIAWNSNN CVIAWNSNK 22621 61
HLA-A*11:01 GCVIAWNSNN GCVIAWNSNK 32767 94
HLA-A*03:01 GCVIAWNSNN GCVIAWNSNK 32767 128
HLA-A*11:01 TGCVIAWNSNN TGCVIAWNSNK 32767 153
HLA-A*68:01 TGCVIAWNSNN TGCVIAWNSNK 32767 180
HLA-A*68:01 DFTGCVIAWNSNN DFTGCVIAWNSNK 32767 255
HLA-A*03:02 GCVIAWNSNN GCVIAWNSNK 32767 277
HLA-A*31:01 NLDSKVGGNYNYL KLDSKVGGNYNYR 31768 301
HLA-A*11:01 FTGCVIAWNSNN FTGCVIAWNSNK 32767 408
HLA-A*31:01 CVIAWNSNN CVIAWNSNK 18631 279
HLA-A*33:03 CVIAWNSNN CVIAWNSNK 20952 493
HLA-A*30:01 CVIAWNSNN CVIAWNSNK 11396 467
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKVGGNYNYRY 193 2088
HLA-A*30:02 NLDSKVGGNYNY KLDSKVGGNYNY 3839 409
HLA-A*30:02 NLDSKVGGNY KLDSKVGGNY 422 52
HLA-B*15:01 NLDSKVGGNY KLDSKVGGNY 1404 179
HLA-A*01:01 NLDSKVGGNY KLDSKVGGNY 371 819
HLA-A*02:11 VIAWNSNNL VIAWNSNKL 269 586
HLA-A*68:02 FTGCVIAWNSNNL FTGCVIAWNSNKL 461 960

L452R

Reference  DDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    DDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGN

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 KVGGNYNYL KVGGNYNYR 5813 13
HLA-A*02:11 YLYRLFRKSNL YRYRLFRKSNL 82 22451
HLA-A*68:01 SKVGGNYNYL SKVGGNYNYR 24692 119
HLA-B*27:05 YLYRLFRK YRYRLFRK 9806 50
HLA-A*02:11 YLYRLFRKS YRYRLFRKS 179 28031
HLA-A*02:02 YLYRLFRKSNL YRYRLFRKSNL 188 23354
HLA-A*02:11 KVGGNYNYL KVGGNYNYR 111 13729
HLA-B*27:05 YLYRLFRKS YRYRLFRKS 13862 117
HLA-A*31:01 NLDSKVGGNYNYL KLDSKVGGNYNYR 31768 301
HLA-A*33:03 DSKVGGNYNYL DSKVGGNYNYR 30679 292
HLA-B*27:05 YLYRLFRKSNLK YRYRLFRKSNLK 2218 22
HLA-A*31:01 SKVGGNYNYL SKVGGNYNYR 21677 233
HLA-A*03:01 YLYRLFRK YRYRLFRK 204 18425
HLA-A*68:01 KVGGNYNYL KVGGNYNYR 25432 286
HLA-A*33:03 KVGGNYNYL KVGGNYNYR 22954 269
HLA-A*11:01 KVGGNYNYL KVGGNYNYR 16150 194
HLA-A*02:02 KVGGNYNYL KVGGNYNYR 279 23086
HLA-A*68:01 DSKVGGNYNYL DSKVGGNYNYR 28915 378
HLA-A*03:02 YLYRLFRK YRYRLFRK 327 22983
HLA-A*02:01 YLYRLFRKSNL YRYRLFRKSNL 471 28211
HLA-A*33:03 SKVGGNYNYL SKVGGNYNYR 27973 469
HLA-A*03:02 KVGGNYNYL KVGGNYNYR 12848 234
HLA-A*02:06 KVGGNYNYL KVGGNYNYR 452 18600
HLA-B*27:05 YLYRLFRKSNLKP YRYRLFRKSNLKP 13004 347
HLA-B*27:05 YLYRLFRKSNLKPF YRYRLFRKSNLKPF 7101 214
HLA-B*27:05 YLYRLFRKSNL YRYRLFRKSNL 1360 48
HLA-B*15:01 YLYRLFRKSNLKPF YRYRLFRKSNLKPF 476 9205
HLA-B*08:01 YLYRLFRKSNL YRYRLFRKSNL 160 1946
HLA-A*30:01 LYRLFRKSN RYRLFRKSN 1444 120
HLA-A*30:01 LYRLFRKSNL RYRLFRKSNL 1104 93
HLA-A*02:11 KVGGNYNYLYRL KVGGNYNYRYRL 274 3087
HLA-A*30:01 LYRLFRKSNLKP RYRLFRKSNLKP 3059 277
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKVGGNYNYRY 193 2088
HLA-A*30:01 LYRLFRKSNLK RYRLFRKSNLK 192 21
HLA-A*03:01 LYRLFRKSNLKP RYRLFRKSNLKP 3564 430
HLA-A*30:01 NYLYRLFRK NYRYRLFRK 512 64
HLA-B*27:05 LYRLFRKSNL RYRLFRKSNL 932 123
HLA-A*23:01 GNYNYLYRLF GNYNYRYRLF 181 1119
HLA-A*23:01 NYNYLYRLF NYNYRYRLF 20 119
HLA-A*23:01 KVGGNYNYLYRLF KVGGNYNYRYRLF 410 2404
HLA-A*23:01 VGGNYNYLYRLF VGGNYNYRYRLF 222 1236
HLA-A*29:02 VGGNYNYLY VGGNYNYRY 94 518
HLA-A*31:01 LYRLFRKSNLK RYRLFRKSNLK 356 67
HLA-A*30:01 YLYRLFRKSNLK YRYRLFRKSNLK 1354 258
HLA-A*24:02 NYNYLYRLF NYNYRYRLF 21 108
HLA-A*29:02 KVGGNYNYLY KVGGNYNYRY 100 505
HLA-A*24:02 GNYNYLYRLF GNYNYRYRLF 325 1597
HLA-A*24:02 VGGNYNYLYRLF VGGNYNYRYRLF 391 1596
HLA-A*03:01 LYRLFRKSNLK RYRLFRKSNLK 65 18
HLA-A*03:02 LYRLFRKSNLK RYRLFRKSNLK 242 72
HLA-A*30:01 YNYLYRLFRK YNYRYRLFRK 379 125
HLA-A*11:01 LYRLFRKSNLK RYRLFRKSNLK 952 401
HLA-B*15:03 SKVGGNYNYLY SKVGGNYNYRY 313 720
HLA-A*30:02 VGGNYNYLY VGGNYNYRY 45 93

477-478 ST->NK

Reference  LYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    RYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPLQSYGFRPTYGV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 STEIYQAGST STEIYQAGNK 30358 67
HLA-A*68:01 STEIYQAGST STEIYQAGNK 22142 157
HLA-A*02:02 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 9447 68
HLA-A*03:01 STEIYQAGST STEIYQAGNK 32241 308
HLA-A*02:11 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 17568 184
HLA-B*35:01 TPCNGVEGF KPCNGVAGV 319 21824
HLA-A*02:06 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 5118 87
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 217 12581
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 408 12442
HLA-A*02:11 YQAGSTPCNGV YQAGNKPCNGV 173 678
HLA-B*50:01 TEIYQAGSTP TEIYQAGNKP 464 1807
HLA-A*02:06 YQAGSTPCNGV YQAGNKPCNGV 39 146
HLA-A*02:01 YQAGSTPCNGV YQAGNKPCNGV 420 1490
HLA-C*14:02 IYQAGSTPC IYQAGNKPC 134 459
HLA-A*02:02 YQAGSTPCNGV YQAGNKPCNGV 107 233

E484A

Reference  SNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYR
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPLQSYGFRPTYGVGHQPYR

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:02 VEGFNCYFPL VAGVNCYFPL 31 19248
HLA-B*40:01 VEGFNCYFPL VAGVNCYFPL 76 26041
HLA-A*02:02 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 9447 68
HLA-A*02:11 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 17568 184
HLA-B*35:01 TPCNGVEGF KPCNGVAGV 319 21824
HLA-A*02:06 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 5118 87
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 217 12581
HLA-A*68:02 EGFNCYFPL AGVNCYFPL 117 4903
HLA-B*15:01 GVEGFNCYF GVAGVNCYF 3125 98
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 408 12442
HLA-B*15:03 GVEGFNCYF GVAGVNCYF 1657 235
HLA-A*30:02 EGFNCYFPLQSY AGVNCYFPLQSY 1806 447
HLA-A*02:02 GVEGFNCYFPL GVAGVNCYFPL 666 171
HLA-B*35:01 NGVEGFNCY NGVAGVNCY 346 866

F486V

Reference  LKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    LKPFERDISTEIYQAGNKPCNGVAGVNCYFPLQSYGFRPTYGVGHQPYRVV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:02 VEGFNCYFPL VAGVNCYFPL 31 19248
HLA-B*40:01 VEGFNCYFPL VAGVNCYFPL 76 26041
HLA-A*02:02 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 9447 68
HLA-A*02:11 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 17568 184
HLA-B*35:01 TPCNGVEGF KPCNGVAGV 319 21824
HLA-A*02:06 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 5118 87
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 217 12581
HLA-A*68:02 EGFNCYFPL AGVNCYFPL 117 4903
HLA-B*15:01 GVEGFNCYF GVAGVNCYF 3125 98
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNKPCNGVAGV 408 12442
HLA-C*03:02 FNCYFPLQSY VNCYFPLQSY 225 1964
HLA-B*15:03 GVEGFNCYF GVAGVNCYF 1657 235
HLA-A*30:02 EGFNCYFPLQSY AGVNCYFPLQSY 1806 447
HLA-A*02:02 GVEGFNCYFPL GVAGVNCYFPL 666 171
HLA-A*29:02 GFNCYFPLQSY GVNCYFPLQSY 191 742
HLA-A*29:02 FNCYFPLQSY VNCYFPLQSY 73 227
HLA-B*35:01 NGVEGFNCY NGVAGVNCY 346 866
HLA-B*15:03 FNCYFPLQSY VNCYFPLQSY 101 240

Q498R

Reference  YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPAT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YQAGNKPCNGVAGVNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPAT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:02 QSYGFQPTN QSYGFRPTY 12903 18
HLA-B*15:01 LQSYGFQPTN LQSYGFRPTY 6135 9
HLA-C*16:01 QSYGFQPTN QSYGFRPTY 10868 16
HLA-A*29:02 QSYGFQPTN QSYGFRPTY 26152 43
HLA-B*15:03 QSYGFQPTN QSYGFRPTY 6543 11
HLA-B*15:03 LQSYGFQPTN LQSYGFRPTY 2045 4
HLA-C*12:03 QSYGFQPTN QSYGFRPTY 12696 25
HLA-A*29:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 19514 47
HLA-B*15:03 PLQSYGFQPTN PLQSYGFRPTY 22802 60
HLA-B*35:01 FPLQSYGFQPTN FPLQSYGFRPTY 8715 27
HLA-A*33:03 YFPLQSYGFQ YFPLQSYGFR 11148 35
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-A*31:01 CYFPLQSYGFQ CYFPLQSYGFR 8535 34
HLA-C*03:02 FPLQSYGFQPTN FPLQSYGFRPTY 23840 111
HLA-C*14:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 18230 85
HLA-A*33:03 CYFPLQSYGFQ CYFPLQSYGFR 11311 54
HLA-C*03:02 LQSYGFQPTN LQSYGFRPTY 23421 125
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-A*30:02 QSYGFQPTN QSYGFRPTY 5297 32
HLA-A*33:03 FPLQSYGFQ FPLQSYGFR 23527 146
HLA-B*15:03 FPLQSYGFQPTN FPLQSYGFRPTY 20159 126
HLA-A*31:01 YFPLQSYGFQ YFPLQSYGFR 16290 103
HLA-B*35:01 QSYGFQPTN QSYGFRPTY 24615 156
HLA-C*03:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 27639 176
HLA-C*16:01 LQSYGFQPTN LQSYGFRPTY 27149 187
HLA-A*30:02 LQSYGFQPTN LQSYGFRPTY 7508 54
HLA-B*15:01 QSYGFQPTN QSYGFRPTY 21529 157
HLA-C*12:02 QSYGFQPTN QSYGFRPTY 21029 169
HLA-B*15:03 YFPLQSYGFQPTN YFPLQSYGFRPTY 22168 189
HLA-C*16:01 FPLQSYGFQPTN FPLQSYGFRPTY 27733 237
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLQSYGFRPTY 27182 240
HLA-A*29:02 LQSYGFQPTN LQSYGFRPTY 28458 265
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*16:01 YFPLQSYGFQPTN YFPLQSYGFRPTY 29358 306
HLA-C*12:03 FPLQSYGFQPTN FPLQSYGFRPTY 27893 295
HLA-C*14:02 QSYGFQPTN QSYGFRPTY 25941 277
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLQSYGFR 21321 230
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLQSYGFR 22134 257
HLA-C*12:03 LQSYGFQPTN LQSYGFRPTY 26641 325
HLA-B*15:03 LQSYGFQPTNG LQSYGFRPTYG 6387 82
HLA-A*32:01 QSYGFQPTN QSYGFRPTY 16619 226
HLA-A*11:01 QSYGFQPTN QSYGFRPTY 22068 301
HLA-A*68:01 FPLQSYGFQ FPLQSYGFR 17691 247
HLA-C*02:02 QSYGFQPTN QSYGFRPTY 26598 412
HLA-C*02:10 QSYGFQPTN QSYGFRPTY 26598 412
HLA-A*68:01 YFPLQSYGFQ YFPLQSYGFR 14480 278
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLQSYGFRPTY 24158 500
HLA-A*30:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 18743 390
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-B*53:01 FPLQSYGFQPTN FPLQSYGFRPTY 8451 351
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-B*57:01 QSYGFQPTN QSYGFRPTY 4070 293
HLA-A*30:01 QSYGFQPTN QSYGFRPTY 3720 308
HLA-B*57:01 LQSYGFQPTN LQSYGFRPTY 3839 375
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-B*58:01 QSYGFQPTN QSYGFRPTY 1532 249
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-B*15:03 LQSYGFQPTNGV LQSYGFRPTYGV 1971 442
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355
HLA-A*02:06 QSYGFQPTNGV QSYGFRPTYGV 1121 425
HLA-A*68:02 QSYGFQPTNGV QSYGFRPTYGV 122 47
HLA-A*02:06 LQSYGFQPT LQSYGFRPT 339 871

N501Y

Reference  GSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GNKPCNGVAGVNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:02 QSYGFQPTN QSYGFRPTY 12903 18
HLA-B*15:01 LQSYGFQPTN LQSYGFRPTY 6135 9
HLA-C*16:01 QSYGFQPTN QSYGFRPTY 10868 16
HLA-A*29:02 QSYGFQPTN QSYGFRPTY 26152 43
HLA-B*15:03 QSYGFQPTN QSYGFRPTY 6543 11
HLA-B*15:03 LQSYGFQPTN LQSYGFRPTY 2045 4
HLA-C*12:03 QSYGFQPTN QSYGFRPTY 12696 25
HLA-A*29:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 19514 47
HLA-B*15:03 PLQSYGFQPTN PLQSYGFRPTY 22802 60
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*35:01 FPLQSYGFQPTN FPLQSYGFRPTY 8715 27
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-C*03:02 FPLQSYGFQPTN FPLQSYGFRPTY 23840 111
HLA-C*14:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 18230 85
HLA-C*03:02 LQSYGFQPTN LQSYGFRPTY 23421 125
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-A*30:02 QSYGFQPTN QSYGFRPTY 5297 32
HLA-B*15:03 FPLQSYGFQPTN FPLQSYGFRPTY 20159 126
HLA-B*35:01 QSYGFQPTN QSYGFRPTY 24615 156
HLA-C*03:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 27639 176
HLA-C*16:01 LQSYGFQPTN LQSYGFRPTY 27149 187
HLA-A*30:02 LQSYGFQPTN LQSYGFRPTY 7508 54
HLA-B*15:01 QSYGFQPTN QSYGFRPTY 21529 157
HLA-C*12:02 QSYGFQPTN QSYGFRPTY 21029 169
HLA-B*15:03 YFPLQSYGFQPTN YFPLQSYGFRPTY 22168 189
HLA-C*16:01 FPLQSYGFQPTN FPLQSYGFRPTY 27733 237
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLQSYGFRPTY 27182 240
HLA-A*29:02 LQSYGFQPTN LQSYGFRPTY 28458 265
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*16:01 YFPLQSYGFQPTN YFPLQSYGFRPTY 29358 306
HLA-C*12:03 FPLQSYGFQPTN FPLQSYGFRPTY 27893 295
HLA-C*14:02 QSYGFQPTN QSYGFRPTY 25941 277
HLA-C*12:03 LQSYGFQPTN LQSYGFRPTY 26641 325
HLA-B*15:03 LQSYGFQPTNG LQSYGFRPTYG 6387 82
HLA-A*32:01 QSYGFQPTN QSYGFRPTY 16619 226
HLA-A*11:01 QSYGFQPTN QSYGFRPTY 22068 301
HLA-C*02:02 QSYGFQPTN QSYGFRPTY 26598 412
HLA-C*02:10 QSYGFQPTN QSYGFRPTY 26598 412
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLQSYGFRPTY 24158 500
HLA-A*30:02 YFPLQSYGFQPTN YFPLQSYGFRPTY 18743 390
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-B*53:01 FPLQSYGFQPTN FPLQSYGFRPTY 8451 351
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-B*57:01 QSYGFQPTN QSYGFRPTY 4070 293
HLA-A*30:01 QSYGFQPTN QSYGFRPTY 3720 308
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-B*57:01 LQSYGFQPTN LQSYGFRPTY 3839 375
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-B*58:01 QSYGFQPTN QSYGFRPTY 1532 249
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-B*15:03 LQSYGFQPTNGV LQSYGFRPTYGV 1971 442
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355
HLA-A*02:06 QSYGFQPTNGV QSYGFRPTYGV 1121 425
HLA-A*68:02 QSYGFQPTNGV QSYGFRPTYGV 122 47
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

Y505H

Reference  CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CNGVAGVNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-C*14:02 GYQPYRVVV GHQPYRVVV 78 3539
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-A*24:02 GYQPYRVVVLSF GHQPYRVVVLSF 220 6955
HLA-A*23:01 GYQPYRVVVLSF GHQPYRVVVLSF 107 3241
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-C*14:02 GYQPYRVVVL GHQPYRVVVL 213 4430
HLA-C*14:02 VGYQPYRVVV VGHQPYRVVV 413 7561
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*02:11 YQPYRVVVL HQPYRVVVL 332 4009
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-A*02:06 YQPYRVVVL HQPYRVVVL 223 2206
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*02:02 YQPYRVVVL HQPYRVVVL 360 2683
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-C*01:02 YQPYRVVVL HQPYRVVVL 41 241
HLA-A*02:06 YQPYRVVVLSFEL HQPYRVVVLSFEL 430 2495
HLA-C*03:03 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*03:04 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*07:02 YQPYRVVVL HQPYRVVVL 135 590
HLA-C*12:03 YQPYRVVVL HQPYRVVVL 132 555
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-C*14:02 YQPYRVVVL HQPYRVVVL 102 347
HLA-C*16:01 YQPYRVVVL HQPYRVVVL 214 726
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-C*12:03 VGYQPYRVV VGHQPYRVV 398 1196
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*23:01 YQPYRVVVLSF HQPYRVVVLSF 465 1280
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

D614G

Reference  PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*05:01 YQDVNCTEV YQGVNCTEV 82 8597
HLA-C*08:02 YQDVNCTEV YQGVNCTEV 89 8066
HLA-A*02:11 DVNCTEVPV GVNCTEVPV 2140 72
HLA-A*02:02 DVNCTEVPV GVNCTEVPV 4099 213
HLA-A*68:02 DVNCTEVPV GVNCTEVPV 36 659
HLA-A*02:06 DVNCTEVPV GVNCTEVPV 3807 208
HLA-A*68:02 QVAVLYQDV QVAVLYQGV 183 13
HLA-A*68:02 NQVAVLYQDV NQVAVLYQGV 650 52
HLA-A*02:06 QVAVLYQDV QVAVLYQGV 1312 148
HLA-A*02:11 QVAVLYQDV QVAVLYQGV 2169 268
HLA-A*68:02 NTSNQVAVLYQDV NTSNQVAVLYQGV 1858 231
HLA-A*68:02 TSNQVAVLYQDV TSNQVAVLYQGV 3281 457
HLA-A*02:02 QVAVLYQDV QVAVLYQGV 1107 188
HLA-A*02:01 YQDVNCTEV YQGVNCTEV 75 315
HLA-A*02:06 YQDVNCTEV YQGVNCTEV 17 57
HLA-A*02:11 VLYQDVNCT VLYQGVNCT 224 74
HLA-A*02:11 YQDVNCTEV YQGVNCTEV 31 93
HLA-A*02:11 VLYQDVNCTEVP VLYQGVNCTEVP 1000 402
HLA-A*02:02 NQVAVLYQDV NQVAVLYQGV 269 116
HLA-A*02:11 AVLYQDVNCTEV AVLYQGVNCTEV 500 238
HLA-A*02:01 NQVAVLYQDV NQVAVLYQGV 558 267
HLA-A*02:06 NQVAVLYQDV NQVAVLYQGV 36 18

H655Y

Reference  TPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:01 RAGCLIGAEH RAGCLIGAEY 7377 156
HLA-A*30:02 RAGCLIGAEH RAGCLIGAEY 1881 43
HLA-B*15:01 FQTRAGCLIGAEH FQTRAGCLIGAEY 7512 178
HLA-B*15:03 FQTRAGCLIGAEH FQTRAGCLIGAEY 5076 125
HLA-A*30:02 AGCLIGAEH AGCLIGAEY 5331 179
HLA-B*15:03 RAGCLIGAEH RAGCLIGAEY 5254 179
HLA-A*30:02 QTRAGCLIGAEH QTRAGCLIGAEY 8425 342
HLA-B*15:03 AGCLIGAEH AGCLIGAEY 9025 461
HLA-A*02:11 HVNNSYECDIPI YVNNSYECDIPI 1593 109
HLA-A*02:01 HVNNSYECDIPI YVNNSYECDIPI 2384 226
HLA-A*02:06 HVNNSYECDIPI YVNNSYECDIPI 837 92
HLA-A*02:02 HVNNSYECDIPI YVNNSYECDIPI 1466 187
HLA-A*02:11 CLIGAEHV CLIGAEYV 983 221
HLA-B*15:03 AEHVNNSY AEYVNNSY 986 267
HLA-B*18:01 AEHVNNSY AEYVNNSY 902 286

N679K

Reference  EHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-A*68:01 CASYQTQTN CASYQTQTK 28102 123
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-A*11:01 CASYQTQTN CASYQTQTK 32767 431
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

P681H

Reference  VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVA
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 SPRRARSVA SHRRARSVA 4 4721
HLA-B*42:01 SPRRARSVA SHRRARSVA 8 6169
HLA-B*07:02 SPRRARSVASQSI SHRRARSVASQSI 17 11433
HLA-B*07:02 SPRRARSV SHRRARSV 24 12728
HLA-B*07:02 SPRRARSVAS SHRRARSVAS 37 14758
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-B*07:02 SPRRARSVASQSII SHRRARSVASQSII 55 17736
HLA-B*42:01 SPRRARSV SHRRARSV 38 11622
HLA-B*42:01 SPRRARSVASQSI SHRRARSVASQSI 48 14418
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*42:01 SPRRARSVAS SHRRARSVAS 158 17461
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-B*42:01 SPRRARSVASQSII SHRRARSVASQSII 321 21521
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-B*08:01 SPRRARSVA SHRRARSVA 372 3831
HLA-B*08:01 SPRRARSV SHRRARSV 428 2448
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

N764K

Reference  TMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:02 LLQYGSFCTQLN LLQYGSFCTQLK 29153 102
HLA-A*11:01 LQYGSFCTQLN LQYGSFCTQLK 32767 191
HLA-A*03:01 LQYGSFCTQLN LQYGSFCTQLK 28204 214
HLA-A*68:01 YGSFCTQLN YGSFCTQLK 23773 187
HLA-A*03:02 LQYGSFCTQLN LQYGSFCTQLK 31227 331
HLA-A*03:02 LLLQYGSFCTQLN LLLQYGSFCTQLK 32767 377
HLA-A*11:01 YGSFCTQLN YGSFCTQLK 32767 386
HLA-A*03:01 LLQYGSFCTQLN LLQYGSFCTQLK 29424 350
HLA-A*03:01 LLLQYGSFCTQLN LLLQYGSFCTQLK 32355 410
HLA-A*02:11 QLNRALTGI QLKRALTGI 27 440
HLA-A*02:11 FCTQLNRALTGI FCTQLKRALTGI 63 898
HLA-B*08:01 CTQLNRAL CTQLKRAL 3325 279
HLA-A*02:01 FCTQLNRALTGI FCTQLKRALTGI 493 4878
HLA-A*02:02 FCTQLNRALTGI FCTQLKRALTGI 62 503
HLA-A*02:02 QLNRALTGI QLKRALTGI 45 307
HLA-C*03:03 FCTQLNRAL FCTQLKRAL 138 752
HLA-C*03:04 FCTQLNRAL FCTQLKRAL 138 752
HLA-A*02:02 TQLNRALTGI TQLKRALTGI 180 882
HLA-A*02:11 TQLNRALTGI TQLKRALTGI 267 1284
HLA-B*27:05 NRALTGIAV KRALTGIAV 1251 276
HLA-A*02:11 QLNRALTGIAV QLKRALTGIAV 259 1123
HLA-C*03:02 FCTQLNRAL FCTQLKRAL 361 1438
HLA-C*14:02 SFCTQLNRAL SFCTQLKRAL 234 511
HLA-A*02:06 TQLNRALTGI TQLKRALTGI 54 113

D796Y

Reference  AVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*23:01 KDFGGFNF KYFGGFNF 15419 23
HLA-A*23:01 KDFGGFNFSQI KYFGGFNFSQI 15932 37
HLA-A*24:02 KDFGGFNF KYFGGFNF 21008 55
HLA-C*14:02 IYKTPPIKD IYKTPPIKY 16538 55
HLA-A*24:02 KDFGGFNFSQI KYFGGFNFSQI 20251 68
HLA-B*15:03 KQIYKTPPIKD KQIYKTPPIKY 7773 29
HLA-A*23:01 KDFGGFNFSQIL KYFGGFNFSQIL 15831 63
HLA-C*14:02 KDFGGFNF KYFGGFNF 22081 90
HLA-A*24:02 KDFGGFNFSQIL KYFGGFNFSQIL 21565 126
HLA-B*15:01 KQIYKTPPIKD KQIYKTPPIKY 22193 141
HLA-C*14:02 KDFGGFNFSQIL KYFGGFNFSQIL 14873 165
HLA-A*30:01 KDFGGFNFS KYFGGFNFS 9496 156
HLA-C*14:02 DFGGFNFSQIL YFGGFNFSQIL 6960 139
HLA-A*30:02 KQIYKTPPIKD KQIYKTPPIKY 15917 386
HLA-B*15:03 VKQIYKTPPIKD VKQIYKTPPIKY 16977 446
HLA-B*15:03 IKDFGGFNF IKYFGGFNF 97 4
HLA-B*15:03 PIKDFGGFNF PIKYFGGFNF 7546 321
HLA-B*15:03 TPPIKDFGGFNF TPPIKYFGGFNF 10071 484
HLA-B*15:03 KTPPIKDFGGFNF KTPPIKYFGGFNF 6427 331
HLA-A*32:01 KTPPIKDFGGFNF KTPPIKYFGGFNF 6031 381
HLA-A*23:01 DFGGFNFSQI YFGGFNFSQI 5424 461
HLA-B*15:03 YKTPPIKDFGGFNF YKTPPIKYFGGFNF 2588 394
HLA-C*06:02 YKTPPIKDF YKTPPIKYF 2488 460
HLA-C*07:02 YKTPPIKDF YKTPPIKYF 1804 378
HLA-A*23:01 IYKTPPIKDF IYKTPPIKYF 273 98
HLA-A*24:02 IYKTPPIKDF IYKTPPIKYF 375 147
HLA-C*14:02 IYKTPPIKDF IYKTPPIKYF 341 158
HLA-B*15:03 YKTPPIKDF YKTPPIKYF 92 43

Q954H

Reference  SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLND

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*38:01 NQNAQALNTL NHNAQALNTL 2805 97
HLA-A*68:02 DVVNQNAQA DVVNHNAQA 703 344

N969K

Reference  ALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQID
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQID

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 TLVKQLSSN TLVKQLSSK 29207 56
HLA-A*68:01 NTLVKQLSSN NTLVKQLSSK 28063 86
HLA-A*11:01 TLVKQLSSN TLVKQLSSK 32767 125
HLA-A*03:02 TLVKQLSSN TLVKQLSSK 31915 131
HLA-A*11:01 NTLVKQLSSN NTLVKQLSSK 32767 147
HLA-A*03:01 ALNTLVKQLSSN ALNTLVKQLSSK 32767 154
HLA-A*03:02 ALNTLVKQLSSN ALNTLVKQLSSK 32767 304
HLA-A*03:01 NTLVKQLSSN NTLVKQLSSK 32767 482
HLA-A*68:02 SNFGAISSV SKFGAISSV 117 5329
HLA-B*15:03 SNFGAISSVL SKFGAISSVL 688 25
HLA-B*08:01 QLSSNFGAI QLSSKFGAI 4755 265
HLA-C*15:02 SNFGAISSV SKFGAISSV 374 5700
HLA-A*30:01 SSNFGAISS SSKFGAISS 1320 88
HLA-B*15:03 SNFGAISSV SKFGAISSV 727 49
HLA-A*30:01 SSNFGAISSV SSKFGAISSV 587 71
HLA-A*02:06 KQLSSNFGA KQLSSKFGA 62 269
HLA-A*02:01 KQLSSNFGAI KQLSSKFGAI 407 1567
HLA-A*02:11 KQLSSNFGA KQLSSKFGA 228 807
HLA-A*02:06 SNFGAISSV SKFGAISSV 361 1100
HLA-C*06:02 SNFGAISSV SKFGAISSV 1423 485
HLA-A*02:11 KQLSSNFGAI KQLSSKFGAI 152 428
HLA-A*02:06 KQLSSNFGAI KQLSSKFGAI 58 159
HLA-A*02:02 KQLSSNFGAI KQLSSKFGAI 261 668
HLA-B*15:03 KQLSSNFGA KQLSSKFGA 497 1076

N protein

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N

P13L

Reference  MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSK
           |||||||||||| |||||||||||||||||||||||||
Mutated    MSDNGPQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 MSDNGPQNQRNAP MSDNGPQNQRNAL 11146 27
HLA-B*07:02 GPQNQRNAP GPQNQRNAL 2464 6
HLA-B*42:01 GPQNQRNAP GPQNQRNAL 3035 8
HLA-B*07:02 SDNGPQNQRNAP SDNGPQNQRNAL 11353 32
HLA-B*42:01 SDNGPQNQRNAP SDNGPQNQRNAL 13042 39
HLA-B*42:01 NGPQNQRNAP NGPQNQRNAL 12875 41
HLA-B*07:02 MSDNGPQNQRNAP MSDNGPQNQRNAL 13138 58
HLA-B*07:02 NGPQNQRNAP NGPQNQRNAL 14898 72
HLA-B*07:02 APRITFGGPS ALRITFGGPS 191 17534
HLA-B*42:01 PQNQRNAP PQNQRNAL 30142 436
HLA-B*07:02 GPQNQRNAPR GPQNQRNALR 13964 345
HLA-B*27:05 QRNAPRITF QRNALRITF 509 83
HLA-B*27:05 NQRNAPRITF NQRNALRITF 1716 350
HLA-B*27:05 GPQNQRNAPRITF GPQNQRNALRITF 2076 442
HLA-B*15:01 NQRNAPRITF NQRNALRITF 96 40

ERS 31-33 deletion

Reference  PQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQ
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    PQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSKQRRPQGLPNNTASWFTALTQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 RSGARSKQR GARSKQR 77 -
HLA-A*68:01 STGSNQNGER - 137 -
HLA-A*31:01 RSGARSKQRR - 254 -

P151S

Reference  NKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NKDGIIWVATEGALNTPKDHIGTRNSANNAAIVLQLPQGTTLPKGFYAEGS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:03 PANNAAIVL SANNAAIVL 3749 9
HLA-C*03:04 PANNAAIVL SANNAAIVL 3749 9
HLA-C*16:01 PANNAAIVL SANNAAIVL 1730 8
HLA-C*12:03 PANNAAIVL SANNAAIVL 5617 27
HLA-C*03:02 PANNAAIVL SANNAAIVL 5558 30
HLA-B*07:02 RNPANNAAIV RNSANNAAIV 199 19874
HLA-C*12:02 PANNAAIVL SANNAAIVL 10293 123
HLA-C*17:01 PANNAAIVL SANNAAIVL 5437 65
HLA-B*15:03 PANNAAIVL SANNAAIVL 10239 129
HLA-B*42:01 NPANNAAIVL NSANNAAIVL 144 9452
HLA-B*42:01 RNPANNAAIV RNSANNAAIV 340 20370
HLA-C*15:02 PANNAAIVL SANNAAIVL 10150 225
HLA-B*42:01 NPANNAAIV NSANNAAIV 364 16078
HLA-B*07:02 NPANNAAIVL NSANNAAIVL 346 15227
HLA-A*68:02 NPANNAAIV NSANNAAIV 3031 72
HLA-C*08:01 PANNAAIVL SANNAAIVL 12500 326
HLA-C*02:02 PANNAAIVL SANNAAIVL 13200 452
HLA-C*02:10 PANNAAIVL SANNAAIVL 13200 452
HLA-C*14:02 PANNAAIVL SANNAAIVL 10601 476
HLA-C*12:03 NPANNAAIV NSANNAAIV 8213 461
HLA-C*16:01 NPANNAAIV NSANNAAIV 7224 478

203-204 RG->KR

Reference  GGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQ
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    GGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 NSTPGSSRG NSTPGSSKR 32767 34
HLA-A*33:03 NSTPGSSRG NSTPGSSKR 32767 300
HLA-B*15:03 SRGTSPARM SKRTSPARM 2669 106
HLA-A*31:01 RNSTPGSSRG RNSTPGSSKR 7013 340
HLA-A*30:01 SSRNSTPGSSR SSRNSTPGSSK 356 20
HLA-A*30:01 GTSPARMAG RTSPARMAG 493 30
HLA-A*31:01 SSRNSTPGSSRG SSRNSTPGSSKR 3757 231
HLA-A*30:01 GTSPARMAGNGG RTSPARMAGNGG 6051 411
HLA-A*31:01 SSRNSTPGSSR SSRNSTPGSSK 127 1853
HLA-A*30:01 NSSRNSTPGSSR NSSRNSTPGSSK 4255 353
HLA-A*30:01 RNSTPGSSR RNSTPGSSK 2120 188
HLA-A*31:01 RNSTPGSSR RNSTPGSSK 123 1335
HLA-A*03:01 SSRNSTPGSSR SSRNSTPGSSK 4753 442
HLA-A*11:01 SSRNSTPGSSR SSRNSTPGSSK 2231 263
HLA-A*68:01 NSSRNSTPGSSR NSSRNSTPGSSK 270 1385
HLA-A*30:01 GSSRGTSPA GSSKRTSPA 555 145
HLA-A*30:01 SSRNSTPGSSRG SSRNSTPGSSKR 1625 469
HLA-A*30:01 SSRGTSPARMAG SSKRTSPARMAG 449 1031

S413R

Reference  KQQTVTLLPAADLDDFSKQLQQSMSSADSTQA
           ||||||||||||||||||||||||| ||||||
Mutated    KQQTVTLLPAADLDDFSKQLQQSMSRADSTQA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 KQLQQSMSS KQLQQSMSR 20016 55
HLA-A*30:01 MSSADSTQA MSRADSTQA 2953 37
HLA-A*33:03 DFSKQLQQSMSS DFSKQLQQSMSR 32767 494
HLA-B*15:03 KQLQQSMSS KQLQQSMSR 236 5105
HLA-A*30:01 SMSSADSTQA SMSRADSTQA 6453 416
HLA-A*02:02 FSKQLQQSMSSA FSKQLQQSMSRA 345 1138
HLA-A*02:11 FSKQLQQSMSSA FSKQLQQSMSRA 353 1118
HLA-A*02:11 QLQQSMSSA QLQQSMSRA 436 1175
HLA-A*02:02 SMSSADSTQA SMSRADSTQA 355 725

M protein

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M

Q19E

Reference  MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNR

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*44:03 EQWNLVIGF EEWNLVIGF 1268 15
HLA-B*44:02 EQWNLVIGF EEWNLVIGF 2396 34
HLA-B*44:03 EQWNLVIGFLF EEWNLVIGFLF 5200 85
HLA-B*44:03 EQWNLVIGFL EEWNLVIGFL 8038 135
HLA-B*44:03 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5966 126
HLA-B*44:02 EQWNLVIGFLF EEWNLVIGFLF 6607 162
HLA-B*44:02 EQWNLVIGFL EEWNLVIGFL 9054 237
HLA-B*44:02 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5922 170
HLA-B*15:01 LEQWNLVIGF LEEWNLVIGF 256 8100
HLA-B*18:01 EQWNLVIGF EEWNLVIGF 482 16
HLA-A*02:06 EQWNLVIGFL EEWNLVIGFL 418 10916
HLA-B*15:03 EQWNLVIGF EEWNLVIGF 101 2397
HLA-B*18:01 EQWNLVIGFLF EEWNLVIGFLF 3471 190
HLA-B*40:02 EQWNLVIGFL EEWNLVIGFL 3775 245
HLA-B*15:03 LEQWNLVIGF LEEWNLVIGF 88 1227
HLA-B*40:02 EQWNLVIGF EEWNLVIGF 1765 242
HLA-B*15:03 KLLEQWNLVIGF KLLEEWNLVIGF 365 2285
HLA-A*02:11 LLEQWNLVI LLEEWNLVI 142 24
HLA-A*02:11 LLEQWNLVIGFL LLEEWNLVIGFL 1120 210
HLA-A*02:01 LLEQWNLVI LLEEWNLVI 644 131
HLA-A*29:02 QWNLVIGFLF EWNLVIGFLF 159 780
HLA-A*24:02 QWNLVIGFLF EWNLVIGFLF 53 246
HLA-A*23:01 QWNLVIGFLF EWNLVIGFLF 18 79
HLA-A*02:02 LLEQWNLVI LLEEWNLVI 781 187
HLA-A*02:06 LLEQWNLVI LLEEWNLVI 1869 487
HLA-B*40:02 LEQWNLVI LEEWNLVI 367 1301
HLA-A*02:02 LLEQWNLVIGFL LLEEWNLVIGFL 1047 329

A63T

Reference  AYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*35:01 LACFVLAAVY LTCFVLAAVY 121 1943
HLA-A*68:01 ACFVLAAVYR TCFVLAAVYR 694 80
HLA-B*35:01 ACFVLAAVY TCFVLAAVY 2289 331
HLA-C*03:02 LACFVLAAVY LTCFVLAAVY 145 935
HLA-C*16:01 LACFVLAAV LTCFVLAAV 346 1994
HLA-A*02:01 WLLWPVTLA WLLWPVTLT 33 190
HLA-A*02:02 WLLWPVTLA WLLWPVTLT 32 180
HLA-A*02:11 LWLLWPVTLA LWLLWPVTLT 66 363
HLA-A*02:11 IFLWLLWPVTLA IFLWLLWPVTLT 190 1034
HLA-A*02:11 LLWPVTLA LLWPVTLT 242 1313
HLA-A*33:03 ACFVLAAVYR TCFVLAAVYR 252 47
HLA-A*02:02 LWLLWPVTLA LWLLWPVTLT 304 1623
HLA-C*12:03 LACFVLAAV LTCFVLAAV 214 1116
HLA-A*02:06 WLLWPVTLA WLLWPVTLT 60 302
HLA-A*02:01 LWLLWPVTLA LWLLWPVTLT 228 1142
HLA-A*02:02 TLACFVLAAVY TLTCFVLAAVY 337 1467
HLA-A*02:02 VTLACFVLAAV VTLTCFVLAAV 160 678
HLA-A*68:02 LACFVLAAV LTCFVLAAV 44 11
HLA-A*02:02 PVTLACFVLAAV PVTLTCFVLAAV 479 1907
HLA-A*02:11 LIFLWLLWPVTLA LIFLWLLWPVTLT 406 1602
HLA-A*02:02 TLACFVLAAVYRI TLTCFVLAAVYRI 293 1148
HLA-A*02:11 LACFVLAAV LTCFVLAAV 122 32
HLA-A*02:11 WLLWPVTLA WLLWPVTLT 6 22
HLA-B*15:03 LACFVLAAVY LTCFVLAAVY 81 284
HLA-A*68:02 TLACFVLAA TLTCFVLAA 395 1376
HLA-A*02:02 FLWLLWPVTLACFV FLWLLWPVTLTCFV 485 146
HLA-A*68:01 LACFVLAAVY LTCFVLAAVY 1184 359
HLA-A*02:02 TLACFVLAA TLTCFVLAA 13 41
HLA-A*02:11 TLACFVLAAVY TLTCFVLAAVY 310 929
HLA-A*02:02 FLWLLWPVTLA FLWLLWPVTLT 291 867
HLA-A*02:11 KLIFLWLLWPVTLA KLIFLWLLWPVTLT 290 859
HLA-A*29:02 LACFVLAAVY LTCFVLAAVY 232 81
HLA-A*02:02 VTLACFVLAA VTLTCFVLAA 100 285
HLA-A*02:06 TLACFVLAAV TLTCFVLAAV 16 45
HLA-A*68:02 VTLACFVLAA VTLTCFVLAA 481 1321
HLA-B*15:01 TLACFVLAAVY TLTCFVLAAVY 414 1136
HLA-A*23:01 LWPVTLACF LWPVTLTCF 57 155
HLA-A*24:02 LWPVTLACF LWPVTLTCF 49 133
HLA-A*02:11 FLWLLWPVTLA FLWLLWPVTLT 25 67
HLA-A*02:06 TLACFVLAA TLTCFVLAA 40 107
HLA-A*02:01 LACFVLAAV LTCFVLAAV 471 179
HLA-A*02:02 TLACFVLAAV TLTCFVLAAV 5 13
HLA-A*02:11 VTLACFVLAA VTLTCFVLAA 97 245
HLA-A*02:01 FLWLLWPVTLA FLWLLWPVTLT 107 269
HLA-A*02:06 FLWLLWPVTLA FLWLLWPVTLT 495 1240
HLA-A*02:11 TLACFVLAA TLTCFVLAA 8 20
HLA-A*02:11 VTLACFVLAAV VTLTCFVLAAV 128 318
HLA-A*02:01 TLACFVLAAV TLTCFVLAAV 11 27
HLA-A*02:02 LACFVLAAV LTCFVLAAV 198 81
HLA-A*02:01 TLACFVLAA TLTCFVLAA 25 61
HLA-A*02:01 VTLACFVLAAV VTLTCFVLAAV 436 1029
HLA-B*07:02 WPVTLACFVL WPVTLTCFVL 362 155
HLA-A*02:01 FLWLLWPVTLACFV FLWLLWPVTLTCFV 329 142
HLA-A*02:11 TLACFVLAAV TLTCFVLAAV 4 9
HLA-A*30:02 LACFVLAAVY LTCFVLAAVY 218 98
HLA-A*02:06 LACFVLAAV LTCFVLAAV 51 23
HLA-A*03:02 TLACFVLAAVYR TLTCFVLAAVYR 480 1047
HLA-A*68:02 TLACFVLAAV TLTCFVLAAV 26 12
HLA-B*42:01 WPVTLACFV WPVTLTCFV 209 102
HLA-A*32:01 LLWPVTLACF LLWPVTLTCF 427 212

E protein

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E

T9I

Reference  MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAIL
           |||||||| |||||||||||||||||||||||||
Mutated    MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAIL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*24:02 MYSFVSEET MYSFVSEEI 5532 18
HLA-A*23:01 MYSFVSEET MYSFVSEEI 5604 31
HLA-C*16:01 YSFVSEET YSFVSEEI 7157 226
HLA-C*14:02 MYSFVSEET MYSFVSEEI 901 30
HLA-C*12:03 YSFVSEET YSFVSEEI 10273 457
HLA-A*68:02 MYSFVSEET MYSFVSEEI 3879 472
HLA-A*68:02 ETGTLIVNSV EIGTLIVNSV 13 91
HLA-A*68:02 FVSEETGTLI FVSEEIGTLI 247 60
HLA-A*68:02 TGTLIVNSV IGTLIVNSV 491 1976
HLA-A*02:11 FVSEETGTLI FVSEEIGTLI 307 89
HLA-B*40:01 EETGTLIVNSVL EEIGTLIVNSVL 1578 499
HLA-A*02:01 FVSEETGTL FVSEEIGTL 575 186
HLA-A*02:11 FVSEETGTL FVSEEIGTL 97 32
HLA-A*02:06 FVSEETGTLI FVSEEIGTLI 423 144
HLA-A*02:06 FVSEETGTL FVSEEIGTL 120 41
HLA-A*02:01 FVSEETGTLI FVSEEIGTLI 1293 442
HLA-A*02:06 FVSEETGTLIV FVSEEIGTLIV 670 266
HLA-C*03:03 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-C*03:04 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-B*44:03 EETGTLIVNSVLLF EEIGTLIVNSVLLF 877 375
HLA-A*02:11 FVSEETGTLIV FVSEEIGTLIV 538 251
HLA-A*02:02 FVSEETGTLI FVSEEIGTLI 85 40
HLA-A*68:02 YSFVSEETGTLI YSFVSEEIGTLI 1008 485

NS3 protein

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NS3

T223I

Reference  KDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:03 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*03:04 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*12:03 YSTQLSTDT YSTQLSTDI 11751 430
HLA-C*16:01 YSTQLSTDT YSTQLSTDI 7819 294
HLA-C*03:02 YSTQLSTDT YSTQLSTDI 6466 347
HLA-A*02:06 YQLYSTQLSTDT YQLYSTQLSTDI 4179 287
HLA-A*02:11 QLYSTQLSTDT QLYSTQLSTDI 5151 437
HLA-A*68:01 TGVEHVTFFIYNK IGVEHVTFFIYNK 213 1427
HLA-A*68:02 LSTDTGVEHV LSTDIGVEHV 1765 265
HLA-A*68:02 TGVEHVTFFI IGVEHVTFFI 212 1093
HLA-A*02:01 TQLSTDTGV TQLSTDIGV 1084 283
HLA-A*02:01 YSTQLSTDTGV YSTQLSTDIGV 1288 379
HLA-A*02:11 STQLSTDTGV STQLSTDIGV 1485 443
HLA-A*25:01 DTGVEHVTFF DIGVEHVTFF 180 596
HLA-A*02:11 TQLSTDTGV TQLSTDIGV 436 133
HLA-A*02:06 STQLSTDTGV STQLSTDIGV 264 83
HLA-A*02:11 YSTQLSTDTGV YSTQLSTDIGV 1184 381
HLA-A*26:01 DTGVEHVTFF DIGVEHVTFF 37 108
HLA-A*02:06 YSTQLSTDTGV YSTQLSTDIGV 157 56
HLA-C*03:02 TGVEHVTFF IGVEHVTFF 237 88
HLA-A*02:06 TQLSTDTGV TQLSTDIGV 70 26
HLA-B*15:03 TGVEHVTFF IGVEHVTFF 305 115
HLA-A*02:06 LYSTQLSTDTGV LYSTQLSTDIGV 855 330
HLA-C*16:01 TGVEHVTFF IGVEHVTFF 392 185

NS9b protein

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NS9b

P10S

Reference  MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQN
           ||||||||| |||||||||||||||||||||||||
Mutated    MDPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 HPALRLVDPQIQL HSALRLVDPQIQL 148 15057
HLA-B*42:01 HPALRLVDPQI HSALRLVDPQI 297 15937
HLA-A*02:11 PALRLVDPQIQL SALRLVDPQIQL 3683 325
HLA-B*38:01 MHPALRLVDPQI MHSALRLVDPQI 3064 395
HLA-A*02:02 PALRLVDPQIQL SALRLVDPQIQL 2220 388
HLA-A*02:01 KISEMHPAL KISEMHSAL 139 774
HLA-A*02:06 KISEMHPAL KISEMHSAL 62 310
HLA-B*07:02 KISEMHPAL KISEMHSAL 436 134
HLA-A*02:11 KISEMHPAL KISEMHSAL 14 42
HLA-C*08:02 ISEMHPAL ISEMHSAL 896 414
HLA-B*15:03 SEMHPALRL SEMHSALRL 493 245

ENA 27-29 deletion

Reference  DPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSL
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    DPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQNNVGPKVYPIILRLGSPLSL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 VTRMENAVGR VTRMVGR 28 -
HLA-A*31:01 VTRMENAVGR VTRMVGR 113 -
HLA-A*03:01 RMENAVGRDQNNVGPK RMVGRDQNNVGPK - 168
HLA-A*33:03 VTRMENAVGR VTRMVGR 218 -
HLA-B*27:05 TRMENAVGR TRMVGR 260 -
HLA-A*11:01 VTRMENAVGR VTRMVGR 268 -
HLA-A*30:01 VTRMENAVG VTRMVG 395 -
HLA-A*68:02 MENAVGRDQNNV MVGRDQNNV 13036 480
HLA-A*33:03 LAVTRMENAVGR LAVTRMVGR 927 45
HLA-A*02:11 IQLAVTRMENAV IQLAVTRMV 1418 70
HLA-A*31:01 LAVTRMENAVGR LAVTRMVGR 1898 115
HLA-A*02:02 RMENAVGRDQNNV RMVGRDQNNV 3078 195
HLA-A*68:01 QLAVTRMENAVGR QLAVTRMVGR 1673 108
HLA-B*15:03 IQLAVTRMENAV IQLAVTRMV 2775 183
HLA-A*33:03 QLAVTRMENAVGR QLAVTRMVGR 1778 188
HLA-A*02:11 RMENAVGRDQNNV RMVGRDQNNV 1928 213
HLA-A*31:01 IQLAVTRMENAVGR IQLAVTRMVGR 1758 236
HLA-A*31:01 QLAVTRMENAVGR QLAVTRMVGR 2442 329
HLA-A*68:01 LAVTRMENAVGR LAVTRMVGR 207 32
HLA-A*02:06 IQLAVTRMENAV IQLAVTRMV 263 47
HLA-A*02:01 IQLAVTRMENAV IQLAVTRMV 2387 463

NS9c protein

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NS9c

G50N

Reference  AAVKPLLVPHHVVATVQEIQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
           ||||||||||||||||||||||||| |||||||||||||||||||||||
Mutated    AAVKPLLVPHHVVATVQEIQLQAAVNELLLLEWLAMAVMLLLLCCCLTD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*18:01 GELLLLEWLAM NELLLLEWLAM 4979 247
HLA-B*18:01 GELLLLEW NELLLLEW 3915 401
HLA-B*40:01 GELLLLEWL NELLLLEWL 28 140
HLA-A*02:11 QLQAAVGEL QLQAAVNEL 120 27
HLA-A*02:11 IQLQAAVGEL IQLQAAVNEL 338 81
HLA-B*40:02 GELLLLEWL NELLLLEWL 52 204
HLA-B*40:02 GELLLLEWLAM NELLLLEWLAM 201 772
HLA-A*02:01 QLQAAVGEL QLQAAVNEL 1290 358
HLA-A*02:02 QLQAAVGEL QLQAAVNEL 92 28
HLA-B*58:01 VGELLLLEW VNELLLLEW 330 1071
HLA-A*02:02 IQLQAAVGEL IQLQAAVNEL 170 58
HLA-A*02:01 LQAAVGELL LQAAVNELL 938 352
HLA-A*02:02 LQAAVGELL LQAAVNELL 44 17
HLA-B*40:06 GELLLLEWLA NELLLLEWLA 268 677
HLA-B*40:02 GELLLLEWLA NELLLLEWLA 475 1195
HLA-A*02:11 LQAAVGELL LQAAVNELL 386 154
HLA-A*02:01 IQLQAAVGEL IQLQAAVNEL 1138 475
HLA-A*02:01 QLQAAVGELL QLQAAVNELL 961 403
HLA-A*02:01 GELLLLEWLAMA NELLLLEWLAMA 109 258
HLA-A*02:02 QLQAAVGELL QLQAAVNELL 35 15
HLA-A*02:02 IQLQAAVGELL IQLQAAVNELL 724 313
HLA-A*02:11 QLQAAVGELL QLQAAVNELL 303 131
HLA-B*58:01 AVGELLLLEW AVNELLLLEW 196 87
HLA-A*02:11 GELLLLEWLAMA NELLLLEWLAMA 29 61
HLA-B*57:01 AVGELLLLEW AVNELLLLEW 432 206
HLA-A*68:02 EIQLQAAVGELL EIQLQAAVNELL 697 346

NSP1 protein

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NSP1

S135R

Reference  HVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQEN
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    HVGEIPVAYRKVLLRKNGNKGAGGHRYGADL‑‑‑DLGDELGTDPYEDFQEN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 SYGADLKSF RYGADL 37 -
HLA-B*15:03 HSYGADLKSF HRYGADL 41 -
HLA-B*58:01 HSYGADLKSF HRYGADL 59 -
HLA-A*24:02 SYGADLKSF RYGADL 84 -
HLA-B*15:01 HSYGADLKSF HRYGADL 94 -
HLA-C*03:02 HSYGADLKSF HRYGADL 94 -
HLA-A*23:01 SYGADLKSF RYGADL 129 -
HLA-B*57:01 HSYGADLKSF HRYGADL 158 -
HLA-C*16:01 HSYGADLKSF HRYGADL 329 -
HLA-B*27:05 HSYGADLKSFDL HRYGADLDL 23268 225
HLA-C*06:02 HSYGADLKSFDL HRYGADLDL 22732 410
HLA-C*07:01 HSYGADLKSFDL HRYGADLDL 18869 378
HLA-B*15:03 RKNGNKGAGGHSY RKNGNKGAGGHRY 183 1186
HLA-B*15:03 NKGAGGHSY NKGAGGHRY 129 774
HLA-B*15:03 GNKGAGGHSY GNKGAGGHRY 478 2611

KSF 141-143 deletion

Reference  VAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSG
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    VAYRKVLLRKNGNKGAGGHRYGADL‑‑‑DLGDELGTDPYEDFQENWNTKHSSG

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 SYGADLKSF RYGADL 37 -
HLA-B*15:03 HSYGADLKSF HRYGADL 41 -
HLA-B*58:01 HSYGADLKSF HRYGADL 59 -
HLA-A*24:02 SYGADLKSF RYGADL 84 -
HLA-B*15:01 HSYGADLKSF HRYGADL 94 -
HLA-C*03:02 HSYGADLKSF HRYGADL 94 -
HLA-A*23:01 SYGADLKSF RYGADL 129 -
HLA-C*03:03 KSFDLGDEL DLGDEL 148 -
HLA-C*03:04 KSFDLGDEL DLGDEL 148 -
HLA-B*57:01 HSYGADLKSF HRYGADL 158 -
HLA-C*16:01 KSFDLGDEL DLGDEL 170 -
HLA-A*30:02 KSFDLGDELGTDPY - 237 -
HLA-C*17:01 KSFDLGDEL DLGDEL 271 -
HLA-C*05:01 YGADLKSFDL YGADLDL 275 -
HLA-C*03:02 KSFDLGDEL DLGDEL 283 -
HLA-C*08:02 YGADLKSFDL YGADLDL 297 -
HLA-B*15:03 KSFDLGDEL DLGDEL 309 -
HLA-C*16:01 HSYGADLKSF HRYGADL 329 -
HLA-C*05:01 GADLKSFDL GADLDL 343 -
HLA-C*12:03 KSFDLGDEL DLGDEL 358 -
HLA-C*08:02 GADLKSFDL GADLDL 361 -
HLA-B*58:01 KSFDLGDEL DLGDEL 366 -
HLA-C*15:02 KSFDLGDEL DLGDEL 414 -
HLA-B*27:05 HSYGADLKSFDL HRYGADLDL 23268 225
HLA-C*06:02 HSYGADLKSFDL HRYGADLDL 22732 410
HLA-C*07:01 HSYGADLKSFDL HRYGADLDL 18869 378

NSP3 protein

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NSP3

T24I

Reference  APTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTE
           ||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    APTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTE

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*58:01 ITFELDERI IIFELDERI 270 4454
HLA-B*15:03 VQGYKSVNIT VQGYKSVNII 3702 395
HLA-A*02:01 ITFELDERI IIFELDERI 1637 223
HLA-A*02:11 ITFELDERI IIFELDERI 261 37
HLA-A*02:02 ITFELDERI IIFELDERI 428 65
HLA-A*24:02 VQGYKSVNITF VQGYKSVNIIF 194 811
HLA-A*24:02 IEVQGYKSVNITF IEVQGYKSVNIIF 366 1499
HLA-A*68:02 ITFELDERI IIFELDERI 253 1036
HLA-A*68:01 NITFELDER NIIFELDER 68 20
HLA-A*33:03 NITFELDER NIIFELDER 874 262
HLA-A*23:01 IEVQGYKSVNITF IEVQGYKSVNIIF 191 635
HLA-C*03:03 YKSVNITFEL YKSVNIIFEL 305 1007
HLA-C*03:04 YKSVNITFEL YKSVNIIFEL 305 1007
HLA-A*23:01 VIEVQGYKSVNITF VIEVQGYKSVNIIF 413 1337
HLA-A*23:01 VQGYKSVNITF VQGYKSVNIIF 111 353
HLA-A*02:11 KSVNITFEL KSVNIIFEL 169 55
HLA-C*14:02 GYKSVNITF GYKSVNIIF 53 160
HLA-A*11:01 ITFELDERIDK IIFELDERIDK 446 1259
HLA-A*02:01 KSVNITFEL KSVNIIFEL 863 307
HLA-C*03:02 YKSVNITFEL YKSVNIIFEL 299 784
HLA-A*68:01 VNITFELDER VNIIFELDER 1032 394
HLA-A*02:06 KSVNITFEL KSVNIIFEL 80 31
HLA-C*16:01 YKSVNITFEL YKSVNIIFEL 310 793
HLA-A*68:02 NITFELDERI NIIFELDERI 209 533
HLA-A*24:02 GYKSVNITF GYKSVNIIF 83 192
HLA-A*02:11 ITFELDERIDKV IIFELDERIDKV 397 175
HLA-A*68:01 SVNITFELDER SVNIIFELDER 405 180
HLA-A*24:02 QGYKSVNITF QGYKSVNIIF 208 455
HLA-A*02:06 ITFELDERI IIFELDERI 402 185
HLA-A*02:11 YKSVNITFEL YKSVNIIFEL 715 337
HLA-C*03:03 KSVNITFEL KSVNIIFEL 115 233
HLA-C*03:04 KSVNITFEL KSVNIIFEL 115 233

G489S

Reference  DAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQ
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    DAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 AGGTTEMLAK ASGTTEMLAK 1254 37
HLA-A*03:01 AGGTTEMLAK ASGTTEMLAK 3665 277
HLA-A*03:02 AGGTTEMLAK ASGTTEMLAK 2689 228
HLA-C*03:03 KAGGTTEML KASGTTEML 2418 212
HLA-C*03:04 KAGGTTEML KASGTTEML 2418 212
HLA-C*16:01 KAGGTTEML KASGTTEML 1012 116
HLA-C*17:01 KAGGTTEML KASGTTEML 1802 287
HLA-A*31:01 AGGTTEMLAKALR ASGTTEMLAKALR 787 133
HLA-B*58:01 KAGGTTEML KASGTTEML 2117 440
HLA-C*16:01 KAGGTTEM KASGTTEM 863 191
HLA-A*03:02 GGTTEMLAKALRK SGTTEMLAKALRK 1693 453
HLA-A*11:01 KAGGTTEMLAK KASGTTEMLAK 589 203
HLA-A*03:01 KAGGTTEMLAK KASGTTEMLAK 1236 449
HLA-A*03:01 GGTTEMLAKALRK SGTTEMLAKALRK 467 181
HLA-A*31:01 GGTTEMLAKALR SGTTEMLAKALR 677 335

NSP4 protein

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NSP4

L264F

Reference  GRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGI
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGI

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 LLTNMFTPL LFTNMFTPL 5 2700
HLA-A*02:01 LLTNMFTPL LFTNMFTPL 16 6477
HLA-A*02:02 LLTNMFTPL LFTNMFTPL 5 1518
HLA-A*02:06 LLTNMFTPL LFTNMFTPL 28 3590
HLA-A*02:11 LLTNMFTPLI LFTNMFTPLI 17 1231
HLA-A*02:01 LLTNMFTPLI LFTNMFTPLI 55 3749
HLA-C*14:02 LLTNMFTPL LFTNMFTPL 453 7
HLA-A*02:02 LLTNMFTPLI LFTNMFTPLI 22 967
HLA-B*15:01 LLTNMFTPL LFTNMFTPL 228 5949
HLA-C*03:03 LTNMFTPL FTNMFTPL 1113 61
HLA-C*03:04 LTNMFTPL FTNMFTPL 1113 61
HLA-A*23:01 VFCGVDAVNLL VFCGVDAVNLF 2671 151
HLA-A*02:02 LLTNMFTPLIQPI LFTNMFTPLIQPI 294 4718
HLA-A*02:02 GVFCGVDAVNLL GVFCGVDAVNLF 439 6440
HLA-C*14:02 NLLTNMFTPL NLFTNMFTPL 4861 337
HLA-B*15:03 CGVDAVNLL CGVDAVNLF 6087 490
HLA-A*02:11 LLTNMFTPLIQPI LFTNMFTPLIQPI 297 3332
HLA-C*03:02 LTNMFTPL FTNMFTPL 829 77
HLA-C*03:03 LTNMFTPLI FTNMFTPLI 2207 207
HLA-C*03:04 LTNMFTPLI FTNMFTPLI 2207 207
HLA-A*02:01 LTNMFTPLI FTNMFTPLI 1097 103
HLA-A*02:11 LTNMFTPLI FTNMFTPLI 136 13
HLA-C*12:03 LTNMFTPLI FTNMFTPLI 430 42
HLA-A*02:06 LLTNMFTPLI LFTNMFTPLI 136 1345
HLA-A*02:06 LTNMFTPLI FTNMFTPLI 223 23
HLA-C*12:02 LTNMFTPLI FTNMFTPLI 1404 157
HLA-A*02:02 LTNMFTPLI FTNMFTPLI 364 41
HLA-A*68:02 LTNMFTPLIQPI FTNMFTPLIQPI 1086 129
HLA-C*12:03 LTNMFTPL FTNMFTPL 2677 324
HLA-C*03:02 LTNMFTPLI FTNMFTPLI 716 87
HLA-C*02:02 LTNMFTPLI FTNMFTPLI 1268 158
HLA-C*02:10 LTNMFTPLI FTNMFTPLI 1268 158
HLA-C*17:01 LTNMFTPLI FTNMFTPLI 599 86
HLA-A*68:02 LTNMFTPLI FTNMFTPLI 82 12
HLA-C*03:03 LLTNMFTPL LFTNMFTPL 253 1728
HLA-C*03:04 LLTNMFTPL LFTNMFTPL 253 1728
HLA-C*12:02 LTNMFTPL FTNMFTPL 3002 450
HLA-B*15:03 LLTNMFTPL LFTNMFTPL 108 704
HLA-A*68:02 NLLTNMFTPL NLFTNMFTPL 2741 480
HLA-C*14:02 LTNMFTPL FTNMFTPL 2589 467
HLA-A*02:06 LTNMFTPLIQPI FTNMFTPLIQPI 2171 394
HLA-C*16:01 LTNMFTPL FTNMFTPL 293 61
HLA-C*16:01 LTNMFTPLI FTNMFTPLI 267 56
HLA-A*30:01 LTNMFTPLI FTNMFTPLI 144 648
HLA-A*02:02 AVNLLTNMFTPL AVNLFTNMFTPL 249 948
HLA-B*08:01 LLTNMFTPL LFTNMFTPL 271 983
HLA-A*02:11 LTNMFTPLIQPI FTNMFTPLIQPI 1413 409
HLA-C*03:02 LLTNMFTPL LFTNMFTPL 307 951
HLA-A*02:02 NLLTNMFTPLI NLFTNMFTPLI 658 224
HLA-A*02:02 NLLTNMFTPL NLFTNMFTPL 58 21
HLA-C*15:02 LTNMFTPLI FTNMFTPLI 67 25
HLA-A*02:11 AVNLLTNMFTPL AVNLFTNMFTPL 390 1009
HLA-A*02:02 VNLLTNMFTPL VNLFTNMFTPL 375 919
HLA-A*02:11 NLLTNMFTP NLFTNMFTP 1166 476
HLA-B*15:03 AVNLLTNMF AVNLFTNMF 390 172
HLA-A*02:11 NLLTNMFTPLIQPI NLFTNMFTPLIQPI 274 129

T327I

Reference  MRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    MRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 NTLLFLMSFT NTLLFLMSFI 1059 51
HLA-A*68:02 NTLLFLMSFT NTLLFLMSFI 741 41
HLA-A*02:11 FNTLLFLMSFT FNTLLFLMSFI 1509 110
HLA-A*02:11 TLLFLMSFT TLLFLMSFI 82 6
HLA-A*68:02 TLLFLMSFT TLLFLMSFI 3858 286
HLA-A*68:02 FTVLCLTPVYSFL FIVLCLTPVYSFL 129 1580
HLA-A*02:11 AFNTLLFLMSFT AFNTLLFLMSFI 4598 420
HLA-A*68:02 FTVLCLTPV FIVLCLTPV 8 83
HLA-A*68:02 SFTVLCLTPV SFIVLCLTPV 63 597
HLA-A*02:01 TLLFLMSFT TLLFLMSFI 239 26
HLA-A*02:01 NTLLFLMSFT NTLLFLMSFI 1593 179
HLA-A*02:02 TLLFLMSFT TLLFLMSFI 235 28
HLA-B*15:01 LLFLMSFTVL LLFLMSFIVL 229 1839
HLA-A*02:11 LFLMSFTV LFLMSFIV 279 2222
HLA-A*02:02 NTLLFLMSFT NTLLFLMSFI 1462 186
HLA-A*02:11 LLFLMSFT LLFLMSFI 2935 377
HLA-A*32:01 LLFLMSFTV LLFLMSFIV 369 2631
HLA-A*02:06 LLFLMSFTV LLFLMSFIV 34 231
HLA-C*12:03 FTVLCLTPV FIVLCLTPV 161 1041
HLA-C*14:02 LFLMSFTVL LFLMSFIVL 18 112
HLA-A*02:11 AFNTLLFLMSFTV AFNTLLFLMSFIV 74 448
HLA-C*16:01 FTVLCLTPVY FIVLCLTPVY 395 2359
HLA-A*02:06 TLLFLMSFT TLLFLMSFI 397 68
HLA-A*02:01 LLFLMSFTV LLFLMSFIV 9 50
HLA-A*02:11 VAFNTLLFLMSFTV VAFNTLLFLMSFIV 225 1206
HLA-A*02:01 AFNTLLFLMSFTV AFNTLLFLMSFIV 357 1842
HLA-A*68:02 NTLLFLMSFTV NTLLFLMSFIV 106 539
HLA-A*02:11 NTLLFLMSFTV NTLLFLMSFIV 59 300
HLA-A*02:01 NTLLFLMSFTV NTLLFLMSFIV 212 1074
HLA-C*03:03 FTVLCLTPV FIVLCLTPV 302 1526
HLA-C*03:04 FTVLCLTPV FIVLCLTPV 302 1526
HLA-B*15:03 LLFLMSFTVL LLFLMSFIVL 318 1563
HLA-A*02:02 LLFLMSFTV LLFLMSFIV 11 53
HLA-A*02:06 NTLLFLMSFT NTLLFLMSFI 945 197
HLA-A*02:11 SFTVLCLTPV SFIVLCLTPV 250 53
HLA-A*02:11 FNTLLFLMSFTV FNTLLFLMSFIV 23 108
HLA-A*02:01 FNTLLFLMSFTV FNTLLFLMSFIV 131 602
HLA-C*03:02 FTVLCLTPV FIVLCLTPV 198 902
HLA-C*14:02 FLMSFTVL FLMSFIVL 475 2138
HLA-C*12:02 FTVLCLTPV FIVLCLTPV 218 961
HLA-C*03:03 FLMSFTVL FLMSFIVL 309 1359
HLA-C*03:04 FLMSFTVL FLMSFIVL 309 1359
HLA-A*26:01 FTVLCLTPVY FIVLCLTPVY 176 760
HLA-A*02:01 SFTVLCLTPV SFIVLCLTPV 470 111
HLA-B*15:01 FLMSFTVLCL FLMSFIVLCL 455 1914
HLA-B*15:03 LFLMSFTVL LFLMSFIVL 353 1462
HLA-A*68:01 FTVLCLTPVY FIVLCLTPVY 485 1972
HLA-A*02:02 FNTLLFLMSFTV FNTLLFLMSFIV 186 704
HLA-B*15:01 LMSFTVLCL LMSFIVLCL 110 408
HLA-C*03:02 FLMSFTVL FLMSFIVL 352 1285
HLA-A*02:02 NTLLFLMSFTV NTLLFLMSFIV 424 1515
HLA-A*02:11 LLFLMSFTV LLFLMSFIV 2 7
HLA-C*03:02 FTVLCLTPVY FIVLCLTPVY 50 175
HLA-B*15:03 LMSFTVLCL LMSFIVLCL 54 186
HLA-C*12:02 FTVLCLTPVY FIVLCLTPVY 331 1137
HLA-A*02:02 LLFLMSFTVL LLFLMSFIVL 42 144
HLA-A*68:02 MSFTVLCLTPV MSFIVLCLTPV 34 114
HLA-C*03:02 LMSFTVLCL LMSFIVLCL 467 1520
HLA-A*02:01 LLFLMSFTVL LLFLMSFIVL 74 240
HLA-A*02:11 LLFLMSFTVL LLFLMSFIVL 25 80
HLA-A*02:02 SFTVLCLTPV SFIVLCLTPV 261 84
HLA-A*02:02 LFLMSFTVLCL LFLMSFIVLCL 73 216
HLA-A*02:06 LLFLMSFTVL LLFLMSFIVL 331 973
HLA-C*16:01 MSFTVLCL MSFIVLCL 171 496
HLA-A*68:02 FLMSFTVLCLTPV FLMSFIVLCLTPV 331 927
HLA-A*68:02 MSFTVLCLT MSFIVLCLT 68 186
HLA-A*02:06 MSFTVLCLT MSFIVLCLT 239 650
HLA-A*02:11 TVLCLTPVYSFL IVLCLTPVYSFL 533 199
HLA-B*15:03 FLMSFTVL FLMSFIVL 371 993
HLA-A*02:02 FLMSFTVLCL FLMSFIVLCL 3 8
HLA-A*02:02 LLFLMSFTVLCL LLFLMSFIVLCL 134 356
HLA-A*02:01 LLFLMSFTVLCL LLFLMSFIVLCL 237 602
HLA-A*02:01 LFLMSFTVLCL LFLMSFIVLCL 73 185
HLA-A*02:06 FLMSFTVLCL FLMSFIVLCL 15 38
HLA-C*03:02 TVLCLTPVY IVLCLTPVY 136 54
HLA-A*23:01 LFLMSFTVL LFLMSFIVL 411 1026
HLA-A*02:06 TLLFLMSFTV TLLFLMSFIV 47 116
HLA-B*08:01 FLMSFTVL FLMSFIVL 118 291
HLA-A*02:06 NTLLFLMSFTV NTLLFLMSFIV 373 906
HLA-A*02:01 TLLFLMSFTV TLLFLMSFIV 14 33
HLA-A*02:06 VAFNTLLFLMSFTV VAFNTLLFLMSFIV 479 1101
HLA-A*02:06 MSFTVLCLTPV MSFIVLCLTPV 48 110
HLA-B*58:01 MSFTVLCLT MSFIVLCLT 412 943
HLA-A*02:01 FLMSFTVLCL FLMSFIVLCL 4 9
HLA-A*02:02 FLMSFTVLCLTP FLMSFIVLCLTP 194 430
HLA-A*02:11 TLLFLMSFTV TLLFLMSFIV 5 11
HLA-A*02:02 FTVLCLTPV FIVLCLTPV 23 11
HLA-A*02:01 FTVLCLTPV FIVLCLTPV 25 12
HLA-A*30:02 FTVLCLTPVY FIVLCLTPVY 327 671
HLA-A*02:02 TVLCLTPVYSFL IVLCLTPVYSFL 176 86
HLA-B*58:01 MSFTVLCLTP MSFIVLCLTP 497 1015
HLA-A*02:11 FTVLCLTPV FIVLCLTPV 12 6

T492I

Reference  ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ
           ||||||||||||||||||||||||| ||||||||
Mutated    ACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*16:01 QTSITSAVL QISITSAVL 201 1829
HLA-A*68:02 QTSITSAVL QISITSAVL 206 1702
HLA-A*02:06 QPPQTSITSAV QPPQISITSAV 3097 393
HLA-A*02:06 LYQPPQTSITSAV LYQPPQISITSAV 1485 214
HLA-A*02:06 YQPPQTSITSAV YQPPQISITSAV 156 26
HLA-A*02:01 YQPPQTSITSAV YQPPQISITSAV 1613 341
HLA-A*02:11 YQPPQTSITSAV YQPPQISITSAV 498 120
HLA-C*03:03 TSITSAVL ISITSAVL 532 198
HLA-C*03:04 TSITSAVL ISITSAVL 532 198
HLA-C*03:03 QTSITSAVL QISITSAVL 311 831
HLA-C*03:04 QTSITSAVL QISITSAVL 311 831
HLA-C*16:01 TSITSAVL ISITSAVL 381 156
HLA-A*02:01 VLYQPPQTSI VLYQPPQISI 1084 474
HLA-A*23:01 VLYQPPQTSI VLYQPPQISI 979 462
HLA-A*23:01 LYQPPQTSI LYQPPQISI 278 132

NSP5 protein

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NSP5

P132H

Reference  QPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 RPNFTIKGSF RHNFTIKGSF 14 15756
HLA-B*07:02 RPNFTIKGSFL RHNFTIKGSFL 24 18650
HLA-B*42:01 RPNFTIKGSF RHNFTIKGSF 31 15129
HLA-B*42:01 RPNFTIKGSFL RHNFTIKGSFL 39 17143
HLA-B*15:03 PNFTIKGSF HNFTIKGSF 7728 117
HLA-A*03:01 GVYQCAMRP GVYQCAMRH 20799 417
HLA-B*08:01 CAMRPNFTI CAMRHNFTI 3487 242
HLA-B*27:05 MRPNFTIKG MRHNFTIKG 4762 366
HLA-B*27:05 MRPNFTIKGSFL MRHNFTIKGSFL 827 86
HLA-B*15:03 RPNFTIKGSF RHNFTIKGSF 432 54
HLA-B*27:05 MRPNFTIK MRHNFTIK 2132 276
HLA-B*15:03 MRPNFTIKGSF MRHNFTIKGSF 397 96
HLA-C*07:02 MRPNFTIKGSF MRHNFTIKGSF 361 1054
HLA-B*27:05 MRPNFTIKGSF MRHNFTIKGSF 218 78
HLA-A*30:01 QCAMRPNFTIK QCAMRHNFTIK 199 513
HLA-A*68:02 CAMRPNFTI CAMRHNFTI 199 493
HLA-C*16:01 CAMRPNFTI CAMRHNFTI 125 52
HLA-A*30:01 AMRPNFTIKG AMRHNFTIKG 123 279
HLA-C*12:03 CAMRPNFTI CAMRHNFTI 317 143
HLA-A*30:01 VYQCAMRPNFTIK VYQCAMRHNFTIK 316 683
HLA-A*11:01 AMRPNFTIK AMRHNFTIK 175 376
HLA-A*11:01 CAMRPNFTIK CAMRHNFTIK 42 88
HLA-A*68:01 CAMRPNFTIK CAMRHNFTIK 127 254

NSP6 protein

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NSP6

SGF 106-108 deletion

Reference  FNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYD
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    FNMVYMPASWVMRIMTWLDMVDTSL‑‑‑KLKDCVMYASAVVLLILMTARTVYD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:02 FKLKDCVMYA - 8 -
HLA-A*02:11 FKLKDCVMYA - 12 -
HLA-A*68:01 MVDTSLSGFK MVDTSLK 13 -
HLA-B*15:03 FKLKDCVMY - 15 -
HLA-A*11:01 MVDTSLSGFK MVDTSLK 21 -
HLA-A*11:01 TSLSGFKLK TSLKLK 22 -
HLA-A*03:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSLK - 25
HLA-A*02:01 FKLKDCVMYA - 27 -
HLA-A*68:01 DTSLSGFKLK DTSLKLK 33 -
HLA-A*03:02 MVDTSLSGFK MVDTSLK 35 -
HLA-A*68:01 MTWLDMVDTSLSGFK MTWLDMVDTSLK - 37
HLA-A*03:01 MVDTSLSGFK MVDTSLK 54 -
HLA-A*03:02 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSLK - 59
HLA-C*05:01 MVDTSLSGF MVDTSL 64 -
HLA-A*11:01 MTWLDMVDTSLSGFK MTWLDMVDTSLK - 71
HLA-A*02:06 FKLKDCVMYA - 90 -
HLA-A*30:01 TSLSGFKLK TSLKLK 107 -
HLA-A*02:02 SGFKLKDCVMYA - 126 -
HLA-A*11:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSLK - 128
HLA-A*03:02 MTWLDMVDTSLSGFK MTWLDMVDTSLK - 147
HLA-C*08:02 MVDTSLSGF MVDTSL 159 -
HLA-A*03:02 IMTWLDMVDTSLSGFK IMTWLDMVDTSLK - 168
HLA-A*02:11 SGFKLKDCVMYA - 200 -
HLA-A*02:02 MTWLDMVDTSLSGFKL MTWLDMVDTSLKL - 202
HLA-A*01:01 MVDTSLSGFKLKDCVMY MVDTSLKLKDCVMY - 207
HLA-C*03:02 MVDTSLSGF MVDTSL 211 -
HLA-A*02:02 GFKLKDCVMYA - 239 -
HLA-A*02:02 TSLSGFKLKDCVMYA TSLKLKDCVMYA - 244
HLA-A*03:01 TSLSGFKLK TSLKLK 244 -
HLA-B*15:03 MVDTSLSGF MVDTSL 276 -
HLA-A*68:01 TSLSGFKLK TSLKLK 286 -
HLA-A*03:02 TSLSGFKLK TSLKLK 289 -
HLA-A*03:01 IMTWLDMVDTSLSGFK IMTWLDMVDTSLK - 309
HLA-A*68:02 DTSLSGFKL DTSLKL 313 -
HLA-A*02:11 MTWLDMVDTSLSGFKL MTWLDMVDTSLKL - 346
HLA-B*15:01 DMVDTSLSGF DMVDTSL 362 -
HLA-A*23:01 TWLDMVDTSLSGF - 387 -
HLA-A*02:11 GFKLKDCVMYA - 394 -
HLA-A*03:01 MTWLDMVDTSLSGFK MTWLDMVDTSLK - 415
HLA-A*26:01 DMVDTSLSGF DMVDTSL 417 -
HLA-B*08:01 MVDTSLSGFKLKDCVM MVDTSLKLKDCVM - 426
HLA-A*02:02 WLDMVDTSLS - 441 -
HLA-A*02:11 FKLKDCVMYASAVV - 481 -
HLA-A*11:01 DTSLSGFKLK DTSLKLK 488 -
HLA-B*35:01 MVDTSLSGF MVDTSL 490 -
HLA-A*31:01 RIMTWLDMVDTSLSGFK RIMTWLDMVDTSLK - 493
HLA-B*15:03 LSGFKLKDCVMY LKLKDCVMY 3466 22
HLA-A*02:11 LDMVDTSLSGFKL LDMVDTSLKL 16396 166
HLA-A*02:02 LDMVDTSLSGFKL LDMVDTSLKL 9971 106
HLA-A*02:11 SLSGFKLKDCV SLKLKDCV 122 9934
HLA-A*02:01 LDMVDTSLSGFKL LDMVDTSLKL 20579 311
HLA-B*08:01 SLSGFKLKDCVM SLKLKDCVM 929 36
HLA-A*02:02 SLSGFKLKDCV SLKLKDCV 408 10216
HLA-C*05:01 WLDMVDTSLSGFKL WLDMVDTSLKL 8375 417
HLA-B*15:01 SLSGFKLKDCVMY SLKLKDCVMY 2952 158
HLA-B*08:01 TSLSGFKLKDCVM TSLKLKDCVM 4628 289
HLA-B*15:01 SLSGFKLKDCVM SLKLKDCVM 2654 197
HLA-A*68:01 DMVDTSLSGFK DMVDTSLK 366 4919
HLA-A*02:11 WLDMVDTSLSGFKL WLDMVDTSLKL 1342 108
HLA-C*08:02 MVDTSLSGFKL MVDTSLKL 2134 174
HLA-B*15:03 SLSGFKLKDCVM SLKLKDCVM 3634 297
HLA-A*02:01 WLDMVDTSLSGFKL WLDMVDTSLKL 2214 195
HLA-A*03:02 WLDMVDTSLSGFK WLDMVDTSLK 1756 156
HLA-A*02:02 LSGFKLKDCVMYA LKLKDCVMYA 305 28
HLA-A*02:01 LSGFKLKDCVMYA LKLKDCVMYA 1788 165
HLA-A*02:11 LSGFKLKDCVMYA LKLKDCVMYA 578 54
HLA-B*15:03 SLSGFKLKDCVMY SLKLKDCVMY 3626 349
HLA-A*03:01 WLDMVDTSLSGFK WLDMVDTSLK 2900 287
HLA-C*05:01 MVDTSLSGFKL MVDTSLKL 1125 124
HLA-A*11:01 WLDMVDTSLSGFK WLDMVDTSLK 4020 492
HLA-A*02:02 WLDMVDTSLSGFKL WLDMVDTSLKL 788 116
HLA-A*68:01 DMVDTSLSGFKLK DMVDTSLKLK 1679 251
HLA-A*02:01 SLSGFKLKDCVMYA SLKLKDCVMYA 203 853
HLA-A*02:11 SLSGFKLKDCVMYA SLKLKDCVMYA 64 223
HLA-A*02:02 SLSGFKLKDCVMYA SLKLKDCVMYA 55 171
HLA-A*29:02 SLSGFKLKDCVMY SLKLKDCVMY 404 1192
HLA-A*11:01 MVDTSLSGFKLK MVDTSLKLK 143 50
HLA-A*03:02 MVDTSLSGFKLK MVDTSLKLK 312 127
HLA-A*68:01 MVDTSLSGFKLK MVDTSLKLK 602 246
HLA-A*03:01 MVDTSLSGFKLK MVDTSLKLK 441 190

NSP12 protein

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NSP12

P323L

Reference  CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:01 FPPTSFGPLV FPLTSFGPLV 8999 21
HLA-A*02:02 FPPTSFGPLV FPLTSFGPLV 7237 18
HLA-A*02:11 FPPTSFGPLV FPLTSFGPLV 3405 9
HLA-A*32:01 VLFSTVFPP VLFSTVFPL 5415 27
HLA-A*02:11 LFSTVFPP LFSTVFPL 6706 35
HLA-A*02:11 ANFNVLFSTVFPP ANFNVLFSTVFPL 1827 12
HLA-A*02:11 NFNVLFSTVFPP NFNVLFSTVFPL 1779 13
HLA-A*02:11 NVLFSTVFPP NVLFSTVFPL 739 6
HLA-C*03:03 VLFSTVFPP VLFSTVFPL 28468 265
HLA-C*03:04 VLFSTVFPP VLFSTVFPL 28468 265
HLA-A*02:11 FNVLFSTVFPP FNVLFSTVFPL 413 4
HLA-C*14:02 VLFSTVFPP VLFSTVFPL 21407 220
HLA-A*02:11 FNVLFSTVFPPT FNVLFSTVFPLT 2618 27
HLA-A*02:01 LFSTVFPP LFSTVFPL 7475 81
HLA-C*14:02 LFSTVFPP LFSTVFPL 11979 138
HLA-B*15:03 VLFSTVFPP VLFSTVFPL 3115 36
HLA-A*02:11 VLFSTVFPP VLFSTVFPL 78 1
HLA-C*03:02 VLFSTVFPP VLFSTVFPL 20533 273
HLA-A*02:01 FNVLFSTVFPP FNVLFSTVFPL 656 9
HLA-A*02:01 ANFNVLFSTVFPP ANFNVLFSTVFPL 2569 37
HLA-A*02:11 FNVLFSTVFPPTS FNVLFSTVFPLTS 9448 142
HLA-A*02:02 NVLFSTVFPP NVLFSTVFPL 1088 17
HLA-A*02:11 CANFNVLFSTVFPP CANFNVLFSTVFPL 6143 96
HLA-A*02:02 FNVLFSTVFPP FNVLFSTVFPL 1014 16
HLA-A*68:02 NVLFSTVFPP NVLFSTVFPL 2213 37
HLA-A*02:02 ANFNVLFSTVFPP ANFNVLFSTVFPL 3126 53
HLA-A*02:11 PPTSFGPLV PLTSFGPLV 28329 483
HLA-C*16:01 VLFSTVFPP VLFSTVFPL 24733 432
HLA-C*17:01 VLFSTVFPP VLFSTVFPL 25087 439
HLA-A*02:01 FNVLFSTVFPPT FNVLFSTVFPLT 3765 66
HLA-A*02:02 LFSTVFPP LFSTVFPL 9311 167
HLA-A*02:01 NVLFSTVFPP NVLFSTVFPL 928 17
HLA-A*02:02 NFNVLFSTVFPP NFNVLFSTVFPL 2542 47
HLA-A*02:02 VLFSTVFPP VLFSTVFPL 269 5
HLA-A*02:01 NFNVLFSTVFPP NFNVLFSTVFPL 2286 44
HLA-A*02:06 FPPTSFGPLV FPLTSFGPLV 3379 73
HLA-A*02:01 VLFSTVFPP VLFSTVFPL 179 4
HLA-A*02:06 FNVLFSTVFPP FNVLFSTVFPL 1609 37
HLA-A*02:02 FNVLFSTVFPPT FNVLFSTVFPLT 4116 110
HLA-A*02:11 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6695 180
HLA-A*02:01 FNVLFSTVFPPTS FNVLFSTVFPLTS 11451 311
HLA-A*02:06 VLFSTVFPP VLFSTVFPL 368 10
HLA-A*02:11 ANFNVLFSTVFPPT ANFNVLFSTVFPLT 14639 409
HLA-A*02:01 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 12596 425
HLA-A*68:01 PTSFGPLVR LTSFGPLVR 908 36
HLA-A*02:06 NVLFSTVFPP NVLFSTVFPL 1611 66
HLA-B*15:01 VLFSTVFPP VLFSTVFPL 5731 243
HLA-B*35:01 FPPTSFGPL FPLTSFGPL 304 13
HLA-B*53:01 FPPTSFGPL FPLTSFGPL 3581 154
HLA-C*01:02 FPPTSFGPL FPLTSFGPL 217 4855
HLA-A*02:01 CANFNVLFSTVFPP CANFNVLFSTVFPL 8519 384
HLA-A*02:02 FNVLFSTVFPPTS FNVLFSTVFPLTS 10920 497
HLA-A*02:02 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6958 322
HLA-A*02:11 VFPPTSFGPLV VFPLTSFGPLV 4242 199
HLA-A*02:02 CANFNVLFSTVFPP CANFNVLFSTVFPL 8183 391
HLA-A*02:11 NFNVLFSTVFPPT NFNVLFSTVFPLT 9111 472
HLA-A*02:06 ANFNVLFSTVFPP ANFNVLFSTVFPL 5191 304
HLA-A*02:06 NFNVLFSTVFPP NFNVLFSTVFPL 4220 274
HLA-A*02:06 FNVLFSTVFPPT FNVLFSTVFPLT 4868 388
HLA-B*35:03 FPPTSFGPL FPLTSFGPL 286 24
HLA-A*03:01 PTSFGPLVRK LTSFGPLVRK 554 47
HLA-A*31:01 PTSFGPLVR LTSFGPLVR 4402 390
HLA-A*11:01 PTSFGPLVR LTSFGPLVR 4068 379
HLA-A*03:02 PTSFGPLVRK LTSFGPLVRK 868 88
HLA-B*07:02 STVFPPTSFGPL STVFPLTSFGPL 777 79
HLA-A*68:01 PTSFGPLVRK LTSFGPLVRK 308 34
HLA-B*07:02 TVFPPTSFGPL TVFPLTSFGPL 1498 171
HLA-A*02:11 STVFPPTSFGPLV STVFPLTSFGPLV 2427 285
HLA-A*02:11 NVLFSTVFPPT NVLFSTVFPLT 1183 139
HLA-A*33:03 PTSFGPLVR LTSFGPLVR 3228 381
HLA-A*26:01 STVFPPTSF STVFPLTSF 786 95
HLA-B*07:02 VFPPTSFGPL VFPLTSFGPL 339 43
HLA-A*02:01 NVLFSTVFPPT NVLFSTVFPLT 2111 290
HLA-B*42:01 FSTVFPPTSFGPL FSTVFPLTSFGPL 1320 185
HLA-B*42:01 STVFPPTSFGPL STVFPLTSFGPL 738 111
HLA-A*02:01 VLFSTVFPPTSF VLFSTVFPLTSF 2225 342
HLA-B*08:01 FPPTSFGPL FPLTSFGPL 973 153
HLA-B*42:01 TVFPPTSFGPL TVFPLTSFGPL 843 142
HLA-A*11:01 PTSFGPLVRK LTSFGPLVRK 123 21
HLA-B*42:01 VFPPTSFGPL VFPLTSFGPL 274 47
HLA-A*02:01 VLFSTVFPPTS VLFSTVFPLTS 708 124
HLA-B*07:02 FSTVFPPTSFGPL FSTVFPLTSFGPL 2537 466
HLA-B*07:02 FPPTSFGPL FPLTSFGPL 42 8
HLA-A*02:11 VLFSTVFPPTSF VLFSTVFPLTSF 1019 195
HLA-A*25:01 STVFPPTSF STVFPLTSF 1533 296
HLA-B*07:02 FPPTSFGPLV FPLTSFGPLV 1131 236
HLA-B*42:01 FPPTSFGPL FPLTSFGPL 21 5
HLA-A*26:01 FSTVFPPTSF FSTVFPLTSF 1667 398
HLA-B*51:01 FPPTSFGPL FPLTSFGPL 1809 433
HLA-A*02:11 VLFSTVFPPTS VLFSTVFPLTS 309 74
HLA-B*42:01 FPPTSFGPLV FPLTSFGPLV 368 89
HLA-A*02:02 VLFSTVFPPTS VLFSTVFPLTS 1210 377
HLA-C*03:02 FPPTSFGPL FPLTSFGPL 960 313
HLA-A*32:01 STVFPPTSF STVFPLTSF 230 86
HLA-B*58:01 FSTVFPPTSF FSTVFPLTSF 88 33
HLA-B*15:01 STVFPPTSF STVFPLTSF 130 49
HLA-A*02:01 VLFSTVFPPT VLFSTVFPLT 61 23
HLA-C*03:03 FPPTSFGPL FPLTSFGPL 375 145
HLA-C*03:04 FPPTSFGPL FPLTSFGPL 375 145
HLA-A*02:02 VLFSTVFPPT VLFSTVFPLT 113 44
HLA-C*16:01 FSTVFPPTS FSTVFPLTS 1127 460
HLA-C*14:02 LFSTVFPPTSF LFSTVFPLTSF 396 950
HLA-C*01:02 VFPPTSFGPL VFPLTSFGPL 429 997
HLA-A*02:02 TVFPPTSFGPLV TVFPLTSFGPLV 789 343
HLA-A*68:02 STVFPPTSFGPLV STVFPLTSFGPLV 169 74
HLA-A*02:11 VLFSTVFPPT VLFSTVFPLT 25 11
HLA-A*03:01 TVFPPTSFGPLVRK TVFPLTSFGPLVRK 92 198
HLA-C*14:02 VFPPTSFGPL VFPLTSFGPL 47 99
HLA-A*23:01 LFSTVFPPTSF LFSTVFPLTSF 370 179

NSP13 protein

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NSP13

R392C

Reference  TADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 DLSVVNARLR DLSVVNARLC 44 30873
HLA-C*06:02 LRAKHYVYI LCAKHYVYI 36 16159
HLA-A*68:01 LSVVNARLR LSVVNARLC 140 32767
HLA-A*33:03 DLSVVNARLR DLSVVNARLC 154 32767
HLA-A*31:01 LSVVNARLR LSVVNARLC 261 30993
HLA-C*07:01 LRAKHYVYI LCAKHYVYI 133 15165
HLA-B*27:05 LRAKHYVYI LCAKHYVYI 379 32767
HLA-A*30:01 RLRAKHYVY RLCAKHYVY 27 1483
HLA-B*27:05 RLRAKHYVYI RLCAKHYVYI 208 10096
HLA-C*07:02 LRAKHYVYI LCAKHYVYI 433 17614
HLA-A*30:01 RAKHYVYIG CAKHYVYIG 76 2630
HLA-A*68:01 TNYDLSVVNARLR TNYDLSVVNARLC 477 15989
HLA-A*30:01 RLRAKHYV RLCAKHYV 218 5721
HLA-A*30:01 RLRAKHYVYI RLCAKHYVYI 17 427
HLA-A*30:01 RAKHYVYIGDPA CAKHYVYIGDPA 188 4601
HLA-A*30:01 RAKHYVYI CAKHYVYI 211 4134
HLA-B*08:01 RLRAKHYV RLCAKHYV 363 6671
HLA-A*30:01 ARLRAKHYVYI ARLCAKHYVYI 422 6081
HLA-B*08:01 RLRAKHYVYI RLCAKHYVYI 230 2547
HLA-B*15:03 LRAKHYVY LCAKHYVY 395 4119
HLA-A*29:02 RLRAKHYVY RLCAKHYVY 535 101
HLA-A*02:11 RLRAKHYV RLCAKHYV 1483 352
HLA-A*68:01 VVNARLRAK VVNARLCAK 1428 381
HLA-A*11:01 VVNARLRAK VVNARLCAK 145 44
HLA-A*03:02 VVNARLRAK VVNARLCAK 257 79
HLA-B*15:01 ARLRAKHYVY ARLCAKHYVY 402 1223
HLA-B*15:01 RLRAKHYVY RLCAKHYVY 49 133
HLA-A*68:01 SVVNARLRAK SVVNARLCAK 158 63
HLA-A*03:02 SVVNARLRAK SVVNARLCAK 196 86

NSP14 protein

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NSP14

I42V

Reference  GLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVN
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 DIPGIPKDMTYRR DVPGIPKDMTYRR 570 271

D301G

Reference  MTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    MTRCLAVHECFVKRVDWTIEYPIIGGELKINAACRKVQHMVVKAALLADKF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*18:01 DELKINAA GELKINAA 365 11741
HLA-B*40:02 DELKINAAC GELKINAAC 4412 153
HLA-B*18:01 DELKINAAC GELKINAAC 435 11957
HLA-B*40:06 DELKINAA GELKINAA 7148 373
HLA-B*40:06 DELKINAAC GELKINAAC 5446 438
HLA-B*07:02 YPIIGDEL YPIIGGEL 1141 185
HLA-B*42:01 YPIIGDEL YPIIGGEL 288 70
HLA-B*42:01 YPIIGDELKI YPIIGGELKI 1320 359
HLA-C*14:02 EYPIIGDEL EYPIIGGEL 678 236
HLA-C*14:02 IEYPIIGDEL IEYPIIGGEL 796 293
HLA-B*35:03 YPIIGDEL YPIIGGEL 345 853
HLA-B*35:01 YPIIGDEL YPIIGGEL 364 758
HLA-B*40:01 IEYPIIGDEL IEYPIIGGEL 49 99

NSP15 protein

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NSP15

T112I

Reference  DYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNA
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    DYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:02 SMTDIAKKPT SMTDIAKKPI 3353 375
HLA-A*68:02 TETICAPLTV IETICAPLTV 64 161
HLA-C*03:03 IAKKPTETI IAKKPIETI 497 1187
HLA-C*03:04 IAKKPTETI IAKKPIETI 497 1187
HLA-A*02:11 SMTDIAKKPTETI SMTDIAKKPIETI 560 263