Summary

This strain contains 46 protein-level mutations:

  • 29 mutations in Spike protein: A67V, HV 69-70 deletion, T95I, GVY 142-144 deletion, Y145D, N211 deletion, L212I, G339D, S371F, S373P, S375F, D405N, K417T, N440K, G446S, 477-478 ST->NK, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
  • 3 mutations in N protein: P13L, ERS 31-33 deletion, 203-204 RG->KR
  • 2 mutations in M protein: Q19E, A63T
  • 1 mutation in E protein: T9I
  • 1 mutation in NS3 protein: T223I
  • 2 mutations in NS9b protein: P10S, ENA 27-29 deletion
  • 1 mutation in NS9c protein: G50N
  • 1 mutation in NSP1 protein: S135R
  • 2 mutations in NSP4 protein: T327I, T492I
  • 1 mutation in NSP5 protein: P132H
  • 1 mutation in NSP6 protein: A88V
  • 2 mutations in NSP12 protein: R249M, P323L

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of HLA-peptide interactions affected by the mutations

For each allele we calculated the number of peptides with increased and decreased affinitiy (two or more times). The absolute number of such peptides is showed on the left side of the figure (blue bars — weaker binding, orange bars — stronger).

While absolute numbers are of interest, they do not reflect the initial number of tighly binding peptides for the specific allele. Roughly speaking, if an allele had high number of tight binders, then vanished affinity of several peptides will not affect much the integral ability of peptide presentation. To the contrary, low number of vanished peptides could be important if the particular allele initially had narrow epitope repertoire. To account for this effect, we normalized the absolute numbers of new/vanished tight binders (IC50 affinity ≤ 50 nM) by the total number of tight binders for each allele. To avoid possible divisions by zero, we used + 1 regularization term in all denominators. For example, if some allele had no tight binders in the reference genome, and three new tight binders appeared as a result of the mutation, the relative increase will be 300%. The results are showed in the right part of the figure. Protein-specific plots are listed below.

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Summary

Spike protein

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Spike

A67V

Reference  VFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VFRSSVLHSTQDLFLPFFSNVTWFHVI‑‑SGTNGTKRFDNPVLPFNDGVYF

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 VTWFHAIHV VTWFHVI 18 -
HLA-A*02:06 VTWFHAIHV VTWFHVI 40 -
HLA-A*68:02 VTWFHAIHV VTWFHVI 45 -
HLA-C*15:02 VTWFHAIHV VTWFHVI 107 -
HLA-A*02:01 VTWFHAIHV VTWFHVI 134 -
HLA-C*12:03 VTWFHAIHV VTWFHVI 341 -
HLA-A*02:02 VTWFHAIHV VTWFHVI 369 -
HLA-C*16:01 VTWFHAIHV VTWFHVI 421 -
HLA-A*32:01 VTWFHAIHV VTWFHVI 442 -
HLA-A*68:02 NVTWFHAIHV NVTWFHVI 16 5547
HLA-A*02:11 NVTWFHAIHV NVTWFHVI 125 10192
HLA-A*02:06 NVTWFHAIHV NVTWFHVI 263 10869
HLA-C*15:02 FSNVTWFHAIH FSNVTWFHVI 15930 389
HLA-A*68:02 FSNVTWFHAIH FSNVTWFHVI 13953 418
HLA-A*02:02 NVTWFHAIHV NVTWFHVI 468 14619
HLA-B*58:01 FSNVTWFHAIH FSNVTWFHVI 7866 292
HLA-B*51:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 11466 430
HLA-B*58:01 FSNVTWFHAIHV FSNVTWFHVI 6877 292
HLA-A*11:01 HAIHVSGTNGTK HVISGTNGTK 2998 135
HLA-C*12:03 FSNVTWFHAIH FSNVTWFHVI 8069 365
HLA-A*02:06 FSNVTWFHAIH FSNVTWFHVI 7820 387
HLA-C*15:02 FSNVTWFHA FSNVTWFHV 1444 73
HLA-A*68:01 AIHVSGTNGTKR VISGTNGTKR 5916 313
HLA-A*68:02 HAIHVSGTNGT HVISGTNGT 7705 415
HLA-C*16:01 FSNVTWFHAIH FSNVTWFHVI 5156 295
HLA-B*42:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 7318 437
HLA-A*03:01 HAIHVSGTNGTK HVISGTNGTK 3368 205
HLA-A*02:11 FSNVTWFHA FSNVTWFHV 366 23
HLA-C*03:02 FSNVTWFHAIHV FSNVTWFHVI 7468 494
HLA-C*16:01 FSNVTWFHAIHV FSNVTWFHVI 4412 295
HLA-C*12:03 FSNVTWFHAIHV FSNVTWFHVI 4736 365
HLA-A*03:02 HAIHVSGTNGTK HVISGTNGTK 4597 368
HLA-C*03:02 FSNVTWFHAIH FSNVTWFHVI 4526 494
HLA-A*68:02 FSNVTWFHA FSNVTWFHV 189 22
HLA-A*02:01 FSNVTWFHA FSNVTWFHV 1863 240
HLA-A*68:02 FFSNVTWFHAIHV FFSNVTWFHVI 492 3778
HLA-A*02:06 FSNVTWFHA FSNVTWFHV 182 24
HLA-C*12:03 FSNVTWFHA FSNVTWFHV 1369 181
HLA-A*02:11 FFSNVTWFHA FFSNVTWFHV 362 50
HLA-C*15:02 FSNVTWFHAIHV FSNVTWFHVI 2711 389
HLA-A*02:02 FSNVTWFHA FSNVTWFHV 741 115
HLA-A*02:11 FLPFFSNVTWFHA FLPFFSNVTWFHV 93 15
HLA-C*16:01 FSNVTWFHA FSNVTWFHV 906 156
HLA-A*68:01 HAIHVSGTNGTK HVISGTNGTK 174 30
HLA-A*68:02 FFSNVTWFHA FFSNVTWFHV 639 128
HLA-A*02:11 FFSNVTWFHAIHV FFSNVTWFHVI 219 1076
HLA-A*02:01 FFSNVTWFHA FFSNVTWFHV 1440 306
HLA-A*02:01 FLPFFSNVTWFHA FLPFFSNVTWFHV 424 94
HLA-A*02:06 FFSNVTWFHA FFSNVTWFHV 972 227
HLA-A*02:02 FFSNVTWFHA FFSNVTWFHV 328 79
HLA-A*02:11 FSNVTWFHAIHV FSNVTWFHVI 250 973
HLA-A*68:02 SNVTWFHAI SNVTWFHVI 196 729
HLA-A*02:02 FLPFFSNVTWFHA FLPFFSNVTWFHV 117 32
HLA-A*03:02 AIHVSGTNGTK VISGTNGTK 1179 326
HLA-A*02:06 SNVTWFHAI SNVTWFHVI 317 1145
HLA-A*02:06 FLPFFSNVTWFHA FLPFFSNVTWFHV 608 172
HLA-C*03:02 FSNVTWFHA FSNVTWFHV 1383 404
HLA-A*68:02 FSNVTWFHAI FSNVTWFHVI 124 418
HLA-A*02:11 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 54 176
HLA-A*02:06 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 457 1475
HLA-A*02:06 FSNVTWFHAI FSNVTWFHVI 123 387
HLA-B*58:01 FSNVTWFHA FSNVTWFHV 1061 354
HLA-A*02:01 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 484 1319
HLA-A*02:02 FLPFFSNVTWFHAI FLPFFSNVTWFHVI 151 392
HLA-A*02:11 FSNVTWFHAI FSNVTWFHVI 398 973
HLA-B*42:01 LPFFSNVTWFHAI LPFFSNVTWFHVI 199 437
HLA-A*11:01 AIHVSGTNGTK VISGTNGTK 742 341
HLA-A*03:01 AIHVSGTNGTK VISGTNGTK 534 251

HV 69-70 deletion

Reference  RSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    RSSVLHSTQDLFLPFFSNVTWFHVI‑‑SGTNGTKRFDNPVLPFNDGVYFASI

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 VTWFHAIHV VTWFHVI 18 -
HLA-A*02:06 VTWFHAIHV VTWFHVI 40 -
HLA-A*68:01 HVSGTNGTKR - 42 -
HLA-A*68:02 VTWFHAIHV VTWFHVI 45 -
HLA-A*68:01 HVSGTNGTK SGTNGTK 54 -
HLA-C*15:02 VTWFHAIHV VTWFHVI 107 -
HLA-A*02:01 VTWFHAIHV VTWFHVI 134 -
HLA-C*12:03 VTWFHAIHV VTWFHVI 341 -
HLA-A*02:02 VTWFHAIHV VTWFHVI 369 -
HLA-C*16:01 VTWFHAIHV VTWFHVI 421 -
HLA-A*32:01 VTWFHAIHV VTWFHVI 442 -
HLA-A*68:02 NVTWFHAIHV NVTWFHVI 16 5547
HLA-A*02:11 NVTWFHAIHV NVTWFHVI 125 10192
HLA-A*02:06 NVTWFHAIHV NVTWFHVI 263 10869
HLA-C*15:02 FSNVTWFHAIH FSNVTWFHVI 15930 389
HLA-A*68:02 FSNVTWFHAIH FSNVTWFHVI 13953 418
HLA-A*02:02 NVTWFHAIHV NVTWFHVI 468 14619
HLA-B*58:01 FSNVTWFHAIH FSNVTWFHVI 7866 292
HLA-B*51:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 11466 430
HLA-B*58:01 FSNVTWFHAIHV FSNVTWFHVI 6877 292
HLA-A*11:01 HAIHVSGTNGTK HVISGTNGTK 2998 135
HLA-C*12:03 FSNVTWFHAIH FSNVTWFHVI 8069 365
HLA-A*02:06 FSNVTWFHAIH FSNVTWFHVI 7820 387
HLA-A*68:01 AIHVSGTNGTKR VISGTNGTKR 5916 313
HLA-A*68:02 HAIHVSGTNGT HVISGTNGT 7705 415
HLA-C*16:01 FSNVTWFHAIH FSNVTWFHVI 5156 295
HLA-B*42:01 LPFFSNVTWFHAIH LPFFSNVTWFHVI 7318 437
HLA-A*03:01 HAIHVSGTNGTK HVISGTNGTK 3368 205
HLA-C*03:02 FSNVTWFHAIHV FSNVTWFHVI 7468 494
HLA-C*16:01 FSNVTWFHAIHV FSNVTWFHVI 4412 295
HLA-C*12:03 FSNVTWFHAIHV FSNVTWFHVI 4736 365
HLA-A*03:02 HAIHVSGTNGTK HVISGTNGTK 4597 368
HLA-C*03:02 FSNVTWFHAIH FSNVTWFHVI 4526 494
HLA-A*68:02 FFSNVTWFHAIHV FFSNVTWFHVI 492 3778
HLA-C*15:02 FSNVTWFHAIHV FSNVTWFHVI 2711 389
HLA-A*68:01 HAIHVSGTNGTK HVISGTNGTK 174 30
HLA-A*02:11 FFSNVTWFHAIHV FFSNVTWFHVI 219 1076
HLA-A*02:11 FSNVTWFHAIHV FSNVTWFHVI 250 973
HLA-A*03:02 AIHVSGTNGTK VISGTNGTK 1179 326
HLA-A*11:01 AIHVSGTNGTK VISGTNGTK 742 341
HLA-A*03:01 AIHVSGTNGTK VISGTNGTK 534 251

T95I

Reference  VSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ‑SGTNGTKRFDNPVLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*57:01 STEKSNIIRGW SIEKSNIIRGW 135 2014
HLA-B*58:01 STEKSNIIRGW SIEKSNIIRGW 183 2582
HLA-B*42:01 LPFNDGVYFAST LPFNDGVYFASI 4329 325
HLA-B*53:01 LPFNDGVYFAST LPFNDGVYFASI 6125 497
HLA-C*12:03 ASTEKSNII ASIEKSNII 2443 439
HLA-A*31:01 ASTEKSNIIR ASIEKSNIIR 1324 354
HLA-C*03:03 FASTEKSNII FASIEKSNII 1633 453
HLA-C*03:04 FASTEKSNII FASIEKSNII 1633 453
HLA-A*68:01 ASTEKSNIIR ASIEKSNIIR 1387 410
HLA-C*12:03 FASTEKSNII FASIEKSNII 902 268
HLA-A*11:01 ASTEKSNIIR ASIEKSNIIR 1555 495
HLA-C*15:02 ASTEKSNII ASIEKSNII 729 264
HLA-B*44:02 TEKSNIIRGW IEKSNIIRGW 20 55
HLA-B*44:03 TEKSNIIRGW IEKSNIIRGW 33 84
HLA-C*16:01 ASTEKSNII ASIEKSNII 603 239
HLA-A*68:01 STEKSNIIR SIEKSNIIR 186 458
HLA-A*33:03 YFASTEKSNIIR YFASIEKSNIIR 337 148
HLA-A*11:01 GVYFASTEKS GVYFASIEKS 648 298
HLA-A*11:01 DGVYFASTEK DGVYFASIEK 205 96
HLA-B*58:01 ASTEKSNIIRGW ASIEKSNIIRGW 245 122

GVY 142-144 deletion

Reference  LLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFE
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Mutated    LLIVNNATNVVIKVCEFQFCNDPFL‑‑‑DHKNNKSWMESEFRVYSSANNCTFE

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:06 FQFCNDPFLGV - 7 -
HLA-B*15:03 FQFCNDPFLGVY - 11 -
HLA-A*02:11 FQFCNDPFLGV - 17 -
HLA-A*03:01 GVYYHKNNK DHKNNK 27 -
HLA-B*15:01 FQFCNDPFLGVY - 28 -
HLA-A*02:01 FQFCNDPFLGV - 39 -
HLA-A*02:02 FQFCNDPFLGV - 45 -
HLA-A*11:01 GVYYHKNNK DHKNNK 51 -
HLA-A*30:01 GVYYHKNNK DHKNNK 51 -
HLA-A*02:06 EFQFCNDPFLGV - 87 -
HLA-A*02:11 FCNDPFLGV FCNDPFL 87 -
HLA-A*02:06 FCNDPFLGV FCNDPFL 116 -
HLA-A*03:02 GVYYHKNNK DHKNNK 119 -
HLA-A*03:01 LGVYYHKNNK LDHKNNK 131 -
HLA-A*02:06 FQFCNDPFLGVY - 135 -
HLA-C*03:02 FCNDPFLGVY FCNDPFL 164 -
HLA-A*29:02 QFCNDPFLGVY - 192 -
HLA-A*01:01 CNDPFLGVYY CNDPFLD 202 -
HLA-A*02:06 FQFCNDPFLG - 207 -
HLA-A*01:01 CNDPFLGVY CNDPFL 232 -
HLA-B*15:03 EFQFCNDPFLGVY - 253 -
HLA-A*33:03 DPFLGVYYHK DPFLDHK 280 -
HLA-A*68:02 FCNDPFLGV FCNDPFL 281 -
HLA-A*30:02 CNDPFLGVY CNDPFL 310 -
HLA-A*01:01 FCNDPFLGVY FCNDPFL 317 -
HLA-A*02:11 EFQFCNDPFLGV - 334 -
HLA-A*30:02 FQFCNDPFLGVY - 336 -
HLA-A*68:01 GVYYHKNNK DHKNNK 363 -
HLA-A*02:02 FCNDPFLGV FCNDPFL 365 -
HLA-A*31:01 GVYYHKNNK DHKNNK 375 -
HLA-A*29:02 FQFCNDPFLGVY - 388 -
HLA-A*02:02 FQFCNDPFLG - 392 -
HLA-A*68:01 DPFLGVYYHK DPFLDHK 398 -
HLA-A*30:02 FCNDPFLGVY FCNDPFL 408 -
HLA-A*29:02 CNDPFLGVYY CNDPFLD 439 -
HLA-A*02:02 EFQFCNDPFLGV - 477 -
HLA-A*02:11 FQFCNDPFLGVY - 488 -
HLA-A*68:01 LGVYYHKNNK LDHKNNK 494 -
HLA-C*14:02 YYHKNNKSWM DHKNNKSWM 19 12782
HLA-C*14:02 YYHKNNKSW DHKNNKSW 52 32767
HLA-A*24:02 YYHKNNKSW DHKNNKSW 116 32767
HLA-A*23:01 YYHKNNKSW DHKNNKSW 150 32767
HLA-A*29:02 QFCNDPFLGVYY QFCNDPFLD 113 23669
HLA-A*23:01 VYYHKNNKSW DHKNNKSW 230 32767
HLA-C*14:02 YYHKNNKSWMESEF DHKNNKSWMESEF 227 28734
HLA-A*24:02 VYYHKNNKSW DHKNNKSW 326 32767
HLA-A*29:02 FQFCNDPFLGVYY FQFCNDPFLD 184 14059
HLA-B*15:01 FQFCNDPFLGVYY FQFCNDPFLD 129 7936
HLA-B*15:03 FQFCNDPFLGVYY FQFCNDPFLD 47 2235
HLA-C*14:02 VYYHKNNKSWM DHKNNKSWM 327 12782
HLA-A*03:01 FLGVYYHKNNK FLDHKNNK 455 10120
HLA-A*02:11 FLGVYYHKNNKSWM FLDHKNNKSWM 5849 374
HLA-A*02:11 FLGVYYHKNNKS FLDHKNNKS 5702 488
HLA-A*02:06 FQFCNDPFLGVYY FQFCNDPFLD 1024 258

Y145D

Reference  VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VNNATNVVIKVCEFQFCNDPFL‑‑‑DHKNNKSWMESEFRVYSSANNCTFEY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 GVYYHKNNK DHKNNK 27 -
HLA-A*11:01 GVYYHKNNK DHKNNK 51 -
HLA-A*30:01 GVYYHKNNK DHKNNK 51 -
HLA-A*03:02 GVYYHKNNK DHKNNK 119 -
HLA-A*03:01 LGVYYHKNNK LDHKNNK 131 -
HLA-A*01:01 CNDPFLGVYY CNDPFLD 202 -
HLA-A*33:03 DPFLGVYYHK DPFLDHK 280 -
HLA-A*68:01 GVYYHKNNK DHKNNK 363 -
HLA-A*31:01 GVYYHKNNK DHKNNK 375 -
HLA-A*68:01 DPFLGVYYHK DPFLDHK 398 -
HLA-A*29:02 CNDPFLGVYY CNDPFLD 439 -
HLA-A*68:01 LGVYYHKNNK LDHKNNK 494 -
HLA-C*14:02 YYHKNNKSWM DHKNNKSWM 19 12782
HLA-C*14:02 YYHKNNKSW DHKNNKSW 52 32767
HLA-A*24:02 YYHKNNKSW DHKNNKSW 116 32767
HLA-A*23:01 YYHKNNKSW DHKNNKSW 150 32767
HLA-A*29:02 QFCNDPFLGVYY QFCNDPFLD 113 23669
HLA-A*23:01 VYYHKNNKSW DHKNNKSW 230 32767
HLA-C*14:02 YYHKNNKSWMESEF DHKNNKSWMESEF 227 28734
HLA-A*24:02 VYYHKNNKSW DHKNNKSW 326 32767
HLA-A*29:02 FQFCNDPFLGVYY FQFCNDPFLD 184 14059
HLA-B*15:01 FQFCNDPFLGVYY FQFCNDPFLD 129 7936
HLA-B*15:03 FQFCNDPFLGVYY FQFCNDPFLD 47 2235
HLA-C*14:02 VYYHKNNKSWM DHKNNKSWM 327 12782
HLA-C*14:02 YHKNNKSWM DHKNNKSWM 392 12782
HLA-A*03:01 FLGVYYHKNNK FLDHKNNK 455 10120
HLA-A*02:11 FLGVYYHKNNKSWM FLDHKNNKSWM 5849 374
HLA-A*02:11 FLGVYYHKNNKS FLDHKNNKS 5702 488
HLA-A*02:06 FQFCNDPFLGVYY FQFCNDPFLD 1024 258

N211 deletion

Reference  FKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINIT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FKNLREFVFKNIDGYFKIYSKHTPI‑IVRDLPQGFSALEPLVDLPIGINIT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 HTPINLVR HTPIIVR 480 -
HLA-C*03:03 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:04 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:02 NLVRDLPQGF IVRDLPQGF 11231 224
HLA-B*42:01 HTPINLVRDL HTPIIVRDL 250 9583
HLA-C*12:03 YSKHTPINLV YSKHTPIIV 1188 31
HLA-C*03:02 YSKHTPINL YSKHTPII 132 4883
HLA-C*16:01 YSKHTPINLV YSKHTPIIV 1785 56
HLA-C*12:03 YSKHTPINL YSKHTPII 47 1130
HLA-C*17:01 YSKHTPINL YSKHTPII 368 6895
HLA-C*16:01 YSKHTPINL YSKHTPII 31 571
HLA-B*15:03 NLVRDLPQGF IVRDLPQGF 4233 298
HLA-C*12:02 YSKHTPINL YSKHTPII 388 4751
HLA-A*68:02 YSKHTPINLV YSKHTPIIV 199 2110
HLA-C*01:02 NLVRDLPQGFSAL IVRDLPQGFSAL 4051 434
HLA-C*15:02 YSKHTPINL YSKHTPII 175 1560
HLA-C*12:02 YSKHTPINLV YSKHTPIIV 3439 393
HLA-A*24:02 IYSKHTPINL IYSKHTPII 278 34
HLA-A*30:01 KIYSKHTPINL KIYSKHTPII 645 85
HLA-C*15:02 YSKHTPINLV YSKHTPIIV 601 101
HLA-B*15:01 NLVRDLPQGF IVRDLPQGF 1478 264
HLA-A*23:01 IYSKHTPINL IYSKHTPII 345 65
HLA-B*07:02 TPINLVRDL TPIIVRDL 213 1052
HLA-B*42:01 TPINLVRDL TPIIVRDL 43 198
HLA-A*32:01 KIYSKHTPINL KIYSKHTPII 1321 333
HLA-A*68:01 YSKHTPINLVR YSKHTPIIVR 362 103
HLA-C*07:02 IYSKHTPINL IYSKHTPII 1553 464
HLA-A*33:03 YSKHTPINLVR YSKHTPIIVR 762 228
HLA-C*14:02 IYSKHTPINL IYSKHTPII 139 44
HLA-A*31:01 FKIYSKHTPINLVR FKIYSKHTPIIVR 990 352
HLA-A*31:01 YSKHTPINLVR YSKHTPIIVR 337 122
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPIIV 104 221

L212I

Reference  KNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITR
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KNLREFVFKNIDGYFKIYSKHTPI‑IVRDLPQGFSALEPLVDLPIGINITR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 HTPINLVR HTPIIVR 480 -
HLA-C*03:03 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:04 YSKHTPINL YSKHTPII 83 6095
HLA-C*03:02 NLVRDLPQGF IVRDLPQGF 11231 224
HLA-B*42:01 HTPINLVRDL HTPIIVRDL 250 9583
HLA-C*12:03 YSKHTPINLV YSKHTPIIV 1188 31
HLA-C*03:02 YSKHTPINL YSKHTPII 132 4883
HLA-C*16:01 YSKHTPINLV YSKHTPIIV 1785 56
HLA-C*12:03 YSKHTPINL YSKHTPII 47 1130
HLA-C*17:01 YSKHTPINL YSKHTPII 368 6895
HLA-C*16:01 YSKHTPINL YSKHTPII 31 571
HLA-B*15:03 NLVRDLPQGF IVRDLPQGF 4233 298
HLA-C*12:02 YSKHTPINL YSKHTPII 388 4751
HLA-A*68:02 YSKHTPINLV YSKHTPIIV 199 2110
HLA-C*01:02 NLVRDLPQGFSAL IVRDLPQGFSAL 4051 434
HLA-C*15:02 YSKHTPINL YSKHTPII 175 1560
HLA-C*12:02 YSKHTPINLV YSKHTPIIV 3439 393
HLA-A*24:02 IYSKHTPINL IYSKHTPII 278 34
HLA-A*30:01 KIYSKHTPINL KIYSKHTPII 645 85
HLA-C*15:02 YSKHTPINLV YSKHTPIIV 601 101
HLA-B*15:01 NLVRDLPQGF IVRDLPQGF 1478 264
HLA-A*23:01 IYSKHTPINL IYSKHTPII 345 65
HLA-B*07:02 TPINLVRDL TPIIVRDL 213 1052
HLA-B*42:01 TPINLVRDL TPIIVRDL 43 198
HLA-A*32:01 KIYSKHTPINL KIYSKHTPII 1321 333
HLA-A*68:01 YSKHTPINLVR YSKHTPIIVR 362 103
HLA-C*07:02 IYSKHTPINL IYSKHTPII 1553 464
HLA-A*33:03 YSKHTPINLVR YSKHTPIIVR 762 228
HLA-C*14:02 IYSKHTPINL IYSKHTPII 139 44
HLA-A*31:01 FKIYSKHTPINLVR FKIYSKHTPIIVR 990 352
HLA-A*31:01 YSKHTPINLVR YSKHTPIIVR 337 122
HLA-A*02:11 KIYSKHTPINLV KIYSKHTPIIV 104 221
HLA-C*01:02 LVRDLPQGFSAL IVRDLPQGFSAL 893 434

G339D

Reference  QTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVAD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*40:01 GEVFNATRF DEVFNATRF 164 7112
HLA-B*18:01 GEVFNATRFASVY DEVFNATRFASVY 2165 64
HLA-B*18:01 GEVFNATRF DEVFNATRF 971 32
HLA-B*50:01 GEVFNATRFA DEVFNATRFA 147 4233
HLA-B*40:02 GEVFNATRF DEVFNATRF 283 7625
HLA-B*40:06 GEVFNATRFA DEVFNATRFA 201 5089
HLA-B*15:03 GEVFNATRF DEVFNATRF 359 4698
HLA-A*68:01 FGEVFNATR FDEVFNATR 338 2409
HLA-B*45:01 GEVFNATRFA DEVFNATRFA 116 688
HLA-B*44:02 GEVFNATRF DEVFNATRF 158 889
HLA-B*44:03 GEVFNATRF DEVFNATRF 136 673
HLA-B*15:01 TNLCPFGEVF TNLCPFDEVF 368 1059
HLA-B*15:03 TNLCPFGEVF TNLCPFDEVF 442 1176
HLA-B*15:03 NLCPFGEVF NLCPFDEVF 130 341
HLA-A*68:02 GEVFNATRFA DEVFNATRFA 879 342
HLA-B*15:01 NLCPFGEVF NLCPFDEVF 315 773

S371F

Reference  RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    RFASVYAWNRKRISNCVADYSVLYNFAPFFTFKCYGVSPTKLNDLCFTNVY

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*23:01 NSASFSTF NFAPFFTF 12240 75
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-C*05:01 VADYSVLYNS VADYSVLYNF 11802 122
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*24:02 NSASFSTF NFAPFFTF 14241 153
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-C*03:02 VADYSVLYNS VADYSVLYNF 20606 367
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-B*58:01 VADYSVLYNS VADYSVLYNF 6124 129
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-A*01:01 NSASFSTFKCY NFAPFFTFKCY 328 11908
HLA-C*16:01 NSASFSTF NFAPFFTF 243 8738
HLA-C*08:02 VADYSVLYNS VADYSVLYNF 16435 470
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-B*57:01 VADYSVLYNS VADYSVLYNF 11273 384
HLA-A*32:01 YNSASFSTF YNFAPFFTF 4333 169
HLA-A*68:02 NSASFSTFKCYGV NFAPFFTFKCYGV 48 1156
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-A*29:02 YNSASFSTF YNFAPFFTF 1671 85
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*23:01 YNSASFSTF YNFAPFFTF 352 19
HLA-A*11:01 LYNSASFSTFK LYNFAPFFTFK 43 779
HLA-B*40:02 ADYSVLYNS ADYSVLYNF 4645 259
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2385 135
HLA-C*14:02 NSASFSTF NFAPFFTF 2544 153
HLA-A*30:02 SASFSTFKCY FAPFFTFKCY 71 1044
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFTF 50 657
HLA-A*29:02 NSASFSTFKCY NFAPFFTFKCY 662 67
HLA-A*11:01 NSASFSTFK NFAPFFTFK 9 88
HLA-A*33:03 YNSASFSTFK YNFAPFFTFK 823 85
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-A*02:06 SVLYNSASF SVLYNFAPF 2112 234
HLA-B*18:01 YNSASFSTF YNFAPFFTF 3495 395
HLA-A*23:01 YSVLYNSASFSTF YSVLYNFAPFFTF 1474 167
HLA-A*29:02 YNSASFSTFKCY YNFAPFFTFKCY 842 101
HLA-B*35:01 SASFSTFKCY FAPFFTFKCY 490 61
HLA-A*02:01 VLYNSASFST VLYNFAPFFT 243 31
HLA-A*33:03 NSASFSTFK NFAPFFTFK 181 24
HLA-A*24:02 YNSASFSTF YNFAPFFTF 473 66
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFTF 1624 231
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2634 382
HLA-A*23:01 SVLYNSASFSTF SVLYNFAPFFTF 656 98
HLA-A*31:01 YNSASFSTFK YNFAPFFTFK 607 93
HLA-A*29:02 LYNSASFSTF LYNFAPFFTF 387 61
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*02:11 VLYNSASFST VLYNFAPFFT 77 14
HLA-A*03:01 LYNSASFSTFK LYNFAPFFTFK 295 1567
HLA-A*31:01 NSASFSTFK NFAPFFTFK 293 56
HLA-A*23:01 SVLYNSASF SVLYNFAPF 990 197
HLA-A*30:02 NSASFSTFKCY NFAPFFTFKCY 387 1942
HLA-C*14:02 LYNSASFSTF LYNFAPFFTF 20 99
HLA-A*02:02 VLYNSASFST VLYNFAPFFT 202 42
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFTFK 857 180
HLA-A*68:01 NSASFSTFK NFAPFFTFK 4 19
HLA-A*23:01 LYNSASFSTFKC LYNFAPFFTFKC 1642 351
HLA-C*12:03 SASFSTFKCY FAPFFTFKCY 498 107
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFTFK 113 522
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFTF 164 752
HLA-A*03:02 LYNSASFSTFK LYNFAPFFTFK 202 911
HLA-A*03:02 NSASFSTFK NFAPFFTFK 37 166
HLA-A*02:06 VLYNSASFST VLYNFAPFFT 710 161
HLA-A*11:01 SASFSTFK FAPFFTFK 452 1893
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*02:06 SASFSTFKCYGV FAPFFTFKCYGV 1416 368
HLA-A*23:01 VLYNSASFSTF VLYNFAPFFTF 133 35
HLA-A*32:01 VLYNSASFSTF VLYNFAPFFTF 699 185
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFTF 113 415
HLA-A*68:01 NSASFSTFKC NFAPFFTFKC 281 1027
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFTF 38 138
HLA-A*29:02 SVLYNSASF SVLYNFAPF 1130 313
HLA-C*12:02 SASFSTFKCY FAPFFTFKCY 710 202
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFTFKCY 272 915
HLA-A*23:01 LYNSASFSTFK LYNFAPFFTFK 265 81
HLA-B*15:01 LYNSASFSTF LYNFAPFFTF 468 1484
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFTF 221 694
HLA-A*11:01 YNSASFSTFK YNFAPFFTFK 12 37
HLA-A*26:01 SVLYNSASF SVLYNFAPF 1313 431
HLA-C*03:02 SASFSTFKCY FAPFFTFKCY 212 73
HLA-A*01:01 SASFSTFKCY FAPFFTFKCY 461 1323
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFTFK 565 197
HLA-A*23:01 YSVLYNSASF YSVLYNFAPF 1120 403
HLA-C*02:02 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-C*02:10 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFTFKCY 297 117
HLA-A*03:01 YNSASFSTFK YNFAPFFTFK 80 200
HLA-B*15:01 YNSASFSTF YNFAPFFTF 123 303
HLA-A*31:01 LYNSASFSTFK LYNFAPFFTFK 299 122
HLA-A*24:02 SVLYNSASFSTF SVLYNFAPFFTF 1041 432
HLA-A*23:01 LYNSASFSTF LYNFAPFFTF 7 3
HLA-A*68:01 SASFSTFK FAPFFTFK 1114 489
HLA-A*03:02 YNSASFSTFK YNFAPFFTFK 40 87
HLA-A*23:01 DYSVLYNSASF DYSVLYNFAPF 1039 482
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFTFKC 312 646
HLA-A*68:01 LYNSASFSTFK LYNFAPFFTFK 201 406

S373P

Reference  ASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ASVYAWNRKRISNCVADYSVLYNFAPFFTFKCYGVSPTKLNDLCFTNVYAD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*23:01 NSASFSTF NFAPFFTF 12240 75
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*24:02 NSASFSTF NFAPFFTF 14241 153
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*30:02 ASFSTFKCY APFFTFKCY 43 2759
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-A*02:06 ASFSTFKCYGV APFFTFKCYGV 231 13051
HLA-B*15:01 ASFSTFKCY APFFTFKCY 107 6034
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-C*16:01 ASFSTFKCY APFFTFKCY 68 2875
HLA-C*12:03 ASFSTFKCY APFFTFKCY 115 4791
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-C*03:02 ASFSTFKCY APFFTFKCY 64 2361
HLA-A*01:01 NSASFSTFKCY NFAPFFTFKCY 328 11908
HLA-C*16:01 NSASFSTF NFAPFFTF 243 8738
HLA-A*11:01 ASFSTFKCY APFFTFKCY 379 12650
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-A*32:01 YNSASFSTF YNFAPFFTF 4333 169
HLA-B*35:01 ASFSTFKCY APFFTFKCY 2345 92
HLA-A*68:02 NSASFSTFKCYGV NFAPFFTFKCYGV 48 1156
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-C*12:02 ASFSTFKCY APFFTFKCY 338 7588
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-B*15:03 ASFSTFKCY APFFTFKCY 25 495
HLA-A*29:02 YNSASFSTF YNFAPFFTF 1671 85
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*23:01 YNSASFSTF YNFAPFFTF 352 19
HLA-A*11:01 LYNSASFSTFK LYNFAPFFTFK 43 779
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2385 135
HLA-C*14:02 NSASFSTF NFAPFFTF 2544 153
HLA-C*14:02 SFSTFKCY PFFTFKCY 386 6068
HLA-A*30:02 SASFSTFKCY FAPFFTFKCY 71 1044
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFTF 50 657
HLA-A*29:02 NSASFSTFKCY NFAPFFTFKCY 662 67
HLA-A*11:01 NSASFSTFK NFAPFFTFK 9 88
HLA-A*33:03 YNSASFSTFK YNFAPFFTFK 823 85
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-A*02:06 SVLYNSASF SVLYNFAPF 2112 234
HLA-B*18:01 YNSASFSTF YNFAPFFTF 3495 395
HLA-A*23:01 YSVLYNSASFSTF YSVLYNFAPFFTF 1474 167
HLA-A*29:02 YNSASFSTFKCY YNFAPFFTFKCY 842 101
HLA-A*29:02 ASFSTFKCY APFFTFKCY 201 1653
HLA-B*35:01 SASFSTFKCY FAPFFTFKCY 490 61
HLA-A*02:01 VLYNSASFST VLYNFAPFFT 243 31
HLA-A*33:03 NSASFSTFK NFAPFFTFK 181 24
HLA-A*24:02 YNSASFSTF YNFAPFFTF 473 66
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFTF 1624 231
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2634 382
HLA-A*23:01 SVLYNSASFSTF SVLYNFAPFFTF 656 98
HLA-A*31:01 YNSASFSTFK YNFAPFFTFK 607 93
HLA-A*29:02 LYNSASFSTF LYNFAPFFTF 387 61
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*02:11 VLYNSASFST VLYNFAPFFT 77 14
HLA-A*03:01 LYNSASFSTFK LYNFAPFFTFK 295 1567
HLA-A*31:01 NSASFSTFK NFAPFFTFK 293 56
HLA-A*23:01 SVLYNSASF SVLYNFAPF 990 197
HLA-A*30:02 NSASFSTFKCY NFAPFFTFKCY 387 1942
HLA-C*14:02 LYNSASFSTF LYNFAPFFTF 20 99
HLA-A*02:02 VLYNSASFST VLYNFAPFFT 202 42
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFTFK 857 180
HLA-A*68:01 NSASFSTFK NFAPFFTFK 4 19
HLA-A*23:01 LYNSASFSTFKC LYNFAPFFTFKC 1642 351
HLA-C*12:03 SASFSTFKCY FAPFFTFKCY 498 107
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFTFK 113 522
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFTF 164 752
HLA-A*03:02 LYNSASFSTFK LYNFAPFFTFK 202 911
HLA-A*03:02 NSASFSTFK NFAPFFTFK 37 166
HLA-A*02:06 VLYNSASFST VLYNFAPFFT 710 161
HLA-A*11:01 SASFSTFK FAPFFTFK 452 1893
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*02:06 SASFSTFKCYGV FAPFFTFKCYGV 1416 368
HLA-A*23:01 VLYNSASFSTF VLYNFAPFFTF 133 35
HLA-A*32:01 VLYNSASFSTF VLYNFAPFFTF 699 185
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFTF 113 415
HLA-A*68:01 NSASFSTFKC NFAPFFTFKC 281 1027
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFTF 38 138
HLA-A*29:02 SVLYNSASF SVLYNFAPF 1130 313
HLA-C*12:02 SASFSTFKCY FAPFFTFKCY 710 202
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFTFKCY 272 915
HLA-A*23:01 LYNSASFSTFK LYNFAPFFTFK 265 81
HLA-B*15:01 LYNSASFSTF LYNFAPFFTF 468 1484
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFTF 221 694
HLA-A*11:01 YNSASFSTFK YNFAPFFTFK 12 37
HLA-A*26:01 SVLYNSASF SVLYNFAPF 1313 431
HLA-C*03:02 SASFSTFKCY FAPFFTFKCY 212 73
HLA-A*01:01 SASFSTFKCY FAPFFTFKCY 461 1323
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFTFK 565 197
HLA-A*23:01 YSVLYNSASF YSVLYNFAPF 1120 403
HLA-C*02:02 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-C*02:10 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFTFKCY 297 117
HLA-A*03:01 YNSASFSTFK YNFAPFFTFK 80 200
HLA-B*15:01 YNSASFSTF YNFAPFFTF 123 303
HLA-A*31:01 LYNSASFSTFK LYNFAPFFTFK 299 122
HLA-A*24:02 SVLYNSASFSTF SVLYNFAPFFTF 1041 432
HLA-A*23:01 LYNSASFSTF LYNFAPFFTF 7 3
HLA-A*68:01 SASFSTFK FAPFFTFK 1114 489
HLA-A*03:02 YNSASFSTFK YNFAPFFTFK 40 87
HLA-A*23:01 DYSVLYNSASF DYSVLYNFAPF 1039 482
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFTFKC 312 646
HLA-A*68:01 LYNSASFSTFK LYNFAPFFTFK 201 406

S375F

Reference  VYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VYAWNRKRISNCVADYSVLYNFAPFFTFKCYGVSPTKLNDLCFTNVYADSF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*32:01 VLYNSASFS VLYNFAPFF 22186 33
HLA-A*23:01 VLYNSASFS VLYNFAPFF 32767 84
HLA-B*15:03 VLYNSASFS VLYNFAPFF 3280 11
HLA-A*23:01 NSASFSTF NFAPFFTF 12240 75
HLA-A*29:02 VLYNSASFS VLYNFAPFF 10439 66
HLA-A*23:01 LYNSASFS LYNFAPFF 22508 183
HLA-A*24:02 LYNSASFS LYNFAPFF 25164 266
HLA-A*24:02 NSASFSTF NFAPFFTF 14241 153
HLA-A*32:01 SVLYNSASFS SVLYNFAPFF 14340 178
HLA-A*24:02 VLYNSASFS VLYNFAPFF 32767 429
HLA-A*30:02 ASFSTFKCY APFFTFKCY 43 2759
HLA-A*29:02 SVLYNSASFS SVLYNFAPFF 16185 256
HLA-B*15:01 VLYNSASFS VLYNFAPFF 8189 139
HLA-C*03:02 VLYNSASFS VLYNFAPFF 13004 222
HLA-C*15:02 FSTFKCYGV FFTFKCYGV 431 24744
HLA-A*68:02 FSTFKCYGV FFTFKCYGV 17 973
HLA-A*02:06 ASFSTFKCYGV APFFTFKCYGV 231 13051
HLA-B*15:01 ASFSTFKCY APFFTFKCY 107 6034
HLA-A*23:01 SVLYNSASFS SVLYNFAPFF 24524 482
HLA-C*14:02 LYNSASFS LYNFAPFF 5693 117
HLA-A*02:06 FSTFKCYGV FFTFKCYGV 61 2768
HLA-C*16:01 ASFSTFKCY APFFTFKCY 68 2875
HLA-C*12:03 ASFSTFKCY APFFTFKCY 115 4791
HLA-B*15:03 SVLYNSASFS SVLYNFAPFF 2850 70
HLA-A*23:01 DYSVLYNSASFS DYSVLYNFAPFF 14260 374
HLA-C*03:02 ASFSTFKCY APFFTFKCY 64 2361
HLA-C*16:01 FSTFKCYGV FFTFKCYGV 302 11120
HLA-A*01:01 NSASFSTFKCY NFAPFFTFKCY 328 11908
HLA-C*16:01 NSASFSTF NFAPFFTF 243 8738
HLA-A*11:01 ASFSTFKCY APFFTFKCY 379 12650
HLA-C*14:02 VLYNSASFS VLYNFAPFF 11085 354
HLA-A*32:01 YNSASFSTF YNFAPFFTF 4333 169
HLA-B*35:01 ASFSTFKCY APFFTFKCY 2345 92
HLA-A*68:02 NSASFSTFKCYGV NFAPFFTFKCYGV 48 1156
HLA-B*58:01 YSVLYNSASFS YSVLYNFAPFF 6920 296
HLA-C*12:02 ASFSTFKCY APFFTFKCY 338 7588
HLA-B*15:01 SVLYNSASFS SVLYNFAPFF 2838 139
HLA-C*03:02 SVLYNSASFS SVLYNFAPFF 8888 443
HLA-B*15:03 ASFSTFKCY APFFTFKCY 25 495
HLA-A*29:02 YNSASFSTF YNFAPFFTF 1671 85
HLA-B*15:03 YSVLYNSASFS YSVLYNFAPFF 3170 164
HLA-A*23:01 YNSASFSTF YNFAPFFTF 352 19
HLA-A*11:01 LYNSASFSTFK LYNFAPFFTFK 43 779
HLA-A*23:01 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2385 135
HLA-C*14:02 NSASFSTF NFAPFFTF 2544 153
HLA-C*14:02 SFSTFKCY PFFTFKCY 386 6068
HLA-A*30:02 SASFSTFKCY FAPFFTFKCY 71 1044
HLA-B*15:01 VLYNSASFSTF VLYNFAPFFTF 50 657
HLA-A*29:02 NSASFSTFKCY NFAPFFTFKCY 662 67
HLA-A*11:01 NSASFSTFK NFAPFFTFK 9 88
HLA-A*33:03 YNSASFSTFK YNFAPFFTFK 823 85
HLA-C*03:02 YSVLYNSASFS YSVLYNFAPFF 2405 264
HLA-B*18:01 YNSASFSTF YNFAPFFTF 3495 395
HLA-A*23:01 YSVLYNSASFSTF YSVLYNFAPFFTF 1474 167
HLA-A*11:01 FSTFKCYGVSPTK FFTFKCYGVSPTK 426 3618
HLA-A*29:02 YNSASFSTFKCY YNFAPFFTFKCY 842 101
HLA-A*29:02 ASFSTFKCY APFFTFKCY 201 1653
HLA-B*35:01 SASFSTFKCY FAPFFTFKCY 490 61
HLA-A*02:01 VLYNSASFST VLYNFAPFFT 243 31
HLA-A*11:01 STFKCYGVSPTK FTFKCYGVSPTK 25 191
HLA-A*02:02 FSTFKCYGV FFTFKCYGV 89 676
HLA-A*30:01 STFKCYGVS FTFKCYGVS 438 3311
HLA-A*33:03 NSASFSTFK NFAPFFTFK 181 24
HLA-A*30:01 STFKCYGVSPTK FTFKCYGVSPTK 194 1399
HLA-A*24:02 YNSASFSTF YNFAPFFTF 473 66
HLA-A*32:01 SVLYNSASFSTF SVLYNFAPFFTF 1624 231
HLA-A*24:02 DYSVLYNSASFSTF DYSVLYNFAPFFTF 2634 382
HLA-A*23:01 SVLYNSASFSTF SVLYNFAPFFTF 656 98
HLA-A*02:01 FSTFKCYGV FFTFKCYGV 457 3016
HLA-A*31:01 YNSASFSTFK YNFAPFFTFK 607 93
HLA-A*02:11 STFKCYGV FTFKCYGV 2124 327
HLA-A*29:02 LYNSASFSTF LYNFAPFFTF 387 61
HLA-A*02:11 FSTFKCYGV FFTFKCYGV 75 475
HLA-A*02:06 STFKCYGV FTFKCYGV 2045 328
HLA-A*30:02 VLYNSASFS VLYNFAPFF 2919 476
HLA-A*02:11 VLYNSASFST VLYNFAPFFT 77 14
HLA-A*03:01 LYNSASFSTFK LYNFAPFFTFK 295 1567
HLA-A*31:01 NSASFSTFK NFAPFFTFK 293 56
HLA-A*03:01 STFKCYGVSPTK FTFKCYGVSPTK 83 419
HLA-A*30:02 NSASFSTFKCY NFAPFFTFKCY 387 1942
HLA-C*14:02 LYNSASFSTF LYNFAPFFTF 20 99
HLA-A*02:02 VLYNSASFST VLYNFAPFFT 202 42
HLA-A*31:01 SVLYNSASFSTFK SVLYNFAPFFTFK 857 180
HLA-A*68:01 NSASFSTFK NFAPFFTFK 4 19
HLA-A*23:01 LYNSASFSTFKC LYNFAPFFTFKC 1642 351
HLA-C*12:03 SASFSTFKCY FAPFFTFKCY 498 107
HLA-A*02:11 SVLYNSASFS SVLYNFAPFF 2012 435
HLA-A*03:01 NSASFSTFK NFAPFFTFK 113 522
HLA-B*15:01 YSVLYNSASFSTF YSVLYNFAPFFTF 164 752
HLA-A*03:02 LYNSASFSTFK LYNFAPFFTFK 202 911
HLA-A*03:02 NSASFSTFK NFAPFFTFK 37 166
HLA-A*02:06 VLYNSASFST VLYNFAPFFT 710 161
HLA-A*11:01 SASFSTFK FAPFFTFK 452 1893
HLA-A*02:01 VLYNSASFS VLYNFAPFF 1548 377
HLA-A*02:11 VLYNSASFS VLYNFAPFF 258 63
HLA-A*68:02 STFKCYGVSPT FTFKCYGVSPT 1247 305
HLA-A*03:02 STFKCYGVSPTK FTFKCYGVSPTK 142 572
HLA-A*68:02 STFKCYGV FTFKCYGV 745 193
HLA-A*02:06 SASFSTFKCYGV FAPFFTFKCYGV 1416 368
HLA-A*23:01 VLYNSASFSTF VLYNFAPFFTF 133 35
HLA-A*32:01 VLYNSASFSTF VLYNFAPFFTF 699 185
HLA-C*03:02 YSVLYNSASFSTF YSVLYNFAPFFTF 113 415
HLA-A*68:01 NSASFSTFKC NFAPFFTFKC 281 1027
HLA-B*15:03 VLYNSASFSTF VLYNFAPFFTF 38 138
HLA-C*12:02 SASFSTFKCY FAPFFTFKCY 710 202
HLA-A*30:02 VLYNSASFSTFKCY VLYNFAPFFTFKCY 272 915
HLA-A*23:01 LYNSASFSTFK LYNFAPFFTFK 265 81
HLA-B*15:01 LYNSASFSTF LYNFAPFFTF 468 1484
HLA-B*15:01 SVLYNSASFSTF SVLYNFAPFFTF 221 694
HLA-A*11:01 YNSASFSTFK YNFAPFFTFK 12 37
HLA-C*03:02 SASFSTFKCY FAPFFTFKCY 212 73
HLA-A*01:01 SASFSTFKCY FAPFFTFKCY 461 1323
HLA-A*31:01 VLYNSASFSTFK VLYNFAPFFTFK 565 197
HLA-A*68:01 STFKCYGVSPTK FTFKCYGVSPTK 106 41
HLA-C*02:02 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-C*02:10 SASFSTFKCY FAPFFTFKCY 1213 472
HLA-A*29:02 LYNSASFSTFKCY LYNFAPFFTFKCY 297 117
HLA-A*03:01 YNSASFSTFK YNFAPFFTFK 80 200
HLA-B*15:01 YNSASFSTF YNFAPFFTF 123 303
HLA-A*31:01 LYNSASFSTFK LYNFAPFFTFK 299 122
HLA-A*24:02 SVLYNSASFSTF SVLYNFAPFFTF 1041 432
HLA-A*23:01 LYNSASFSTF LYNFAPFFTF 7 3
HLA-A*68:01 SASFSTFK FAPFFTFK 1114 489
HLA-A*03:02 YNSASFSTFK YNFAPFFTFK 40 87
HLA-A*68:01 FSTFKCYGVSPTK FFTFKCYGVSPTK 288 603
HLA-A*03:01 VLYNSASFSTFKC VLYNFAPFFTFKC 312 646
HLA-A*68:01 LYNSASFSTFK LYNFAPFFTFK 201 406

D405N

Reference  YGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YGVSPTKLNDLCFTNVYADSFVIRGNEVRQIAPGQTGTIADYNYKLPDDFT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*30:01 RGDEVRQIA RGNEVRQIA 7488 332
HLA-C*14:02 SFVIRGDEV SFVIRGNEV 216 46
HLA-A*31:01 SFVIRGDEVR SFVIRGNEVR 537 225
HLA-A*33:03 FVIRGDEVR FVIRGNEVR 320 141
HLA-A*33:03 SFVIRGDEVR SFVIRGNEVR 459 206

K417T

Reference  FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    FTNVYADSFVIRGNEVRQIAPGQTGTIADYNYKLPDDFTGCVIAWNSNKLD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 GKIADYNYK GTIADYNYK 8565 6
HLA-A*03:01 RQIAPGQTGK RQIAPGQTGT 49 23113
HLA-A*68:01 GKIADYNYK GTIADYNYK 12087 32
HLA-A*03:02 GKIADYNYK GTIADYNYK 14291 44
HLA-A*11:01 RQIAPGQTGK RQIAPGQTGT 103 30673
HLA-A*03:02 RQIAPGQTGK RQIAPGQTGT 123 25727
HLA-A*11:01 QIAPGQTGK QIAPGQTGT 165 32767
HLA-A*68:01 EVRQIAPGQTGK EVRQIAPGQTGT 144 27700
HLA-A*68:01 QIAPGQTGK QIAPGQTGT 136 20478
HLA-A*03:01 GKIADYNYK GTIADYNYK 15362 118
HLA-A*03:02 QIAPGQTGK QIAPGQTGT 278 32767
HLA-A*11:01 GKIADYNYKL GTIADYNYKL 30153 269
HLA-A*03:01 QIAPGQTGK QIAPGQTGT 296 32213
HLA-A*11:01 APGQTGKIADYNYK APGQTGTIADYNYK 15790 166
HLA-A*68:01 TGKIADYNYK TGTIADYNYK 957 13
HLA-A*11:01 TGKIADYNYK TGTIADYNYK 1113 19
HLA-A*68:02 KIADYNYKL TIADYNYKL 1274 34
HLA-A*30:01 GKIADYNYK GTIADYNYK 5364 151
HLA-A*32:01 KIADYNYKL TIADYNYKL 58 1664
HLA-A*31:01 GKIADYNYK GTIADYNYK 11055 392
HLA-A*30:01 RQIAPGQTGK RQIAPGQTGT 275 7151
HLA-A*11:01 GQTGKIADYNYK GQTGTIADYNYK 1342 63
HLA-A*03:02 TGKIADYNYK TGTIADYNYK 3525 241
HLA-C*01:02 IAPGQTGKI IAPGQTGTI 529 115
HLA-A*03:02 KIADYNYK TIADYNYK 476 2050
HLA-A*30:01 TGKIADYNYK TGTIADYNYK 292 948
HLA-C*12:03 IAPGQTGKI IAPGQTGTI 806 253
HLA-A*02:01 KIADYNYKL TIADYNYKL 23 69
HLA-A*02:06 KIADYNYKL TIADYNYKL 20 51
HLA-A*30:02 GQTGKIADY GQTGTIADY 337 135
HLA-A*02:11 KIADYNYKL TIADYNYKL 5 12
HLA-A*01:01 QTGKIADYNY QTGTIADYNY 580 276
HLA-B*07:02 APGQTGKIA APGQTGTIA 507 248

N440K

Reference  TGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFE
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TGTIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFE

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 CVIAWNSNN CVIAWNSNK 24486 26
HLA-A*68:01 CVIAWNSNN CVIAWNSNK 11802 16
HLA-A*68:01 FTGCVIAWNSNN FTGCVIAWNSNK 25655 59
HLA-A*03:01 CVIAWNSNN CVIAWNSNK 24643 61
HLA-A*03:02 CVIAWNSNN CVIAWNSNK 22621 61
HLA-A*11:01 GCVIAWNSNN GCVIAWNSNK 32767 94
HLA-A*03:01 GCVIAWNSNN GCVIAWNSNK 32767 128
HLA-A*11:01 TGCVIAWNSNN TGCVIAWNSNK 32767 153
HLA-A*68:01 TGCVIAWNSNN TGCVIAWNSNK 32767 180
HLA-A*68:01 DFTGCVIAWNSNN DFTGCVIAWNSNK 32767 255
HLA-A*03:02 GCVIAWNSNN GCVIAWNSNK 32767 277
HLA-A*11:01 FTGCVIAWNSNN FTGCVIAWNSNK 32767 408
HLA-A*31:01 CVIAWNSNN CVIAWNSNK 18631 279
HLA-A*33:03 CVIAWNSNN CVIAWNSNK 20952 493
HLA-A*30:01 CVIAWNSNN CVIAWNSNK 11396 467
HLA-A*03:01 NLDSKVGGNY KLDSKVSGNY 11143 467
HLA-A*30:02 NLDSKVGGNY KLDSKVSGNY 422 38
HLA-A*30:02 NLDSKVGGNYNYLY KLDSKVSGNYNYLY 3335 352
HLA-B*15:01 NLDSKVGGNY KLDSKVSGNY 1404 160
HLA-A*02:11 NLDSKVGGNYNYL KLDSKVSGNYNYL 671 77
HLA-A*30:02 NLDSKVGGNYNY KLDSKVSGNYNY 3839 443
HLA-A*02:02 NLDSKVGGNYNYL KLDSKVSGNYNYL 1730 205
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKVSGNYNYLY 193 444
HLA-A*02:11 VIAWNSNNL VIAWNSNKL 269 586
HLA-A*68:02 FTGCVIAWNSNNL FTGCVIAWNSNKL 461 960

G446S

Reference  YNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTE
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTE

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*01:01 VGGNYNYLY VSGNYNYLY 2993 60
HLA-A*03:01 NLDSKVGGNY KLDSKVSGNY 11143 467
HLA-B*58:01 VGGNYNYLY VSGNYNYLY 2198 98
HLA-A*11:01 VGGNYNYLYR VSGNYNYLYR 2420 146
HLA-A*30:02 NLDSKVGGNY KLDSKVSGNY 422 38
HLA-A*68:01 VGGNYNYLYR VSGNYNYLYR 1759 168
HLA-C*16:01 VGGNYNYLY VSGNYNYLY 1599 158
HLA-A*30:02 NLDSKVGGNYNYLY KLDSKVSGNYNYLY 3335 352
HLA-B*15:01 NLDSKVGGNY KLDSKVSGNY 1404 160
HLA-A*02:11 NLDSKVGGNYNYL KLDSKVSGNYNYL 671 77
HLA-B*58:01 KVGGNYNYLY KVSGNYNYLY 1217 140
HLA-A*30:02 NLDSKVGGNYNY KLDSKVSGNYNY 3839 443
HLA-A*02:02 NLDSKVGGNYNYL KLDSKVSGNYNYL 1730 205
HLA-C*03:03 KVGGNYNYL KVSGNYNYL 3215 422
HLA-C*03:04 KVGGNYNYL KVSGNYNYL 3215 422
HLA-C*12:03 KVGGNYNYL KVSGNYNYL 3025 471
HLA-A*03:02 VGGNYNYLYR VSGNYNYLYR 3049 478
HLA-B*57:01 KVGGNYNYLY KVSGNYNYLY 3057 488
HLA-C*16:01 KVGGNYNYL KVSGNYNYL 1979 331
HLA-A*24:02 GGNYNYLYRLF SGNYNYLYRLF 1816 313
HLA-A*68:01 GGNYNYLYR SGNYNYLYR 1245 229
HLA-C*17:01 KVGGNYNYL KVSGNYNYL 1103 203
HLA-A*23:01 GGNYNYLYRLF SGNYNYLYRLF 988 186
HLA-A*33:03 GGNYNYLYR SGNYNYLYR 1064 201
HLA-C*15:02 KVGGNYNYL KVSGNYNYL 1464 313
HLA-A*29:02 VGGNYNYLY VSGNYNYLY 94 22
HLA-A*02:02 KVGGNYNYL KVSGNYNYL 279 67
HLA-A*31:01 VGGNYNYLYRLFR VSGNYNYLYRLFR 253 64
HLA-A*33:03 VGGNYNYLYR VSGNYNYLYR 1215 325
HLA-A*31:01 VGGNYNYLYR VSGNYNYLYR 138 39
HLA-A*11:01 KVGGNYNYLY KVSGNYNYLY 802 243
HLA-B*15:01 KVGGNYNYLY KVSGNYNYLY 1300 401
HLA-B*15:03 VGGNYNYLY VSGNYNYLY 1324 427
HLA-A*30:01 KVGGNYNYL KVSGNYNYL 502 163
HLA-A*02:06 KVGGNYNYL KVSGNYNYL 452 162
HLA-A*31:01 GGNYNYLYRLFR SGNYNYLYRLFR 153 56
HLA-A*32:01 KVGGNYNYL KVSGNYNYL 1203 445
HLA-A*03:02 KVGGNYNYLY KVSGNYNYLY 941 351
HLA-A*30:02 KVGGNYNYLYR KVSGNYNYLYR 1309 497
HLA-A*33:03 GGNYNYLYRLFR SGNYNYLYRLFR 636 251
HLA-A*30:02 SKVGGNYNYLY SKVSGNYNYLY 362 143
HLA-A*29:02 KVGGNYNYLY KVSGNYNYLY 100 40
HLA-A*30:02 DSKVGGNYNYLY DSKVSGNYNYLY 1093 465
HLA-A*01:01 NLDSKVGGNYNYLY KLDSKVSGNYNYLY 193 444
HLA-A*30:02 VGGNYNYLY VSGNYNYLY 45 20
HLA-A*11:01 GGNYNYLYR SGNYNYLYR 876 391
HLA-A*02:11 KVGGNYNYL KVSGNYNYL 111 54

477-478 ST->NK

Reference  LYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGV
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    LYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*11:01 STEIYQAGST STEIYQAGNK 30358 67
HLA-A*68:01 STEIYQAGST STEIYQAGNK 22142 157
HLA-A*03:01 STEIYQAGST STEIYQAGNK 32241 308
HLA-B*35:01 TPCNGVEGF KPCNGVAGF 319 1522
HLA-B*42:01 TPCNGVEGF KPCNGVAGF 2031 454
HLA-A*02:11 YQAGSTPCNGV YQAGNKPCNGV 173 678
HLA-B*50:01 TEIYQAGSTP TEIYQAGNKP 464 1807
HLA-A*02:06 YQAGSTPCNGV YQAGNKPCNGV 39 146
HLA-A*02:01 YQAGSTPCNGV YQAGNKPCNGV 420 1490
HLA-C*14:02 IYQAGSTPC IYQAGNKPC 134 459
HLA-A*02:02 YQAGSTPCNGV YQAGNKPCNGV 107 233

E484A

Reference  SNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYR
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 EGFNCYFPLQ AGFNCYFPLR 13906 13
HLA-B*40:02 VEGFNCYFPL VAGFNCYFPL 31 10868
HLA-A*68:01 GVEGFNCYFPLQ GVAGFNCYFPLR 27995 107
HLA-B*40:01 VEGFNCYFPL VAGFNCYFPL 76 19416
HLA-A*31:01 GVEGFNCYFPLQ GVAGFNCYFPLR 15109 90
HLA-A*31:01 VEGFNCYFPLQ VAGFNCYFPLR 15897 151
HLA-A*11:01 EGFNCYFPLQ AGFNCYFPLR 25719 362
HLA-A*33:03 GVEGFNCYFPLQ GVAGFNCYFPLR 24534 414
HLA-A*33:03 NGVEGFNCYFPLQ NGVAGFNCYFPLR 23008 416
HLA-A*33:03 EGFNCYFPLQ AGFNCYFPLR 7445 148
HLA-B*15:01 GVEGFNCYF GVAGFNCYF 3125 128
HLA-A*68:02 EGFNCYFPL AGFNCYFPL 117 2032
HLA-A*68:01 EGFNCYFPLQ AGFNCYFPLR 5231 331
HLA-A*32:01 GVEGFNCYF GVAGFNCYF 5606 430
HLA-B*15:03 GVEGFNCYF GVAGFNCYF 1657 141
HLA-B*15:03 EGFNCYFPL AGFNCYFPL 2980 308
HLA-A*30:02 EGFNCYFPLQSY AGFNCYFPLRSY 1806 189
HLA-A*02:06 EGFNCYFPL AGFNCYFPL 1266 185
HLA-A*02:11 EGFNCYFPL AGFNCYFPL 2508 401
HLA-A*02:02 GVEGFNCYFPL GVAGFNCYFPL 666 124
HLA-A*02:06 VEGFNCYFPL VAGFNCYFPL 1553 310
HLA-B*35:01 TPCNGVEGF KPCNGVAGF 319 1522
HLA-B*42:01 TPCNGVEGF KPCNGVAGF 2031 454
HLA-A*02:11 GVEGFNCYFPL GVAGFNCYFPL 464 172
HLA-A*02:06 GVEGFNCYFPL GVAGFNCYFPL 400 174

Q493R

Reference  ISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYGFRPTY 6543 5
HLA-C*16:01 QSYGFQPTN RSYGFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYGFRPTY 12903 11
HLA-A*31:01 EGFNCYFPLQ AGFNCYFPLR 13906 13
HLA-A*32:01 QSYGFQPTN RSYGFRPTY 16619 17
HLA-C*12:03 QSYGFQPTN RSYGFRPTY 12696 21
HLA-A*30:02 QSYGFQPTN RSYGFRPTY 5297 10
HLA-A*29:02 QSYGFQPTN RSYGFRPTY 26152 55
HLA-A*31:01 CYFPLQSYGFQ CYFPLRSYGFR 8535 18
HLA-A*33:03 YFPLQSYGFQ YFPLRSYGFR 11148 26
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 19514 51
HLA-A*31:01 YFPLQSYGFQ YFPLRSYGFR 16290 49
HLA-A*33:03 CYFPLQSYGFQ CYFPLRSYGFR 11311 35
HLA-A*31:01 GFNCYFPLQ GFNCYFPLR 8660 27
HLA-A*33:03 FPLQSYGFQ FPLRSYGFR 23527 81
HLA-B*15:01 QSYGFQPTN RSYGFRPTY 21529 75
HLA-A*68:01 GVEGFNCYFPLQ GVAGFNCYFPLR 27995 107
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18230 74
HLA-C*14:02 QSYGFQPTN RSYGFRPTY 25941 110
HLA-B*35:01 FPLQSYGFQPTN FPLRSYGFRPTY 8715 39
HLA-C*03:02 FPLQSYGFQPTN FPLRSYGFRPTY 23840 111
HLA-C*12:02 QSYGFQPTN RSYGFRPTY 21029 102
HLA-A*03:01 QSYGFQPTN RSYGFRPTY 24499 125
HLA-A*11:01 QSYGFQPTN RSYGFRPTY 22068 116
HLA-B*27:05 LQSYGFQPTN LRSYGFRPTY 22303 124
HLA-C*03:02 LQSYGFQPTN LRSYGFRPTY 23421 138
HLA-A*30:01 QSYGFQPTN RSYGFRPTY 3720 22
HLA-A*31:01 GVEGFNCYFPLQ GVAGFNCYFPLR 15109 90
HLA-C*02:02 QSYGFQPTN RSYGFRPTY 26598 166
HLA-C*02:10 QSYGFQPTN RSYGFRPTY 26598 166
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLRSYGFR 21321 135
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 27639 176
HLA-A*30:01 QSYGFQPTNG RSYGFRPTYG 4998 34
HLA-C*16:01 LQSYGFQPTN LRSYGFRPTY 27149 185
HLA-B*15:01 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 180 26350
HLA-A*30:02 LQSYGFQPTN LRSYGFRPTY 7508 53
HLA-A*33:03 GFNCYFPLQ GFNCYFPLR 15908 119
HLA-B*15:03 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 113 13480
HLA-C*16:01 FPLQSYGFQPTN FPLRSYGFRPTY 27733 235
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLRSYGFR 22134 197
HLA-B*15:03 FPLQSYGFQPTN FPLRSYGFRPTY 20159 184
HLA-A*68:01 FPLQSYGFQ FPLRSYGFR 17691 164
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYGFRPTY 22168 209
HLA-A*31:01 VEGFNCYFPLQ VAGFNCYFPLR 15897 151
HLA-B*57:01 QSYGFQPTN RSYGFRPTY 4070 39
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYGFRPTY 29358 304
HLA-C*12:03 FPLQSYGFQPTN FPLRSYGFRPTY 27893 295
HLA-A*31:01 QSYGFQPTN RSYGFRPTY 23046 284
HLA-A*02:06 LQSYGFQPT LRSYGFRPT 339 27440
HLA-B*15:03 QSYGFQPTNG RSYGFRPTYG 16794 211
HLA-A*33:03 FNCYFPLQSYGFQ FNCYFPLRSYGFR 23280 295
HLA-C*12:03 LQSYGFQPTN LRSYGFRPTY 26641 344
HLA-C*07:01 QSYGFQPTN RSYGFRPTY 29907 403
HLA-A*29:02 LQSYGFQPTN LRSYGFRPTY 28458 387
HLA-A*11:01 EGFNCYFPLQ AGFNCYFPLR 25719 362
HLA-A*30:02 QSYGFQPTNG RSYGFRPTYG 9959 143
HLA-B*15:03 LQSYGFQPTN LRSYGFRPTY 2045 30
HLA-A*30:02 PLQSYGFQPTN PLRSYGFRPTY 26291 402
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 27182 428
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 24158 394
HLA-A*31:01 FNCYFPLQSYGFQ FNCYFPLRSYGFR 23471 389
HLA-A*33:03 GVEGFNCYFPLQ GVAGFNCYFPLR 24534 414
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18743 328
HLA-A*33:03 NGVEGFNCYFPLQ NGVAGFNCYFPLR 23008 416
HLA-A*30:02 FPLQSYGFQPTN FPLRSYGFRPTY 21475 393
HLA-A*68:01 YFPLQSYGFQ YFPLRSYGFR 14480 280
HLA-B*58:01 QSYGFQPTN RSYGFRPTY 1532 30
HLA-A*33:03 EGFNCYFPLQ AGFNCYFPLR 7445 148
HLA-B*15:03 LQSYGFQPT LRSYGFRPT 138 6040
HLA-A*31:01 CYFPLQSYGFQP CYFPLRSYGFRP 17123 405
HLA-B*27:05 LQSYGFQPTNGV LRSYGFRPTYGV 17291 480
HLA-A*30:01 QSYGFQPTNGV RSYGFRPTYGV 5404 152
HLA-A*30:01 QSYGFQPTNGVG RSYGFRPTYGVG 11201 316
HLA-A*30:01 LQSYGFQPTN LRSYGFRPTY 9833 373
HLA-B*15:01 LQSYGFQPTN LRSYGFRPTY 6135 249
HLA-A*32:01 QSYGFQPTNGV RSYGFRPTYGV 10242 485
HLA-A*68:01 EGFNCYFPLQ AGFNCYFPLR 5231 331
HLA-A*02:06 LQSYGFQPTNGV LRSYGFRPTYGV 249 3135
HLA-B*57:01 LQSYGFQPTN LRSYGFRPTY 3839 339
HLA-B*08:01 FPLQSYGF FPLRSYGF 3941 395
HLA-A*02:11 QSYGFQPTNGV RSYGFRPTYGV 2666 268
HLA-A*30:02 EGFNCYFPLQSY AGFNCYFPLRSY 1806 189
HLA-C*15:02 QSYGFQPTNGV RSYGFRPTYGV 2452 362
HLA-A*02:06 QSYGFQPTNGV RSYGFRPTYGV 1121 176
HLA-A*68:02 QSYGFQPTNGV RSYGFRPTYGV 122 633
HLA-A*30:02 QSYGFQPTNGVGY RSYGFRPTYGVGH 258 1311
HLA-B*58:01 QSYGFQPTNG RSYGFRPTYG 2069 475
HLA-B*35:01 NCYFPLQSY NCYFPLRSY 330 1198
HLA-B*42:01 FPLQSYGF FPLRSYGF 551 178
HLA-B*35:01 FPLQSYGF FPLRSYGF 197 450
HLA-C*07:02 YFPLQSYGF YFPLRSYGF 447 217
HLA-B*53:01 FPLQSYGF FPLRSYGF 323 665

Q498R

Reference  YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPAT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    YQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPAT

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYGFRPTY 6543 5
HLA-C*16:01 QSYGFQPTN RSYGFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYGFRPTY 12903 11
HLA-A*32:01 QSYGFQPTN RSYGFRPTY 16619 17
HLA-C*12:03 QSYGFQPTN RSYGFRPTY 12696 21
HLA-A*30:02 QSYGFQPTN RSYGFRPTY 5297 10
HLA-A*29:02 QSYGFQPTN RSYGFRPTY 26152 55
HLA-A*31:01 CYFPLQSYGFQ CYFPLRSYGFR 8535 18
HLA-A*33:03 YFPLQSYGFQ YFPLRSYGFR 11148 26
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 19514 51
HLA-A*31:01 YFPLQSYGFQ YFPLRSYGFR 16290 49
HLA-A*33:03 CYFPLQSYGFQ CYFPLRSYGFR 11311 35
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-A*33:03 FPLQSYGFQ FPLRSYGFR 23527 81
HLA-B*15:01 QSYGFQPTN RSYGFRPTY 21529 75
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18230 74
HLA-C*14:02 QSYGFQPTN RSYGFRPTY 25941 110
HLA-B*35:01 FPLQSYGFQPTN FPLRSYGFRPTY 8715 39
HLA-C*03:02 FPLQSYGFQPTN FPLRSYGFRPTY 23840 111
HLA-C*12:02 QSYGFQPTN RSYGFRPTY 21029 102
HLA-A*03:01 QSYGFQPTN RSYGFRPTY 24499 125
HLA-A*11:01 QSYGFQPTN RSYGFRPTY 22068 116
HLA-B*27:05 LQSYGFQPTN LRSYGFRPTY 22303 124
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-C*03:02 LQSYGFQPTN LRSYGFRPTY 23421 138
HLA-A*30:01 QSYGFQPTN RSYGFRPTY 3720 22
HLA-C*02:02 QSYGFQPTN RSYGFRPTY 26598 166
HLA-C*02:10 QSYGFQPTN RSYGFRPTY 26598 166
HLA-A*31:01 NCYFPLQSYGFQ NCYFPLRSYGFR 21321 135
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 27639 176
HLA-A*30:01 QSYGFQPTNG RSYGFRPTYG 4998 34
HLA-C*16:01 LQSYGFQPTN LRSYGFRPTY 27149 185
HLA-B*15:01 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 180 26350
HLA-A*30:02 LQSYGFQPTN LRSYGFRPTY 7508 53
HLA-B*15:03 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 113 13480
HLA-C*16:01 FPLQSYGFQPTN FPLRSYGFRPTY 27733 235
HLA-A*33:03 NCYFPLQSYGFQ NCYFPLRSYGFR 22134 197
HLA-B*15:03 FPLQSYGFQPTN FPLRSYGFRPTY 20159 184
HLA-A*68:01 FPLQSYGFQ FPLRSYGFR 17691 164
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYGFRPTY 22168 209
HLA-B*57:01 QSYGFQPTN RSYGFRPTY 4070 39
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYGFRPTY 29358 304
HLA-C*12:03 FPLQSYGFQPTN FPLRSYGFRPTY 27893 295
HLA-A*31:01 QSYGFQPTN RSYGFRPTY 23046 284
HLA-A*02:06 LQSYGFQPT LRSYGFRPT 339 27440
HLA-B*15:03 QSYGFQPTNG RSYGFRPTYG 16794 211
HLA-A*33:03 FNCYFPLQSYGFQ FNCYFPLRSYGFR 23280 295
HLA-C*12:03 LQSYGFQPTN LRSYGFRPTY 26641 344
HLA-C*07:01 QSYGFQPTN RSYGFRPTY 29907 403
HLA-A*29:02 LQSYGFQPTN LRSYGFRPTY 28458 387
HLA-A*30:02 QSYGFQPTNG RSYGFRPTYG 9959 143
HLA-B*15:03 LQSYGFQPTN LRSYGFRPTY 2045 30
HLA-A*30:02 PLQSYGFQPTN PLRSYGFRPTY 26291 402
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 27182 428
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 24158 394
HLA-A*31:01 FNCYFPLQSYGFQ FNCYFPLRSYGFR 23471 389
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18743 328
HLA-A*30:02 FPLQSYGFQPTN FPLRSYGFRPTY 21475 393
HLA-A*68:01 YFPLQSYGFQ YFPLRSYGFR 14480 280
HLA-B*58:01 QSYGFQPTN RSYGFRPTY 1532 30
HLA-B*15:03 LQSYGFQPT LRSYGFRPT 138 6040
HLA-A*31:01 CYFPLQSYGFQP CYFPLRSYGFRP 17123 405
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-B*27:05 LQSYGFQPTNGV LRSYGFRPTYGV 17291 480
HLA-A*30:01 QSYGFQPTNGV RSYGFRPTYGV 5404 152
HLA-A*30:01 QSYGFQPTNGVG RSYGFRPTYGVG 11201 316
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:01 LQSYGFQPTN LRSYGFRPTY 9833 373
HLA-B*15:01 LQSYGFQPTN LRSYGFRPTY 6135 249
HLA-A*32:01 QSYGFQPTNGV RSYGFRPTYGV 10242 485
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*02:06 LQSYGFQPTNGV LRSYGFRPTYGV 249 3135
HLA-B*57:01 LQSYGFQPTN LRSYGFRPTY 3839 339
HLA-A*02:11 QSYGFQPTNGV RSYGFRPTYGV 2666 268
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-C*15:02 QSYGFQPTNGV RSYGFRPTYGV 2452 362
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-A*02:06 QSYGFQPTNGV RSYGFRPTYGV 1121 176
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-A*68:02 QSYGFQPTNGV RSYGFRPTYGV 122 633
HLA-A*30:02 QSYGFQPTNGVGY RSYGFRPTYGVGH 258 1311
HLA-B*58:01 QSYGFQPTNG RSYGFRPTYG 2069 475
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355

N501Y

Reference  GSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    GNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:03 QSYGFQPTN RSYGFRPTY 6543 5
HLA-C*16:01 QSYGFQPTN RSYGFRPTY 10868 9
HLA-C*03:02 QSYGFQPTN RSYGFRPTY 12903 11
HLA-A*32:01 QSYGFQPTN RSYGFRPTY 16619 17
HLA-C*12:03 QSYGFQPTN RSYGFRPTY 12696 21
HLA-A*30:02 QSYGFQPTN RSYGFRPTY 5297 10
HLA-A*29:02 QSYGFQPTN RSYGFRPTY 26152 55
HLA-A*29:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 19514 51
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-C*14:02 SYGFQPTN SYGFRPTY 20230 66
HLA-B*15:01 QSYGFQPTN RSYGFRPTY 21529 75
HLA-C*14:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18230 74
HLA-C*14:02 QSYGFQPTN RSYGFRPTY 25941 110
HLA-B*35:01 FPLQSYGFQPTN FPLRSYGFRPTY 8715 39
HLA-C*03:02 FPLQSYGFQPTN FPLRSYGFRPTY 23840 111
HLA-C*12:02 QSYGFQPTN RSYGFRPTY 21029 102
HLA-A*03:01 QSYGFQPTN RSYGFRPTY 24499 125
HLA-A*11:01 QSYGFQPTN RSYGFRPTY 22068 116
HLA-B*27:05 LQSYGFQPTN LRSYGFRPTY 22303 124
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-C*03:02 LQSYGFQPTN LRSYGFRPTY 23421 138
HLA-A*30:01 QSYGFQPTN RSYGFRPTY 3720 22
HLA-C*02:02 QSYGFQPTN RSYGFRPTY 26598 166
HLA-C*02:10 QSYGFQPTN RSYGFRPTY 26598 166
HLA-C*03:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 27639 176
HLA-A*30:01 QSYGFQPTNG RSYGFRPTYG 4998 34
HLA-C*16:01 LQSYGFQPTN LRSYGFRPTY 27149 185
HLA-B*15:01 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 180 26350
HLA-A*30:02 LQSYGFQPTN LRSYGFRPTY 7508 53
HLA-B*15:03 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 113 13480
HLA-C*16:01 FPLQSYGFQPTN FPLRSYGFRPTY 27733 235
HLA-B*15:03 FPLQSYGFQPTN FPLRSYGFRPTY 20159 184
HLA-B*15:03 YFPLQSYGFQPTN YFPLRSYGFRPTY 22168 209
HLA-B*57:01 QSYGFQPTN RSYGFRPTY 4070 39
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*16:01 YFPLQSYGFQPTN YFPLRSYGFRPTY 29358 304
HLA-C*12:03 FPLQSYGFQPTN FPLRSYGFRPTY 27893 295
HLA-A*31:01 QSYGFQPTN RSYGFRPTY 23046 284
HLA-B*15:03 QSYGFQPTNG RSYGFRPTYG 16794 211
HLA-C*12:03 LQSYGFQPTN LRSYGFRPTY 26641 344
HLA-C*07:01 QSYGFQPTN RSYGFRPTY 29907 403
HLA-A*29:02 LQSYGFQPTN LRSYGFRPTY 28458 387
HLA-A*30:02 QSYGFQPTNG RSYGFRPTYG 9959 143
HLA-B*15:03 LQSYGFQPTN LRSYGFRPTY 2045 30
HLA-A*30:02 PLQSYGFQPTN PLRSYGFRPTY 26291 402
HLA-A*29:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 27182 428
HLA-C*14:02 CYFPLQSYGFQPTN CYFPLRSYGFRPTY 24158 394
HLA-A*30:02 YFPLQSYGFQPTN YFPLRSYGFRPTY 18743 328
HLA-A*30:02 FPLQSYGFQPTN FPLRSYGFRPTY 21475 393
HLA-B*58:01 QSYGFQPTN RSYGFRPTY 1532 30
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-B*27:05 LQSYGFQPTNGV LRSYGFRPTYGV 17291 480
HLA-A*30:01 QSYGFQPTNGV RSYGFRPTYGV 5404 152
HLA-A*30:01 QSYGFQPTNGVG RSYGFRPTYGVG 11201 316
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-A*30:01 LQSYGFQPTN LRSYGFRPTY 9833 373
HLA-B*15:01 LQSYGFQPTN LRSYGFRPTY 6135 249
HLA-A*32:01 QSYGFQPTNGV RSYGFRPTYGV 10242 485
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*02:06 LQSYGFQPTNGV LRSYGFRPTYGV 249 3135
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*57:01 LQSYGFQPTN LRSYGFRPTY 3839 339
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-A*02:11 QSYGFQPTNGV RSYGFRPTYGV 2666 268
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-C*15:02 QSYGFQPTNGV RSYGFRPTYGV 2452 362
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-A*02:06 QSYGFQPTNGV RSYGFRPTYGV 1121 176
HLA-A*23:01 SYGFQPTNGV SYGFRPTYGV 2697 483
HLA-A*02:11 YGFQPTNGV YGFRPTYGV 307 59
HLA-A*68:02 QSYGFQPTNGV RSYGFRPTYGV 122 633
HLA-A*30:02 QSYGFQPTNGVGY RSYGFRPTYGVGH 258 1311
HLA-B*58:01 QSYGFQPTNG RSYGFRPTYG 2069 475
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*02:02 YGFQPTNGV YGFRPTYGV 868 281
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*02:06 YGFQPTNGV YGFRPTYGV 174 61
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*68:02 YGFQPTNGV YGFRPTYGV 73 26
HLA-C*12:03 YGFQPTNGV YGFRPTYGV 127 355
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

Y505H

Reference  CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*14:02 TNGVGYQPY TYGVGHQPY 5468 16
HLA-B*15:01 FQPTNGVGY FRPTYGVGH 166 29043
HLA-B*15:01 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 180 26350
HLA-B*15:03 LQSYGFQPTNGVGY LRSYGFRPTYGVGH 113 13480
HLA-B*15:03 FQPTNGVGY FRPTYGVGH 63 6390
HLA-A*29:02 GFQPTNGVGY GFRPTYGVGH 188 18753
HLA-C*14:02 GYQPYRVVV GHQPYRVVV 78 3539
HLA-B*15:01 FQPTNGVGYQPY FRPTYGVGHQPY 290 11634
HLA-C*03:02 NGVGYQPY YGVGHQPY 10463 322
HLA-A*24:02 GYQPYRVVVLSF GHQPYRVVVLSF 220 6955
HLA-A*23:01 GYQPYRVVVLSF GHQPYRVVVLSF 107 3241
HLA-B*15:03 YGFQPTNGVGY YGFRPTYGVGH 368 10641
HLA-A*30:02 GFQPTNGVGY GFRPTYGVGH 169 4730
HLA-C*14:02 GYQPYRVVVL GHQPYRVVVL 213 4430
HLA-C*14:02 VGYQPYRVVV VGHQPYRVVV 413 7561
HLA-C*16:01 NGVGYQPY YGVGHQPY 8669 488
HLA-C*07:02 FQPTNGVGYQPY FRPTYGVGHQPY 6169 356
HLA-A*02:11 YQPYRVVVL HQPYRVVVL 332 4009
HLA-A*02:11 NGVGYQPYRV YGVGHQPYRV 5989 500
HLA-B*15:03 NGVGYQPY YGVGHQPY 4677 418
HLA-A*02:06 YQPYRVVVL HQPYRVVVL 223 2206
HLA-C*14:02 FQPTNGVGYQPY FRPTYGVGHQPY 3107 366
HLA-A*29:02 TNGVGYQPY TYGVGHQPY 2031 243
HLA-A*31:01 TNGVGYQPYR TYGVGHQPYR 811 103
HLA-A*02:02 YQPYRVVVL HQPYRVVVL 360 2683
HLA-A*33:03 TNGVGYQPYR TYGVGHQPYR 573 79
HLA-B*15:03 FQPTNGVGYQPY FRPTYGVGHQPY 183 1236
HLA-A*31:01 QPTNGVGYQPYR RPTYGVGHQPYR 3100 478
HLA-C*01:02 YQPYRVVVL HQPYRVVVL 41 241
HLA-A*02:06 YQPYRVVVLSFEL HQPYRVVVLSFEL 430 2495
HLA-C*03:03 YQPYRVVVL HQPYRVVVL 410 2128
HLA-C*03:04 YQPYRVVVL HQPYRVVVL 410 2128
HLA-A*30:02 QSYGFQPTNGVGY RSYGFRPTYGVGH 258 1311
HLA-C*07:02 YQPYRVVVL HQPYRVVVL 135 590
HLA-C*12:03 YQPYRVVVL HQPYRVVVL 132 555
HLA-A*68:01 PTNGVGYQPYR PTYGVGHQPYR 1073 303
HLA-C*14:02 YQPYRVVVL HQPYRVVVL 102 347
HLA-C*16:01 YQPYRVVVL HQPYRVVVL 214 726
HLA-A*33:03 PTNGVGYQPYR PTYGVGHQPYR 1345 417
HLA-A*31:01 GFQPTNGVGYQPYR GFRPTYGVGHQPYR 616 201
HLA-A*29:02 PTNGVGYQPY PTYGVGHQPY 1211 401
HLA-C*12:03 VGYQPYRVV VGHQPYRVV 398 1196
HLA-A*31:01 PTNGVGYQPYR PTYGVGHQPYR 1377 470
HLA-A*68:01 TNGVGYQPYR TYGVGHQPYR 263 740
HLA-A*23:01 YQPYRVVVLSF HQPYRVVVLSF 465 1280
HLA-A*30:02 PTNGVGYQPY PTYGVGHQPY 465 205
HLA-A*31:01 NGVGYQPYR YGVGHQPYR 438 207

D614G

Reference  PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*05:01 YQDVNCTEV YQGVNCTEV 82 8597
HLA-C*08:02 YQDVNCTEV YQGVNCTEV 89 8066
HLA-A*02:11 DVNCTEVPV GVNCTEVPV 2140 72
HLA-A*02:02 DVNCTEVPV GVNCTEVPV 4099 213
HLA-A*68:02 DVNCTEVPV GVNCTEVPV 36 659
HLA-A*02:06 DVNCTEVPV GVNCTEVPV 3807 208
HLA-A*68:02 QVAVLYQDV QVAVLYQGV 183 13
HLA-A*68:02 NQVAVLYQDV NQVAVLYQGV 650 52
HLA-A*02:06 QVAVLYQDV QVAVLYQGV 1312 148
HLA-A*02:11 QVAVLYQDV QVAVLYQGV 2169 268
HLA-A*68:02 NTSNQVAVLYQDV NTSNQVAVLYQGV 1858 231
HLA-A*68:02 TSNQVAVLYQDV TSNQVAVLYQGV 3281 457
HLA-A*02:02 QVAVLYQDV QVAVLYQGV 1107 188
HLA-A*02:01 YQDVNCTEV YQGVNCTEV 75 315
HLA-A*02:06 YQDVNCTEV YQGVNCTEV 17 57
HLA-A*02:11 VLYQDVNCT VLYQGVNCT 224 74
HLA-A*02:11 YQDVNCTEV YQGVNCTEV 31 93
HLA-A*02:11 VLYQDVNCTEVP VLYQGVNCTEVP 1000 402
HLA-A*02:02 NQVAVLYQDV NQVAVLYQGV 269 116
HLA-A*02:11 AVLYQDVNCTEV AVLYQGVNCTEV 500 238
HLA-A*02:01 NQVAVLYQDV NQVAVLYQGV 558 267
HLA-A*02:06 NQVAVLYQDV NQVAVLYQGV 36 18

H655Y

Reference  TPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:01 RAGCLIGAEH RAGCLIGAEY 7377 156
HLA-A*30:02 RAGCLIGAEH RAGCLIGAEY 1881 43
HLA-B*15:01 FQTRAGCLIGAEH FQTRAGCLIGAEY 7512 178
HLA-B*15:03 FQTRAGCLIGAEH FQTRAGCLIGAEY 5076 125
HLA-A*30:02 AGCLIGAEH AGCLIGAEY 5331 179
HLA-B*15:03 RAGCLIGAEH RAGCLIGAEY 5254 179
HLA-A*30:02 QTRAGCLIGAEH QTRAGCLIGAEY 8425 342
HLA-B*15:03 AGCLIGAEH AGCLIGAEY 9025 461
HLA-A*02:11 HVNNSYECDIPI YVNNSYECDIPI 1593 109
HLA-A*02:01 HVNNSYECDIPI YVNNSYECDIPI 2384 226
HLA-A*02:06 HVNNSYECDIPI YVNNSYECDIPI 837 92
HLA-A*02:02 HVNNSYECDIPI YVNNSYECDIPI 1466 187
HLA-A*02:11 CLIGAEHV CLIGAEYV 983 221
HLA-B*15:03 AEHVNNSY AEYVNNSY 986 267
HLA-B*18:01 AEHVNNSY AEYVNNSY 902 286

N679K

Reference  EHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-A*68:01 CASYQTQTN CASYQTQTK 28102 123
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-A*11:01 CASYQTQTN CASYQTQTK 32767 431
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

P681H

Reference  VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVA
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    VNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVA

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 SPRRARSVA SHRRARSVA 4 4721
HLA-B*42:01 SPRRARSVA SHRRARSVA 8 6169
HLA-B*07:02 SPRRARSVASQSI SHRRARSVASQSI 17 11433
HLA-B*07:02 SPRRARSV SHRRARSV 24 12728
HLA-B*07:02 SPRRARSVAS SHRRARSVAS 37 14758
HLA-A*30:01 NSPRRARSV KSHRRARSV 7195 22
HLA-B*07:02 SPRRARSVASQSII SHRRARSVASQSII 55 17736
HLA-B*42:01 SPRRARSV SHRRARSV 38 11622
HLA-B*42:01 SPRRARSVASQSI SHRRARSVASQSI 48 14418
HLA-B*07:02 TNSPRRARSVA TKSHRRARSVA 125 19196
HLA-B*42:01 SPRRARSVAS SHRRARSVAS 158 17461
HLA-B*07:02 NSPRRARSVA KSHRRARSVA 69 5330
HLA-B*42:01 SPRRARSVASQSII SHRRARSVASQSII 321 21521
HLA-B*07:02 TQTNSPRRARSVA TQTKSHRRARSVA 270 17591
HLA-B*07:02 QTNSPRRARSVA QTKSHRRARSVA 249 13621
HLA-B*42:01 TNSPRRARSVA TKSHRRARSVA 437 22045
HLA-B*42:01 NSPRRARSVA KSHRRARSVA 217 9050
HLA-A*30:01 NSPRRARSVAS KSHRRARSVAS 4546 185
HLA-A*30:01 NSPRRARSVA KSHRRARSVA 630 27
HLA-C*15:02 NSPRRARSV KSHRRARSV 4094 215
HLA-A*68:01 QTNSPRRAR QTKSHRRAR 95 1735
HLA-C*14:02 SYQTQTNSP SYQTQTKSH 3691 214
HLA-A*68:01 TQTNSPRRAR TQTKSHRRAR 254 4244
HLA-B*08:01 SPRRARSVA SHRRARSVA 372 3831
HLA-B*08:01 SPRRARSV SHRRARSV 428 2448
HLA-A*68:01 CASYQTQTNSPR CASYQTQTKSHR 142 713
HLA-C*16:01 NSPRRARSV KSHRRARSV 1247 297
HLA-A*11:01 ASYQTQTNSPR ASYQTQTKSHR 346 1426
HLA-A*31:01 QTQTNSPRR QTQTKSHRR 355 96
HLA-A*33:03 YQTQTNSPRR YQTQTKSHRR 967 273
HLA-A*33:03 YQTQTNSPRRAR YQTQTKSHRRAR 306 1077
HLA-A*31:01 YQTQTNSPRR YQTQTKSHRR 965 276
HLA-A*33:03 TQTNSPRRAR TQTKSHRRAR 195 659
HLA-A*33:03 QTQTNSPRR QTQTKSHRR 445 143
HLA-A*31:01 ASYQTQTNSPRR ASYQTQTKSHRR 433 144
HLA-A*33:03 QTNSPRRAR QTKSHRRAR 48 144
HLA-A*30:01 QTNSPRRAR QTKSHRRAR 1146 463
HLA-A*31:01 YQTQTNSPRRAR YQTQTKSHRRAR 317 771
HLA-A*31:01 SYQTQTNSPR SYQTQTKSHR 62 147
HLA-A*33:03 SYQTQTNSPR SYQTQTKSHR 130 304
HLA-A*31:01 TQTNSPRRAR TQTKSHRRAR 144 336
HLA-A*31:01 QTNSPRRAR QTKSHRRAR 34 79
HLA-A*31:01 ASYQTQTNSPR ASYQTQTKSHR 139 315
HLA-A*31:01 YQTQTNSPR YQTQTKSHR 441 982
HLA-A*31:01 SYQTQTNSPRRAR SYQTQTKSHRRAR 193 427
HLA-A*33:03 SYQTQTNSPRRAR SYQTQTKSHRRAR 448 972

N764K

Reference  TMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:02 LLQYGSFCTQLN LLQYGSFCTQLK 29153 102
HLA-A*11:01 LQYGSFCTQLN LQYGSFCTQLK 32767 191
HLA-A*03:01 LQYGSFCTQLN LQYGSFCTQLK 28204 214
HLA-A*68:01 YGSFCTQLN YGSFCTQLK 23773 187
HLA-A*03:02 LQYGSFCTQLN LQYGSFCTQLK 31227 331
HLA-A*03:02 LLLQYGSFCTQLN LLLQYGSFCTQLK 32767 377
HLA-A*11:01 YGSFCTQLN YGSFCTQLK 32767 386
HLA-A*03:01 LLQYGSFCTQLN LLQYGSFCTQLK 29424 350
HLA-A*03:01 LLLQYGSFCTQLN LLLQYGSFCTQLK 32355 410
HLA-A*02:11 QLNRALTGI QLKRALTGI 27 440
HLA-A*02:11 FCTQLNRALTGI FCTQLKRALTGI 63 898
HLA-B*08:01 CTQLNRAL CTQLKRAL 3325 279
HLA-A*02:01 FCTQLNRALTGI FCTQLKRALTGI 493 4878
HLA-A*02:02 FCTQLNRALTGI FCTQLKRALTGI 62 503
HLA-A*02:02 QLNRALTGI QLKRALTGI 45 307
HLA-C*03:03 FCTQLNRAL FCTQLKRAL 138 752
HLA-C*03:04 FCTQLNRAL FCTQLKRAL 138 752
HLA-A*02:02 TQLNRALTGI TQLKRALTGI 180 882
HLA-A*02:11 TQLNRALTGI TQLKRALTGI 267 1284
HLA-B*27:05 NRALTGIAV KRALTGIAV 1251 276
HLA-A*02:11 QLNRALTGIAV QLKRALTGIAV 259 1123
HLA-C*03:02 FCTQLNRAL FCTQLKRAL 361 1438
HLA-C*14:02 SFCTQLNRAL SFCTQLKRAL 234 511
HLA-A*02:06 TQLNRALTGI TQLKRALTGI 54 113

D796Y

Reference  AVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*23:01 KDFGGFNF KYFGGFNF 15419 23
HLA-A*23:01 KDFGGFNFSQI KYFGGFNFSQI 15932 37
HLA-A*24:02 KDFGGFNF KYFGGFNF 21008 55
HLA-C*14:02 IYKTPPIKD IYKTPPIKY 16538 55
HLA-A*24:02 KDFGGFNFSQI KYFGGFNFSQI 20251 68
HLA-B*15:03 KQIYKTPPIKD KQIYKTPPIKY 7773 29
HLA-A*23:01 KDFGGFNFSQIL KYFGGFNFSQIL 15831 63
HLA-C*14:02 KDFGGFNF KYFGGFNF 22081 90
HLA-A*24:02 KDFGGFNFSQIL KYFGGFNFSQIL 21565 126
HLA-B*15:01 KQIYKTPPIKD KQIYKTPPIKY 22193 141
HLA-C*14:02 KDFGGFNFSQIL KYFGGFNFSQIL 14873 165
HLA-A*30:01 KDFGGFNFS KYFGGFNFS 9496 156
HLA-C*14:02 DFGGFNFSQIL YFGGFNFSQIL 6960 139
HLA-A*30:02 KQIYKTPPIKD KQIYKTPPIKY 15917 386
HLA-B*15:03 VKQIYKTPPIKD VKQIYKTPPIKY 16977 446
HLA-B*15:03 IKDFGGFNF IKYFGGFNF 97 4
HLA-B*15:03 PIKDFGGFNF PIKYFGGFNF 7546 321
HLA-B*15:03 TPPIKDFGGFNF TPPIKYFGGFNF 10071 484
HLA-B*15:03 KTPPIKDFGGFNF KTPPIKYFGGFNF 6427 331
HLA-A*32:01 KTPPIKDFGGFNF KTPPIKYFGGFNF 6031 381
HLA-A*23:01 DFGGFNFSQI YFGGFNFSQI 5424 461
HLA-B*15:03 YKTPPIKDFGGFNF YKTPPIKYFGGFNF 2588 394
HLA-C*06:02 YKTPPIKDF YKTPPIKYF 2488 460
HLA-C*07:02 YKTPPIKDF YKTPPIKYF 1804 378
HLA-A*23:01 IYKTPPIKDF IYKTPPIKYF 273 98
HLA-A*24:02 IYKTPPIKDF IYKTPPIKYF 375 147
HLA-C*14:02 IYKTPPIKDF IYKTPPIKYF 341 158
HLA-B*15:03 YKTPPIKDF YKTPPIKYF 92 43

Q954H

Reference  SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    SAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLND

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*38:01 NQNAQALNTL NHNAQALNTL 2805 97
HLA-A*68:02 DVVNQNAQA DVVNHNAQA 703 344

N969K

Reference  ALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQID
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQID

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*03:01 TLVKQLSSN TLVKQLSSK 29207 56
HLA-A*68:01 NTLVKQLSSN NTLVKQLSSK 28063 86
HLA-A*11:01 TLVKQLSSN TLVKQLSSK 32767 125
HLA-A*03:02 TLVKQLSSN TLVKQLSSK 31915 131
HLA-A*11:01 NTLVKQLSSN NTLVKQLSSK 32767 147
HLA-A*03:01 ALNTLVKQLSSN ALNTLVKQLSSK 32767 154
HLA-A*03:02 ALNTLVKQLSSN ALNTLVKQLSSK 32767 304
HLA-A*03:01 NTLVKQLSSN NTLVKQLSSK 32767 482
HLA-A*68:02 SNFGAISSV SKFGAISSV 117 5329
HLA-B*15:03 SNFGAISSVL SKFGAISSVL 688 25
HLA-B*08:01 QLSSNFGAI QLSSKFGAI 4755 265
HLA-C*15:02 SNFGAISSV SKFGAISSV 374 5700
HLA-A*30:01 SSNFGAISS SSKFGAISS 1320 88
HLA-B*15:03 SNFGAISSV SKFGAISSV 727 49
HLA-A*30:01 SSNFGAISSV SSKFGAISSV 587 71
HLA-A*02:06 KQLSSNFGA KQLSSKFGA 62 269
HLA-A*02:01 KQLSSNFGAI KQLSSKFGAI 407 1567
HLA-A*02:11 KQLSSNFGA KQLSSKFGA 228 807
HLA-A*02:06 SNFGAISSV SKFGAISSV 361 1100
HLA-C*06:02 SNFGAISSV SKFGAISSV 1423 485
HLA-A*02:11 KQLSSNFGAI KQLSSKFGAI 152 428
HLA-A*02:06 KQLSSNFGAI KQLSSKFGAI 58 159
HLA-A*02:02 KQLSSNFGAI KQLSSKFGAI 261 668
HLA-B*15:03 KQLSSNFGA KQLSSKFGA 497 1076

N protein

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N

P13L

Reference  MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSK
           |||||||||||| |||||||||||||||||||||||||
Mutated    MSDNGPQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 MSDNGPQNQRNAP MSDNGPQNQRNAL 11146 27
HLA-B*07:02 GPQNQRNAP GPQNQRNAL 2464 6
HLA-B*42:01 GPQNQRNAP GPQNQRNAL 3035 8
HLA-B*07:02 SDNGPQNQRNAP SDNGPQNQRNAL 11353 32
HLA-B*42:01 SDNGPQNQRNAP SDNGPQNQRNAL 13042 39
HLA-B*42:01 NGPQNQRNAP NGPQNQRNAL 12875 41
HLA-B*07:02 MSDNGPQNQRNAP MSDNGPQNQRNAL 13138 58
HLA-B*07:02 NGPQNQRNAP NGPQNQRNAL 14898 72
HLA-B*07:02 APRITFGGPS ALRITFGGPS 191 17534
HLA-B*42:01 PQNQRNAP PQNQRNAL 30142 436
HLA-B*07:02 GPQNQRNAPR GPQNQRNALR 13964 345
HLA-B*27:05 QRNAPRITF QRNALRITF 509 83
HLA-B*27:05 NQRNAPRITF NQRNALRITF 1716 350
HLA-B*27:05 GPQNQRNAPRITF GPQNQRNALRITF 2076 442
HLA-B*15:01 NQRNAPRITF NQRNALRITF 96 40

ERS 31-33 deletion

Reference  PQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQ
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    PQNQRNALRITFGGPSDSTGSNQNG‑‑‑GARSKQRRPQGLPNNTASWFTALTQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*31:01 RSGARSKQR GARSKQR 77 -
HLA-A*68:01 STGSNQNGER - 137 -
HLA-A*31:01 RSGARSKQRR - 254 -

203-204 RG->KR

Reference  GGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQ
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    GGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 NSTPGSSRG NSTPGSSKR 32767 34
HLA-A*33:03 NSTPGSSRG NSTPGSSKR 32767 300
HLA-B*15:03 SRGTSPARM SKRTSPARM 2669 106
HLA-A*31:01 RNSTPGSSRG RNSTPGSSKR 7013 340
HLA-A*30:01 SSRNSTPGSSR SSRNSTPGSSK 356 20
HLA-A*30:01 GTSPARMAG RTSPARMAG 493 30
HLA-A*31:01 SSRNSTPGSSRG SSRNSTPGSSKR 3757 231
HLA-A*30:01 GTSPARMAGNGG RTSPARMAGNGG 6051 411
HLA-A*31:01 SSRNSTPGSSR SSRNSTPGSSK 127 1853
HLA-A*30:01 NSSRNSTPGSSR NSSRNSTPGSSK 4255 353
HLA-A*30:01 RNSTPGSSR RNSTPGSSK 2120 188
HLA-A*31:01 RNSTPGSSR RNSTPGSSK 123 1335
HLA-A*03:01 SSRNSTPGSSR SSRNSTPGSSK 4753 442
HLA-A*11:01 SSRNSTPGSSR SSRNSTPGSSK 2231 263
HLA-A*68:01 NSSRNSTPGSSR NSSRNSTPGSSK 270 1385
HLA-A*30:01 GSSRGTSPA GSSKRTSPA 555 145
HLA-A*30:01 SSRNSTPGSSRG SSRNSTPGSSKR 1625 469
HLA-A*30:01 SSRGTSPARMAG SSKRTSPARMAG 449 1031

M protein

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M

Q19E

Reference  MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNR
           |||||||||||||||||| |||||||||||||||||||||||||
Mutated    MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNR

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*44:03 EQWNLVIGF EEWNLVIGF 1268 15
HLA-B*44:02 EQWNLVIGF EEWNLVIGF 2396 34
HLA-B*44:03 EQWNLVIGFLF EEWNLVIGFLF 5200 85
HLA-B*44:03 EQWNLVIGFL EEWNLVIGFL 8038 135
HLA-B*44:03 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5966 126
HLA-B*44:02 EQWNLVIGFLF EEWNLVIGFLF 6607 162
HLA-B*44:02 EQWNLVIGFL EEWNLVIGFL 9054 237
HLA-B*44:02 EQWNLVIGFLFLTW EEWNLVIGFLFLTW 5922 170
HLA-B*15:01 LEQWNLVIGF LEEWNLVIGF 256 8100
HLA-B*18:01 EQWNLVIGF EEWNLVIGF 482 16
HLA-A*02:06 EQWNLVIGFL EEWNLVIGFL 418 10916
HLA-B*15:03 EQWNLVIGF EEWNLVIGF 101 2397
HLA-B*18:01 EQWNLVIGFLF EEWNLVIGFLF 3471 190
HLA-B*40:02 EQWNLVIGFL EEWNLVIGFL 3775 245
HLA-B*15:03 LEQWNLVIGF LEEWNLVIGF 88 1227
HLA-B*40:02 EQWNLVIGF EEWNLVIGF 1765 242
HLA-B*15:03 KLLEQWNLVIGF KLLEEWNLVIGF 365 2285
HLA-A*02:11 LLEQWNLVI LLEEWNLVI 142 24
HLA-A*02:11 LLEQWNLVIGFL LLEEWNLVIGFL 1120 210
HLA-A*02:01 LLEQWNLVI LLEEWNLVI 644 131
HLA-A*29:02 QWNLVIGFLF EWNLVIGFLF 159 780
HLA-A*24:02 QWNLVIGFLF EWNLVIGFLF 53 246
HLA-A*23:01 QWNLVIGFLF EWNLVIGFLF 18 79
HLA-A*02:02 LLEQWNLVI LLEEWNLVI 781 187
HLA-A*02:06 LLEQWNLVI LLEEWNLVI 1869 487
HLA-B*40:02 LEQWNLVI LEEWNLVI 367 1301
HLA-A*02:02 LLEQWNLVIGFL LLEEWNLVIGFL 1047 329

A63T

Reference  AYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    AYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*35:01 LACFVLAAVY LTCFVLAAVY 121 1943
HLA-A*68:01 ACFVLAAVYR TCFVLAAVYR 694 80
HLA-B*35:01 ACFVLAAVY TCFVLAAVY 2289 331
HLA-C*03:02 LACFVLAAVY LTCFVLAAVY 145 935
HLA-C*16:01 LACFVLAAV LTCFVLAAV 346 1994
HLA-A*02:01 WLLWPVTLA WLLWPVTLT 33 190
HLA-A*02:02 WLLWPVTLA WLLWPVTLT 32 180
HLA-A*02:11 LWLLWPVTLA LWLLWPVTLT 66 363
HLA-A*02:11 IFLWLLWPVTLA IFLWLLWPVTLT 190 1034
HLA-A*02:11 LLWPVTLA LLWPVTLT 242 1313
HLA-A*33:03 ACFVLAAVYR TCFVLAAVYR 252 47
HLA-A*02:02 LWLLWPVTLA LWLLWPVTLT 304 1623
HLA-C*12:03 LACFVLAAV LTCFVLAAV 214 1116
HLA-A*02:06 WLLWPVTLA WLLWPVTLT 60 302
HLA-A*02:01 LWLLWPVTLA LWLLWPVTLT 228 1142
HLA-A*02:02 TLACFVLAAVY TLTCFVLAAVY 337 1467
HLA-A*02:02 VTLACFVLAAV VTLTCFVLAAV 160 678
HLA-A*68:02 LACFVLAAV LTCFVLAAV 44 11
HLA-A*02:02 PVTLACFVLAAV PVTLTCFVLAAV 479 1907
HLA-A*02:11 LIFLWLLWPVTLA LIFLWLLWPVTLT 406 1602
HLA-A*02:02 TLACFVLAAVYRI TLTCFVLAAVYRI 293 1148
HLA-A*02:11 LACFVLAAV LTCFVLAAV 122 32
HLA-A*02:11 WLLWPVTLA WLLWPVTLT 6 22
HLA-B*15:03 LACFVLAAVY LTCFVLAAVY 81 284
HLA-A*68:02 TLACFVLAA TLTCFVLAA 395 1376
HLA-A*02:02 FLWLLWPVTLACFV FLWLLWPVTLTCFV 485 146
HLA-A*68:01 LACFVLAAVY LTCFVLAAVY 1184 359
HLA-A*02:02 TLACFVLAA TLTCFVLAA 13 41
HLA-A*02:11 TLACFVLAAVY TLTCFVLAAVY 310 929
HLA-A*02:02 FLWLLWPVTLA FLWLLWPVTLT 291 867
HLA-A*02:11 KLIFLWLLWPVTLA KLIFLWLLWPVTLT 290 859
HLA-A*29:02 LACFVLAAVY LTCFVLAAVY 232 81
HLA-A*02:02 VTLACFVLAA VTLTCFVLAA 100 285
HLA-A*02:06 TLACFVLAAV TLTCFVLAAV 16 45
HLA-A*68:02 VTLACFVLAA VTLTCFVLAA 481 1321
HLA-B*15:01 TLACFVLAAVY TLTCFVLAAVY 414 1136
HLA-A*23:01 LWPVTLACF LWPVTLTCF 57 155
HLA-A*24:02 LWPVTLACF LWPVTLTCF 49 133
HLA-A*02:11 FLWLLWPVTLA FLWLLWPVTLT 25 67
HLA-A*02:06 TLACFVLAA TLTCFVLAA 40 107
HLA-A*02:01 LACFVLAAV LTCFVLAAV 471 179
HLA-A*02:02 TLACFVLAAV TLTCFVLAAV 5 13
HLA-A*02:11 VTLACFVLAA VTLTCFVLAA 97 245
HLA-A*02:01 FLWLLWPVTLA FLWLLWPVTLT 107 269
HLA-A*02:06 FLWLLWPVTLA FLWLLWPVTLT 495 1240
HLA-A*02:11 TLACFVLAA TLTCFVLAA 8 20
HLA-A*02:11 VTLACFVLAAV VTLTCFVLAAV 128 318
HLA-A*02:01 TLACFVLAAV TLTCFVLAAV 11 27
HLA-A*02:02 LACFVLAAV LTCFVLAAV 198 81
HLA-A*02:01 TLACFVLAA TLTCFVLAA 25 61
HLA-A*02:01 VTLACFVLAAV VTLTCFVLAAV 436 1029
HLA-B*07:02 WPVTLACFVL WPVTLTCFVL 362 155
HLA-A*02:01 FLWLLWPVTLACFV FLWLLWPVTLTCFV 329 142
HLA-A*02:11 TLACFVLAAV TLTCFVLAAV 4 9
HLA-A*30:02 LACFVLAAVY LTCFVLAAVY 218 98
HLA-A*02:06 LACFVLAAV LTCFVLAAV 51 23
HLA-A*03:02 TLACFVLAAVYR TLTCFVLAAVYR 480 1047
HLA-A*68:02 TLACFVLAAV TLTCFVLAAV 26 12
HLA-B*42:01 WPVTLACFV WPVTLTCFV 209 102
HLA-A*32:01 LLWPVTLACF LLWPVTLTCF 427 212

E protein

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E

T9I

Reference  MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAIL
           |||||||| |||||||||||||||||||||||||
Mutated    MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAIL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*24:02 MYSFVSEET MYSFVSEEI 5532 18
HLA-A*23:01 MYSFVSEET MYSFVSEEI 5604 31
HLA-C*16:01 YSFVSEET YSFVSEEI 7157 226
HLA-C*14:02 MYSFVSEET MYSFVSEEI 901 30
HLA-C*12:03 YSFVSEET YSFVSEEI 10273 457
HLA-A*68:02 MYSFVSEET MYSFVSEEI 3879 472
HLA-A*68:02 ETGTLIVNSV EIGTLIVNSV 13 91
HLA-A*68:02 FVSEETGTLI FVSEEIGTLI 247 60
HLA-A*68:02 TGTLIVNSV IGTLIVNSV 491 1976
HLA-A*02:11 FVSEETGTLI FVSEEIGTLI 307 89
HLA-B*40:01 EETGTLIVNSVL EEIGTLIVNSVL 1578 499
HLA-A*02:01 FVSEETGTL FVSEEIGTL 575 186
HLA-A*02:11 FVSEETGTL FVSEEIGTL 97 32
HLA-A*02:06 FVSEETGTLI FVSEEIGTLI 423 144
HLA-A*02:06 FVSEETGTL FVSEEIGTL 120 41
HLA-A*02:01 FVSEETGTLI FVSEEIGTLI 1293 442
HLA-A*02:06 FVSEETGTLIV FVSEEIGTLIV 670 266
HLA-C*03:03 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-C*03:04 YSFVSEETGTL YSFVSEEIGTL 293 711
HLA-B*44:03 EETGTLIVNSVLLF EEIGTLIVNSVLLF 877 375
HLA-A*02:11 FVSEETGTLIV FVSEEIGTLIV 538 251
HLA-A*02:02 FVSEETGTLI FVSEEIGTLI 85 40
HLA-A*68:02 YSFVSEETGTLI YSFVSEEIGTLI 1008 485

NS3 protein

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NS3

T223I

Reference  KDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHT
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHT

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*03:03 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*03:04 YSTQLSTDT YSTQLSTDI 12349 241
HLA-C*12:03 YSTQLSTDT YSTQLSTDI 11751 430
HLA-C*16:01 YSTQLSTDT YSTQLSTDI 7819 294
HLA-C*03:02 YSTQLSTDT YSTQLSTDI 6466 347
HLA-A*02:06 YQLYSTQLSTDT YQLYSTQLSTDI 4179 287
HLA-A*02:11 QLYSTQLSTDT QLYSTQLSTDI 5151 437
HLA-A*68:01 TGVEHVTFFIYNK IGVEHVTFFIYNK 213 1427
HLA-A*68:02 LSTDTGVEHV LSTDIGVEHV 1765 265
HLA-A*68:02 TGVEHVTFFI IGVEHVTFFI 212 1093
HLA-A*02:01 TQLSTDTGV TQLSTDIGV 1084 283
HLA-A*02:01 YSTQLSTDTGV YSTQLSTDIGV 1288 379
HLA-A*02:11 STQLSTDTGV STQLSTDIGV 1485 443
HLA-A*25:01 DTGVEHVTFF DIGVEHVTFF 180 596
HLA-A*02:11 TQLSTDTGV TQLSTDIGV 436 133
HLA-A*02:06 STQLSTDTGV STQLSTDIGV 264 83
HLA-A*02:11 YSTQLSTDTGV YSTQLSTDIGV 1184 381
HLA-A*26:01 DTGVEHVTFF DIGVEHVTFF 37 108
HLA-A*02:06 YSTQLSTDTGV YSTQLSTDIGV 157 56
HLA-C*03:02 TGVEHVTFF IGVEHVTFF 237 88
HLA-A*02:06 TQLSTDTGV TQLSTDIGV 70 26
HLA-B*15:03 TGVEHVTFF IGVEHVTFF 305 115
HLA-A*02:06 LYSTQLSTDTGV LYSTQLSTDIGV 855 330
HLA-C*16:01 TGVEHVTFF IGVEHVTFF 392 185

NS9b protein

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NS9b

P10S

Reference  MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQN
           ||||||||| |||||||||||||||||||||||||
Mutated    MDPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*42:01 HPALRLVDPQIQL HSALRLVDPQIQL 148 15057
HLA-B*42:01 HPALRLVDPQI HSALRLVDPQI 297 15937
HLA-A*02:11 PALRLVDPQIQL SALRLVDPQIQL 3683 325
HLA-B*38:01 MHPALRLVDPQI MHSALRLVDPQI 3064 395
HLA-A*02:02 PALRLVDPQIQL SALRLVDPQIQL 2220 388
HLA-A*02:01 KISEMHPAL KISEMHSAL 139 774
HLA-A*02:06 KISEMHPAL KISEMHSAL 62 310
HLA-B*07:02 KISEMHPAL KISEMHSAL 436 134
HLA-A*02:11 KISEMHPAL KISEMHSAL 14 42
HLA-C*08:02 ISEMHPAL ISEMHSAL 896 414
HLA-B*15:03 SEMHPALRL SEMHSALRL 493 245

ENA 27-29 deletion

Reference  DPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSL
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    DPKISEMHSALRLVDPQIQLAVTRM‑‑‑VGRDQNNVGPKVYPIILRLGSPLSL

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*68:01 VTRMENAVGR VTRMVGR 28 -
HLA-A*31:01 VTRMENAVGR VTRMVGR 113 -
HLA-A*03:01 RMENAVGRDQNNVGPK RMVGRDQNNVGPK - 168
HLA-A*33:03 VTRMENAVGR VTRMVGR 218 -
HLA-B*27:05 TRMENAVGR TRMVGR 260 -
HLA-A*11:01 VTRMENAVGR VTRMVGR 268 -
HLA-A*30:01 VTRMENAVG VTRMVG 395 -
HLA-A*68:02 MENAVGRDQNNV MVGRDQNNV 13036 480
HLA-A*33:03 LAVTRMENAVGR LAVTRMVGR 927 45
HLA-A*02:11 IQLAVTRMENAV IQLAVTRMV 1418 70
HLA-A*31:01 LAVTRMENAVGR LAVTRMVGR 1898 115
HLA-A*02:02 RMENAVGRDQNNV RMVGRDQNNV 3078 195
HLA-A*68:01 QLAVTRMENAVGR QLAVTRMVGR 1673 108
HLA-B*15:03 IQLAVTRMENAV IQLAVTRMV 2775 183
HLA-A*33:03 QLAVTRMENAVGR QLAVTRMVGR 1778 188
HLA-A*02:11 RMENAVGRDQNNV RMVGRDQNNV 1928 213
HLA-A*31:01 IQLAVTRMENAVGR IQLAVTRMVGR 1758 236
HLA-A*31:01 QLAVTRMENAVGR QLAVTRMVGR 2442 329
HLA-A*68:01 LAVTRMENAVGR LAVTRMVGR 207 32
HLA-A*02:06 IQLAVTRMENAV IQLAVTRMV 263 47
HLA-A*02:01 IQLAVTRMENAV IQLAVTRMV 2387 463

NS9c protein

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NS9c

G50N

Reference  AAVKPLLVPHHVVATVQEIQLQAAVGELLLLEWLAMAVMLLLLCCCLTD
           ||||||||||||||||||||||||| |||||||||||||||||||||||
Mutated    AAVKPLLVPHHVVATVQEIQLQAAVNELLLLEWLAMAVMLLLLCCCLTD

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*18:01 GELLLLEWLAM NELLLLEWLAM 4979 247
HLA-B*18:01 GELLLLEW NELLLLEW 3915 401
HLA-B*40:01 GELLLLEWL NELLLLEWL 28 140
HLA-A*02:11 QLQAAVGEL QLQAAVNEL 120 27
HLA-A*02:11 IQLQAAVGEL IQLQAAVNEL 338 81
HLA-B*40:02 GELLLLEWL NELLLLEWL 52 204
HLA-B*40:02 GELLLLEWLAM NELLLLEWLAM 201 772
HLA-A*02:01 QLQAAVGEL QLQAAVNEL 1290 358
HLA-A*02:02 QLQAAVGEL QLQAAVNEL 92 28
HLA-B*58:01 VGELLLLEW VNELLLLEW 330 1071
HLA-A*02:02 IQLQAAVGEL IQLQAAVNEL 170 58
HLA-A*02:01 LQAAVGELL LQAAVNELL 938 352
HLA-A*02:02 LQAAVGELL LQAAVNELL 44 17
HLA-B*40:06 GELLLLEWLA NELLLLEWLA 268 677
HLA-B*40:02 GELLLLEWLA NELLLLEWLA 475 1195
HLA-A*02:11 LQAAVGELL LQAAVNELL 386 154
HLA-A*02:01 IQLQAAVGEL IQLQAAVNEL 1138 475
HLA-A*02:01 QLQAAVGELL QLQAAVNELL 961 403
HLA-A*02:01 GELLLLEWLAMA NELLLLEWLAMA 109 258
HLA-A*02:02 QLQAAVGELL QLQAAVNELL 35 15
HLA-A*02:02 IQLQAAVGELL IQLQAAVNELL 724 313
HLA-A*02:11 QLQAAVGELL QLQAAVNELL 303 131
HLA-B*58:01 AVGELLLLEW AVNELLLLEW 196 87
HLA-A*02:11 GELLLLEWLAMA NELLLLEWLAMA 29 61
HLA-B*57:01 AVGELLLLEW AVNELLLLEW 432 206
HLA-A*68:02 EIQLQAAVGELL EIQLQAAVNELL 697 346

NSP1 protein

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NSP1

S135R

Reference  HVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQEN
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    HVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQEN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*58:01 HSYGADLKSF HRYGADLKSF 59 18326
HLA-B*27:05 HSYGADLKSF HRYGADLKSF 15851 60
HLA-B*57:01 HSYGADLKSF HRYGADLKSF 158 23790
HLA-B*27:05 HSYGADLKSFDL HRYGADLKSFDL 23268 171
HLA-B*15:01 HSYGADLKSF HRYGADLKSF 94 6548
HLA-C*03:02 HSYGADLKSF HRYGADLKSF 94 6500
HLA-C*16:01 HSYGADLKSF HRYGADLKSF 329 14251
HLA-B*15:03 RKNGNKGAGGHSY RKNGNKGAGGHRY 183 1186
HLA-B*15:03 NKGAGGHSY NKGAGGHRY 129 774
HLA-B*15:03 GNKGAGGHSY GNKGAGGHRY 478 2611

NSP4 protein

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NSP4

T327I

Reference  MRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    MRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:11 NTLLFLMSFT NTLLFLMSFI 1059 51
HLA-A*68:02 NTLLFLMSFT NTLLFLMSFI 741 41
HLA-A*02:11 FNTLLFLMSFT FNTLLFLMSFI 1509 110
HLA-A*02:11 TLLFLMSFT TLLFLMSFI 82 6
HLA-A*68:02 TLLFLMSFT TLLFLMSFI 3858 286
HLA-A*68:02 FTVLCLTPVYSFL FIVLCLTPVYSFL 129 1580
HLA-A*02:11 AFNTLLFLMSFT AFNTLLFLMSFI 4598 420
HLA-A*68:02 FTVLCLTPV FIVLCLTPV 8 83
HLA-A*68:02 SFTVLCLTPV SFIVLCLTPV 63 597
HLA-A*02:01 TLLFLMSFT TLLFLMSFI 239 26
HLA-A*02:01 NTLLFLMSFT NTLLFLMSFI 1593 179
HLA-A*02:02 TLLFLMSFT TLLFLMSFI 235 28
HLA-B*15:01 LLFLMSFTVL LLFLMSFIVL 229 1839
HLA-A*02:11 LFLMSFTV LFLMSFIV 279 2222
HLA-A*02:02 NTLLFLMSFT NTLLFLMSFI 1462 186
HLA-A*02:11 LLFLMSFT LLFLMSFI 2935 377
HLA-A*32:01 LLFLMSFTV LLFLMSFIV 369 2631
HLA-A*02:06 LLFLMSFTV LLFLMSFIV 34 231
HLA-C*12:03 FTVLCLTPV FIVLCLTPV 161 1041
HLA-C*14:02 LFLMSFTVL LFLMSFIVL 18 112
HLA-A*02:11 AFNTLLFLMSFTV AFNTLLFLMSFIV 74 448
HLA-C*16:01 FTVLCLTPVY FIVLCLTPVY 395 2359
HLA-A*02:06 TLLFLMSFT TLLFLMSFI 397 68
HLA-A*02:01 LLFLMSFTV LLFLMSFIV 9 50
HLA-A*02:11 VAFNTLLFLMSFTV VAFNTLLFLMSFIV 225 1206
HLA-A*02:01 AFNTLLFLMSFTV AFNTLLFLMSFIV 357 1842
HLA-A*68:02 NTLLFLMSFTV NTLLFLMSFIV 106 539
HLA-A*02:11 NTLLFLMSFTV NTLLFLMSFIV 59 300
HLA-A*02:01 NTLLFLMSFTV NTLLFLMSFIV 212 1074
HLA-C*03:03 FTVLCLTPV FIVLCLTPV 302 1526
HLA-C*03:04 FTVLCLTPV FIVLCLTPV 302 1526
HLA-B*15:03 LLFLMSFTVL LLFLMSFIVL 318 1563
HLA-A*02:02 LLFLMSFTV LLFLMSFIV 11 53
HLA-A*02:06 NTLLFLMSFT NTLLFLMSFI 945 197
HLA-A*02:11 SFTVLCLTPV SFIVLCLTPV 250 53
HLA-A*02:11 FNTLLFLMSFTV FNTLLFLMSFIV 23 108
HLA-A*02:01 FNTLLFLMSFTV FNTLLFLMSFIV 131 602
HLA-C*03:02 FTVLCLTPV FIVLCLTPV 198 902
HLA-C*14:02 FLMSFTVL FLMSFIVL 475 2138
HLA-C*12:02 FTVLCLTPV FIVLCLTPV 218 961
HLA-C*03:03 FLMSFTVL FLMSFIVL 309 1359
HLA-C*03:04 FLMSFTVL FLMSFIVL 309 1359
HLA-A*26:01 FTVLCLTPVY FIVLCLTPVY 176 760
HLA-A*02:01 SFTVLCLTPV SFIVLCLTPV 470 111
HLA-B*15:01 FLMSFTVLCL FLMSFIVLCL 455 1914
HLA-B*15:03 LFLMSFTVL LFLMSFIVL 353 1462
HLA-A*68:01 FTVLCLTPVY FIVLCLTPVY 485 1972
HLA-A*02:02 FNTLLFLMSFTV FNTLLFLMSFIV 186 704
HLA-B*15:01 LMSFTVLCL LMSFIVLCL 110 408
HLA-C*03:02 FLMSFTVL FLMSFIVL 352 1285
HLA-A*02:02 NTLLFLMSFTV NTLLFLMSFIV 424 1515
HLA-A*02:11 LLFLMSFTV LLFLMSFIV 2 7
HLA-C*03:02 FTVLCLTPVY FIVLCLTPVY 50 175
HLA-B*15:03 LMSFTVLCL LMSFIVLCL 54 186
HLA-C*12:02 FTVLCLTPVY FIVLCLTPVY 331 1137
HLA-A*02:02 LLFLMSFTVL LLFLMSFIVL 42 144
HLA-A*68:02 MSFTVLCLTPV MSFIVLCLTPV 34 114
HLA-C*03:02 LMSFTVLCL LMSFIVLCL 467 1520
HLA-A*02:01 LLFLMSFTVL LLFLMSFIVL 74 240
HLA-A*02:11 LLFLMSFTVL LLFLMSFIVL 25 80
HLA-A*02:02 SFTVLCLTPV SFIVLCLTPV 261 84
HLA-A*02:02 LFLMSFTVLCL LFLMSFIVLCL 73 216
HLA-A*02:06 LLFLMSFTVL LLFLMSFIVL 331 973
HLA-C*16:01 MSFTVLCL MSFIVLCL 171 496
HLA-A*68:02 FLMSFTVLCLTPV FLMSFIVLCLTPV 331 927
HLA-A*68:02 MSFTVLCLT MSFIVLCLT 68 186
HLA-A*02:06 MSFTVLCLT MSFIVLCLT 239 650
HLA-A*02:11 TVLCLTPVYSFL IVLCLTPVYSFL 533 199
HLA-B*15:03 FLMSFTVL FLMSFIVL 371 993
HLA-A*02:02 FLMSFTVLCL FLMSFIVLCL 3 8
HLA-A*02:02 LLFLMSFTVLCL LLFLMSFIVLCL 134 356
HLA-A*02:01 LLFLMSFTVLCL LLFLMSFIVLCL 237 602
HLA-A*02:01 LFLMSFTVLCL LFLMSFIVLCL 73 185
HLA-A*02:06 FLMSFTVLCL FLMSFIVLCL 15 38
HLA-C*03:02 TVLCLTPVY IVLCLTPVY 136 54
HLA-A*23:01 LFLMSFTVL LFLMSFIVL 411 1026
HLA-A*02:06 TLLFLMSFTV TLLFLMSFIV 47 116
HLA-B*08:01 FLMSFTVL FLMSFIVL 118 291
HLA-A*02:06 NTLLFLMSFTV NTLLFLMSFIV 373 906
HLA-A*02:01 TLLFLMSFTV TLLFLMSFIV 14 33
HLA-A*02:06 VAFNTLLFLMSFTV VAFNTLLFLMSFIV 479 1101
HLA-A*02:06 MSFTVLCLTPV MSFIVLCLTPV 48 110
HLA-B*58:01 MSFTVLCLT MSFIVLCLT 412 943
HLA-A*02:01 FLMSFTVLCL FLMSFIVLCL 4 9
HLA-A*02:02 FLMSFTVLCLTP FLMSFIVLCLTP 194 430
HLA-A*02:11 TLLFLMSFTV TLLFLMSFIV 5 11
HLA-A*02:02 FTVLCLTPV FIVLCLTPV 23 11
HLA-A*02:01 FTVLCLTPV FIVLCLTPV 25 12
HLA-A*30:02 FTVLCLTPVY FIVLCLTPVY 327 671
HLA-A*02:02 TVLCLTPVYSFL IVLCLTPVYSFL 176 86
HLA-B*58:01 MSFTVLCLTP MSFIVLCLTP 497 1015
HLA-A*02:11 FTVLCLTPV FIVLCLTPV 12 6

T492I

Reference  ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ
           ||||||||||||||||||||||||| ||||||||
Mutated    ACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQ

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-C*16:01 QTSITSAVL QISITSAVL 201 1829
HLA-A*68:02 QTSITSAVL QISITSAVL 206 1702
HLA-A*02:06 QPPQTSITSAV QPPQISITSAV 3097 393
HLA-A*02:06 LYQPPQTSITSAV LYQPPQISITSAV 1485 214
HLA-A*02:06 YQPPQTSITSAV YQPPQISITSAV 156 26
HLA-A*02:01 YQPPQTSITSAV YQPPQISITSAV 1613 341
HLA-A*02:11 YQPPQTSITSAV YQPPQISITSAV 498 120
HLA-C*03:03 TSITSAVL ISITSAVL 532 198
HLA-C*03:04 TSITSAVL ISITSAVL 532 198
HLA-C*03:03 QTSITSAVL QISITSAVL 311 831
HLA-C*03:04 QTSITSAVL QISITSAVL 311 831
HLA-C*16:01 TSITSAVL ISITSAVL 381 156
HLA-A*02:01 VLYQPPQTSI VLYQPPQISI 1084 474
HLA-A*23:01 VLYQPPQTSI VLYQPPQISI 979 462
HLA-A*23:01 LYQPPQTSI LYQPPQISI 278 132

NSP5 protein

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NSP5

P132H

Reference  QPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*07:02 RPNFTIKGSF RHNFTIKGSF 14 15756
HLA-B*07:02 RPNFTIKGSFL RHNFTIKGSFL 24 18650
HLA-B*42:01 RPNFTIKGSF RHNFTIKGSF 31 15129
HLA-B*42:01 RPNFTIKGSFL RHNFTIKGSFL 39 17143
HLA-B*15:03 PNFTIKGSF HNFTIKGSF 7728 117
HLA-A*03:01 GVYQCAMRP GVYQCAMRH 20799 417
HLA-B*08:01 CAMRPNFTI CAMRHNFTI 3487 242
HLA-B*27:05 MRPNFTIKG MRHNFTIKG 4762 366
HLA-B*27:05 MRPNFTIKGSFL MRHNFTIKGSFL 827 86
HLA-B*15:03 RPNFTIKGSF RHNFTIKGSF 432 54
HLA-B*27:05 MRPNFTIK MRHNFTIK 2132 276
HLA-B*15:03 MRPNFTIKGSF MRHNFTIKGSF 397 96
HLA-C*07:02 MRPNFTIKGSF MRHNFTIKGSF 361 1054
HLA-B*27:05 MRPNFTIKGSF MRHNFTIKGSF 218 78
HLA-A*30:01 QCAMRPNFTIK QCAMRHNFTIK 199 513
HLA-A*68:02 CAMRPNFTI CAMRHNFTI 199 493
HLA-C*16:01 CAMRPNFTI CAMRHNFTI 125 52
HLA-A*30:01 AMRPNFTIKG AMRHNFTIKG 123 279
HLA-C*12:03 CAMRPNFTI CAMRHNFTI 317 143
HLA-A*30:01 VYQCAMRPNFTIK VYQCAMRHNFTIK 316 683
HLA-A*11:01 AMRPNFTIK AMRHNFTIK 175 376
HLA-A*11:01 CAMRPNFTIK CAMRHNFTIK 42 88
HLA-A*68:01 CAMRPNFTIK CAMRHNFTIK 127 254

NSP6 protein

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NSP6

A88V

Reference  KHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDC
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    KHAFLCLFLLPSLATVAYFNMVYMPVSWVMRIMTWLDMVDTSLSGFKLKDC

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*23:01 AYFNMVYMPA AYFNMVYMPV 1996 163
HLA-C*16:01 MPASWVMRIM MPVSWVMRIM 194 2086
HLA-A*02:11 TVAYFNMVYMPA TVAYFNMVYMPV 2916 307
HLA-A*24:02 AYFNMVYMPA AYFNMVYMPV 4316 455
HLA-C*12:03 MPASWVMRIM MPVSWVMRIM 218 1789
HLA-A*68:02 TVAYFNMVYMPA TVAYFNMVYMPV 106 13
HLA-A*68:02 ATVAYFNMVYMPA ATVAYFNMVYMPV 1492 191
HLA-A*02:11 YFNMVYMPA YFNMVYMPV 568 78
HLA-A*02:02 TVAYFNMVYMPA TVAYFNMVYMPV 1519 270
HLA-C*03:02 MPASWVMRIM MPVSWVMRIM 213 1174
HLA-A*02:06 TVAYFNMVYMPA TVAYFNMVYMPV 1164 222
HLA-C*14:02 YFNMVYMPA YFNMVYMPV 154 33
HLA-A*68:02 YFNMVYMPA YFNMVYMPV 1084 237
HLA-C*14:02 AYFNMVYMPA AYFNMVYMPV 1096 243
HLA-A*02:06 ATVAYFNMVYMPA ATVAYFNMVYMPV 588 135
HLA-C*12:02 MPASWVMRIM MPVSWVMRIM 431 1830
HLA-A*02:02 YFNMVYMPA YFNMVYMPV 836 241
HLA-A*02:02 VYMPASWVMRI VYMPVSWVMRI 366 1079
HLA-A*68:02 MPASWVMRI MPVSWVMRI 94 271
HLA-C*14:02 FNMVYMPASWVM FNMVYMPVSWVM 72 205
HLA-A*02:02 YMPASWVMRI YMPVSWVMRI 9 23
HLA-B*07:02 MPASWVMRI MPVSWVMRI 99 251
HLA-A*02:11 VYMPASWVMRI VYMPVSWVMRI 81 203
HLA-A*02:11 YMPASWVMRIM YMPVSWVMRIM 113 282
HLA-A*23:01 ASWVMRIMTW VSWVMRIMTW 631 260
HLA-C*14:02 YFNMVYMPASWVM YFNMVYMPVSWVM 57 136
HLA-A*29:02 VYMPASWVM VYMPVSWVM 556 234
HLA-A*02:11 YMPASWVM YMPVSWVM 147 65
HLA-B*42:01 YMPASWVMRI YMPVSWVMRI 425 956
HLA-A*02:01 YMPASWVM YMPVSWVM 517 233
HLA-A*02:01 MVYMPASWV MVYMPVSWV 213 99
HLA-A*02:06 MVYMPASWV MVYMPVSWV 64 30
HLA-C*01:02 YMPASWVM YMPVSWVM 254 540
HLA-A*02:11 NMVYMPASWV NMVYMPVSWV 72 34
HLA-B*42:01 MPASWVMRI MPVSWVMRI 19 40
HLA-B*07:02 MPASWVMRIM MPVSWVMRIM 40 84
HLA-A*02:11 MVYMPASWVM MVYMPVSWVM 279 134
HLA-A*02:02 YMPASWVMRIM YMPVSWVMRIM 346 715
HLA-A*02:01 NMVYMPASWV NMVYMPVSWV 357 175
HLA-A*02:11 MVYMPASWV MVYMPVSWV 18 9

NSP12 protein

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NSP12

R249M

Reference  QTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYD
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QTTPGSGVPVVDSYYSLLMPILTLTMALTAESHVDTDLTKPYIKWDLLKYD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-B*15:01 LLMPILTLTR LLMPILTLTM 14330 30
HLA-B*35:01 MPILTLTR MPILTLTM 6886 17
HLA-A*02:02 TRALTAESHV TMALTAESHV 13599 49
HLA-B*15:03 LMPILTLTR LMPILTLTM 17400 66
HLA-B*15:03 LLMPILTLTR LLMPILTLTM 18999 88
HLA-C*01:02 LMPILTLTR LMPILTLTM 25262 130
HLA-B*42:01 MPILTLTR MPILTLTM 7102 38
HLA-B*15:01 LMPILTLTR LMPILTLTM 17437 103
HLA-A*02:11 TRALTAESHV TMALTAESHV 18123 116
HLA-A*31:01 SYYSLLMPILTLTR SYYSLLMPILTLTM 70 10308
HLA-B*35:03 MPILTLTR MPILTLTM 27676 197
HLA-A*31:01 LLMPILTLTR LLMPILTLTM 59 7057
HLA-B*53:01 MPILTLTR MPILTLTM 11662 104
HLA-A*68:01 LLMPILTLTR LLMPILTLTM 114 12031
HLA-A*33:03 LLMPILTLTR LLMPILTLTM 121 12656
HLA-C*03:02 LMPILTLTR LMPILTLTM 20625 206
HLA-A*31:01 LMPILTLTR LMPILTLTM 225 18180
HLA-A*68:01 LMPILTLTR LMPILTLTM 291 19819
HLA-A*02:02 LMPILTLTR LMPILTLTM 9138 136
HLA-C*14:02 SYYSLLMPILTLTR SYYSLLMPILTLTM 8532 128
HLA-A*33:03 LMPILTLTR LMPILTLTM 365 22357
HLA-B*07:02 MPILTLTR MPILTLTM 10454 176
HLA-C*14:02 LMPILTLTR LMPILTLTM 7220 123
HLA-A*02:11 LMPILTLTR LMPILTLTM 9764 170
HLA-A*33:03 SYYSLLMPILTLTR SYYSLLMPILTLTM 265 14938
HLA-C*03:02 LLMPILTLTR LLMPILTLTM 25907 471
HLA-A*02:01 TRALTAESHV TMALTAESHV 22104 446
HLA-A*02:11 LTRALTAESHV LTMALTAESHV 10858 227
HLA-A*68:02 RALTAESHV MALTAESHV 10878 229
HLA-A*03:02 LLMPILTLTR LLMPILTLTM 98 4645
HLA-C*14:02 YYSLLMPILTLTR YYSLLMPILTLTM 8631 191
HLA-A*68:02 LTRALTAESHV LTMALTAESHV 3735 84
HLA-A*11:01 LLMPILTLTR LLMPILTLTM 299 12375
HLA-C*16:01 LMPILTLTR LMPILTLTM 16954 447
HLA-A*02:11 LLMPILTLTR LLMPILTLTM 338 9
HLA-A*02:06 LTRALTAESHV LTMALTAESHV 7086 196
HLA-A*74:01 LLMPILTLTR LLMPILTLTM 260 9398
HLA-C*12:03 LMPILTLTR LMPILTLTM 17467 499
HLA-A*68:02 LTRALTAES LTMALTAES 6326 246
HLA-A*02:02 LTRALTAESHV LTMALTAESHV 8505 377
HLA-A*02:02 LLMPILTLTR LLMPILTLTM 329 16
HLA-A*02:01 LLMPILTLTR LLMPILTLTM 459 23
HLA-A*03:01 LLMPILTLTR LLMPILTLTM 215 3837
HLA-A*02:11 MPILTLTRAL MPILTLTMAL 1458 90
HLA-A*30:01 LTRALTAES LTMALTAES 101 1610
HLA-A*02:01 MPILTLTRAL MPILTLTMAL 2729 192
HLA-A*02:06 LLMPILTLTR LLMPILTLTM 779 57
HLA-A*02:01 LMPILTLTRAL LMPILTLTMAL 1991 163
HLA-A*02:11 LMPILTLTRAL LMPILTLTMAL 966 82
HLA-A*02:11 ILTLTRAL ILTLTMAL 4631 424
HLA-A*02:06 MPILTLTRAL MPILTLTMAL 1654 155
HLA-A*02:02 ILTLTRAL ILTLTMAL 2605 274
HLA-A*02:02 MPILTLTRAL MPILTLTMAL 1213 143
HLA-C*12:03 RALTAESHV MALTAESHV 1624 228
HLA-C*03:03 RALTAESHV MALTAESHV 2222 324
HLA-C*03:04 RALTAESHV MALTAESHV 2222 324
HLA-C*03:02 RALTAESHV MALTAESHV 2963 486
HLA-B*15:03 TRALTAESH TMALTAESH 2376 397
HLA-A*02:11 ILTLTRALT ILTLTMALT 1787 314
HLA-A*02:02 ILTLTRALT ILTLTMALT 1279 230
HLA-A*02:02 SLLMPILTLTR SLLMPILTLTM 2605 489
HLA-A*02:02 TLTRALTAES TLTMALTAES 1805 350
HLA-A*02:01 ILTLTRALTA ILTLTMALTA 831 186
HLA-A*02:02 LMPILTLTRAL LMPILTLTMAL 813 184
HLA-A*02:06 RALTAESHV MALTAESHV 2100 495
HLA-A*30:01 LTLTRALTA LTLTMALTA 320 1316
HLA-B*53:01 MPILTLTRAL MPILTLTMAL 139 34
HLA-A*02:02 ILTLTRALTA ILTLTMALTA 570 141
HLA-A*02:06 LTLTRALTA LTLTMALTA 1358 380
HLA-A*02:11 SLLMPILTLTR SLLMPILTLTM 945 265
HLA-B*35:01 LMPILTLTRAL LMPILTLTMAL 1587 461
HLA-A*02:11 SLLMPILTLTRAL SLLMPILTLTMAL 147 49
HLA-A*02:11 ILTLTRALTA ILTLTMALTA 451 153
HLA-A*02:01 SLLMPILTLTRAL SLLMPILTLTMAL 390 135
HLA-C*16:01 RALTAESHV MALTAESHV 717 249
HLA-B*35:01 MPILTLTRAL MPILTLTMAL 28 10
HLA-B*35:03 MPILTLTRAL MPILTLTMAL 70 27
HLA-A*02:01 LLMPILTLTRAL LLMPILTLTMAL 44 22

P323L

Reference  CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-A*02:01 FPPTSFGPLV FPLTSFGPLV 8999 21
HLA-A*02:02 FPPTSFGPLV FPLTSFGPLV 7237 18
HLA-A*02:11 FPPTSFGPLV FPLTSFGPLV 3405 9
HLA-A*32:01 VLFSTVFPP VLFSTVFPL 5415 27
HLA-A*02:11 LFSTVFPP LFSTVFPL 6706 35
HLA-A*02:11 ANFNVLFSTVFPP ANFNVLFSTVFPL 1827 12
HLA-A*02:11 NFNVLFSTVFPP NFNVLFSTVFPL 1779 13
HLA-A*02:11 NVLFSTVFPP NVLFSTVFPL 739 6
HLA-C*03:03 VLFSTVFPP VLFSTVFPL 28468 265
HLA-C*03:04 VLFSTVFPP VLFSTVFPL 28468 265
HLA-A*02:11 FNVLFSTVFPP FNVLFSTVFPL 413 4
HLA-C*14:02 VLFSTVFPP VLFSTVFPL 21407 220
HLA-A*02:11 FNVLFSTVFPPT FNVLFSTVFPLT 2618 27
HLA-A*02:01 LFSTVFPP LFSTVFPL 7475 81
HLA-C*14:02 LFSTVFPP LFSTVFPL 11979 138
HLA-B*15:03 VLFSTVFPP VLFSTVFPL 3115 36
HLA-A*02:11 VLFSTVFPP VLFSTVFPL 78 1
HLA-C*03:02 VLFSTVFPP VLFSTVFPL 20533 273
HLA-A*02:01 FNVLFSTVFPP FNVLFSTVFPL 656 9
HLA-A*02:01 ANFNVLFSTVFPP ANFNVLFSTVFPL 2569 37
HLA-A*02:11 FNVLFSTVFPPTS FNVLFSTVFPLTS 9448 142
HLA-A*02:02 NVLFSTVFPP NVLFSTVFPL 1088 17
HLA-A*02:11 CANFNVLFSTVFPP CANFNVLFSTVFPL 6143 96
HLA-A*02:02 FNVLFSTVFPP FNVLFSTVFPL 1014 16
HLA-A*68:02 NVLFSTVFPP NVLFSTVFPL 2213 37
HLA-A*02:02 ANFNVLFSTVFPP ANFNVLFSTVFPL 3126 53
HLA-A*02:11 PPTSFGPLV PLTSFGPLV 28329 483
HLA-C*16:01 VLFSTVFPP VLFSTVFPL 24733 432
HLA-C*17:01 VLFSTVFPP VLFSTVFPL 25087 439
HLA-A*02:01 FNVLFSTVFPPT FNVLFSTVFPLT 3765 66
HLA-A*02:02 LFSTVFPP LFSTVFPL 9311 167
HLA-A*02:01 NVLFSTVFPP NVLFSTVFPL 928 17
HLA-A*02:02 NFNVLFSTVFPP NFNVLFSTVFPL 2542 47
HLA-A*02:02 VLFSTVFPP VLFSTVFPL 269 5
HLA-A*02:01 NFNVLFSTVFPP NFNVLFSTVFPL 2286 44
HLA-A*02:06 FPPTSFGPLV FPLTSFGPLV 3379 73
HLA-A*02:01 VLFSTVFPP VLFSTVFPL 179 4
HLA-A*02:06 FNVLFSTVFPP FNVLFSTVFPL 1609 37
HLA-A*02:02 FNVLFSTVFPPT FNVLFSTVFPLT 4116 110
HLA-A*02:11 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6695 180
HLA-A*02:01 FNVLFSTVFPPTS FNVLFSTVFPLTS 11451 311
HLA-A*02:06 VLFSTVFPP VLFSTVFPL 368 10
HLA-A*02:11 ANFNVLFSTVFPPT ANFNVLFSTVFPLT 14639 409
HLA-A*02:01 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 12596 425
HLA-A*68:01 PTSFGPLVR LTSFGPLVR 908 36
HLA-A*02:06 NVLFSTVFPP NVLFSTVFPL 1611 66
HLA-B*15:01 VLFSTVFPP VLFSTVFPL 5731 243
HLA-B*35:01 FPPTSFGPL FPLTSFGPL 304 13
HLA-B*53:01 FPPTSFGPL FPLTSFGPL 3581 154
HLA-C*01:02 FPPTSFGPL FPLTSFGPL 217 4855
HLA-A*02:01 CANFNVLFSTVFPP CANFNVLFSTVFPL 8519 384
HLA-A*02:02 FNVLFSTVFPPTS FNVLFSTVFPLTS 10920 497
HLA-A*02:02 FSTVFPPTSFGPLV FSTVFPLTSFGPLV 6958 322
HLA-A*02:11 VFPPTSFGPLV VFPLTSFGPLV 4242 199
HLA-A*02:02 CANFNVLFSTVFPP CANFNVLFSTVFPL 8183 391
HLA-A*02:11 NFNVLFSTVFPPT NFNVLFSTVFPLT 9111 472
HLA-A*02:06 ANFNVLFSTVFPP ANFNVLFSTVFPL 5191 304
HLA-A*02:06 NFNVLFSTVFPP NFNVLFSTVFPL 4220 274
HLA-A*02:06 FNVLFSTVFPPT FNVLFSTVFPLT 4868 388
HLA-B*35:03 FPPTSFGPL FPLTSFGPL 286 24
HLA-A*03:01 PTSFGPLVRK LTSFGPLVRK 554 47
HLA-A*31:01 PTSFGPLVR LTSFGPLVR 4402 390
HLA-A*11:01 PTSFGPLVR LTSFGPLVR 4068 379
HLA-A*03:02 PTSFGPLVRK LTSFGPLVRK 868 88
HLA-B*07:02 STVFPPTSFGPL STVFPLTSFGPL 777 79
HLA-A*68:01 PTSFGPLVRK LTSFGPLVRK 308 34
HLA-B*07:02 TVFPPTSFGPL TVFPLTSFGPL 1498 171
HLA-A*02:11 STVFPPTSFGPLV STVFPLTSFGPLV 2427 285
HLA-A*02:11 NVLFSTVFPPT NVLFSTVFPLT 1183 139
HLA-A*33:03 PTSFGPLVR LTSFGPLVR 3228 381
HLA-A*26:01 STVFPPTSF STVFPLTSF 786 95
HLA-B*07:02 VFPPTSFGPL VFPLTSFGPL 339 43
HLA-A*02:01 NVLFSTVFPPT NVLFSTVFPLT 2111 290
HLA-B*42:01 FSTVFPPTSFGPL FSTVFPLTSFGPL 1320 185
HLA-B*42:01 STVFPPTSFGPL STVFPLTSFGPL 738 111
HLA-A*02:01 VLFSTVFPPTSF VLFSTVFPLTSF 2225 342
HLA-B*08:01 FPPTSFGPL FPLTSFGPL 973 153
HLA-B*42:01 TVFPPTSFGPL TVFPLTSFGPL 843 142
HLA-A*11:01 PTSFGPLVRK LTSFGPLVRK 123 21
HLA-B*42:01 VFPPTSFGPL VFPLTSFGPL 274 47
HLA-A*02:01 VLFSTVFPPTS VLFSTVFPLTS 708 124
HLA-B*07:02 FSTVFPPTSFGPL FSTVFPLTSFGPL 2537 466
HLA-B*07:02 FPPTSFGPL FPLTSFGPL 42 8
HLA-A*02:11 VLFSTVFPPTSF VLFSTVFPLTSF 1019 195
HLA-A*25:01 STVFPPTSF STVFPLTSF 1533 296
HLA-B*07:02 FPPTSFGPLV FPLTSFGPLV 1131 236
HLA-B*42:01 FPPTSFGPL FPLTSFGPL 21 5
HLA-A*26:01 FSTVFPPTSF FSTVFPLTSF 1667 398
HLA-B*51:01 FPPTSFGPL FPLTSFGPL 1809 433
HLA-A*02:11 VLFSTVFPPTS VLFSTVFPLTS 309 74
HLA-B*42:01 FPPTSFGPLV FPLTSFGPLV 368 89
HLA-A*02:02 VLFSTVFPPTS VLFSTVFPLTS 1210 377
HLA-C*03:02 FPPTSFGPL FPLTSFGPL 960 313
HLA-A*32:01 STVFPPTSF STVFPLTSF 230 86
HLA-B*58:01 FSTVFPPTSF FSTVFPLTSF 88 33
HLA-B*15:01 STVFPPTSF STVFPLTSF 130 49
HLA-A*02:01 VLFSTVFPPT VLFSTVFPLT 61 23
HLA-C*03:03 FPPTSFGPL FPLTSFGPL 375 145
HLA-C*03:04 FPPTSFGPL FPLTSFGPL 375 145
HLA-A*02:02 VLFSTVFPPT VLFSTVFPLT 113 44
HLA-C*16:01 FSTVFPPTS FSTVFPLTS 1127 460
HLA-C*14:02 LFSTVFPPTSF LFSTVFPLTSF 396 950
HLA-C*01:02 VFPPTSFGPL VFPLTSFGPL 429 997
HLA-A*02:02 TVFPPTSFGPLV TVFPLTSFGPLV 789 343
HLA-A*68:02 STVFPPTSFGPLV STVFPLTSFGPLV 169 74
HLA-A*02:11 VLFSTVFPPT VLFSTVFPLT 25 11
HLA-A*03:01 TVFPPTSFGPLVRK TVFPLTSFGPLVRK 92 198
HLA-C*14:02 VFPPTSFGPL VFPLTSFGPL 47 99
HLA-A*23:01 LFSTVFPPTSF LFSTVFPLTSF 370 179