Summary

This strain contains 70 protein-level mutations:

  • 36 mutations in Spike protein: T19I, L24S, A27S, V83A, G142D, H146Q, E180V, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, 375-376 ST->FA, D405N, R408S, K417N, N440K, 445-446 VG->PS, N460K, 477-478 ST->NR, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
  • 4 mutations in N protein: P13L, S33G, 203-204 RG->KR, S413R
  • 2 mutations in M protein: Q19E, A63T
  • 2 mutations in E protein: T9I, T11A
  • 1 mutation in NS3 protein: T223I
  • 1 mutation in NS8 protein: G8stop
  • 4 mutations in NS9b protein: I5T, P10S, E27V, N55S
  • 1 mutation in NS9c protein: G50N
  • 2 mutations in NSP1 protein: K47R, S135R
  • 2 mutations in NSP3 protein: T24I, G489S
  • 4 mutations in NSP4 protein: L264F, T327I, L438F, T492I
  • 1 mutation in NSP5 protein: P132H
  • 2 mutations in NSP6 protein: 106-108 SGF->TSL, L260F
  • 2 mutations in NSP12 protein: P323L, G671S
  • 2 mutations in NSP13 protein: S36P, R392C
  • 3 mutations in NSP14 protein: I42V, L157F, D222Y
  • 1 mutation in NSP15 protein: T112I

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of HLA-peptide interactions affected by the mutations

For each allele we calculated the number of peptides with increased and decreased affinitiy (two or more times). The absolute number of such peptides is showed on the left side of the figure (blue bars — weaker binding, orange bars — stronger).

While absolute numbers are of interest, they do not reflect the initial number of tighly binding peptides for the specific allele. Roughly speaking, if an allele had high number of tight binders, then vanished affinity of several peptides will not affect much the integral ability of peptide presentation. To the contrary, low number of vanished peptides could be important if the particular allele initially had narrow epitope repertoire. To account for this effect, we normalized the absolute numbers of new/vanished tight binders (IC50 affinity ≤ 50 nM) by the total number of tight binders for each allele. To avoid possible divisions by zero, we used + 1 regularization term in all denominators. For example, if some allele had no tight binders in the reference genome, and three new tight binders appeared as a result of the mutation, the relative increase will be 300%. The results are showed in the right part of the figure. Protein-specific plots are listed below.

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Summary

Spike protein

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Spike

T19I

Reference  MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MFVFLVLLPLVSSQCVNLITRTQSPPSYTNSFTRGVYYPDKVFR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*58:01 VSSQCVNLT VSSQCVNLI 3986 159
HLA-C*15:02 VSSQCVNLT VSSQCVNLI 10208 479
HLA-A*02:02 LVSSQCVNLT LVSSQCVNLI 3376 271
HLA-A*02:11 VLLPLVSSQCVNLT VLLPLVSSQCVNLI 4460 394
HLA-A*30:01 VNLTTRTQLPPA VNLITRTQSPPS 254 1670
HLA-A*30:01 LTTRTQLPPA LITRTQSPPS 82 460
HLA-A*30:01 TTRTQLPPA ITRTQSPPS 9 33
HLA-B*15:03 TTRTQLPPAY ITRTQSPPSY 888 396

L24S

Reference  MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLH
           ||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    MFVFLVLLPLVSSQCVNLITRTQSPPSYTNSFTRGVYYPDKVFRSSVLH

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 LPPAYTNSFTR SPPSYTNSFTR 3363 229
HLA-A*30:01 VNLTTRTQLPPA VNLITRTQSPPS 254 1670
HLA-B*15:01 QLPPAYTNSF QSPPSYTNSF 300 1776
HLA-A*30:01 LTTRTQLPPA LITRTQSPPS 82 460
HLA-B*53:01 LPPAYTNSF SPPSYTNSF 366 1877
HLA-A*31:01 LPPAYTNSFTR SPPSYTNSFTR 757 195
HLA-B*35:01 LPPAYTNSF SPPSYTNSF 43 161
HLA-A*30:01 TTRTQLPPA ITRTQSPPS 9 33
HLA-B*15:03 TTRTQLPPAY ITRTQSPPSY 888 396
HLA-B*07:02 LPPAYTNSF SPPSYTNSF 293 137

A27S

Reference  FVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQ
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FVFLVLLPLVSSQCVNLITRTQSPPSYTNSFTRGVYYPDKVFRSSVLHSTQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 LPPAYTNSFTR SPPSYTNSFTR 3363 229
HLA-A*30:01 VNLTTRTQLPPA VNLITRTQSPPS 254 1670
HLA-B*15:01 QLPPAYTNSF QSPPSYTNSF 300 1776
HLA-A*30:01 LTTRTQLPPA LITRTQSPPS 82 460
HLA-B*53:01 LPPAYTNSF SPPSYTNSF 366 1877
HLA-A*31:01 LPPAYTNSFTR SPPSYTNSFTR 757 195
HLA-B*35:01 LPPAYTNSF SPPSYTNSF 43 161
HLA-A*30:01 TTRTQLPPA ITRTQSPPS 9 33
HLA-A*68:02 AYTNSFTRGV SYTNSFTRGV 350 114
HLA-C*14:02 AYTNSFTRGVYY SYTNSFTRGVYY 444 145
HLA-C*14:02 AYTNSFTRGVY SYTNSFTRGVY 431 145
HLA-B*15:03 TTRTQLPPAY ITRTQSPPSY 888 396
HLA-B*07:02 LPPAYTNSF SPPSYTNSF 293 137

V83A

Reference  FFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FFSNVTWFHAIHVSGTNGTKRFDNPALPFNDGVYFASTEKSNIIRGWIFGT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 FDNPVLPFNDGV FDNPALPFNDGV 198 2056
HLA-A*68:02 NGTKRFDNPV NGTKRFDNPA 249 2355
HLA-A*02:01 FDNPVLPFNDGV FDNPALPFNDGV 426 3508
HLA-A*02:02 FDNPVLPFNDGV FDNPALPFNDGV 257 1936
HLA-A*02:06 FDNPVLPFNDGV FDNPALPFNDGV 55 374
HLA-A*02:06 NPVLPFNDGV NPALPFNDGV 298 1704
HLA-A*68:02 NPVLPFNDGV NPALPFNDGV 97 263

G142D

Reference  LLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    LLIVNNATNVVIKVCEFQFCNDPFLDVYYQKNNKSWMESEFRVYSSANNCT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 GVYYHKNNK DVYYQKNNK 27 4630
HLA-A*30:01 GVYYHKNNK DVYYQKNNK 51 7391
HLA-A*11:01 GVYYHKNNK DVYYQKNNK 51 2839
HLA-A*03:02 GVYYHKNNK DVYYQKNNK 119 5703
HLA-A*31:01 GVYYHKNNK DVYYQKNNK 375 9562
HLA-A*68:02 FCNDPFLGV FCNDPFLDV 281 3555
HLA-A*68:01 GVYYHKNNK DVYYQKNNK 363 33
HLA-A*02:06 FCNDPFLGV FCNDPFLDV 116 1132
HLA-A*02:11 FCNDPFLGV FCNDPFLDV 87 751
HLA-A*02:06 EFQFCNDPFLGV EFQFCNDPFLDV 87 554
HLA-A*30:02 CNDPFLGVY CNDPFLDVY 310 1959
HLA-A*02:02 FCNDPFLGV FCNDPFLDV 365 2187
HLA-A*02:06 FQFCNDPFLGVY FQFCNDPFLDVY 135 784
HLA-A*30:02 FCNDPFLGVY FCNDPFLDVY 408 1738
HLA-A*02:11 EFQFCNDPFLGV EFQFCNDPFLDV 334 1214
HLA-A*02:02 EFQFCNDPFLGV EFQFCNDPFLDV 477 1725
HLA-A*02:11 FQFCNDPFLGVY FQFCNDPFLDVY 488 1737
HLA-A*02:06 FQFCNDPFLGV FQFCNDPFLDV 7 21
HLA-A*02:11 FQFCNDPFLGV FQFCNDPFLDV 17 49
HLA-A*02:01 FQFCNDPFLGV FQFCNDPFLDV 39 111
HLA-A*30:02 FQFCNDPFLGVY FQFCNDPFLDVY 336 923
HLA-A*02:02 FQFCNDPFLGV FQFCNDPFLDV 45 122
HLA-B*15:01 FQFCNDPFLGVY FQFCNDPFLDVY 28 56

H146Q

Reference  NNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NNATNVVIKVCEFQFCNDPFLDVYYQKNNKSWMESEFRVYSSANNCTFEYV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 GVYYHKNNK DVYYQKNNK 27 4630
HLA-A*30:01 GVYYHKNNK DVYYQKNNK 51 7391
HLA-B*15:01 YHKNNKSWMESEF YQKNNKSWMESEF 15739 226
HLA-B*15:01 YHKNNKSWM YQKNNKSWM 18557 271
HLA-A*11:01 GVYYHKNNK DVYYQKNNK 51 2839
HLA-A*03:02 GVYYHKNNK DVYYQKNNK 119 5703
HLA-A*31:01 GVYYHKNNK DVYYQKNNK 375 9562
HLA-B*15:03 YHKNNKSWM YQKNNKSWM 1065 50
HLA-A*68:01 GVYYHKNNK DVYYQKNNK 363 33
HLA-B*15:03 YHKNNKSWMESEF YQKNNKSWMESEF 1283 143
HLA-A*24:02 YYHKNNKSW YYQKNNKSW 116 58

E180V

Reference  SEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SEFRVYSSANNCTFEYVSQPFLMDLVGKEGNFKNLREFVFKNIDGYFKIYS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:06 SQPFLMDLE SQPFLMDLV 11827 43
HLA-A*02:11 SQPFLMDLE SQPFLMDLV 25287 173
HLA-A*02:02 SQPFLMDLE SQPFLMDLV 16774 115
HLA-A*11:01 LEGKQGNFK LVGKEGNFK 19398 215
HLA-A*68:02 YVSQPFLMDLE YVSQPFLMDLV 21186 274
HLA-A*02:06 VSQPFLMDLE VSQPFLMDLV 15579 288
HLA-A*03:02 LEGKQGNFK LVGKEGNFK 21955 465
HLA-C*15:02 VSQPFLMDLE VSQPFLMDLV 13114 340
HLA-A*02:11 YVSQPFLMDLE YVSQPFLMDLV 9341 419
HLA-A*02:06 YVSQPFLMDLE YVSQPFLMDLV 4972 233
HLA-A*02:02 YVSQPFLMDLE YVSQPFLMDLV 5038 261
HLA-A*02:11 FLMDLEGKQ FLMDLVGKE 1662 133
HLA-A*02:11 FLMDLEGKQG FLMDLVGKEG 3366 340
HLA-A*02:02 FLMDLEGKQ FLMDLVGKE 1621 220
HLA-A*68:01 DLEGKQGNFK DLVGKEGNFK 2888 402
HLA-A*02:02 FLMDLEGKQG FLMDLVGKEG 561 86

Q183E

Reference  RVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    RVYSSANNCTFEYVSQPFLMDLVGKEGNFKNLREFVFKNIDGYFKIYSKHT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 KQGNFKNLR KEGNFKNLR 17 1692
HLA-A*11:01 LEGKQGNFK LVGKEGNFK 19398 215
HLA-A*03:02 LEGKQGNFK LVGKEGNFK 21955 465
HLA-B*15:03 KQGNFKNLREF KEGNFKNLREF 42 1050
HLA-A*31:01 GKQGNFKNLR GKEGNFKNLR 475 9702
HLA-A*02:11 FLMDLEGKQ FLMDLVGKE 1662 133
HLA-A*02:11 FLMDLEGKQG FLMDLVGKEG 3366 340
HLA-B*15:03 KQGNFKNLREFVF KEGNFKNLREFVF 323 2837
HLA-A*02:02 FLMDLEGKQ FLMDLVGKE 1621 220
HLA-A*68:01 DLEGKQGNFK DLVGKEGNFK 2888 402
HLA-A*02:02 FLMDLEGKQG FLMDLVGKEG 561 86

V213E

Reference  NLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NLREFVFKNIDGYFKIYSKHTPINLERDLPQGFSALEPLVDLPIGINITRF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:02 YSKHTPINLV YSKHTPINLE 199 19799
HLA-B*18:01 LVRDLPQGF LERDLPQGF 22292 292
HLA-C*03:02 LVRDLPQGF LERDLPQGF 259 18781
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPINLE 104 7199
HLA-B*40:02 LVRDLPQGFSAL LERDLPQGFSAL 17495 450
HLA-B*15:01 LVRDLPQGF LERDLPQGF 160 2582
HLA-C*01:02 VRDLPQGFSAL ERDLPQGFSAL 431 4216
HLA-B*42:01 TPINLVRDL TPINLERDL 43 173
HLA-B*42:01 HTPINLVRDL HTPINLERDL 250 983
HLA-B*07:02 TPINLVRDL TPINLERDL 213 783

G339H

Reference  QTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QTSNFRVQPTESIVRFPNITNLCPFHEVFNATTFASVYAWNRKRISNCVAD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*38:01 FGEVFNATRF FHEVFNATTF 16707 108
HLA-A*68:01 FGEVFNATR FHEVFNATT 338 32767
HLA-A*68:01 CPFGEVFNATR CPFHEVFNATT 457 32129
HLA-B*18:01 GEVFNATRF HEVFNATTF 971 24
HLA-A*68:02 GEVFNATRFA HEVFNATTFA 879 50
HLA-B*15:03 GEVFNATRF HEVFNATTF 359 26
HLA-B*15:03 FGEVFNATRF FHEVFNATTF 694 60
HLA-A*02:11 NLCPFGEV NLCPFHEV 2369 286
HLA-B*18:01 GEVFNATRFASVY HEVFNATTFASVY 2165 265
HLA-A*02:02 FGEVFNATRFA FHEVFNATTFA 2678 413
HLA-B*18:01 FGEVFNATRF FHEVFNATTF 1074 179
HLA-A*02:06 FGEVFNATRFA FHEVFNATTFA 1063 209
HLA-B*40:01 FGEVFNATRF FHEVFNATTF 1994 435
HLA-B*40:02 FGEVFNATRF FHEVFNATTF 1615 380
HLA-A*68:02 FGEVFNATRFA FHEVFNATTFA 939 230
HLA-A*02:11 NITNLCPFGEV NITNLCPFHEV 1609 422
HLA-B*35:01 CPFGEVFNATRF CPFHEVFNATTF 1090 291
HLA-A*02:06 ITNLCPFGEV ITNLCPFHEV 324 104
HLA-B*40:02 GEVFNATRF HEVFNATTF 283 96
HLA-A*02:11 ITNLCPFGEV ITNLCPFHEV 412 147
HLA-A*02:02 NLCPFGEVFNA NLCPFHEVFNA 182 472
HLA-B*15:03 GEVFNATRFASVY HEVFNATTFASVY 1058 423
HLA-A*23:01 PFGEVFNATRF PFHEVFNATTF 1002 401
HLA-A*68:02 TNLCPFGEV TNLCPFHEV 963 398
HLA-A*02:01 NLCPFGEVFNA NLCPFHEVFNA 164 354
HLA-B*40:01 GEVFNATRF HEVFNATTF 164 77

R346T

Reference  QPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QPTESIVRFPNITNLCPFHEVFNATTFASVYAWNRKRISNCVADYSVIYNF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*57:01 TRFASVYAW TTFASVYAW 4769 8
HLA-B*58:01 TRFASVYAW TTFASVYAW 1649 4
HLA-B*27:05 TRFASVYAWNRK TTFASVYAWNRK 127 22943
HLA-B*38:01 FGEVFNATRF FHEVFNATTF 16707 108
HLA-B*57:01 TRFASVYAWN TTFASVYAWN 21401 141
HLA-B*58:01 TRFASVYAWN TTFASVYAWN 13964 99
HLA-A*32:01 TRFASVYAW TTFASVYAW 1237 9
HLA-A*68:01 TRFASVYAWNRK TTFASVYAWNRK 1585 15
HLA-A*11:01 TRFASVYAWNRK TTFASVYAWNRK 2010 20
HLA-B*27:05 TRFASVYAWNR TTFASVYAWNR 253 25190
HLA-A*68:01 FGEVFNATR FHEVFNATT 338 32767
HLA-A*30:01 NATRFASVYA NATTFASVYA 40 3756
HLA-A*68:02 TRFASVYAWNRKRI TTFASVYAWNRKRI 20921 226
HLA-A*30:01 ATRFASVYA ATTFASVYA 3 275
HLA-A*68:01 TRFASVYAWNRKR TTFASVYAWNRKR 692 8
HLA-B*27:05 ATRFASVYAW ATTFASVYAW 325 24180
HLA-A*68:01 CPFGEVFNATR CPFHEVFNATT 457 32129
HLA-A*30:01 ATRFASVYAW ATTFASVYAW 100 6909
HLA-A*30:01 ATRFASVYAWNRK ATTFASVYAWNRK 45 3053
HLA-B*27:05 TRFASVYAW TTFASVYAW 301 19581
HLA-A*68:01 TRFASVYAWNR TTFASVYAWNR 513 8
HLA-A*11:01 TRFASVYAWNR TTFASVYAWNR 8088 141
HLA-B*08:01 FNATRFASV FNATTFASV 38 2163
HLA-B*53:01 TRFASVYAW TTFASVYAW 3827 71
HLA-B*58:01 VFNATRFASVYAW VFNATTFASVYAW 2154 44
HLA-A*30:01 ATRFASVY ATTFASVY 303 14033
HLA-B*58:02 TRFASVYAW TTFASVYAW 13911 307
HLA-B*57:01 VFNATRFASVYAW VFNATTFASVYAW 1811 40
HLA-B*18:01 GEVFNATRF HEVFNATTF 971 24
HLA-A*30:01 VFNATRFASVYA VFNATTFASVYA 112 4258
HLA-A*03:02 TRFASVYAWNRK TTFASVYAWNRK 5014 134
HLA-A*30:01 FNATRFASVYA FNATTFASVYA 316 10821
HLA-A*03:01 TRFASVYAWNRK TTFASVYAWNRK 6885 252
HLA-A*68:02 GEVFNATRFA HEVFNATTFA 879 50
HLA-B*15:03 GEVFNATRF HEVFNATTF 359 26
HLA-C*03:02 TRFASVYAW TTFASVYAW 6240 464
HLA-B*15:03 FGEVFNATRF FHEVFNATTF 694 60
HLA-A*33:03 TRFASVYAWNR TTFASVYAWNR 494 43
HLA-C*12:03 TRFASVYAW TTFASVYAW 4688 426
HLA-B*58:01 FNATRFASVYAW FNATTFASVYAW 462 42
HLA-A*30:01 RFASVYAWNRK TFASVYAWNRK 336 3487
HLA-A*31:01 RFASVYAWNRK TFASVYAWNRK 103 884
HLA-A*68:01 ATRFASVYAWNR ATTFASVYAWNR 280 33
HLA-B*18:01 GEVFNATRFASVY HEVFNATTFASVY 2165 265
HLA-B*57:01 FNATRFASVYAW FNATTFASVYAW 489 60
HLA-A*31:01 ATRFASVYAWNR ATTFASVYAWNR 19 152
HLA-A*31:01 ATRFASVYAWNRK ATTFASVYAWNRK 469 3463
HLA-A*33:03 TRFASVYAWNRKR TTFASVYAWNRKR 417 57
HLA-A*68:01 ATRFASVYAWNRK ATTFASVYAWNRK 1400 193
HLA-A*68:01 ATRFASVYAWNRKR ATTFASVYAWNRKR 1024 145
HLA-A*02:02 FGEVFNATRFA FHEVFNATTFA 2678 413
HLA-A*31:01 RFASVYAWNRKR TFASVYAWNRKR 14 90
HLA-B*18:01 FGEVFNATRF FHEVFNATTF 1074 179
HLA-A*68:02 ATRFASVYA ATTFASVYA 485 90
HLA-A*68:01 RFASVYAWNRKR TFASVYAWNRKR 1357 254
HLA-A*68:02 FNATRFASVYA FNATTFASVYA 1312 254
HLA-A*02:06 FGEVFNATRFA FHEVFNATTFA 1063 209
HLA-A*31:01 ATRFASVYAWNRKR ATTFASVYAWNRKR 78 363
HLA-A*33:03 RFASVYAWNRKR TFASVYAWNRKR 200 43
HLA-A*68:01 RFASVYAWNR TFASVYAWNR 147 32
HLA-B*40:01 FGEVFNATRF FHEVFNATTF 1994 435
HLA-A*31:01 NATRFASVYAWNR NATTFASVYAWNR 263 1165
HLA-A*03:01 ATRFASVYAWNRK ATTFASVYAWNRK 151 656
HLA-B*40:02 FGEVFNATRF FHEVFNATTF 1615 380
HLA-A*31:01 RFASVYAWNR TFASVYAWNR 7 29
HLA-A*23:01 TRFASVYAW TTFASVYAW 1649 403
HLA-A*68:02 FGEVFNATRFA FHEVFNATTFA 939 230
HLA-B*57:01 RFASVYAW TFASVYAW 586 144
HLA-A*33:03 RFASVYAWNRK TFASVYAWNRK 1936 492
HLA-B*35:01 CPFGEVFNATRF CPFHEVFNATTF 1090 291
HLA-A*68:02 NATRFASVYA NATTFASVYA 204 55
HLA-B*58:01 RFASVYAW TFASVYAW 296 83
HLA-A*24:02 RFASVYAW TFASVYAW 446 1553
HLA-A*33:03 RFASVYAWNR TFASVYAWNR 38 11
HLA-A*23:01 RFASVYAW TFASVYAW 277 951
HLA-A*68:01 NATRFASVYAWNR NATTFASVYAWNR 444 130
HLA-A*11:01 ATRFASVYAWNRK ATTFASVYAWNRK 130 39
HLA-A*68:01 EVFNATRFA EVFNATTFA 579 181
HLA-B*40:02 GEVFNATRF HEVFNATTF 283 96
HLA-B*35:01 FNATRFASVY FNATTFASVY 106 36
HLA-A*68:02 EVFNATRFA EVFNATTFA 14 5
HLA-A*11:01 ATRFASVYAWNR ATTFASVYAWNR 733 271
HLA-A*68:01 EVFNATRFASVY EVFNATTFASVY 407 155
HLA-A*68:02 FNATRFASV FNATTFASV 96 38
HLA-A*29:02 EVFNATRFASVY EVFNATTFASVY 1045 415
HLA-B*15:03 GEVFNATRFASVY HEVFNATTFASVY 1058 423
HLA-A*23:01 PFGEVFNATRF PFHEVFNATTF 1002 401
HLA-A*29:02 VFNATRFASVY VFNATTFASVY 130 53
HLA-B*15:03 TRFASVYAW TTFASVYAW 224 496
HLA-A*31:01 TRFASVYAWNRKR TTFASVYAWNRKR 213 98
HLA-A*02:06 FNATRFASV FNATTFASV 210 98
HLA-B*40:01 GEVFNATRF HEVFNATTF 164 77
HLA-A*68:01 FNATRFASVYAWNR FNATTFASVYAWNR 934 442
HLA-A*03:02 ATRFASVYAWNRK ATTFASVYAWNRK 493 242
HLA-A*02:02 FNATRFASV FNATTFASV 408 202

L368I

Reference  NATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NATTFASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VIYNFAPFF 22186 48
HLA-A*23:01 LYNSASFS IYNFAPFF 22508 99
HLA-A*24:02 LYNSASFS IYNFAPFF 25164 136
HLA-A*23:01 VLYNSASFS VIYNFAPFF 32767 178
HLA-A*29:02 VLYNSASFS VIYNFAPFF 10439 76
HLA-C*03:02 VLYNSASFS VIYNFAPFF 13004 100
HLA-B*15:03 VLYNSASFS VIYNFAPFF 3280 27
HLA-A*26:01 SVLYNSASFS SVIYNFAPFF 21993 202
HLA-C*14:02 LYNSASFS IYNFAPFF 5693 80
HLA-C*05:01 VADYSVLYNS VADYSVIYNF 11802 172
HLA-A*32:01 SVLYNSASFS SVIYNFAPFF 14340 227
HLA-A*29:02 SVLYNSASFS SVIYNFAPFF 16185 274
HLA-B*15:01 SVLYNSASFS SVIYNFAPFF 2838 50
HLA-A*26:01 SVLYNSASF SVIYNFAPF 1313 24
HLA-A*23:01 SVLYNSASFS SVIYNFAPFF 24524 498
HLA-C*03:02 SVLYNSASFS SVIYNFAPFF 8888 192
HLA-A*68:02 SVLYNSASFST SVIYNFAPFFA 14147 319
HLA-B*58:01 VADYSVLYNS VADYSVIYNF 6124 141
HLA-C*16:01 VLYNSASFS VIYNFAPFF 18639 432
HLA-B*15:03 SVLYNSASFS SVIYNFAPFF 2850 68
HLA-A*23:01 DYSVLYNSASFS DYSVIYNFAPFF 14260 341
HLA-C*03:02 VADYSVLYNS VADYSVIYNF 20606 498
HLA-A*68:02 VLYNSASFST VIYNFAPFFA 11417 297
HLA-A*25:01 SVLYNSASF SVIYNFAPF 2252 59
HLA-C*12:03 VLYNSASFS VIYNFAPFF 12383 333
HLA-C*14:02 VLYNSASFS VIYNFAPFF 11085 360
HLA-A*68:02 SVLYNSASF SVIYNFAPF 6927 241
HLA-B*15:01 VLYNSASFS VIYNFAPFF 8189 317
HLA-B*57:01 VADYSVLYNS VADYSVIYNF 11273 446
HLA-B*58:01 YSVLYNSASFS YSVIYNFAPFF 6920 277
HLA-A*02:06 SVLYNSASF SVIYNFAPF 2112 98
HLA-A*02:06 SVLYNSASFST SVIYNFAPFFA 4097 193
HLA-A*68:01 SVLYNSASF SVIYNFAPF 6337 311
HLA-B*15:01 VLYNSASFSTF VIYNFAPFFAF 50 951
HLA-B*40:02 ADYSVLYNS ADYSVIYNF 4645 272
HLA-B*15:03 YSVLYNSASFS YSVIYNFAPFF 3170 196
HLA-A*11:01 LYNSASFSTFK IYNFAPFFAFK 43 681
HLA-A*26:01 YSVLYNSASF YSVIYNFAPF 1544 107
HLA-A*02:06 VLYNSASFST VIYNFAPFFA 710 58
HLA-A*30:01 LYNSASFST IYNFAPFFA 3467 316
HLA-C*03:02 YSVLYNSASFS YSVIYNFAPFF 2405 260
HLA-A*02:11 SVLYNSASFST SVIYNFAPFFA 3830 425
HLA-A*33:03 SVLYNSASFSTFK SVIYNFAPFFAFK 2778 320
HLA-C*12:02 SVLYNSASF SVIYNFAPF 507 63
HLA-A*25:01 YSVLYNSASF YSVIYNFAPF 2498 338
HLA-A*23:01 SVLYNSASF SVIYNFAPF 990 145
HLA-A*30:02 VLYNSASFS VIYNFAPFF 2919 448
HLA-A*02:06 YSVLYNSASF YSVIYNFAPF 2478 397
HLA-B*15:03 VLYNSASFSTF VIYNFAPFFAF 38 235
HLA-A*29:02 LYNSASFSTF IYNFAPFFAF 387 63
HLA-A*29:02 SVLYNSASF SVIYNFAPF 1130 186
HLA-C*12:03 SVLYNSASF SVIYNFAPF 748 127
HLA-A*29:02 SNCVADYSVLY SNCVADYSVIY 83 483
HLA-A*31:01 SVLYNSASFSTFK SVIYNFAPFFAFK 857 150
HLA-A*02:01 VLYNSASFST VIYNFAPFFA 243 43
HLA-A*29:02 NCVADYSVLY NCVADYSVIY 57 320
HLA-A*29:02 ISNCVADYSVLY ISNCVADYSVIY 116 625
HLA-A*03:01 VLYNSASFSTFKC VIYNFAPFFAFKC 312 1619
HLA-A*29:02 RISNCVADYSVLY RISNCVADYSVIY 249 1271
HLA-C*02:02 SVLYNSASF SVIYNFAPF 1090 218
HLA-C*02:10 SVLYNSASF SVIYNFAPF 1090 218
HLA-A*01:01 CVADYSVLY CVADYSVIY 76 367
HLA-A*24:02 SVLYNSASF SVIYNFAPF 1977 410
HLA-A*03:01 LYNSASFSTFK IYNFAPFFAFK 295 1419
HLA-A*01:01 VADYSVLY VADYSVIY 339 1549
HLA-B*15:01 SVLYNSASF SVIYNFAPF 52 12
HLA-B*35:01 SVLYNSASF SVIYNFAPF 153 36
HLA-A*02:02 VLYNSASFST VIYNFAPFFA 202 49
HLA-A*31:01 VLYNSASFSTFK VIYNFAPFFAFK 565 139
HLA-A*11:01 CVADYSVLY CVADYSVIY 169 673
HLA-A*68:01 CVADYSVLY CVADYSVIY 78 304
HLA-A*03:01 VLYNSASFSTFK VIYNFAPFFAFK 7 27
HLA-A*02:11 VLYNSASFST VIYNFAPFFA 77 20
HLA-A*68:01 NCVADYSVLY NCVADYSVIY 267 1017
HLA-A*03:02 LYNSASFSTFK IYNFAPFFAFK 202 760
HLA-A*68:02 CVADYSVLYNSA CVADYSVIYNFA 1306 349
HLA-A*31:01 LYNSASFSTFK IYNFAPFFAFK 299 81
HLA-B*15:01 YSVLYNSASFSTF YSVIYNFAPFFAF 164 604
HLA-A*29:02 YSVLYNSASF YSVIYNFAPF 1696 462
HLA-A*30:02 VLYNSASFSTFKCY VIYNFAPFFAFKCY 272 973
HLA-B*15:01 LYNSASFSTF IYNFAPFFAF 468 1565
HLA-C*03:02 SVLYNSASF SVIYNFAPF 29 9
HLA-A*23:01 YSVLYNSASF YSVIYNFAPF 1120 364
HLA-B*27:05 KRISNCVADYSVLY KRISNCVADYSVIY 358 1096
HLA-A*26:01 NCVADYSVLY NCVADYSVIY 183 556
HLA-A*29:02 CVADYSVLY CVADYSVIY 6 18
HLA-C*03:02 YSVLYNSASFSTF YSVIYNFAPFFAF 113 331
HLA-A*26:01 CVADYSVLY CVADYSVIY 33 95
HLA-A*29:02 LYNSASFSTFKCY IYNFAPFFAFKCY 297 105
HLA-A*68:01 VLYNSASFSTFK VIYNFAPFFAFK 257 91
HLA-A*03:02 VLYNSASFSTFK VIYNFAPFFAFK 13 36
HLA-C*14:02 SVLYNSASF SVIYNFAPF 152 56
HLA-B*15:03 VLYNSASF VIYNFAPF 34 92
HLA-B*58:01 YSVLYNSASFSTF YSVIYNFAPFFAF 429 1153
HLA-A*01:01 ISNCVADYSVLY ISNCVADYSVIY 123 327
HLA-C*03:03 SVLYNSASF SVIYNFAPF 114 45
HLA-C*03:04 SVLYNSASF SVIYNFAPF 114 45
HLA-A*02:11 VLYNSASFS VIYNFAPFF 258 645
HLA-A*23:01 DYSVLYNSASF DYSVIYNFAPF 1039 424
HLA-A*33:03 LYNSASFSTFK IYNFAPFFAFK 1158 476
HLA-B*35:01 YSVLYNSASF YSVIYNFAPF 328 136
HLA-A*30:02 SVLYNSASF SVIYNFAPF 1057 444
HLA-A*23:01 SVLYNSASFSTF SVIYNFAPFFAF 656 277
HLA-B*15:01 VLYNSASF VIYNFAPF 224 518
HLA-A*30:02 SNCVADYSVLY SNCVADYSVIY 427 982
HLA-A*30:02 CVADYSVLY CVADYSVIY 72 159
HLA-C*14:02 LYNSASFSTF IYNFAPFFAF 20 43
HLA-A*68:01 YSVLYNSASFSTFK YSVIYNFAPFFAFK 144 67
HLA-A*30:02 KRISNCVADYSVLY KRISNCVADYSVIY 456 969
HLA-A*30:02 RISNCVADYSVLY RISNCVADYSVIY 81 170
HLA-A*68:01 SVLYNSASFSTFK SVIYNFAPFFAFK 41 20
HLA-A*03:01 SVLYNSASFSTFK SVIYNFAPFFAFK 47 96

S371F

Reference  RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TFASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVY

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VIYNFAPFF 22186 48
HLA-A*23:01 LYNSASFS IYNFAPFF 22508 99
HLA-A*24:02 LYNSASFS IYNFAPFF 25164 136
HLA-A*23:01 VLYNSASFS VIYNFAPFF 32767 178
HLA-A*29:02 VLYNSASFS VIYNFAPFF 10439 76
HLA-C*03:02 VLYNSASFS VIYNFAPFF 13004 100
HLA-B*15:03 VLYNSASFS VIYNFAPFF 3280 27
HLA-A*26:01 SVLYNSASFS SVIYNFAPFF 21993 202
HLA-C*14:02 LYNSASFS IYNFAPFF 5693 80
HLA-C*05:01 VADYSVLYNS VADYSVIYNF 11802 172
HLA-A*32:01 SVLYNSASFS SVIYNFAPFF 14340 227
HLA-A*29:02 SVLYNSASFS SVIYNFAPFF 16185 274
HLA-B*15:01 SVLYNSASFS SVIYNFAPFF 2838 50
HLA-A*26:01 SVLYNSASF SVIYNFAPF 1313 24
HLA-A*23:01 SVLYNSASFS SVIYNFAPFF 24524 498
HLA-C*03:02 SVLYNSASFS SVIYNFAPFF 8888 192
HLA-A*68:02 SVLYNSASFST SVIYNFAPFFA 14147 319
HLA-B*58:01 VADYSVLYNS VADYSVIYNF 6124 141
HLA-C*16:01 VLYNSASFS VIYNFAPFF 18639 432
HLA-B*15:03 SVLYNSASFS SVIYNFAPFF 2850 68
HLA-A*23:01 DYSVLYNSASFS DYSVIYNFAPFF 14260 341
HLA-C*03:02 VADYSVLYNS VADYSVIYNF 20606 498
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*68:02 VLYNSASFST VIYNFAPFFA 11417 297
HLA-A*25:01 SVLYNSASF SVIYNFAPF 2252 59
HLA-C*12:03 VLYNSASFS VIYNFAPFF 12383 333
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-C*14:02 VLYNSASFS VIYNFAPFF 11085 360
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*68:02 SVLYNSASF SVIYNFAPF 6927 241
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-B*15:01 VLYNSASFS VIYNFAPFF 8189 317
HLA-B*57:01 VADYSVLYNS VADYSVIYNF 11273 446
HLA-B*58:01 YSVLYNSASFS YSVIYNFAPFF 6920 277
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-A*02:06 SVLYNSASF SVIYNFAPF 2112 98
HLA-A*02:06 SVLYNSASFST SVIYNFAPFFA 4097 193
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-A*68:01 SVLYNSASF SVIYNFAPF 6337 311
HLA-B*15:01 VLYNSASFSTF VIYNFAPFFAF 50 951
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-B*40:02 ADYSVLYNS ADYSVIYNF 4645 272
HLA-B*15:03 YSVLYNSASFS YSVIYNFAPFF 3170 196
HLA-A*11:01 LYNSASFSTFK IYNFAPFFAFK 43 681
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*26:01 YSVLYNSASF YSVIYNFAPF 1544 107
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*02:06 VLYNSASFST VIYNFAPFFA 710 58
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-A*30:01 LYNSASFST IYNFAPFFA 3467 316
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-C*03:02 YSVLYNSASFS YSVIYNFAPFF 2405 260
HLA-A*02:11 SVLYNSASFST SVIYNFAPFFA 3830 425
HLA-A*33:03 SVLYNSASFSTFK SVIYNFAPFFAFK 2778 320
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-C*12:02 SVLYNSASF SVIYNFAPF 507 63
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*25:01 YSVLYNSASF YSVIYNFAPF 2498 338
HLA-A*23:01 SVLYNSASF SVIYNFAPF 990 145
HLA-A*30:02 VLYNSASFS VIYNFAPFF 2919 448
HLA-A*02:06 YSVLYNSASF YSVIYNFAPF 2478 397
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-B*15:03 VLYNSASFSTF VIYNFAPFFAF 38 235
HLA-A*29:02 LYNSASFSTF IYNFAPFFAF 387 63
HLA-A*29:02 SVLYNSASF SVIYNFAPF 1130 186
HLA-C*12:03 SVLYNSASF SVIYNFAPF 748 127
HLA-A*31:01 SVLYNSASFSTFK SVIYNFAPFFAFK 857 150
HLA-A*02:01 VLYNSASFST VIYNFAPFFA 243 43
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 VLYNSASFSTFKC VIYNFAPFFAFKC 312 1619
HLA-C*02:02 SVLYNSASF SVIYNFAPF 1090 218
HLA-C*02:10 SVLYNSASF SVIYNFAPF 1090 218
HLA-A*24:02 SVLYNSASF SVIYNFAPF 1977 410
HLA-A*03:01 LYNSASFSTFK IYNFAPFFAFK 295 1419
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*15:01 SVLYNSASF SVIYNFAPF 52 12
HLA-B*35:01 SVLYNSASF SVIYNFAPF 153 36
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*02:02 VLYNSASFST VIYNFAPFFA 202 49
HLA-A*31:01 VLYNSASFSTFK VIYNFAPFFAFK 565 139
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*03:01 VLYNSASFSTFK VIYNFAPFFAFK 7 27
HLA-A*02:11 VLYNSASFST VIYNFAPFFA 77 20
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-A*03:02 LYNSASFSTFK IYNFAPFFAFK 202 760
HLA-A*68:02 CVADYSVLYNSA CVADYSVIYNFA 1306 349
HLA-A*31:01 LYNSASFSTFK IYNFAPFFAFK 299 81
HLA-B*15:01 YSVLYNSASFSTF YSVIYNFAPFFAF 164 604
HLA-A*29:02 YSVLYNSASF YSVIYNFAPF 1696 462
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-A*30:02 VLYNSASFSTFKCY VIYNFAPFFAFKCY 272 973
HLA-B*15:01 LYNSASFSTF IYNFAPFFAF 468 1565
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-C*03:02 SVLYNSASF SVIYNFAPF 29 9
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*23:01 YSVLYNSASF YSVIYNFAPF 1120 364
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVIYNFAPFFAF 113 331
HLA-A*29:02 LYNSASFSTFKCY IYNFAPFFAFKCY 297 105
HLA-A*68:01 VLYNSASFSTFK VIYNFAPFFAFK 257 91
HLA-A*03:02 VLYNSASFSTFK VIYNFAPFFAFK 13 36
HLA-C*14:02 SVLYNSASF SVIYNFAPF 152 56
HLA-B*15:03 VLYNSASF VIYNFAPF 34 92
HLA-B*58:01 YSVLYNSASFSTF YSVIYNFAPFFAF 429 1153
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-C*03:03 SVLYNSASF SVIYNFAPF 114 45
HLA-C*03:04 SVLYNSASF SVIYNFAPF 114 45
HLA-A*02:11 VLYNSASFS VIYNFAPFF 258 645
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*23:01 DYSVLYNSASF DYSVIYNFAPF 1039 424
HLA-A*33:03 LYNSASFSTFK IYNFAPFFAFK 1158 476
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-B*35:01 YSVLYNSASF YSVIYNFAPF 328 136
HLA-A*30:02 SVLYNSASF SVIYNFAPF 1057 444
HLA-A*23:01 SVLYNSASFSTF SVIYNFAPFFAF 656 277
HLA-B*15:01 VLYNSASF VIYNFAPF 224 518
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-C*14:02 LYNSASFSTF IYNFAPFFAF 20 43
HLA-A*68:01 YSVLYNSASFSTFK YSVIYNFAPFFAFK 144 67
HLA-A*68:01 SVLYNSASFSTFK SVIYNFAPFFAFK 41 20
HLA-A*03:01 SVLYNSASFSTFK SVIYNFAPFFAFK 47 96

S373P

Reference  ASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVYAD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VIYNFAPFF 22186 48
HLA-A*23:01 LYNSASFS IYNFAPFF 22508 99
HLA-A*24:02 LYNSASFS IYNFAPFF 25164 136
HLA-A*23:01 VLYNSASFS VIYNFAPFF 32767 178
HLA-A*29:02 VLYNSASFS VIYNFAPFF 10439 76
HLA-C*03:02 VLYNSASFS VIYNFAPFF 13004 100
HLA-B*15:03 VLYNSASFS VIYNFAPFF 3280 27
HLA-A*26:01 SVLYNSASFS SVIYNFAPFF 21993 202
HLA-C*14:02 LYNSASFS IYNFAPFF 5693 80
HLA-A*32:01 SVLYNSASFS SVIYNFAPFF 14340 227
HLA-A*30:02 ASFSTFKCY APFFAFKCY 43 2647
HLA-A*29:02 SVLYNSASFS SVIYNFAPFF 16185 274
HLA-B*15:01 ASFSTFKCY APFFAFKCY 107 6085
HLA-B*15:01 SVLYNSASFS SVIYNFAPFF 2838 50
HLA-A*26:01 SVLYNSASF SVIYNFAPF 1313 24
HLA-A*02:06 ASFSTFKCYGV APFFAFKCYGV 231 11537
HLA-A*23:01 SVLYNSASFS SVIYNFAPFF 24524 498
HLA-C*03:02 SVLYNSASFS SVIYNFAPFF 8888 192
HLA-C*16:01 ASFSTFKCY APFFAFKCY 68 3117
HLA-A*68:02 SVLYNSASFST SVIYNFAPFFA 14147 319
HLA-C*12:03 ASFSTFKCY APFFAFKCY 115 5066
HLA-C*16:01 VLYNSASFS VIYNFAPFF 18639 432
HLA-B*15:03 SVLYNSASFS SVIYNFAPFF 2850 68
HLA-A*23:01 DYSVLYNSASFS DYSVIYNFAPFF 14260 341
HLA-C*03:02 ASFSTFKCY APFFAFKCY 64 2656
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*68:02 VLYNSASFST VIYNFAPFFA 11417 297
HLA-A*25:01 SVLYNSASF SVIYNFAPF 2252 59
HLA-C*12:03 VLYNSASFS VIYNFAPFF 12383 333
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-A*11:01 ASFSTFKCY APFFAFKCY 379 12606
HLA-C*14:02 VLYNSASFS VIYNFAPFF 11085 360
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*68:02 SVLYNSASF SVIYNFAPF 6927 241
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-B*15:01 VLYNSASFS VIYNFAPFF 8189 317
HLA-B*35:01 ASFSTFKCY APFFAFKCY 2345 92
HLA-B*58:01 YSVLYNSASFS YSVIYNFAPFF 6920 277
HLA-C*12:02 ASFSTFKCY APFFAFKCY 338 8222
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-A*02:06 SVLYNSASF SVIYNFAPF 2112 98
HLA-A*02:06 SVLYNSASFST SVIYNFAPFFA 4097 193
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-B*15:03 ASFSTFKCY APFFAFKCY 25 529
HLA-A*68:01 SVLYNSASF SVIYNFAPF 6337 311
HLA-B*15:01 VLYNSASFSTF VIYNFAPFFAF 50 951
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-C*14:02 SFSTFKCY PFFAFKCY 386 6449
HLA-B*15:03 YSVLYNSASFS YSVIYNFAPFF 3170 196
HLA-A*11:01 LYNSASFSTFK IYNFAPFFAFK 43 681
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*26:01 YSVLYNSASF YSVIYNFAPF 1544 107
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*02:06 VLYNSASFST VIYNFAPFFA 710 58
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-A*30:01 LYNSASFST IYNFAPFFA 3467 316
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-C*03:02 YSVLYNSASFS YSVIYNFAPFF 2405 260
HLA-A*29:02 ASFSTFKCY APFFAFKCY 201 1830
HLA-A*02:11 SVLYNSASFST SVIYNFAPFFA 3830 425
HLA-A*33:03 SVLYNSASFSTFK SVIYNFAPFFAFK 2778 320
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-C*12:02 SVLYNSASF SVIYNFAPF 507 63
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*25:01 YSVLYNSASF YSVIYNFAPF 2498 338
HLA-A*23:01 SVLYNSASF SVIYNFAPF 990 145
HLA-A*30:02 VLYNSASFS VIYNFAPFF 2919 448
HLA-A*02:06 YSVLYNSASF YSVIYNFAPF 2478 397
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-B*15:03 VLYNSASFSTF VIYNFAPFFAF 38 235
HLA-A*29:02 LYNSASFSTF IYNFAPFFAF 387 63
HLA-A*29:02 SVLYNSASF SVIYNFAPF 1130 186
HLA-C*12:03 SVLYNSASF SVIYNFAPF 748 127
HLA-A*31:01 SVLYNSASFSTFK SVIYNFAPFFAFK 857 150
HLA-A*02:01 VLYNSASFST VIYNFAPFFA 243 43
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 VLYNSASFSTFKC VIYNFAPFFAFKC 312 1619
HLA-C*02:02 SVLYNSASF SVIYNFAPF 1090 218
HLA-C*02:10 SVLYNSASF SVIYNFAPF 1090 218
HLA-A*24:02 SVLYNSASF SVIYNFAPF 1977 410
HLA-A*03:01 LYNSASFSTFK IYNFAPFFAFK 295 1419
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*15:01 SVLYNSASF SVIYNFAPF 52 12
HLA-B*35:01 SVLYNSASF SVIYNFAPF 153 36
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*02:02 VLYNSASFST VIYNFAPFFA 202 49
HLA-A*31:01 VLYNSASFSTFK VIYNFAPFFAFK 565 139
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*03:01 VLYNSASFSTFK VIYNFAPFFAFK 7 27
HLA-A*02:11 VLYNSASFST VIYNFAPFFA 77 20
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-A*03:02 LYNSASFSTFK IYNFAPFFAFK 202 760
HLA-A*31:01 LYNSASFSTFK IYNFAPFFAFK 299 81
HLA-B*15:01 YSVLYNSASFSTF YSVIYNFAPFFAF 164 604
HLA-A*29:02 YSVLYNSASF YSVIYNFAPF 1696 462
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-A*30:02 VLYNSASFSTFKCY VIYNFAPFFAFKCY 272 973
HLA-B*15:01 LYNSASFSTF IYNFAPFFAF 468 1565
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-C*03:02 SVLYNSASF SVIYNFAPF 29 9
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*23:01 YSVLYNSASF YSVIYNFAPF 1120 364
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVIYNFAPFFAF 113 331
HLA-A*29:02 LYNSASFSTFKCY IYNFAPFFAFKCY 297 105
HLA-A*68:01 VLYNSASFSTFK VIYNFAPFFAFK 257 91
HLA-A*03:02 VLYNSASFSTFK VIYNFAPFFAFK 13 36
HLA-C*14:02 SVLYNSASF SVIYNFAPF 152 56
HLA-B*15:03 VLYNSASF VIYNFAPF 34 92
HLA-B*58:01 YSVLYNSASFSTF YSVIYNFAPFFAF 429 1153
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-C*03:03 SVLYNSASF SVIYNFAPF 114 45
HLA-C*03:04 SVLYNSASF SVIYNFAPF 114 45
HLA-A*02:11 VLYNSASFS VIYNFAPFF 258 645
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*23:01 DYSVLYNSASF DYSVIYNFAPF 1039 424
HLA-A*33:03 LYNSASFSTFK IYNFAPFFAFK 1158 476
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-B*35:01 YSVLYNSASF YSVIYNFAPF 328 136
HLA-A*30:02 SVLYNSASF SVIYNFAPF 1057 444
HLA-A*23:01 SVLYNSASFSTF SVIYNFAPFFAF 656 277
HLA-B*15:01 VLYNSASF VIYNFAPF 224 518
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-C*14:02 LYNSASFSTF IYNFAPFFAF 20 43
HLA-A*68:01 YSVLYNSASFSTFK YSVIYNFAPFFAFK 144 67
HLA-A*68:01 SVLYNSASFSTFK SVIYNFAPFFAFK 41 20
HLA-A*03:01 SVLYNSASFSTFK SVIYNFAPFFAFK 47 96

375-376 ST->FA

Reference  VYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    VYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VIYNFAPFF 22186 48
HLA-A*23:01 LYNSASFS IYNFAPFF 22508 99
HLA-A*24:02 LYNSASFS IYNFAPFF 25164 136
HLA-A*23:01 VLYNSASFS VIYNFAPFF 32767 178
HLA-A*29:02 VLYNSASFS VIYNFAPFF 10439 76
HLA-C*03:02 VLYNSASFS VIYNFAPFF 13004 100
HLA-B*15:03 VLYNSASFS VIYNFAPFF 3280 27
HLA-A*26:01 SVLYNSASFS SVIYNFAPFF 21993 202
HLA-C*14:02 LYNSASFS IYNFAPFF 5693 80
HLA-A*32:01 SVLYNSASFS SVIYNFAPFF 14340 227
HLA-A*30:02 ASFSTFKCY APFFAFKCY 43 2647
HLA-A*29:02 SVLYNSASFS SVIYNFAPFF 16185 274
HLA-B*15:01 ASFSTFKCY APFFAFKCY 107 6085
HLA-B*15:01 SVLYNSASFS SVIYNFAPFF 2838 50
HLA-A*02:06 ASFSTFKCYGV APFFAFKCYGV 231 11537
HLA-A*23:01 SVLYNSASFS SVIYNFAPFF 24524 498
HLA-C*15:02 FSTFKCYGV FFAFKCYGV 431 20837
HLA-C*03:02 SVLYNSASFS SVIYNFAPFF 8888 192
HLA-C*16:01 ASFSTFKCY APFFAFKCY 68 3117
HLA-A*68:02 SVLYNSASFST SVIYNFAPFFA 14147 319
HLA-C*12:03 ASFSTFKCY APFFAFKCY 115 5066
HLA-C*16:01 VLYNSASFS VIYNFAPFF 18639 432
HLA-B*15:03 SVLYNSASFS SVIYNFAPFF 2850 68
HLA-A*23:01 DYSVLYNSASFS DYSVIYNFAPFF 14260 341
HLA-C*03:02 ASFSTFKCY APFFAFKCY 64 2656
HLA-A*11:01 STFKCYGVSPTK FAFKCYGVSPTK 25 1030
HLA-A*01:01 NSASFSTFKCY NFAPFFAFKCY 328 13051
HLA-A*68:02 VLYNSASFST VIYNFAPFFA 11417 297
HLA-C*12:03 VLYNSASFS VIYNFAPFF 12383 333
HLA-C*16:01 NSASFSTF NFAPFFAF 243 8562
HLA-A*11:01 ASFSTFKCY APFFAFKCY 379 12606
HLA-C*14:02 VLYNSASFS VIYNFAPFF 11085 360
HLA-A*23:01 NSASFSTF NFAPFFAF 12240 424
HLA-A*29:02 YNSASFSTF YNFAPFFAF 1671 60
HLA-C*16:01 FSTFKCYGV FFAFKCYGV 302 8277
HLA-B*15:01 VLYNSASFS VIYNFAPFF 8189 317
HLA-B*35:01 ASFSTFKCY APFFAFKCY 2345 92
HLA-B*58:01 YSVLYNSASFS YSVIYNFAPFF 6920 277
HLA-C*12:02 ASFSTFKCY APFFAFKCY 338 8222
HLA-A*03:01 STFKCYGVSPTK FAFKCYGVSPTK 83 1880
HLA-A*68:02 NSASFSTFKCYGV NFAPFFAFKCYGV 48 1043
HLA-A*02:06 SVLYNSASFST SVIYNFAPFFA 4097 193
HLA-C*14:02 NSASFSTF NFAPFFAF 2544 120
HLA-B*15:03 ASFSTFKCY APFFAFKCY 25 529
HLA-C*03:02 STFKCYGVS FAFKCYGVS 8370 424
HLA-B*15:01 VLYNSASFSTF VIYNFAPFFAF 50 951
HLA-A*03:02 STFKCYGVSPTK FAFKCYGVSPTK 142 2541
HLA-A*30:02 SASFSTFKCY FAPFFAFKCY 71 1241
HLA-C*14:02 SFSTFKCY PFFAFKCY 386 6449
HLA-B*15:03 YSVLYNSASFS YSVIYNFAPFF 3170 196
HLA-A*11:01 LYNSASFSTFK IYNFAPFFAFK 43 681
HLA-A*30:01 STFKCYGVS FAFKCYGVS 438 6895
HLA-A*68:02 FSTFKCYGV FFAFKCYGV 17 261
HLA-A*32:01 YNSASFSTF YNFAPFFAF 4333 294
HLA-A*02:06 FSTFKCYGV FFAFKCYGV 61 882
HLA-A*33:03 YNSASFSTFK YNFAPFFAFK 823 57
HLA-A*11:01 FSTFKCYGVSPTK FFAFKCYGVSPTK 426 5482
HLA-B*18:01 YNSASFSTF YNFAPFFAF 3495 284
HLA-A*02:06 VLYNSASFST VIYNFAPFFA 710 58
HLA-A*33:03 NSASFSTFK NFAPFFAFK 181 16
HLA-A*30:01 LYNSASFST IYNFAPFFA 3467 316
HLA-C*14:02 FSTFKCYGV FFAFKCYGV 4043 371
HLA-A*11:01 NSASFSTFK NFAPFFAFK 9 94
HLA-A*29:02 NSASFSTFKCY NFAPFFAFKCY 662 64
HLA-A*29:02 YNSASFSTFKCY YNFAPFFAFKCY 842 86
HLA-C*03:02 YSVLYNSASFS YSVIYNFAPFF 2405 260
HLA-A*29:02 ASFSTFKCY APFFAFKCY 201 1830
HLA-A*02:11 SVLYNSASFST SVIYNFAPFFA 3830 425
HLA-A*33:03 SVLYNSASFSTFK SVIYNFAPFFAFK 2778 320
HLA-A*31:01 YNSASFSTFK YNFAPFFAFK 607 73
HLA-B*35:01 SASFSTFKCY FAPFFAFKCY 490 65
HLA-A*30:01 STFKCYGVSPTK FAFKCYGVSPTK 194 1428
HLA-A*30:02 VLYNSASFS VIYNFAPFF 2919 448
HLA-A*31:01 NSASFSTFK NFAPFFAFK 293 47
HLA-B*15:03 VLYNSASFSTF VIYNFAPFFAF 38 235
HLA-A*29:02 LYNSASFSTF IYNFAPFFAF 387 63
HLA-A*31:01 SVLYNSASFSTFK SVIYNFAPFFAFK 857 150
HLA-A*02:01 VLYNSASFST VIYNFAPFFA 243 43
HLA-A*23:01 YNSASFSTF YNFAPFFAF 352 63
HLA-A*03:01 VLYNSASFSTFKC VIYNFAPFFAFKC 312 1619
HLA-A*03:01 LYNSASFSTFK IYNFAPFFAFK 295 1419
HLA-A*03:01 NSASFSTFK NFAPFFAFK 113 494
HLA-B*35:01 YNSASFSTF YNFAPFFAF 760 180
HLA-A*02:02 VLYNSASFST VIYNFAPFFA 202 49
HLA-A*31:01 VLYNSASFSTFK VIYNFAPFFAFK 565 139
HLA-A*01:01 SASFSTFKCY FAPFFAFKCY 461 1849
HLA-A*11:01 SASFSTFK FAPFFAFK 452 1795
HLA-A*03:01 VLYNSASFSTFK VIYNFAPFFAFK 7 27
HLA-A*02:11 VLYNSASFST VIYNFAPFFA 77 20
HLA-A*68:01 SASFSTFK FAPFFAFK 1114 290
HLA-A*03:02 LYNSASFSTFK IYNFAPFFAFK 202 760
HLA-A*31:01 LYNSASFSTFK IYNFAPFFAFK 299 81
HLA-B*15:01 YSVLYNSASFSTF YSVIYNFAPFFAF 164 604
HLA-A*03:02 NSASFSTFK NFAPFFAFK 37 135
HLA-A*30:02 NSASFSTFKCY NFAPFFAFKCY 387 1395
HLA-C*12:03 SASFSTFKCY FAPFFAFKCY 498 139
HLA-A*30:02 VLYNSASFSTFKCY VIYNFAPFFAFKCY 272 973
HLA-B*15:01 LYNSASFSTF IYNFAPFFAF 468 1565
HLA-A*68:01 NSASFSTFK NFAPFFAFK 4 13
HLA-A*11:01 YNSASFSTFK YNFAPFFAFK 12 38
HLA-A*02:06 SASFSTFKCYGV FAPFFAFKCYGV 1416 481
HLA-C*03:02 YSVLYNSASFSTF YSVIYNFAPFFAF 113 331
HLA-A*68:01 FSTFKCYGVSPTK FFAFKCYGVSPTK 288 832
HLA-A*29:02 LYNSASFSTFKCY IYNFAPFFAFKCY 297 105
HLA-A*68:01 VLYNSASFSTFK VIYNFAPFFAFK 257 91
HLA-A*03:02 VLYNSASFSTFK VIYNFAPFFAFK 13 36
HLA-B*58:01 YSVLYNSASFSTF YSVIYNFAPFFAF 429 1153
HLA-C*12:02 SASFSTFKCY FAPFFAFKCY 710 275
HLA-A*02:11 VLYNSASFS VIYNFAPFF 258 645
HLA-A*68:01 NSASFSTFKC NFAPFFAFKC 281 702
HLA-A*33:03 LYNSASFSTFK IYNFAPFFAFK 1158 476
HLA-A*03:01 YNSASFSTFK YNFAPFFAFK 80 194
HLA-A*23:01 SVLYNSASFSTF SVIYNFAPFFAF 656 277
HLA-B*15:01 SASFSTFKCY FAPFFAFKCY 256 561
HLA-C*03:02 SASFSTFKCY FAPFFAFKCY 212 97
HLA-C*14:02 LYNSASFSTF IYNFAPFFAF 20 43
HLA-A*68:01 YSVLYNSASFSTFK YSVIYNFAPFFAFK 144 67
HLA-A*30:01 TFKCYGVSPTK AFKCYGVSPTK 319 155
HLA-A*68:01 SVLYNSASFSTFK SVIYNFAPFFAFK 41 20
HLA-A*03:01 SVLYNSASFSTFK SVIYNFAPFFAFK 47 96
HLA-A*02:01 FSTFKCYGV FFAFKCYGV 457 926

D405N

Reference  YGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 FVIRGDEVR FVIRGNEVS 23 15265
HLA-A*68:01 SFVIRGDEVR SFVIRGNEVS 186 29639
HLA-A*68:01 DSFVIRGDEVR DSFVIRGNEVS 220 29286
HLA-A*33:03 FVIRGDEVR FVIRGNEVS 320 29448
HLA-A*33:03 SFVIRGDEVR SFVIRGNEVS 459 31986
HLA-C*14:02 SFVIRGDEV SFVIRGNEV 216 46
HLA-C*06:02 IRGDEVRQI IRGNEVSQI 147 642

R408S

Reference  SPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 FVIRGDEVR FVIRGNEVS 23 15265
HLA-A*03:01 RQIAPGQTGK SQIAPGQTGN 49 32429
HLA-A*11:01 RQIAPGQTGK SQIAPGQTGN 103 32387
HLA-A*03:02 RQIAPGQTGK SQIAPGQTGN 123 32767
HLA-A*68:01 EVRQIAPGQTGK EVSQIAPGQTGN 144 32361
HLA-A*68:01 SFVIRGDEVR SFVIRGNEVS 186 29639
HLA-A*68:01 DSFVIRGDEVR DSFVIRGNEVS 220 29286
HLA-A*33:03 FVIRGDEVR FVIRGNEVS 320 29448
HLA-A*33:03 SFVIRGDEVR SFVIRGNEVS 459 31986
HLA-A*30:01 RQIAPGQTGK SQIAPGQTGN 275 18394
HLA-C*06:02 IRGDEVRQI IRGNEVSQI 147 642
HLA-B*15:03 RQIAPGQT SQIAPGQT 478 1764
HLA-B*15:03 RQIAPGQTGKIADY SQIAPGQTGNIADY 17 55
HLA-A*30:02 RQIAPGQTGKIADY SQIAPGQTGNIADY 324 951
HLA-B*15:03 RQIAPGQTGKI SQIAPGQTGNI 236 691
HLA-B*15:03 RQIAPGQTG SQIAPGQTG 39 107

K417N

Reference  FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 RQIAPGQTGK SQIAPGQTGN 49 32429
HLA-A*11:01 RQIAPGQTGK SQIAPGQTGN 103 32387
HLA-A*03:02 RQIAPGQTGK SQIAPGQTGN 123 32767
HLA-A*68:01 EVRQIAPGQTGK EVSQIAPGQTGN 144 32361
HLA-A*68:01 QIAPGQTGK QIAPGQTGN 136 27997
HLA-A*11:01 QIAPGQTGK QIAPGQTGN 165 32767
HLA-A*03:02 QIAPGQTGK QIAPGQTGN 278 32767
HLA-A*03:01 QIAPGQTGK QIAPGQTGN 296 32767
HLA-A*32:01 KIADYNYKL NIADYNYKL 58 4480
HLA-A*30:01 RQIAPGQTGK SQIAPGQTGN 275 18394
HLA-A*68:02 KIADYNYKL NIADYNYKL 1274 39
HLA-A*03:02 KIADYNYK NIADYNYK 476 6850
HLA-A*02:06 KIADYNYKL NIADYNYKL 20 101
HLA-A*02:01 KIADYNYKL NIADYNYKL 23 110
HLA-C*17:01 KIADYNYKL NIADYNYKL 155 669
HLA-A*30:01 TGKIADYNYK TGNIADYNYK 292 1164
HLA-A*02:11 KIADYNYKL NIADYNYKL 5 19
HLA-B*15:03 RQIAPGQTGKIADY SQIAPGQTGNIADY 17 55
HLA-A*30:02 RQIAPGQTGKIADY SQIAPGQTGNIADY 324 951
HLA-B*15:03 RQIAPGQTGKI SQIAPGQTGNI 236 691
HLA-A*68:01 TGKIADYNYK TGNIADYNYK 957 343
HLA-A*01:01 QTGKIADYNY QTGNIADYNY 580 270

N440K

Reference  TGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFE
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TGNIADYNYKLPDDFTGCVIAWNSNKLDSKPSGNYNYLYRLFRKSKLKPFE

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 CVIAWNSNN CVIAWNSNK 24486 26
HLA-A*68:01 CVIAWNSNN CVIAWNSNK 11802 16
HLA-A*68:01 FTGCVIAWNSNN FTGCVIAWNSNK 25655 59
HLA-A*03:01 CVIAWNSNN CVIAWNSNK 24643 61
HLA-A*03:02 CVIAWNSNN CVIAWNSNK 22621 61
HLA-A*11:01 GCVIAWNSNN GCVIAWNSNK 32767 94
HLA-A*03:01 GCVIAWNSNN GCVIAWNSNK 32767 128
HLA-A*11:01 TGCVIAWNSNN TGCVIAWNSNK 32767 153
HLA-A*68:01 TGCVIAWNSNN TGCVIAWNSNK 32767 180
HLA-A*68:01 DFTGCVIAWNSNN DFTGCVIAWNSNK 32767 255
HLA-A*03:02 GCVIAWNSNN GCVIAWNSNK 32767 277
HLA-A*11:01 FTGCVIAWNSNN FTGCVIAWNSNK 32767 408
HLA-A*31:01 CVIAWNSNN CVIAWNSNK 18631 279
HLA-A*33:03 CVIAWNSNN CVIAWNSNK 20952 493
HLA-A*30:01 CVIAWNSNN CVIAWNSNK 11396 467
HLA-A*30:02 NLDSKVGGNYNYLY KLDSKPSGNYNYLY 3335 366
HLA-A*02:02 NLDSKVGGNYNYL KLDSKPSGNYNYL 1730 219
HLA-A*02:11 NLDSKVGGNYNYL KLDSKPSGNYNYL 671 104
HLA-A*30:02 NLDSKVGGNY KLDSKPSGNY 422 69
HLA-B*15:01 NLDSKVGGNY KLDSKPSGNY 1404 287
HLA-A*01:01 NLDSKVGGNY KLDSKPSGNY 371 887
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKPSGNYNYLY 193 427
HLA-A*02:11 VIAWNSNNL VIAWNSNKL 269 586
HLA-A*68:02 FTGCVIAWNSNNL FTGCVIAWNSNKL 461 960

445-446 VG->PS

Reference  DYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTE
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    DYNYKLPDDFTGCVIAWNSNKLDSKPSGNYNYLYRLFRKSKLKPFERDISTE

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 KVGGNYNYL KPSGNYNYL 12674 46
HLA-B*42:01 KVGGNYNYL KPSGNYNYL 7890 37
HLA-A*02:11 KVGGNYNYL KPSGNYNYL 111 9769
HLA-B*42:01 SKVGGNYNYL SKPSGNYNYL 18106 267
HLA-A*02:11 KVGGNYNYLYRL KPSGNYNYLYRL 274 16428
HLA-B*07:02 SKVGGNYNYL SKPSGNYNYL 23912 402
HLA-A*02:02 KVGGNYNYL KPSGNYNYL 279 10673
HLA-A*02:06 KVGGNYNYL KPSGNYNYL 452 12158
HLA-A*30:02 KVGGNYNY KPSGNYNY 420 6251
HLA-A*01:01 VGGNYNYLY PSGNYNYLY 2993 213
HLA-B*15:03 SKVGGNYNY SKPSGNYNY 25 286
HLA-A*31:01 KVGGNYNYLYRLFR KPSGNYNYLYRLFR 36 337
HLA-A*30:02 NLDSKVGGNYNYLY KLDSKPSGNYNYLY 3335 366
HLA-A*02:02 NLDSKVGGNYNYL KLDSKPSGNYNYL 1730 219
HLA-A*31:01 KVGGNYNYLYR KPSGNYNYLYR 66 491
HLA-A*30:02 VGGNYNYLY PSGNYNYLY 45 291
HLA-A*02:11 NLDSKVGGNYNYL KLDSKPSGNYNYL 671 104
HLA-B*58:01 KVGGNYNYLY KPSGNYNYLY 1217 190
HLA-A*30:02 NLDSKVGGNY KLDSKPSGNY 422 69
HLA-B*15:03 SKVGGNYNYLY SKPSGNYNYLY 313 1847
HLA-A*24:02 GGNYNYLYRLF SGNYNYLYRLF 1816 313
HLA-A*23:01 VGGNYNYLYRLF PSGNYNYLYRLF 222 1273
HLA-A*68:01 GGNYNYLYR SGNYNYLYR 1245 229
HLA-A*23:01 GGNYNYLYRLF SGNYNYLYRLF 988 186
HLA-A*33:03 GGNYNYLYR SGNYNYLYR 1064 201
HLA-B*15:01 NLDSKVGGNY KLDSKPSGNY 1404 287
HLA-A*29:02 VGGNYNYLY PSGNYNYLY 94 438
HLA-A*24:02 VGGNYNYLYRLF PSGNYNYLYRLF 391 1786
HLA-A*31:01 VGGNYNYLYR PSGNYNYLYR 138 585
HLA-A*29:02 KVGGNYNYLY KPSGNYNYLY 100 414
HLA-A*31:01 VGGNYNYLYRLFR PSGNYNYLYRLFR 253 739
HLA-A*31:01 GGNYNYLYRLFR SGNYNYLYRLFR 153 56
HLA-A*33:03 GGNYNYLYRLFR SGNYNYLYRLFR 636 251
HLA-A*01:01 NLDSKVGGNY KLDSKPSGNY 371 887
HLA-A*33:03 DSKVGGNYNYLYR DSKPSGNYNYLYR 528 224
HLA-A*11:01 GGNYNYLYR SGNYNYLYR 876 391
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKPSGNYNYLY 193 427

N460K

Reference  AWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AWNSNKLDSKPSGNYNYLYRLFRKSKLKPFERDISTEIYQAGNRPCNGVAG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 YLYRLFRKSN YLYRLFRKSK 23374 37
HLA-A*03:02 YLYRLFRKSN YLYRLFRKSK 28215 198
HLA-A*31:01 LYRLFRKSN LYRLFRKSK 21575 190
HLA-A*30:01 LYRLFRKSN LYRLFRKSK 1444 30
HLA-A*31:01 YLYRLFRKSN YLYRLFRKSK 21799 460
HLA-A*30:01 YLYRLFRKSN YLYRLFRKSK 5606 156
HLA-A*11:01 KSNLKPFER KSKLKPFER 401 2898
HLA-B*08:01 FRKSNLKPF FRKSKLKPF 777 126
HLA-A*68:01 YRLFRKSNLK YRLFRKSKLK 353 1913
HLA-A*03:02 RLFRKSNLKP RLFRKSKLKP 220 1183
HLA-B*15:03 FRKSNLKPF FRKSKLKPF 72 372
HLA-A*03:02 LYRLFRKSNLK LYRLFRKSKLK 242 1236
HLA-A*11:01 YRLFRKSNLK YRLFRKSKLK 170 837
HLA-A*30:01 KSNLKPFER KSKLKPFER 964 213
HLA-A*03:02 YRLFRKSNLK YRLFRKSKLK 44 186
HLA-B*15:03 RLFRKSNLKPF RLFRKSKLKPF 56 224
HLA-A*11:01 RLFRKSNLK RLFRKSKLK 24 95
HLA-B*15:01 RLFRKSNLKPF RLFRKSKLKPF 113 395
HLA-B*15:03 LFRKSNLKPF LFRKSKLKPF 393 1267
HLA-A*03:02 YLYRLFRKSNLK YLYRLFRKSKLK 134 416
HLA-B*15:03 YRLFRKSNLKPF YRLFRKSKLKPF 454 1357
HLA-A*32:01 RLFRKSNLKPF RLFRKSKLKPF 121 361
HLA-A*03:01 RLFRKSNLKPF RLFRKSKLKPF 439 1261
HLA-B*15:03 RKSNLKPF RKSKLKPF 191 546
HLA-C*14:02 LFRKSNLKPF LFRKSKLKPF 252 673
HLA-A*03:01 RLFRKSNLKP RLFRKSKLKP 32 82
HLA-C*14:02 FRKSNLKPF FRKSKLKPF 232 584
HLA-C*07:02 FRKSNLKPF FRKSKLKPF 135 324
HLA-A*03:02 RLFRKSNLK RLFRKSKLK 8 19
HLA-A*31:01 RLFRKSNLK RLFRKSKLK 25 59
HLA-A*31:01 LYRLFRKSNLK LYRLFRKSKLK 356 840
HLA-A*03:01 LYRLFRKSNLK LYRLFRKSKLK 65 146
HLA-A*74:01 RLFRKSNLK RLFRKSKLK 77 166

477-478 ST->NR

Reference  LYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    LYRLFRKSKLKPFERDISTEIYQAGNRPCNGVAGPNCYSPLQSYGFRPTYGV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 STEIYQAGST STEIYQAGNR 22142 35
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 217 25822
HLA-B*35:01 TPCNGVEGF RPCNGVAGP 319 26613
HLA-A*33:03 STEIYQAGST STEIYQAGNR 32767 483
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 408 26793
HLA-B*50:01 TEIYQAGSTP TEIYQAGNRP 464 1936
HLA-A*02:11 YQAGSTPCNGV YQAGNRPCNGV 173 656
HLA-A*02:06 YQAGSTPCNGV YQAGNRPCNGV 39 144
HLA-A*02:01 YQAGSTPCNGV YQAGNRPCNGV 420 1481
HLA-A*02:02 YQAGSTPCNGV YQAGNRPCNGV 107 230

E484A

Reference  SNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYR
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SKLKPFERDISTEIYQAGNRPCNGVAGPNCYSPLQSYGFRPTYGVGHQPYR

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:02 VEGFNCYFPL VAGPNCYSPL 31 28153
HLA-B*40:01 VEGFNCYFPL VAGPNCYSPL 76 29734
HLA-C*01:02 EGFNCYFPL AGPNCYSPL 14564 97
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 217 25822
HLA-C*01:02 VEGFNCYFPL VAGPNCYSPL 20165 183
HLA-A*68:02 EGFNCYFPL AGPNCYSPL 117 11181
HLA-B*35:01 TPCNGVEGF RPCNGVAGP 319 26613
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 408 26793
HLA-C*03:02 VEGFNCYFPLQSY VAGPNCYSPLQSY 14989 314
HLA-A*02:11 GVEGFNCYFPL GVAGPNCYSPL 464 2693
HLA-B*35:01 NGVEGFNCY NGVAGPNCY 346 1951
HLA-A*02:06 GVEGFNCYFPL GVAGPNCYSPL 400 2162

F486P

Reference  LKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    LKPFERDISTEIYQAGNRPCNGVAGPNCYSPLQSYGFRPTYGVGHQPYRVV

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:02 VEGFNCYFPL VAGPNCYSPL 31 28153
HLA-B*40:01 VEGFNCYFPL VAGPNCYSPL 76 29734
HLA-B*07:02 GFNCYFPL GPNCYSPL 27420 143
HLA-C*01:02 EGFNCYFPL AGPNCYSPL 14564 97
HLA-B*15:03 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 217 25822
HLA-C*01:02 VEGFNCYFPL VAGPNCYSPL 20165 183
HLA-B*42:01 GFNCYFPL GPNCYSPL 15642 154
HLA-A*68:02 EGFNCYFPL AGPNCYSPL 117 11181
HLA-B*35:01 TPCNGVEGF RPCNGVAGP 319 26613
HLA-B*15:01 YQAGSTPCNGVEGF YQAGNRPCNGVAGP 408 26793
HLA-A*29:02 FNCYFPLQSY PNCYSPLQSY 73 4504
HLA-B*15:03 FNCYFPLQSY PNCYSPLQSY 101 6104
HLA-C*03:02 FNCYFPLQSY PNCYSPLQSY 225 12092
HLA-C*03:02 VEGFNCYFPLQSY VAGPNCYSPLQSY 14989 314
HLA-A*29:02 GFNCYFPLQSY GPNCYSPLQSY 191 7026
HLA-A*02:11 GVEGFNCYFPL GVAGPNCYSPL 464 2693
HLA-B*35:01 NGVEGFNCY NGVAGPNCY 346 1951
HLA-A*02:06 GVEGFNCYFPL GVAGPNCYSPL 400 2162
HLA-A*30:02 FNCYFPLQSY PNCYSPLQSY 425 2051

F490S

Reference  ERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ERDISTEIYQAGNRPCNGVAGPNCYSPLQSYGFRPTYGVGHQPYRVVVLSF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:02 VEGFNCYFPL VAGPNCYSPL 31 28153
HLA-B*40:01 VEGFNCYFPL VAGPNCYSPL 76 29734
HLA-A*68:01 YFPLQSYGFQ YSPLQSYGFR 14480 50
HLA-B*07:02 GFNCYFPL GPNCYSPL 27420 143
HLA-C*03:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 27639 179
HLA-C*01:02 EGFNCYFPL AGPNCYSPL 14564 97
HLA-A*31:01 YFPLQSYGFQ YSPLQSYGFR 16290 110
HLA-B*15:03 FPLQSYGFQPTN SPLQSYGFRPTY 20159 178
HLA-B*15:03 YFPLQSYGFQPTN YSPLQSYGFRPTY 22168 197
HLA-A*33:03 YFPLQSYGFQ YSPLQSYGFR 11148 101
HLA-C*01:02 VEGFNCYFPL VAGPNCYSPL 20165 183
HLA-A*30:02 FPLQSYGFQPTN SPLQSYGFRPTY 21475 197
HLA-C*16:01 YFPLQSYGFQPTN YSPLQSYGFRPTY 29358 276
HLA-B*42:01 GFNCYFPL GPNCYSPL 15642 154
HLA-A*33:03 FPLQSYGFQ SPLQSYGFR 23527 238
HLA-A*68:02 EGFNCYFPL AGPNCYSPL 117 11181
HLA-A*31:01 CYFPLQSYGFQ CYSPLQSYGFR 8535 105
HLA-A*33:03 CYFPLQSYGFQ CYSPLQSYGFR 11311 156
HLA-A*29:02 FNCYFPLQSY PNCYSPLQSY 73 4504
HLA-B*15:03 FNCYFPLQSY PNCYSPLQSY 101 6104
HLA-C*03:02 FNCYFPLQSY PNCYSPLQSY 225 12092
HLA-A*33:03 NCYFPLQSYGFQ NCYSPLQSYGFR 22134 435
HLA-A*30:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 18743 373
HLA-A*29:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 19514 389
HLA-C*03:02 VEGFNCYFPLQSY VAGPNCYSPLQSY 14989 314
HLA-A*29:02 GFNCYFPLQSY GPNCYSPLQSY 191 7026
HLA-C*14:02 YFPLQSYGF YSPLQSYGF 18 646
HLA-B*35:01 FPLQSYGF SPLQSYGF 197 6313
HLA-B*53:01 FPLQSYGF SPLQSYGF 323 8460
HLA-A*29:02 YFPLQSYGF YSPLQSYGF 213 4114
HLA-A*23:01 YFPLQSYGF YSPLQSYGF 49 724
HLA-C*16:01 YFPLQSYGF YSPLQSYGF 4518 311
HLA-A*24:02 YFPLQSYGF YSPLQSYGF 50 655
HLA-C*03:02 YFPLQSYGF YSPLQSYGF 3990 334
HLA-C*01:02 YFPLQSYGF YSPLQSYGF 2910 404
HLA-A*02:11 GVEGFNCYFPL GVAGPNCYSPL 464 2693
HLA-A*02:06 GVEGFNCYFPL GVAGPNCYSPL 400 2162
HLA-C*07:02 YFPLQSYGF YSPLQSYGF 447 2163
HLA-A*30:02 FNCYFPLQSY PNCYSPLQSY 425 2051
HLA-A*29:02 CYFPLQSYGF CYSPLQSYGF 93 444
HLA-A*23:01 NCYFPLQSYGF NCYSPLQSYGF 271 1221
HLA-A*23:01 CYFPLQSYGFQ CYSPLQSYGFR 498 1935
HLA-A*23:01 CYFPLQSYGF CYSPLQSYGF 10 28

Q498R

Reference  YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPAT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YQAGNRPCNGVAGPNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPAT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:02 QSYGFQPTN QSYGFRPTY 12903 18
HLA-B*15:01 LQSYGFQPTN LQSYGFRPTY 6135 9
HLA-C*16:01 QSYGFQPTN QSYGFRPTY 10868 16
HLA-A*29:02 QSYGFQPTN QSYGFRPTY 26152 43
HLA-B*15:03 QSYGFQPTN QSYGFRPTY 6543 11
HLA-B*15:03 LQSYGFQPTN LQSYGFRPTY 2045 4
HLA-C*12:03 QSYGFQPTN QSYGFRPTY 12696 25
HLA-B*15:03 PLQSYGFQPTN PLQSYGFRPTY 22802 60
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-A*68:01 YFPLQSYGFQ YSPLQSYGFR 14480 50
HLA-C*03:02 LQSYGFQPTN LQSYGFRPTY 23421 125
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-A*30:02 QSYGFQPTN QSYGFRPTY 5297 32
HLA-B*35:01 QSYGFQPTN QSYGFRPTY 24615 156
HLA-C*03:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 27639 179
HLA-A*31:01 YFPLQSYGFQ YSPLQSYGFR 16290 110
HLA-C*16:01 LQSYGFQPTN LQSYGFRPTY 27149 187
HLA-A*30:02 LQSYGFQPTN LQSYGFRPTY 7508 54
HLA-B*15:01 QSYGFQPTN QSYGFRPTY 21529 157
HLA-C*12:02 QSYGFQPTN QSYGFRPTY 21029 169
HLA-B*15:03 FPLQSYGFQPTN SPLQSYGFRPTY 20159 178
HLA-B*15:03 YFPLQSYGFQPTN YSPLQSYGFRPTY 22168 197
HLA-A*33:03 YFPLQSYGFQ YSPLQSYGFR 11148 101
HLA-A*30:02 FPLQSYGFQPTN SPLQSYGFRPTY 21475 197
HLA-A*29:02 LQSYGFQPTN LQSYGFRPTY 28458 265
HLA-C*16:01 YFPLQSYGFQPTN YSPLQSYGFRPTY 29358 276
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-A*33:03 FPLQSYGFQ SPLQSYGFR 23527 238
HLA-C*14:02 QSYGFQPTN QSYGFRPTY 25941 277
HLA-C*12:03 LQSYGFQPTN LQSYGFRPTY 26641 325
HLA-A*31:01 CYFPLQSYGFQ CYSPLQSYGFR 8535 105
HLA-B*15:03 LQSYGFQPTNG LQSYGFRPTYG 6387 82
HLA-A*32:01 QSYGFQPTN QSYGFRPTY 16619 226
HLA-A*11:01 QSYGFQPTN QSYGFRPTY 22068 301
HLA-A*33:03 CYFPLQSYGFQ CYSPLQSYGFR 11311 156
HLA-C*02:02 QSYGFQPTN QSYGFRPTY 26598 412
HLA-C*02:10 QSYGFQPTN QSYGFRPTY 26598 412
HLA-A*33:03 NCYFPLQSYGFQ NCYSPLQSYGFR 22134 435
HLA-A*30:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 18743 373
HLA-A*29:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 19514 389
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-B*57:01 QSYGFQPTN QSYGFRPTY 4070 293
HLA-A*30:01 QSYGFQPTN QSYGFRPTY 3720 308
HLA-B*57:01 LQSYGFQPTN LQSYGFRPTY 3839 375
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-B*58:01 QSYGFQPTN QSYGFRPTY 1532 249
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-B*15:03 LQSYGFQPTNGV LQSYGFRPTYGV 1971 442
HLA-A*23:01 CYFPLQSYGFQ CYSPLQSYGFR 498 1935
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355
HLA-A*02:06 QSYGFQPTNGV QSYGFRPTYGV 1121 425
HLA-A*68:02 QSYGFQPTNGV QSYGFRPTYGV 122 47
HLA-A*02:06 LQSYGFQPT LQSYGFRPT 339 871

N501Y

Reference  GSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GNRPCNGVAGPNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:02 QSYGFQPTN QSYGFRPTY 12903 18
HLA-B*15:01 LQSYGFQPTN LQSYGFRPTY 6135 9
HLA-C*16:01 QSYGFQPTN QSYGFRPTY 10868 16
HLA-A*29:02 QSYGFQPTN QSYGFRPTY 26152 43
HLA-B*15:03 QSYGFQPTN QSYGFRPTY 6543 11
HLA-B*15:03 LQSYGFQPTN LQSYGFRPTY 2045 4
HLA-C*12:03 QSYGFQPTN QSYGFRPTY 12696 25
HLA-B*15:03 PLQSYGFQPTN PLQSYGFRPTY 22802 60
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-C*03:02 LQSYGFQPTN LQSYGFRPTY 23421 125
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-A*30:02 QSYGFQPTN QSYGFRPTY 5297 32
HLA-B*35:01 QSYGFQPTN QSYGFRPTY 24615 156
HLA-C*03:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 27639 179
HLA-C*16:01 LQSYGFQPTN LQSYGFRPTY 27149 187
HLA-A*30:02 LQSYGFQPTN LQSYGFRPTY 7508 54
HLA-B*15:01 QSYGFQPTN QSYGFRPTY 21529 157
HLA-C*12:02 QSYGFQPTN QSYGFRPTY 21029 169
HLA-B*15:03 FPLQSYGFQPTN SPLQSYGFRPTY 20159 178
HLA-B*15:03 YFPLQSYGFQPTN YSPLQSYGFRPTY 22168 197
HLA-A*30:02 FPLQSYGFQPTN SPLQSYGFRPTY 21475 197
HLA-A*29:02 LQSYGFQPTN LQSYGFRPTY 28458 265
HLA-C*16:01 YFPLQSYGFQPTN YSPLQSYGFRPTY 29358 276
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*14:02 QSYGFQPTN QSYGFRPTY 25941 277
HLA-C*12:03 LQSYGFQPTN LQSYGFRPTY 26641 325
HLA-B*15:03 LQSYGFQPTNG LQSYGFRPTYG 6387 82
HLA-A*32:01 QSYGFQPTN QSYGFRPTY 16619 226
HLA-A*11:01 QSYGFQPTN QSYGFRPTY 22068 301
HLA-C*02:02 QSYGFQPTN QSYGFRPTY 26598 412
HLA-C*02:10 QSYGFQPTN QSYGFRPTY 26598 412
HLA-A*30:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 18743 373
HLA-A*29:02 YFPLQSYGFQPTN YSPLQSYGFRPTY 19514 389
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-B*57:01 QSYGFQPTN QSYGFRPTY 4070 293
HLA-A*30:01 QSYGFQPTN QSYGFRPTY 3720 308
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-B*57:01 LQSYGFQPTN LQSYGFRPTY 3839 375
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-B*58:01 QSYGFQPTN QSYGFRPTY 1532 249
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-B*15:03 LQSYGFQPTNGV LQSYGFRPTYGV 1971 442
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355
HLA-A*02:06 QSYGFQPTNGV QSYGFRPTYGV 1121 425
HLA-A*68:02 QSYGFQPTNGV QSYGFRPTYGV 122 47
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

Y505H

Reference  CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CNGVAGPNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-B*15:01 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 180 8335
HLA-C*14:02 GYQPYRVVV GHQPYRVVV 78 3539
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-A*24:02 GYQPYRVVVLSF GHQPYRVVVLSF 220 6955
HLA-A*23:01 GYQPYRVVVLSF GHQPYRVVVLSF 107 3241
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:02 QSYGFQPTNGVGY QSYGFRPTYGVGH 258 7114
HLA-B*15:03 LQSYGFQPTNGVGY LQSYGFRPTYGVGH 113 2917
HLA-C*14:02 GYQPYRVVVL GHQPYRVVVL 213 4430
HLA-C*14:02 VGYQPYRVVV VGHQPYRVVV 413 7561
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*02:11 YQPYRVVVL HQPYRVVVL 332 4009
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-A*02:06 YQPYRVVVL HQPYRVVVL 223 2206
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*02:02 YQPYRVVVL HQPYRVVVL 360 2683
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-C*01:02 YQPYRVVVL HQPYRVVVL 41 241
HLA-A*02:06 YQPYRVVVLSFEL HQPYRVVVLSFEL 430 2495
HLA-C*03:03 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*03:04 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*07:02 YQPYRVVVL HQPYRVVVL 135 590
HLA-C*12:03 YQPYRVVVL HQPYRVVVL 132 555
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-C*14:02 YQPYRVVVL HQPYRVVVL 102 347
HLA-C*16:01 YQPYRVVVL HQPYRVVVL 214 726
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-C*12:03 VGYQPYRVV VGHQPYRVV 398 1196
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*23:01 YQPYRVVVLSF HQPYRVVVLSF 465 1280
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

D614G

Reference  PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*05:01 YQDVNCTEV YQGVNCTEV 82 8597
HLA-C*08:02 YQDVNCTEV YQGVNCTEV 89 8066
HLA-A*02:11 DVNCTEVPV GVNCTEVPV 2140 72
HLA-A*02:02 DVNCTEVPV GVNCTEVPV 4099 213
HLA-A*68:02 DVNCTEVPV GVNCTEVPV 36 659
HLA-A*02:06 DVNCTEVPV GVNCTEVPV 3807 208
HLA-A*68:02 QVAVLYQDV QVAVLYQGV 183 13
HLA-A*68:02 NQVAVLYQDV NQVAVLYQGV 650 52
HLA-A*02:06 QVAVLYQDV QVAVLYQGV 1312 148
HLA-A*02:11 QVAVLYQDV QVAVLYQGV 2169 268
HLA-A*68:02 NTSNQVAVLYQDV NTSNQVAVLYQGV 1858 231
HLA-A*68:02 TSNQVAVLYQDV TSNQVAVLYQGV 3281 457
HLA-A*02:02 QVAVLYQDV QVAVLYQGV 1107 188
HLA-A*02:01 YQDVNCTEV YQGVNCTEV 75 315
HLA-A*02:06 YQDVNCTEV YQGVNCTEV 17 57
HLA-A*02:11 VLYQDVNCT VLYQGVNCT 224 74
HLA-A*02:11 YQDVNCTEV YQGVNCTEV 31 93
HLA-A*02:11 VLYQDVNCTEVP VLYQGVNCTEVP 1000 402
HLA-A*02:02 NQVAVLYQDV NQVAVLYQGV 269 116
HLA-A*02:11 AVLYQDVNCTEV AVLYQGVNCTEV 500 238
HLA-A*02:01 NQVAVLYQDV NQVAVLYQGV 558 267
HLA-A*02:06 NQVAVLYQDV NQVAVLYQGV 36 18

H655Y

Reference  TPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:01 RAGCLIGAEH RAGCLIGAEY 7377 156
HLA-A*30:02 RAGCLIGAEH RAGCLIGAEY 1881 43
HLA-B*15:01 FQTRAGCLIGAEH FQTRAGCLIGAEY 7512 178
HLA-B*15:03 FQTRAGCLIGAEH FQTRAGCLIGAEY 5076 125
HLA-A*30:02 AGCLIGAEH AGCLIGAEY 5331 179
HLA-B*15:03 RAGCLIGAEH RAGCLIGAEY 5254 179
HLA-A*30:02 QTRAGCLIGAEH QTRAGCLIGAEY 8425 342
HLA-B*15:03 AGCLIGAEH AGCLIGAEY 9025 461
HLA-A*02:11 HVNNSYECDIPI YVNNSYECDIPI 1593 109
HLA-A*02:01 HVNNSYECDIPI YVNNSYECDIPI 2384 226
HLA-A*02:06 HVNNSYECDIPI YVNNSYECDIPI 837 92
HLA-A*02:02 HVNNSYECDIPI YVNNSYECDIPI 1466 187
HLA-A*02:11 CLIGAEHV CLIGAEYV 983 221
HLA-B*15:03 AEHVNNSY AEYVNNSY 986 267
HLA-B*18:01 AEHVNNSY AEYVNNSY 902 286

N679K

Reference  EHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-A*68:01 CASYQTQTN CASYQTQTK 28102 123
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-A*11:01 CASYQTQTN CASYQTQTK 32767 431
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

P681H

Reference  VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVA
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 SPRRARSVA SHRRARSVA 4 4721
HLA-B*42:01 SPRRARSVA SHRRARSVA 8 6169
HLA-B*07:02 SPRRARSVASQSI SHRRARSVASQSI 17 11433
HLA-B*07:02 SPRRARSV SHRRARSV 24 12728
HLA-B*07:02 SPRRARSVAS SHRRARSVAS 37 14758
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-B*07:02 SPRRARSVASQSII SHRRARSVASQSII 55 17736
HLA-B*42:01 SPRRARSV SHRRARSV 38 11622
HLA-B*42:01 SPRRARSVASQSI SHRRARSVASQSI 48 14418
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*42:01 SPRRARSVAS SHRRARSVAS 158 17461
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-B*42:01 SPRRARSVASQSII SHRRARSVASQSII 321 21521
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-B*08:01 SPRRARSVA SHRRARSVA 372 3831
HLA-B*08:01 SPRRARSV SHRRARSV 428 2448
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

N764K

Reference  TMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:02 LLQYGSFCTQLN LLQYGSFCTQLK 29153 102
HLA-A*11:01 LQYGSFCTQLN LQYGSFCTQLK 32767 191
HLA-A*03:01 LQYGSFCTQLN LQYGSFCTQLK 28204 214
HLA-A*68:01 YGSFCTQLN YGSFCTQLK 23773 187
HLA-A*03:02 LQYGSFCTQLN LQYGSFCTQLK 31227 331
HLA-A*03:02 LLLQYGSFCTQLN LLLQYGSFCTQLK 32767 377
HLA-A*11:01 YGSFCTQLN YGSFCTQLK 32767 386
HLA-A*03:01 LLQYGSFCTQLN LLQYGSFCTQLK 29424 350
HLA-A*03:01 LLLQYGSFCTQLN LLLQYGSFCTQLK 32355 410
HLA-A*02:11 QLNRALTGI QLKRALTGI 27 440
HLA-A*02:11 FCTQLNRALTGI FCTQLKRALTGI 63 898
HLA-B*08:01 CTQLNRAL CTQLKRAL 3325 279
HLA-A*02:01 FCTQLNRALTGI FCTQLKRALTGI 493 4878
HLA-A*02:02 FCTQLNRALTGI FCTQLKRALTGI 62 503
HLA-A*02:02 QLNRALTGI QLKRALTGI 45 307
HLA-C*03:03 FCTQLNRAL FCTQLKRAL 138 752
HLA-C*03:04 FCTQLNRAL FCTQLKRAL 138 752
HLA-A*02:02 TQLNRALTGI TQLKRALTGI 180 882
HLA-A*02:11 TQLNRALTGI TQLKRALTGI 267 1284
HLA-B*27:05 NRALTGIAV KRALTGIAV 1251 276
HLA-A*02:11 QLNRALTGIAV QLKRALTGIAV 259 1123
HLA-C*03:02 FCTQLNRAL FCTQLKRAL 361 1438
HLA-C*14:02 SFCTQLNRAL SFCTQLKRAL 234 511
HLA-A*02:06 TQLNRALTGI TQLKRALTGI 54 113

D796Y

Reference  AVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*23:01 KDFGGFNF KYFGGFNF 15419 23
HLA-A*23:01 KDFGGFNFSQI KYFGGFNFSQI 15932 37
HLA-A*24:02 KDFGGFNF KYFGGFNF 21008 55
HLA-C*14:02 IYKTPPIKD IYKTPPIKY 16538 55
HLA-A*24:02 KDFGGFNFSQI KYFGGFNFSQI 20251 68
HLA-B*15:03 KQIYKTPPIKD KQIYKTPPIKY 7773 29
HLA-A*23:01 KDFGGFNFSQIL KYFGGFNFSQIL 15831 63
HLA-C*14:02 KDFGGFNF KYFGGFNF 22081 90
HLA-A*24:02 KDFGGFNFSQIL KYFGGFNFSQIL 21565 126
HLA-B*15:01 KQIYKTPPIKD KQIYKTPPIKY 22193 141
HLA-C*14:02 KDFGGFNFSQIL KYFGGFNFSQIL 14873 165
HLA-A*30:01 KDFGGFNFS KYFGGFNFS 9496 156
HLA-C*14:02 DFGGFNFSQIL YFGGFNFSQIL 6960 139
HLA-A*30:02 KQIYKTPPIKD KQIYKTPPIKY 15917 386
HLA-B*15:03 VKQIYKTPPIKD VKQIYKTPPIKY 16977 446
HLA-B*15:03 IKDFGGFNF IKYFGGFNF 97 4
HLA-B*15:03 PIKDFGGFNF PIKYFGGFNF 7546 321
HLA-B*15:03 TPPIKDFGGFNF TPPIKYFGGFNF 10071 484
HLA-B*15:03 KTPPIKDFGGFNF KTPPIKYFGGFNF 6427 331
HLA-A*32:01 KTPPIKDFGGFNF KTPPIKYFGGFNF 6031 381
HLA-A*23:01 DFGGFNFSQI YFGGFNFSQI 5424 461
HLA-B*15:03 YKTPPIKDFGGFNF YKTPPIKYFGGFNF 2588 394
HLA-C*06:02 YKTPPIKDF YKTPPIKYF 2488 460
HLA-C*07:02 YKTPPIKDF YKTPPIKYF 1804 378
HLA-A*23:01 IYKTPPIKDF IYKTPPIKYF 273 98
HLA-A*24:02 IYKTPPIKDF IYKTPPIKYF 375 147
HLA-C*14:02 IYKTPPIKDF IYKTPPIKYF 341 158
HLA-B*15:03 YKTPPIKDF YKTPPIKYF 92 43

Q954H

Reference  SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLND

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*38:01 NQNAQALNTL NHNAQALNTL 2805 97
HLA-A*68:02 DVVNQNAQA DVVNHNAQA 703 344

N969K

Reference  ALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQID
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQID

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 TLVKQLSSN TLVKQLSSK 29207 56
HLA-A*68:01 NTLVKQLSSN NTLVKQLSSK 28063 86
HLA-A*11:01 TLVKQLSSN TLVKQLSSK 32767 125
HLA-A*03:02 TLVKQLSSN TLVKQLSSK 31915 131
HLA-A*11:01 NTLVKQLSSN NTLVKQLSSK 32767 147
HLA-A*03:01 ALNTLVKQLSSN ALNTLVKQLSSK 32767 154
HLA-A*03:02 ALNTLVKQLSSN ALNTLVKQLSSK 32767 304
HLA-A*03:01 NTLVKQLSSN NTLVKQLSSK 32767 482
HLA-A*68:02 SNFGAISSV SKFGAISSV 117 5329
HLA-B*15:03 SNFGAISSVL SKFGAISSVL 688 25
HLA-B*08:01 QLSSNFGAI QLSSKFGAI 4755 265
HLA-C*15:02 SNFGAISSV SKFGAISSV 374 5700
HLA-A*30:01 SSNFGAISS SSKFGAISS 1320 88
HLA-B*15:03 SNFGAISSV SKFGAISSV 727 49
HLA-A*30:01 SSNFGAISSV SSKFGAISSV 587 71
HLA-A*02:06 KQLSSNFGA KQLSSKFGA 62 269
HLA-A*02:01 KQLSSNFGAI KQLSSKFGAI 407 1567
HLA-A*02:11 KQLSSNFGA KQLSSKFGA 228 807
HLA-A*02:06 SNFGAISSV SKFGAISSV 361 1100
HLA-C*06:02 SNFGAISSV SKFGAISSV 1423 485
HLA-A*02:11 KQLSSNFGAI KQLSSKFGAI 152 428
HLA-A*02:06 KQLSSNFGAI KQLSSKFGAI 58 159
HLA-A*02:02 KQLSSNFGAI KQLSSKFGAI 261 668
HLA-B*15:03 KQLSSNFGA KQLSSKFGA 497 1076

N protein

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N

P13L

Reference  MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSK
           |||||||||||| |||||||||||||||||||||||||
Mutated    MSDNGPQNQRNALRITFGGPSDSTGSNQNGERGGARSK

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 MSDNGPQNQRNAP MSDNGPQNQRNAL 11146 27
HLA-B*07:02 GPQNQRNAP GPQNQRNAL 2464 6
HLA-B*42:01 GPQNQRNAP GPQNQRNAL 3035 8
HLA-B*07:02 SDNGPQNQRNAP SDNGPQNQRNAL 11353 32
HLA-B*42:01 SDNGPQNQRNAP SDNGPQNQRNAL 13042 39
HLA-B*42:01 NGPQNQRNAP NGPQNQRNAL 12875 41
HLA-B*07:02 MSDNGPQNQRNAP MSDNGPQNQRNAL 13138 58
HLA-B*07:02 NGPQNQRNAP NGPQNQRNAL 14898 72
HLA-B*07:02 APRITFGGPS ALRITFGGPS 191 17534
HLA-B*42:01 PQNQRNAP PQNQRNAL 30142 436
HLA-B*07:02 GPQNQRNAPR GPQNQRNALR 13964 345
HLA-B*27:05 QRNAPRITF QRNALRITF 509 83
HLA-B*27:05 NQRNAPRITF NQRNALRITF 1716 350
HLA-B*27:05 GPQNQRNAPRITF GPQNQRNALRITF 2076 442
HLA-B*15:01 NQRNAPRITF NQRNALRITF 96 40

S33G

Reference  NQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQ
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NQRNALRITFGGPSDSTGSNQNGERGGARSKQRRPQGLPNNTASWFTALTQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 RSGARSKQR RGGARSKQR 77 488
HLA-A*31:01 RSGARSKQRR RGGARSKQRR 254 1585

203-204 RG->KR

Reference  GGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQ
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    GGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 NSTPGSSRG NSTPGSSKR 32767 34
HLA-A*33:03 NSTPGSSRG NSTPGSSKR 32767 300
HLA-B*15:03 SRGTSPARM SKRTSPARM 2669 106
HLA-A*31:01 RNSTPGSSRG RNSTPGSSKR 7013 340
HLA-A*30:01 SSRNSTPGSSR SSRNSTPGSSK 356 20
HLA-A*30:01 GTSPARMAG RTSPARMAG 493 30
HLA-A*31:01 SSRNSTPGSSRG SSRNSTPGSSKR 3757 231
HLA-A*30:01 GTSPARMAGNGG RTSPARMAGNGG 6051 411
HLA-A*31:01 SSRNSTPGSSR SSRNSTPGSSK 127 1853
HLA-A*30:01 NSSRNSTPGSSR NSSRNSTPGSSK 4255 353
HLA-A*30:01 RNSTPGSSR RNSTPGSSK 2120 188
HLA-A*31:01 RNSTPGSSR RNSTPGSSK 123 1335
HLA-A*03:01 SSRNSTPGSSR SSRNSTPGSSK 4753 442
HLA-A*11:01 SSRNSTPGSSR SSRNSTPGSSK 2231 263
HLA-A*68:01 NSSRNSTPGSSR NSSRNSTPGSSK 270 1385
HLA-A*30:01 GSSRGTSPA GSSKRTSPA 555 145
HLA-A*30:01 SSRNSTPGSSRG SSRNSTPGSSKR 1625 469
HLA-A*30:01 SSRGTSPARMAG SSKRTSPARMAG 449 1031

S413R

Reference  KQQTVTLLPAADLDDFSKQLQQSMSSADSTQA
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Mutated    KQQTVTLLPAADLDDFSKQLQQSMSRADSTQA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 KQLQQSMSS KQLQQSMSR 20016 55
HLA-A*30:01 MSSADSTQA MSRADSTQA 2953 37
HLA-A*33:03 DFSKQLQQSMSS DFSKQLQQSMSR 32767 494
HLA-B*15:03 KQLQQSMSS KQLQQSMSR 236 5105
HLA-A*30:01 SMSSADSTQA SMSRADSTQA 6453 416
HLA-A*02:02 FSKQLQQSMSSA FSKQLQQSMSRA 345 1138
HLA-A*02:11 FSKQLQQSMSSA FSKQLQQSMSRA 353 1118
HLA-A*02:11 QLQQSMSSA QLQQSMSRA 436 1175
HLA-A*02:02 SMSSADSTQA SMSRADSTQA 355 725

M protein

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M

Q19E

Reference  MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*44:03 EQWNLVIGF EEWNLVIGF 1268 15
HLA-B*44:02 EQWNLVIGF EEWNLVIGF 2396 34
HLA-B*44:03 EQWNLVIGFLF EEWNLVIGFLF 5200 85
HLA-B*44:03 EQWNLVIGFL EEWNLVIGFL 8038 135
HLA-B*44:03 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5966 126
HLA-B*44:02 EQWNLVIGFLF EEWNLVIGFLF 6607 162
HLA-B*44:02 EQWNLVIGFL EEWNLVIGFL 9054 237
HLA-B*44:02 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5922 170
HLA-B*15:01 LEQWNLVIGF LEEWNLVIGF 256 8100
HLA-B*18:01 EQWNLVIGF EEWNLVIGF 482 16
HLA-A*02:06 EQWNLVIGFL EEWNLVIGFL 418 10916
HLA-B*15:03 EQWNLVIGF EEWNLVIGF 101 2397
HLA-B*18:01 EQWNLVIGFLF EEWNLVIGFLF 3471 190
HLA-B*40:02 EQWNLVIGFL EEWNLVIGFL 3775 245
HLA-B*15:03 LEQWNLVIGF LEEWNLVIGF 88 1227
HLA-B*40:02 EQWNLVIGF EEWNLVIGF 1765 242
HLA-B*15:03 KLLEQWNLVIGF KLLEEWNLVIGF 365 2285
HLA-A*02:11 LLEQWNLVI LLEEWNLVI 142 24
HLA-A*02:11 LLEQWNLVIGFL LLEEWNLVIGFL 1120 210
HLA-A*02:01 LLEQWNLVI LLEEWNLVI 644 131
HLA-A*29:02 QWNLVIGFLF EWNLVIGFLF 159 780
HLA-A*24:02 QWNLVIGFLF EWNLVIGFLF 53 246
HLA-A*23:01 QWNLVIGFLF EWNLVIGFLF 18 79
HLA-A*02:02 LLEQWNLVI LLEEWNLVI 781 187
HLA-A*02:06 LLEQWNLVI LLEEWNLVI 1869 487
HLA-B*40:02 LEQWNLVI LEEWNLVI 367 1301
HLA-A*02:02 LLEQWNLVIGFL LLEEWNLVIGFL 1047 329

A63T

Reference  AYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLV
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Mutated    AYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*35:01 LACFVLAAVY LTCFVLAAVY 121 1943
HLA-A*68:01 ACFVLAAVYR TCFVLAAVYR 694 80
HLA-B*35:01 ACFVLAAVY TCFVLAAVY 2289 331
HLA-C*03:02 LACFVLAAVY LTCFVLAAVY 145 935
HLA-C*16:01 LACFVLAAV LTCFVLAAV 346 1994
HLA-A*02:01 WLLWPVTLA WLLWPVTLT 33 190
HLA-A*02:02 WLLWPVTLA WLLWPVTLT 32 180
HLA-A*02:11 LWLLWPVTLA LWLLWPVTLT 66 363
HLA-A*02:11 IFLWLLWPVTLA IFLWLLWPVTLT 190 1034
HLA-A*02:11 LLWPVTLA LLWPVTLT 242 1313
HLA-A*33:03 ACFVLAAVYR TCFVLAAVYR 252 47
HLA-A*02:02 LWLLWPVTLA LWLLWPVTLT 304 1623
HLA-C*12:03 LACFVLAAV LTCFVLAAV 214 1116
HLA-A*02:06 WLLWPVTLA WLLWPVTLT 60 302
HLA-A*02:01 LWLLWPVTLA LWLLWPVTLT 228 1142
HLA-A*02:02 TLACFVLAAVY TLTCFVLAAVY 337 1467
HLA-A*02:02 VTLACFVLAAV VTLTCFVLAAV 160 678
HLA-A*68:02 LACFVLAAV LTCFVLAAV 44 11
HLA-A*02:02 PVTLACFVLAAV PVTLTCFVLAAV 479 1907
HLA-A*02:11 LIFLWLLWPVTLA LIFLWLLWPVTLT 406 1602
HLA-A*02:02 TLACFVLAAVYRI TLTCFVLAAVYRI 293 1148
HLA-A*02:11 LACFVLAAV LTCFVLAAV 122 32
HLA-A*02:11 WLLWPVTLA WLLWPVTLT 6 22
HLA-B*15:03 LACFVLAAVY LTCFVLAAVY 81 284
HLA-A*68:02 TLACFVLAA TLTCFVLAA 395 1376
HLA-A*02:02 FLWLLWPVTLACFV FLWLLWPVTLTCFV 485 146
HLA-A*68:01 LACFVLAAVY LTCFVLAAVY 1184 359
HLA-A*02:02 TLACFVLAA TLTCFVLAA 13 41
HLA-A*02:11 TLACFVLAAVY TLTCFVLAAVY 310 929
HLA-A*02:02 FLWLLWPVTLA FLWLLWPVTLT 291 867
HLA-A*02:11 KLIFLWLLWPVTLA KLIFLWLLWPVTLT 290 859
HLA-A*29:02 LACFVLAAVY LTCFVLAAVY 232 81
HLA-A*02:02 VTLACFVLAA VTLTCFVLAA 100 285
HLA-A*02:06 TLACFVLAAV TLTCFVLAAV 16 45
HLA-A*68:02 VTLACFVLAA VTLTCFVLAA 481 1321
HLA-B*15:01 TLACFVLAAVY TLTCFVLAAVY 414 1136
HLA-A*23:01 LWPVTLACF LWPVTLTCF 57 155
HLA-A*24:02 LWPVTLACF LWPVTLTCF 49 133
HLA-A*02:11 FLWLLWPVTLA FLWLLWPVTLT 25 67
HLA-A*02:06 TLACFVLAA TLTCFVLAA 40 107
HLA-A*02:01 LACFVLAAV LTCFVLAAV 471 179
HLA-A*02:02 TLACFVLAAV TLTCFVLAAV 5 13
HLA-A*02:11 VTLACFVLAA VTLTCFVLAA 97 245
HLA-A*02:01 FLWLLWPVTLA FLWLLWPVTLT 107 269
HLA-A*02:06 FLWLLWPVTLA FLWLLWPVTLT 495 1240
HLA-A*02:11 TLACFVLAA TLTCFVLAA 8 20
HLA-A*02:11 VTLACFVLAAV VTLTCFVLAAV 128 318
HLA-A*02:01 TLACFVLAAV TLTCFVLAAV 11 27
HLA-A*02:02 LACFVLAAV LTCFVLAAV 198 81
HLA-A*02:01 TLACFVLAA TLTCFVLAA 25 61
HLA-A*02:01 VTLACFVLAAV VTLTCFVLAAV 436 1029
HLA-B*07:02 WPVTLACFVL WPVTLTCFVL 362 155
HLA-A*02:01 FLWLLWPVTLACFV FLWLLWPVTLTCFV 329 142
HLA-A*02:11 TLACFVLAAV TLTCFVLAAV 4 9
HLA-A*30:02 LACFVLAAVY LTCFVLAAVY 218 98
HLA-A*02:06 LACFVLAAV LTCFVLAAV 51 23
HLA-A*03:02 TLACFVLAAVYR TLTCFVLAAVYR 480 1047
HLA-A*68:02 TLACFVLAAV TLTCFVLAAV 26 12
HLA-B*42:01 WPVTLACFV WPVTLTCFV 209 102
HLA-A*32:01 LLWPVTLACF LLWPVTLTCF 427 212

E protein

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E

T9I

Reference  MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAIL
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Mutated    MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAIL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*24:02 MYSFVSEET MYSFVSEEI 5532 18
HLA-A*23:01 MYSFVSEET MYSFVSEEI 5604 31
HLA-C*16:01 YSFVSEET YSFVSEEI 7157 226
HLA-C*14:02 MYSFVSEET MYSFVSEEI 901 30
HLA-C*12:03 YSFVSEET YSFVSEEI 10273 457
HLA-A*68:02 FVSEETGTLI FVSEEIGALI 247 22
HLA-A*68:02 MYSFVSEET MYSFVSEEI 3879 472
HLA-A*02:11 FVSEETGTLI FVSEEIGALI 307 45
HLA-A*02:01 FVSEETGTLI FVSEEIGALI 1293 202
HLA-A*02:06 FVSEETGTLI FVSEEIGALI 423 84
HLA-A*02:02 FVSEETGTLI FVSEEIGALI 85 20
HLA-A*26:01 FVSEETGTL FVSEEIGAL 1352 323
HLA-A*02:06 FVSEETGTL FVSEEIGAL 120 30
HLA-A*68:02 YSFVSEETGTLI YSFVSEEIGALI 1008 253
HLA-B*40:01 EETGTLIVNSVL EEIGALIVNSVL 1578 420
HLA-A*24:02 MYSFVSEETGTL MYSFVSEEIGAL 363 1234
HLA-A*23:01 MYSFVSEETGTL MYSFVSEEIGAL 431 1384
HLA-A*02:01 FVSEETGTL FVSEEIGAL 575 183
HLA-A*02:06 FVSEETGTLIV FVSEEIGALIV 670 227
HLA-A*02:11 FVSEETGTL FVSEEIGAL 97 35
HLA-B*44:03 EETGTLIVNSVLLF EEIGALIVNSVLLF 877 385

T11A

Reference  MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTA
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Mutated    MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAILTA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:02 FVSEETGTLI FVSEEIGALI 247 22
HLA-C*03:03 GTLIVNSVL GALIVNSVL 2389 293
HLA-C*03:04 GTLIVNSVL GALIVNSVL 2389 293
HLA-A*02:11 FVSEETGTLI FVSEEIGALI 307 45
HLA-A*02:01 FVSEETGTLI FVSEEIGALI 1293 202
HLA-A*02:06 FVSEETGTLI FVSEEIGALI 423 84
HLA-A*02:02 FVSEETGTLI FVSEEIGALI 85 20
HLA-A*26:01 FVSEETGTL FVSEEIGAL 1352 323
HLA-A*02:06 FVSEETGTL FVSEEIGAL 120 30
HLA-A*68:02 YSFVSEETGTLI YSFVSEEIGALI 1008 253
HLA-B*40:01 EETGTLIVNSVL EEIGALIVNSVL 1578 420
HLA-A*24:02 MYSFVSEETGTL MYSFVSEEIGAL 363 1234
HLA-A*23:01 MYSFVSEETGTL MYSFVSEEIGAL 431 1384
HLA-A*02:01 FVSEETGTL FVSEEIGAL 575 183
HLA-A*02:06 FVSEETGTLIV FVSEEIGALIV 670 227
HLA-A*02:11 FVSEETGTL FVSEEIGAL 97 35
HLA-B*44:03 EETGTLIVNSVLLF EEIGALIVNSVLLF 877 385

NS3 protein

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NS3

T223I

Reference  KDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHT
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Mutated    KDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:03 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*03:04 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*12:03 YSTQLSTDT YSTQLSTDI 11751 430
HLA-C*16:01 YSTQLSTDT YSTQLSTDI 7819 294
HLA-C*03:02 YSTQLSTDT YSTQLSTDI 6466 347
HLA-A*02:06 YQLYSTQLSTDT YQLYSTQLSTDI 4179 287
HLA-A*02:11 QLYSTQLSTDT QLYSTQLSTDI 5151 437
HLA-A*68:01 TGVEHVTFFIYNK IGVEHVTFFIYNK 213 1427
HLA-A*68:02 LSTDTGVEHV LSTDIGVEHV 1765 265
HLA-A*68:02 TGVEHVTFFI IGVEHVTFFI 212 1093
HLA-A*02:01 TQLSTDTGV TQLSTDIGV 1084 283
HLA-A*02:01 YSTQLSTDTGV YSTQLSTDIGV 1288 379
HLA-A*02:11 STQLSTDTGV STQLSTDIGV 1485 443
HLA-A*25:01 DTGVEHVTFF DIGVEHVTFF 180 596
HLA-A*02:11 TQLSTDTGV TQLSTDIGV 436 133
HLA-A*02:06 STQLSTDTGV STQLSTDIGV 264 83
HLA-A*02:11 YSTQLSTDTGV YSTQLSTDIGV 1184 381
HLA-A*26:01 DTGVEHVTFF DIGVEHVTFF 37 108
HLA-A*02:06 YSTQLSTDTGV YSTQLSTDIGV 157 56
HLA-C*03:02 TGVEHVTFF IGVEHVTFF 237 88
HLA-A*02:06 TQLSTDTGV TQLSTDIGV 70 26
HLA-B*15:03 TGVEHVTFF IGVEHVTFF 305 115
HLA-A*02:06 LYSTQLSTDTGV LYSTQLSTDIGV 855 330
HLA-C*16:01 TGVEHVTFF IGVEHVTFF 392 185

NS8 protein

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NS8

G8stop

Reference  MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI
           |||||||                                                                                                                  
Mutated    MKFLVFL‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 YIDIGNYTV - 3 -
HLA-A*29:02 SFYEDFLEY - 3 -
HLA-A*31:01 HFYSKWYIR - 4 -
HLA-A*02:11 FLEYHDVRV - 5 -
HLA-A*33:03 HFYSKWYIR - 5 -
HLA-A*02:06 YIDIGNYTV - 6 -
HLA-B*15:03 IQYIDIGNY - 6 -
HLA-A*02:11 FLVFLGIITTV FLVFL 7 -
HLA-A*68:01 FTINCQEPK - 7 -
HLA-A*02:01 YIDIGNYTV - 8 -
HLA-A*02:02 FLEYHDVRV - 9 -
HLA-A*02:11 FLGIITTV FL 9 -
HLA-A*02:06 YVVDDPCPI - 10 -
HLA-A*02:11 FLEYHDVRVV - 10 -
HLA-B*15:03 LQSCTQHQPY - 10 -
HLA-C*14:02 SFYEDFLEY - 10 -
HLA-A*02:11 YVVDDPCPI - 13 -
HLA-A*31:01 IHFYSKWYIR - 13 -
HLA-B*53:01 CPIHFYSKW - 13 -
HLA-C*14:02 NYTVSCLPF - 13 -
HLA-B*15:01 LQSCTQHQPY - 14 -
HLA-A*29:02 CSFYEDFLEY - 15 -
HLA-A*02:02 YIDIGNYTV - 16 -
HLA-C*05:01 YIDIGNYTV - 16 -
HLA-A*02:06 YTVSCLPFTI - 18 -
HLA-B*15:01 LGIITTVAAF L 18 -
HLA-B*15:01 GIITTVAAF - 18 -
HLA-A*68:02 TVSCLPFTI - 19 -
HLA-A*02:11 FLGIITTVA FL 20 -
HLA-A*02:01 FLEYHDVRV - 22 -
HLA-A*31:01 KWYIRVGAR - 22 -
HLA-A*02:02 FLEYHDVRVV - 24 -
HLA-A*68:02 YTVSCLPFTI - 24 -
HLA-A*02:01 FLVFLGIITTV FLVFL 25 -
HLA-A*02:11 LVFLGIITTV LVFL 25 -
HLA-A*02:02 FLGIITTVA FL 27 -
HLA-A*02:02 FLGIITTV FL 29 -
HLA-A*02:02 YVVDDPCPI - 29 -
HLA-A*02:11 YTVSCLPFTI - 29 -
HLA-C*03:03 YVVDDPCPI - 29 -
HLA-C*03:04 YVVDDPCPI - 29 -
HLA-A*11:01 FTINCQEPK - 30 -
HLA-C*08:02 YIDIGNYTV - 30 -
HLA-A*02:06 LVFLGIITTV LVFL 31 -
HLA-A*02:11 SLQSCTQHQPYV - 31 -
HLA-A*31:01 HFYSKWYIRVGAR - 31 -
HLA-A*02:11 TVSCLPFTI - 32 -
HLA-A*33:03 HFYSKWYIRVGAR - 32 -
HLA-B*15:01 IQYIDIGNY - 32 -
HLA-B*40:01 LEYHDVRVVL - 32 -
HLA-A*33:03 IHFYSKWYIR - 35 -
HLA-A*02:02 YTVSCLPFTI - 36 -
HLA-A*02:11 KFLVFLGIITTV KFLVFL 36 -
HLA-C*14:02 EYHDVRVVL - 38 -
HLA-A*30:02 IQYIDIGNY - 39 -
HLA-B*15:03 SFYEDFLEY - 39 -
HLA-B*15:03 GIITTVAAF - 40 -
HLA-A*02:01 FLGIITTV FL 42 -
HLA-A*02:11 FLVFLGIITT FLVFL 45 -
HLA-A*02:01 FLEYHDVRVV - 46 -
HLA-A*02:02 FLGIITTVAA FL 47 -
HLA-A*24:02 NYTVSCLPF - 47 -
HLA-A*30:01 GSKSPIQYI - 47 -
HLA-A*02:11 FLGIITTVAA FL 48 -
HLA-B*40:02 LEYHDVRVVL - 49 -
HLA-C*03:02 YTVSCLPF - 52 -
HLA-A*23:01 NYTVSCLPF - 53 -
HLA-A*30:02 GSLVVRCSFY - 54 -
HLA-A*29:02 VRCSFYEDFLEY - 55 -
HLA-A*30:01 GARKSAPLI - 55 -
HLA-B*08:01 YIRVGARKSAPL - 55 -
HLA-C*03:02 YVVDDPCPI - 55 -
HLA-A*02:11 FLVFLGIITTVA FLVFL 56 -
HLA-A*02:02 FLVFLGIITTV FLVFL 57 -
HLA-A*68:02 YVVDDPCPI - 57 -
HLA-A*02:01 YVVDDPCPI - 59 -
HLA-A*02:06 YTVSCLPFT - 59 -
HLA-B*15:03 RKSAPLIEL - 59 -
HLA-A*29:02 RCSFYEDFLEY - 60 -
HLA-A*29:02 VVRCSFYEDFLEY - 61 -
HLA-A*02:02 TVSCLPFTI - 63 -
HLA-A*02:06 FLVFLGIITTV FLVFL 64 -
HLA-C*03:03 AAFHQECSL - 65 -
HLA-C*03:04 AAFHQECSL - 65 -
HLA-A*68:02 LVFLGIITTV LVFL 66 -
HLA-B*15:03 MKFLVFLGI MKFLVFL 73 -
HLA-C*16:01 AAFHQECSL - 73 -
HLA-A*31:01 CPIHFYSKWYIR - 74 -
HLA-A*30:01 RVGARKSAPLI - 75 -
HLA-A*01:01 CSFYEDFLEY - 76 -
HLA-A*02:06 FLEYHDVRV - 80 -
HLA-A*02:01 FLVFLGIITT FLVFL 83 -
HLA-A*02:02 FLVFLGIITT FLVFL 83 -
HLA-A*29:02 SLVVRCSFY - 84 -
HLA-A*30:02 LQSCTQHQPY - 84 -
HLA-A*02:06 TVSCLPFTI - 85 -
HLA-A*02:02 FLEYHDVRVVL - 86 -
HLA-A*30:02 CSFYEDFLEY - 89 -
HLA-A*02:11 VFLGIITTV VFL 90 -
HLA-A*30:02 SFYEDFLEY - 90 -
HLA-C*14:02 LEYHDVRVVL - 90 -
HLA-A*02:01 YTVSCLPFTI - 93 -
HLA-A*02:02 LVFLGIITTV LVFL 94 -
HLA-B*58:01 YTVSCLPFTI - 94 -
HLA-A*02:01 LVFLGIITTV LVFL 96 -
HLA-C*12:03 YVVDDPCPI - 97 -
HLA-A*29:02 YVVDDPCPIHFY - 98 -
HLA-A*31:01 HFYSKWYIRV - 98 -
HLA-A*02:11 KLGSLVVRC - 101 -
HLA-B*15:03 GNYTVSCLPF - 101 -
HLA-A*30:02 SLVVRCSFY - 103 -
HLA-A*26:01 YVVDDPCPIHFY - 106 -
HLA-A*02:02 SLQSCTQHQPYV - 108 -
HLA-A*29:02 SFYEDFLEYH - 110 -
HLA-A*68:02 FTINCQEPKL - 113 -
HLA-B*15:01 SLVVRCSFY - 115 -
HLA-C*14:02 FYEDFLEY - 116 -
HLA-A*33:03 DFLEYHDVR - 117 -
HLA-A*02:01 FLGIITTVA FL 118 -
HLA-B*42:01 EPKLGSLVV - 118 -
HLA-A*31:01 YSKWYIRVGAR - 120 -
HLA-A*03:02 FTINCQEPK - 121 -
HLA-A*02:01 FLGIITTVAA FL 122 -
HLA-A*30:02 KSPIQYIDIGNY - 122 -
HLA-B*40:02 LEYHDVRVV - 122 -
HLA-A*33:03 CPIHFYSKWYIR - 123 -
HLA-B*15:03 LGIITTVAAF L 123 -
HLA-C*14:02 FLEYHDVRVVL - 126 -
HLA-B*15:03 CSFYEDFLEY - 128 -
HLA-B*35:01 SFYEDFLEY - 128 -
HLA-A*68:01 PFTINCQEPK - 130 -
HLA-B*15:03 SLVVRCSFY - 130 -
HLA-B*15:01 FLGIITTVAAF FL 131 -
HLA-A*33:03 FYSKWYIRVGAR - 133 -
HLA-B*15:03 GSLVVRCSF - 133 -
HLA-A*02:06 FLGIITTV FL 134 -
HLA-A*02:06 FTINCQEPKL - 134 -
HLA-A*02:11 QYIDIGNYTV - 135 -
HLA-A*02:11 FLEYHDVRVVL - 137 -
HLA-A*02:01 KFLVFLGIITTV KFLVFL 138 -
HLA-B*57:01 LGSLVVRCSF - 138 -
HLA-A*02:02 FTINCQEPKL - 140 -
HLA-A*31:01 KWYIRVGARK - 145 -
HLA-A*68:01 HFYSKWYIR - 146 -
HLA-A*30:01 KWYIRVGARK - 149 -
HLA-C*03:02 SFYEDFLEY - 152 -
HLA-C*12:02 YVVDDPCPI - 156 -
HLA-A*31:01 PIHFYSKWYIR - 158 -
HLA-B*15:03 YTVSCLPF - 158 -
HLA-C*07:02 SFYEDFLEY - 160 -
HLA-A*33:03 YSKWYIRVGAR - 162 -
HLA-C*17:01 YVVDDPCPI - 163 -
HLA-A*02:01 SLQSCTQHQPYV - 164 -
HLA-B*38:01 IHFYSKWYI - 168 -
HLA-A*23:01 FYSKWYIRV - 171 -
HLA-A*29:02 LVVRCSFYEDFLEY - 171 -
HLA-A*02:11 SLQSCTQHQPYVV - 172 -
HLA-A*23:01 QYIDIGNYTV - 174 -
HLA-A*33:03 FYSKWYIR - 174 -
HLA-A*33:03 HFYSKWYIRV - 176 -
HLA-B*58:01 KSAPLIELCV - 177 -
HLA-A*23:01 VFLGIITTVAAF VFL 180 -
HLA-C*17:01 YIDIGNYTV - 181 -
HLA-B*58:01 LGSLVVRCSF - 182 -
HLA-A*31:01 SKWYIRVGAR - 183 -
HLA-A*02:01 FLVFLGIITTVA FLVFL 184 -
HLA-B*38:01 YHDVRVVLDF - 184 -
HLA-C*14:02 VFLGIITTV VFL 189 -
HLA-A*02:06 FLEYHDVRVV - 192 -
HLA-A*30:01 AGSKSPIQYI - 192 -
HLA-C*03:02 AAFHQECSL - 192 -
HLA-C*08:01 YIDIGNYTV - 192 -
HLA-C*12:03 AAFHQECSL - 192 -
HLA-A*11:01 SCLPFTINCQEPK - 193 -
HLA-A*29:02 FYEDFLEY - 195 -
HLA-A*31:01 FYSKWYIR - 195 -
HLA-A*30:02 KLGSLVVRCSFY - 199 -
HLA-B*15:03 SPIQYIDIGNY - 201 -
HLA-B*58:01 GSLVVRCSF - 201 -
HLA-A*02:11 MKFLVFLGIITTV MKFLVFL 205 -
HLA-C*14:02 FYSKWYIRV - 207 -
HLA-B*58:01 CSFYEDFLEY - 208 -
HLA-C*03:02 CSFYEDFLEY - 211 -
HLA-A*02:02 KFLVFLGIITTV KFLVFL 215 -
HLA-B*58:01 KSAPLIELC - 217 -
HLA-B*42:01 QEPKLGSLVV - 218 -
HLA-B*15:01 LVFLGIITTVAAF LVFL 219 -
HLA-A*24:02 NYTVSCLPFTI - 221 -
HLA-B*50:01 LEYHDVRVV - 221 -
HLA-B*40:01 YEDFLEYHDVRVVL - 224 -
HLA-A*01:01 VVDDPCPIHFY - 225 -
HLA-B*07:02 RVGARKSAPL - 225 -
HLA-A*30:01 YSKWYIRVGA - 229 -
HLA-C*16:01 YVVDDPCPI - 229 -
HLA-A*23:01 NYTVSCLPFTI - 231 -
HLA-A*02:06 FLVFLGIITT FLVFL 234 -
HLA-A*30:02 RCSFYEDFLEY - 236 -
HLA-A*68:02 DVRVVLDFI - 236 -
HLA-A*33:03 DPCPIHFYSKWYIR - 238 -
HLA-C*16:01 YTVSCLPF - 240 -
HLA-A*02:01 TVSCLPFTI - 244 -
HLA-A*31:01 FYSKWYIRVGAR - 244 -
HLA-C*05:01 FLEYHDVRV - 244 -
HLA-A*68:02 YTVSCLPFT - 245 -
HLA-C*05:01 VVDDPCPIHF - 247 -
HLA-A*02:11 FLVFLGIITTVAA FLVFL 248 -
HLA-C*16:01 VAAFHQECSL - 251 -
HLA-B*15:03 KSPIQYIDIGNY - 252 -
HLA-A*68:02 FTINCQEPKLGSLV - 254 -
HLA-B*15:01 CSFYEDFLEY - 256 -
HLA-A*24:02 FYSKWYIRV - 261 -
HLA-A*68:02 YSKWYIRVGA - 262 -
HLA-A*02:02 FLVFLGIITTVA FLVFL 263 -
HLA-B*57:01 KLGSLVVRCSF - 263 -
HLA-A*01:01 CVDEAGSKSPIQY - 264 -
HLA-A*33:03 EDFLEYHDVR - 264 -
HLA-A*23:01 IGNYTVSCLPF - 272 -
HLA-B*15:03 SLQSCTQHQPY - 275 -
HLA-C*02:02 YVVDDPCPI - 275 -
HLA-C*02:10 YVVDDPCPI - 275 -
HLA-B*57:01 GSLVVRCSF - 276 -
HLA-A*02:06 FLGIITTVAA FL 282 -
HLA-A*68:02 TTVAAFHQECSL - 288 -
HLA-A*32:01 TVSCLPFTI - 294 -
HLA-A*02:02 SLVVRCSFYEDFL - 298 -
HLA-A*02:11 IQYIDIGNYTV - 299 -
HLA-A*30:02 PIQYIDIGNY - 304 -
HLA-A*24:02 QYIDIGNYTV - 310 -
HLA-A*02:11 YIDIGNYTVS - 313 -
HLA-A*02:06 IQYIDIGNYTV - 320 -
HLA-B*15:01 VVRCSFYEDF - 326 -
HLA-B*40:01 LEYHDVRVV - 328 -
HLA-B*15:03 RCSFYEDFLEY - 332 -
HLA-B*15:01 SLQSCTQHQPY - 333 -
HLA-C*14:02 YEDFLEYHDVRVVL - 333 -
HLA-A*68:01 YVVDDPCPIHFYSK - 335 -
HLA-A*02:02 VFLGIITTVA VFL 336 -
HLA-A*31:01 IHFYSKWYIRVGAR - 336 -
HLA-C*03:02 GIITTVAAF - 338 -
HLA-B*08:01 VGARKSAPL - 346 -
HLA-C*14:02 YHDVRVVL - 346 -
HLA-A*33:03 KWYIRVGAR - 347 -
HLA-B*15:03 QSCTQHQPY - 350 -
HLA-B*15:01 SPIQYIDIGNY - 352 -
HLA-B*40:02 YEDFLEYHDV - 352 -
HLA-A*33:03 WYIRVGARK - 359 -
HLA-A*33:03 SKWYIRVGAR - 361 -
HLA-C*03:02 YVVDDPCPIHF - 364 -
HLA-A*02:06 LVFLGIITT LVFL 366 -
HLA-A*02:02 SLQSCTQHQPYVV - 376 -
HLA-A*02:06 KFLVFLGIITTV KFLVFL 382 -
HLA-A*30:01 KWYIRVGAR - 382 -
HLA-C*16:01 IGNYTVSCL - 383 -
HLA-B*15:03 SKSPIQYIDIGNY - 384 -
HLA-A*30:02 QSCTQHQPY - 386 -
HLA-B*15:03 PIQYIDIGNY - 390 -
HLA-A*02:06 FLGIITTVA FL 391 -
HLA-A*30:02 SLQSCTQHQPY - 393 -
HLA-A*11:01 CSFYEDFLEY - 395 -
HLA-A*68:01 FTINCQEPKL - 395 -
HLA-C*16:01 QSCTQHQPY - 397 -
HLA-A*33:03 PIHFYSKWYIR - 398 -
HLA-B*08:01 SLVVRCSF - 399 -
HLA-B*15:03 AAFHQECSL - 400 -
HLA-C*16:01 GSLVVRCSF - 400 -
HLA-A*11:01 VVDDPCPIHFYSK - 401 -
HLA-A*29:02 GSLVVRCSFY - 402 -
HLA-A*68:01 YSKWYIRVGARK - 402 -
HLA-C*15:02 KSAPLIELCV - 403 -
HLA-C*07:02 EYHDVRVVL - 404 -
HLA-A*29:02 IQYIDIGNY - 410 -
HLA-A*02:11 YIDIGNYTVSCL - 412 -
HLA-B*40:06 LEYHDVRVV - 412 -
HLA-A*68:02 YIDIGNYTV - 413 -
HLA-B*15:03 YHDVRVVLDF - 413 -
HLA-A*33:03 FTINCQEPK - 416 -
HLA-B*38:01 YHDVRVVL - 417 -
HLA-A*24:02 IGNYTVSCLPF - 426 -
HLA-A*30:01 HFYSKWYIR - 430 -
HLA-C*15:02 YTVSCLPFTI - 430 -
HLA-B*15:03 CQEPKLGSL - 432 -
HLA-B*15:01 VFLGIITTVAAF VFL 439 -
HLA-C*12:03 SFYEDFLEY - 443 -
HLA-B*42:01 YIRVGARKSAPL - 448 -
HLA-B*15:03 VRCSFYEDFLEY - 449 -
HLA-B*58:01 KLGSLVVRCSF - 450 -
HLA-C*14:02 CSFYEDFLEY - 454 -
HLA-B*15:01 YTVSCLPF - 456 -
HLA-A*30:02 SKSPIQYIDIGNY - 458 -
HLA-A*02:11 DFLEYHDVRVV - 459 -
HLA-A*11:01 LPFTINCQEPK - 466 -
HLA-B*40:02 YEDFLEYHDVRVVL - 468 -
HLA-B*15:03 IQYIDIGNYT - 483 -
HLA-B*15:03 FLGIITTVAAF FL 484 -
HLA-B*58:01 TVSCLPFTI - 484 -
HLA-B*15:01 FLVFLGIITTVAAF FLVFL 485 -
HLA-C*16:01 SFYEDFLEY - 486 -
HLA-A*30:02 SPIQYIDIGNY - 491 -
HLA-A*02:06 FTINCQEPKLGSL - 492 -
HLA-A*23:01 GNYTVSCLPF - 495 -
HLA-A*33:03 IHFYSKWYIRVGAR - 497 -
HLA-C*14:02 FYEDFLEYH - 497 -
HLA-A*02:01 FLEYHDVRVVL - 499 -
HLA-A*02:06 LQSCTQHQPYV - 500 -
HLA-A*31:01 WYIRVGARK - 500 -

NS9b protein

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NS9b

I5T

Reference  MDPKISEMHPALRLVDPQIQLAVTRMENAV
           |||| |||||||||||||||||||||||||
Mutated    MDPKTSEMHSALRLVDPQIQLAVTRMVNAV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:02 MDPKISEMHPAL MDPKTSEMHSAL 6619 217
HLA-A*02:01 KISEMHPAL KTSEMHSAL 139 3161
HLA-A*02:11 KISEMHPAL KTSEMHSAL 14 277
HLA-B*58:01 KISEMHPAL KTSEMHSAL 5915 431
HLA-C*15:02 KISEMHPAL KTSEMHSAL 746 60
HLA-C*16:01 KISEMHPAL KTSEMHSAL 189 18
HLA-C*12:03 KISEMHPAL KTSEMHSAL 1242 122
HLA-A*68:01 ISEMHPALR TSEMHSALR 372 42
HLA-A*02:06 KISEMHPAL KTSEMHSAL 62 376
HLA-C*12:02 KISEMHPAL KTSEMHSAL 2061 349
HLA-C*03:03 KISEMHPAL KTSEMHSAL 177 34
HLA-C*03:04 KISEMHPAL KTSEMHSAL 177 34
HLA-A*68:01 KISEMHPALR KTSEMHSALR 312 67
HLA-A*02:02 KISEMHPAL KTSEMHSAL 42 187
HLA-C*03:02 KISEMHPAL KTSEMHSAL 371 92
HLA-B*44:02 ISEMHPALRL TSEMHSALRL 493 128
HLA-A*11:01 KISEMHPALR KTSEMHSALR 471 125
HLA-B*44:03 ISEMHPALRL TSEMHSALRL 577 160
HLA-A*30:01 KISEMHPAL KTSEMHSAL 455 143
HLA-C*16:01 ISEMHPAL TSEMHSAL 248 665
HLA-A*33:03 ISEMHPALR TSEMHSALR 395 148
HLA-A*02:11 KISEMHPALRLV KTSEMHSALRLV 249 617
HLA-A*30:01 KISEMHPALRLV KTSEMHSALRLV 722 292
HLA-C*15:02 ISEMHPALRL TSEMHSALRL 480 1127
HLA-A*31:01 PKISEMHPALR PKTSEMHSALR 687 297
HLA-C*17:01 KISEMHPAL KTSEMHSAL 241 105

P10S

Reference  MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQN
           ||||||||| |||||||||||||||||||||||||
Mutated    MDPKTSEMHSALRLVDPQIQLAVTRMVNAVGRDQN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 HPALRLVDPQIQL HSALRLVDPQIQL 148 15057
HLA-B*42:01 HPALRLVDPQI HSALRLVDPQI 297 15937
HLA-A*68:02 MDPKISEMHPAL MDPKTSEMHSAL 6619 217
HLA-A*02:01 KISEMHPAL KTSEMHSAL 139 3161
HLA-A*02:11 KISEMHPAL KTSEMHSAL 14 277
HLA-B*58:01 KISEMHPAL KTSEMHSAL 5915 431
HLA-C*15:02 KISEMHPAL KTSEMHSAL 746 60
HLA-A*02:11 PALRLVDPQIQL SALRLVDPQIQL 3683 325
HLA-C*16:01 KISEMHPAL KTSEMHSAL 189 18
HLA-C*12:03 KISEMHPAL KTSEMHSAL 1242 122
HLA-A*68:01 ISEMHPALR TSEMHSALR 372 42
HLA-B*38:01 MHPALRLVDPQI MHSALRLVDPQI 3064 395
HLA-A*02:06 KISEMHPAL KTSEMHSAL 62 376
HLA-C*12:02 KISEMHPAL KTSEMHSAL 2061 349
HLA-A*02:02 PALRLVDPQIQL SALRLVDPQIQL 2220 388
HLA-C*03:03 KISEMHPAL KTSEMHSAL 177 34
HLA-C*03:04 KISEMHPAL KTSEMHSAL 177 34
HLA-A*68:01 KISEMHPALR KTSEMHSALR 312 67
HLA-A*02:02 KISEMHPAL KTSEMHSAL 42 187
HLA-C*03:02 KISEMHPAL KTSEMHSAL 371 92
HLA-B*44:02 ISEMHPALRL TSEMHSALRL 493 128
HLA-A*11:01 KISEMHPALR KTSEMHSALR 471 125
HLA-B*44:03 ISEMHPALRL TSEMHSALRL 577 160
HLA-A*30:01 KISEMHPAL KTSEMHSAL 455 143
HLA-C*16:01 ISEMHPAL TSEMHSAL 248 665
HLA-A*33:03 ISEMHPALR TSEMHSALR 395 148
HLA-A*02:11 KISEMHPALRLV KTSEMHSALRLV 249 617
HLA-A*30:01 KISEMHPALRLV KTSEMHSALRLV 722 292
HLA-C*15:02 ISEMHPALRL TSEMHSALRL 480 1127
HLA-A*31:01 PKISEMHPALR PKTSEMHSALR 687 297
HLA-C*17:01 KISEMHPAL KTSEMHSAL 241 105
HLA-B*15:03 SEMHPALRL SEMHSALRL 493 245

E27V

Reference  DPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    DPKTSEMHSALRLVDPQIQLAVTRMVNAVGRDQNNVGPKVYPIILRLGSPL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 IQLAVTRME IQLAVTRMV 23336 70
HLA-A*02:06 IQLAVTRME IQLAVTRMV 9694 47
HLA-A*02:01 IQLAVTRME IQLAVTRMV 25623 463
HLA-A*68:02 MENAVGRDQNNV MVNAVGRDQNNV 13036 259
HLA-B*15:03 IQLAVTRME IQLAVTRMV 5099 183
HLA-A*02:06 AVTRMENAV AVTRMVNAV 1575 114
HLA-A*02:11 AVTRMENAV AVTRMVNAV 2404 180
HLA-A*02:02 RMENAVGRDQNNV RMVNAVGRDQNNV 3078 283
HLA-A*02:11 RMENAVGRDQNNV RMVNAVGRDQNNV 1928 188
HLA-A*68:02 AVTRMENAV AVTRMVNAV 2310 404
HLA-A*02:02 AVTRMENAV AVTRMVNAV 1454 300
HLA-A*30:01 VTRMENAVG VTRMVNAVG 395 82
HLA-A*30:01 AVTRMENAVG AVTRMVNAVG 1413 315
HLA-A*31:01 RMENAVGR RMVNAVGR 992 275
HLA-A*31:01 VTRMENAVGR VTRMVNAVGR 113 34
HLA-A*33:03 VTRMENAVGR VTRMVNAVGR 218 89

N55S

Reference  VGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VGRDQNNVGPKVYPIILRLGSPLSLSMARKTLNSLEDKAFQLTPIAVQMTK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*16:01 LNMARKTL LSMARKTL 6455 93
HLA-A*03:01 NMARKTLNSLEDK SMARKTLNSLEDK 2773 186
HLA-A*03:02 NMARKTLNSLEDK SMARKTLNSLEDK 3703 425
HLA-A*30:01 NMARKTLNSL SMARKTLNSL 2051 341
HLA-C*03:03 LGSPLSLNM LGSPLSLSM 699 121
HLA-C*03:04 LGSPLSLNM LGSPLSLSM 699 121
HLA-A*02:11 NMARKTLNSL SMARKTLNSL 388 69
HLA-B*15:01 NMARKTLNSL SMARKTLNSL 1233 246
HLA-C*03:02 LGSPLSLNM LGSPLSLSM 333 71
HLA-B*15:01 RLGSPLSLNM RLGSPLSLSM 257 56
HLA-B*15:03 LGSPLSLNM LGSPLSLSM 515 122
HLA-B*15:03 RLGSPLSLNM RLGSPLSLSM 483 116
HLA-B*15:03 NMARKTLNSL SMARKTLNSL 1813 443
HLA-C*16:01 LGSPLSLNM LGSPLSLSM 219 55
HLA-A*02:01 NMARKTLNSL SMARKTLNSL 1400 368
HLA-A*03:01 SPLSLNMARK SPLSLSMARK 305 81
HLA-B*07:02 NMARKTLNSL SMARKTLNSL 720 196
HLA-A*02:02 NMARKTLNSL SMARKTLNSL 76 26
HLA-A*03:02 SPLSLNMARK SPLSLSMARK 326 112
HLA-C*12:03 LGSPLSLNM LGSPLSLSM 1131 394
HLA-B*15:03 LRLGSPLSLNM LRLGSPLSLSM 1269 463
HLA-A*11:01 SPLSLNMARK SPLSLSMARK 590 232
HLA-A*11:01 GSPLSLNMARK GSPLSLSMARK 943 395
HLA-A*32:01 RLGSPLSLNM RLGSPLSLSM 998 488
HLA-B*08:01 SLNMARKTL SLSMARKTL 454 925

NS9c protein

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NS9c

G50N

Reference  AAVKPLLVPHHVVATVQEIQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
           ||||||||||||||||||||||||| |||||||||||||||||||||||
Mutated    AAVKPLLVPHHVVATVQEIQLQAAVNELLLLEWLAMAVMLLLLCCCLTD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*18:01 GELLLLEWLAM NELLLLEWLAM 4979 247
HLA-B*18:01 GELLLLEW NELLLLEW